Search Results - "KERR, Bradley M"

Metabolism and disposition of lesinurad, a uric acid reabsorption inhibitor, in humans by Shah, Vishal, Yang, Chun, Shen, Zancong, Kerr, Bradley M., Tieu, Kathy, Wilson, David M., Hall, Jesse, Gillen, Michael, Lee, Caroline A.

“…The objectives of this study were to determine the absolute bioavailability of lesinurad and to characterized its disposition in humans. The oral…”
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Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection by HORSMANS, Yves, BERG, Thomas, DESAGER, Jean-Pierre, MUELLER, Tobias, SCHOTT, Eckart, FLETCHER, Simon P, STEFFY, Kevin R, BAUMAN, Lisa A, KERR, Bradley M, AVERETT, Devron R

“…Immune-based therapy is the mainstay treatment for chronic hepatitis C virus (HCV) infection but causes multiple side effects and achieves durable viral…”
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Pharmacokinetic Interactions between Nelfinavir and 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Atorvastatin and Simvastatin by HSYU, Poe-Hirr, SCHULTZ-SMITH, Melissa D, LILLIBRIDGE, James H, LEWIS, Ronald H, KERR, Bradley M

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Pharmacokinetics and Safety of an Antirhinoviral Agent, Ruprintrivir, in Healthy Volunteers by HSYU, Poe-Hirr, PITHAVALA, Yazdi K, GERSTEN, Merril, PENNING, Carol A, KERR, Bradley M

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Discovery of ANA975: An Oral Prodrug of the TLR-7 Agonist Isatoribine by Xiang, Alan X., Webber, Stephen E., Kerr, Bradley M., Rueden, Erik J., Lennox, Joseph R., Haley, Gregory J., Wang, Tingmin, Ng, John S., Herbert, Mark R., Clark, David L., Banh, Virginia N., Li, Wei, Fletcher, Simon P., Steffy, Kevin R., Bartkowski, Darian M., Kirkovsky, Leonid I., Bauman, Lisa A., Averett, Devron R.

“…ANA975, a 5-amino-3-β -D-ribofuranosyl-3H-thiazolo[4,5-d]pyrimidin-2-one derivative, was synthesized in the search of an oral prodrug of isatoribine, a small…”
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A Population Pharmacokinetic Analysis of Nelfinavir Mesylate in Human Immunodeficiency Virus-Infected Patients Enrolled in a Phase III Clinical Trial by JACKSON, K. A, ROSENBAUM, S. E, KERR, B. M, PITHAVALA, Y. K, YUEN, G, DUDLEY, M. N

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Delavirdine: Clinical pharmacokinetics and drug interactions by TRAN, Jonathan Q, GERBER, John G, KERR, Bradley M

“…Delavirdine, a non-nucleoside reverse transcriptase inhibitor (NNRTI), is a potent and specific inhibitor of HIV-1 reverse transcriptase. The approved…”
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Characterization of the Selectivity and Mechanism of Human Cytochrome P450 Inhibition by the Human Immunodeficiency Virus-Protease Inhibitor Nelfinavir Mesylate by LILLIBRIDGE, J. H, BAI HONG LIANG, KERR, B. M, WEBBER, S, QUART, B, SHETTY, B. V, LEE, C. A

“…In vitro studies with human liver microsomes and P450 probe substrates were performed to characterize selectivity and mechanism of cytochrome P450 inhibition…”
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Pharmacokinetic interaction between amprenavir and delavirdine: Evidence of induced clearance by amprenavir by Tran, Jonathan Q., Petersen, Carolyn, Garrett, May, Hee, Brian, Kerr, Bradley M.

“…Objective Our objective was to determine the pharmacokinetic interaction between amprenavir and delavirdine. Methods Healthy volunteers participated in 2…”
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Pharmacokinetic interaction of nelfinavir and methadone in intravenous drug users by Hsyu, Poe-Hirr, Lillibridge, Jim, Daniels, Elaine, Kerr, Bradley M.

“…The effect of nelfinavir 1250 mg twice daily (b.i.d.) on the pharmacokinetics of methadone was determined in 14 HIV‐negative methadone users. Design: The…”
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Stiripentol in atypical absence seizures in children: an open trial by Farwell, J R, Anderson, G D, Kerr, B M, Tor, J A, Levy, R H

“…Stiripentol (STP) was added to the antiepileptic drug (AED) regimen of 10 patients with uncontrolled atypical absence seizures (more than one seizure a day)…”
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Inhibition of human liver microsomal epoxide hydrolase by valproate and valpromide: in vitro/in vivo correlation by Kerr, B M, Rettie, A E, Eddy, A C, Loiseau, P, Guyot, M, Wilensky, A J, Levy, R H

“…On the basis of drug interactions with carbamazepine epoxide, it has been hypothesized that valproic acid and valpromide are inhibitors of epoxide hydrolase,…”
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Measurement of in vivo microsomal epoxide hydrolase activity in white subjects by Kroetz, D L, Kerr, B M, McFarland, L V, Loiseau, P, Wilensky, A J, Levy, R H

“…An impairment or hereditary defect in microsomal epoxide hydrolase is considered a possible risk factor for drug and chemical toxicity. However, nothing is…”
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Gender Differences in College Students’ Representations of Alcohol in Facebook Status Updates by Kerr, Bradley, MS, Yi, Annie, BS, Moreno, Megan, MD, MPH

“…An abstract of a study by Kerr et al exploring the differences in how male and female college students use language to reference alcohol on Facebook is…”
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Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation by Kerr, B M, Thummel, K E, Wurden, C J, Klein, S M, Kroetz, D L, Gonzalez, F J, Levy, R H

“…A number of drugs inhibit the metabolism of carbamazepine catalyzed by cytochrome P450, sometimes resulting in carbamazepine intoxication. However, there is…”
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School’s Out for Summer Scholars: Design of a Research Curriculum for Teens by Gritton, Jesse C., MPH, Kerr, Bradley, MS, Moreno, Megan, MD, MPH

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“People Care”: Recommendations from Native Youth to Address Concerning Mental Health Displays on Social Media by Gritton, Jesse C., MPH, Rushing, Stephanie Craig, PhD, Stephens, David, RN, Kerr, Bradley, MS, Moreno, Megan, MD, MPH

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Flow cytometric assay of modulation of P-glycoprotein function in whole blood by the multidrug resistance inhibitor GG918 by WITHERSPOON, S. M, EMERSON, D. L, KERR, B. M, LLOYD, T. L, DALTON, W. S, WISSEL, P. S

“…We sought to develop an assay for measuring the inhibition of P-glycoprotein (Pgp) function in whole blood as an indicator of in vivo drug activity. Since the…”
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Carbamazepine dose requirements during stiripentol therapy: influence of cytochrome P-450 inhibition by stiripentol by Kerr, B M, Martinez-Lage, J M, Viteri, C, Tor, J, Eddy, A C, Levy, R H

“…The inhibitory effect of stiripentol (STP) on disposition of carbamazepine (CBZ) and carbamazepine-10,11-epoxide (CBZE) was quantitated to establish CBZ dosage…”
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Pharmacokinetics of old, new, and yet-to-be-discovered antiepileptic drugs by Levy, R H, Kerr, B M

“…The pharmacokinetics of antiepileptic drugs have been investigated extensively during the last two decades. It has become evident that the therapeutic…”
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