Search Results - "KERR, Kathleen F"

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice by Bitto, Alessandro, Ito, Takashi K, Pineda, Victor V, LeTexier, Nicolas J, Huang, Heather Z, Sutlief, Elissa, Tung, Herman, Vizzini, Nicholas, Chen, Belle, Smith, Kaleb, Meza, Daniel, Yajima, Masanao, Beyer, Richard P, Kerr, Kathleen F, Davis, Daniel J, Gillespie, Catherine H, Snyder, Jessica M, Treuting, Piper M, Kaeberlein, Matt

“…The FDA approved drug rapamycin increases lifespan in rodents and delays age-related dysfunction in rodents and humans. Nevertheless, important questions…”
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Zoom behavior during visual search modulates pupil diameter and reflects adaptive control states by Brunyé, Tad T, Drew, Trafton, Kerr, Kathleen F, Shucard, Hannah, Powell, Kate, Weaver, Donald L, Elmore, Joann G

“…Adaptive gain theory proposes that the dynamic shifts between exploration and exploitation control states are modulated by the locus coeruleus-norepinephrine…”
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Plasma α-synuclein and cognitive impairment in the Parkinson's Associated Risk Syndrome: A pilot study by Wang, Hua, Atik, Anzari, Stewart, Tessandra, Ginghina, Carmen, Aro, Patrick, Kerr, Kathleen F., Seibyl, John, Jennings, Danna, Jensen, Poul Henning, Marek, Kenneth, Shi, Min, Zhang, Jing

“…Plasma total and nervous system derived exosomal (NDE) α-synuclein have been determined as potential biomarkers of Parkinson's disease (PD). To explore the…”
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European Ancestry as a Risk Factor for Atrial Fibrillation in African Americans by MARCUS, Gregory M, ALONSO, Alvaro, DEO, Rajat, SOTOODEHNIA, Nona, AKYLBEKOVA, Meggie, ELLINOR, Patrick T, PALTOO, Dina N, SOLIMAN, Elsayed Z, BENJAMIN, Emelia J, HECKBERT, Susan R, PERALTA, Carmen A, LETTRE, Guillaume, VITTINGHOFF, Eric, LUBITZ, Steven A, FOX, Ervin R, LEVITZKY, Yamini S, MEHRA, Reena, KERR, Kathleen F

“…Despite a higher burden of standard atrial fibrillation (AF) risk factors, African Americans have a lower risk of AF than whites. It is unknown whether the…”
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African Ancestry-Specific Alleles and Kidney Disease Risk in Hispanics/Latinos by Kramer, Holly J, Stilp, Adrienne M, Laurie, Cathy C, Reiner, Alex P, Lash, James, Daviglus, Martha L, Rosas, Sylvia E, Ricardo, Ana C, Tayo, Bamidele O, Flessner, Michael F, Kerr, Kathleen F, Peralta, Carmen, Durazo-Arvizu, Ramon, Conomos, Matt, Thornton, Timothy, Rotter, Jerome, Taylor, Kent D, Cai, Jainwen, Eckfeldt, John, Chen, Han, Papanicolau, George, Franceschini, Nora

“…African ancestry alleles may contribute to CKD among Hispanics/Latinos, but whether associations differ by Hispanic/Latino background remains unknown. We…”
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Predicting individual cases of major adolescent psychiatric conditions with artificial intelligence by de Lacy, Nina, Ramshaw, Michael J., McCauley, Elizabeth, Kerr, Kathleen F., Kaufman, Joan, Nathan Kutz, J.

“…Three-quarters of lifetime mental illness occurs by the age of 24, but relatively little is known about how to robustly identify youth at risk to target…”
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Interleukin-8 and Tumor Necrosis Factor Predict Acute Kidney Injury After Pediatric Cardiac Surgery by de Fontnouvelle, Christina A., Greenberg, Jason H., Thiessen-Philbrook, Heather R., Zappitelli, Michael, Roth, Jeremy, Kerr, Kathleen F., Devarajan, Prasad, Shlipak, Michael, Coca, Steven, Parikh, Chirag R., Edelstein, Charles, Passik, Cary, Swaminathan, Madhav, Koyner, Jay, Garg, Amit, Krawczeski, Catherine

“…Inflammation is a key component of both acute kidney injury (AKI) and response to cardiopulmonary bypass. Because AKI poses risks to children after cardiac…”
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Epigenome-wide analysis of long-term air pollution exposure and DNA methylation in monocytes: results from the Multi-Ethnic Study of Atherosclerosis by Chi, Gloria C., Liu, Yongmei, MacDonald, James W., Reynolds, Lindsay M., Enquobahrie, Daniel A., Fitzpatrick, Annette L., Kerr, Kathleen F., Budoff, Matthew J., Lee, Su-In, Siscovick, David, Kaufman, Joel D.

“…Air pollution might affect atherosclerosis through DNA methylation changes in cells crucial to atherosclerosis, such as monocytes. We conducted an…”
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BioPETsurv: Methodology and open source software to evaluate biomarkers for prognostic enrichment of time-to-event clinical trials by Cheng, Si, Kerr, Kathleen F, Thiessen-Philbrook, Heather, Coca, Steven G, Parikh, Chirag R, Liu, Qin

“…Biomarkers can be used to enrich a clinical trial for patients at higher risk for an outcome, a strategy termed "prognostic enrichment." Methodology is needed…”
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Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans by Schick, Ursula M., Jain, Deepti, Hodonsky, Chani J., Morrison, Jean V., Davis, James P., Brown, Lisa, Sofer, Tamar, Conomos, Matthew P., Schurmann, Claudia, McHugh, Caitlin P., Nelson, Sarah C., Vadlamudi, Swarooparani, Stilp, Adrienne, Plantinga, Anna, Baier, Leslie, Bien, Stephanie A., Gogarten, Stephanie M., Laurie, Cecelia A., Taylor, Kent D., Liu, Yongmei, Auer, Paul L., Franceschini, Nora, Szpiro, Adam, Rice, Ken, Kerr, Kathleen F., Rotter, Jerome I., Hanson, Robert L., Papanicolaou, George, Rich, Stephen S., Loos, Ruth J.F., Browning, Brian L., Browning, Sharon R., Weir, Bruce S., Laurie, Cathy C., Mohlke, Karen L., North, Kari E., Thornton, Timothy A., Reiner, Alex P.

“…Platelets play an essential role in hemostasis and thrombosis. We performed a genome-wide association study of platelet count in 12,491 participants of the…”
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Assessing the Clinical Impact of Risk Prediction Models With Decision Curves: Guidance for Correct Interpretation and Appropriate Use by Kerr, Kathleen F, Brown, Marshall D, Zhu, Kehao, Janes, Holly

“…The decision curve is a graphical summary recently proposed for assessing the potential clinical impact of risk prediction biomarkers or risk models for…”
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Net Reclassification Index Statistics Do Not Help Assess New Risk Models by Kerr, Kathleen F

“…When evaluating a new risk factor for disease (eg, a measurement from imaging studies), many investigators examine its value above and beyond existing…”
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Genome-wide association study of dental caries in the Hispanic Communities Health Study/Study of Latinos (HCHS/SOL) by Morrison, Jean, Laurie, Cathy C, Marazita, Mary L, Sanders, Anne E, Offenbacher, Steven, Salazar, Christian R, Conomos, Matthew P, Thornton, Timothy, Jain, Deepti, Laurie, Cecelia A, Kerr, Kathleen F, Papanicolaou, George, Taylor, Kent, Kaste, Linda M, Beck, James D, Shaffer, John R

“…Dental caries is the most common chronic disease worldwide, and exhibits profound disparities in the USA with racial and ethnic minorities experiencing…”
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Genome‐wide association study of generalized anxiety symptoms in the Hispanic Community Health Study/Study of Latinos by Dunn, Erin C., Sofer, Tamar, Gallo, Linda C., Gogarten, Stephanie M., Kerr, Kathleen F., Chen, Chia‐Yen, Stein, Murray B., Ursano, Robert J., Guo, Xiuqing, Jia, Yucheng, Qi, Qibin, Rotter, Jerome I., Argos, Maria, Cai, Jianwen, Penedo, Frank J., Perreira, Krista, Wassertheil‐Smoller, Sylvia, Smoller, Jordan W.

“…Although generalized anxiety disorder (GAD) is heritable and aggregates in families, no genomic loci associated with GAD have been reported. We aimed to…”
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Models estimating risk of hepatocellular carcinoma in patients with alcohol or NAFLD-related cirrhosis for risk stratification by Ioannou, George N., Green, Pamela, Kerr, Kathleen F., Berry, Kristin

“…[Display omitted] •HCC risk varies dramatically in patients with cirrhosis.•We developed models estimating HCC risk in patients with NAFLD-cirrhosis or…”
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Evaluating biomarkers for prognostic enrichment of clinical trials by Kerr, Kathleen F, Roth, Jeremy, Zhu, Kehao, Thiessen-Philbrook, Heather, Meisner, Allison, Wilson, Francis Perry, Coca, Steven, Parikh, Chirag R

“…Background/Aims: A potential use of biomarkers is to assist in prognostic enrichment of clinical trials, where only patients at relatively higher risk for an…”
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Association of Triglyceride-Related Genetic Variants With Mitral Annular Calcification by Afshar, Mehdi, MD, Luk, Kevin, BSc, Do, Ron, PhD, Dufresne, Line, MSc, Owens, David S., MD, Harris, Tamara B., MD, Peloso, Gina M., PhD, Kerr, Kathleen F., PhD, Wong, Quenna, MSc, Smith, Albert V., PhD, Budoff, Mathew J., MD, Rotter, Jerome I., MD, Cupples, L. Adrienne, PhD, Rich, Stephen S., PhD, Engert, James C., PhD, Gudnason, Vilmundur, MD, PhD, O’Donnell, Christopher J., MD, Post, Wendy S., MD, Thanassoulis, George, MD

“…Abstract Background Mitral annular calcium (MAC), commonly identified by cardiac imaging, is associated with cardiovascular events and predisposes to the…”
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Population structure of Hispanics in the United States: the multi-ethnic study of atherosclerosis by Manichaikul, Ani, Palmas, Walter, Rodriguez, Carlos J, Peralta, Carmen A, Divers, Jasmin, Guo, Xiuqing, Chen, Wei-Min, Wong, Quenna, Williams, Kayleen, Kerr, Kathleen F, Taylor, Kent D, Tsai, Michael Y, Goodarzi, Mark O, Sale, Michèle M, Diez-Roux, Ana V, Rich, Stephen S, Rotter, Jerome I, Mychaleckyj, Josyf C

“…Using ~60,000 SNPs selected for minimal linkage disequilibrium, we perform population structure analysis of 1,374 unrelated Hispanic individuals from the…”
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Genome-wide association study of PR interval in Hispanics/Latinos identifies novel locus at ID2 by Seyerle, Amanda A, Lin, Henry J, Gogarten, Stephanie M, Stilp, Adrienne, Méndez Giráldez, Raul, Soliman, Elsayed, Baldassari, Antoine, Graff, Mariaelisa, Heckbert, Susan, Kerr, Kathleen F, Kooperberg, Charles, Rodriguez, Carlos, Guo, Xiuqing, Yao, Jie, Sotoodehnia, Nona, Taylor, Kent D, Whitsel, Eric A, Rotter, Jerome I, Laurie, Cathy C, Avery, Christy L

“…PR interval (PR) is a heritable electrocardiographic measure of atrial and atrioventricular nodal conduction. Changes in PR duration may be associated with…”
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Genome-wide association studies of the PR interval in African Americans by Smith, J Gustav, Magnani, Jared W, Palmer, Cameron, Meng, Yan A, Soliman, Elsayed Z, Musani, Solomon K, Kerr, Kathleen F, Schnabel, Renate B, Lubitz, Steven A, Sotoodehnia, Nona, Redline, Susan, Pfeufer, Arne, Müller, Martina, Evans, Daniel S, Nalls, Michael A, Liu, Yongmei, Newman, Anne B, Zonderman, Alan B, Evans, Michele K, Deo, Rajat, Ellinor, Patrick T, Paltoo, Dina N, Newton-Cheh, Christopher, Benjamin, Emelia J, Mehra, Reena, Alonso, Alvaro, Heckbert, Susan R, Fox, Ervin R

“…The PR interval on the electrocardiogram reflects atrial and atrioventricular nodal conduction time. The PR interval is heritable, provides important…”
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