Search Results - "KERN, Scott"

Why Your New Cancer Biomarker May Never Work: Recurrent Patterns and Remarkable Diversity in Biomarker Failures by KERN, Scott E

“…Less than 1% of published cancer biomarkers actually enter clinical practice. Although best practices for biomarker development are published, optimistic…”
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Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis by DeNicola, Gina M., Karreth, Florian A., Humpton, Timothy J., Gopinathan, Aarthi, Wei, Cong, Frese, Kristopher, Mangal, Dipti, Yu, Kenneth H., Yeo, Charles J., Calhoun, Eric S., Scrimieri, Francesca, Winter, Jordan M., Hruban, Ralph H., Iacobuzio-Donahue, Christine, Kern, Scott E., Blair, Ian A., Tuveson, David A.

“…Radical role reversal Reactive oxygen species (ROS), such as free radicals, are mutagenic and might therefore be expected to promote tumorigenesis. However,…”
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Analytic model for academic research productivity having factors, interactions and implications by Kern, Scott

“…Financial support is dear in academia and will tighten further. How can the research mission be accomplished within new restraints? A model is presented for…”
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The genetics of ductal adenocarcinoma of the pancreas in the year 2020: dramatic progress, but far to go by Thompson, Elizabeth D., Roberts, Nicholas J., Wood, Laura D., Eshleman, James R., Goggins, Michael G., Kern, Scott E., Klein, Alison P., Hruban, Ralph H.

“…The publication of the “Pan-Cancer Atlas” by the Pan-Cancer Analysis of Whole Genomes Consortium, a partnership formed by The Cancer Genome Atlas (TCGA) and…”
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The fuzzy math of solid tumor stem cells : A perspective by KERN, Scott E, SHIBATA, Darryl

“…Apparently effective therapeutic agents very often fail to cure cancer patients. It is therefore attractive to wonder whether a specific resistant cell subset…”
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Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses by Jones, Siân, Zhang, Xiaosong, Parsons, D. Williams, Lin, Jimmy Cheng-Ho, Leary, Rebecca J, Angenendt, Philipp, Mankoo, Parminder, Carter, Hannah, Kamiyama, Hirohiko, Jimeno, Antonio, Hong, Seung-Mo, Fu, Baojin, Lin, Ming-Tseh, Calhoun, Eric S, Kamiyama, Mihoko, Walter, Kimberly, Nikolskaya, Tatiana, Nikolsky, Yuri, Hartigan, James, Smith, Douglas R, Hidalgo, Manuel, Leach, Steven D, Klein, Alison P, Jaffee, Elizabeth M, Goggins, Michael, Maitra, Anirban, Iacobuzio-Donahue, Christine, Eshleman, James R, Kern, Scott E, Hruban, Ralph H, Karchin, Rachel, Papadopoulos, Nickolas, Parmigiani, Giovanni, Vogelstein, Bert, Velculescu, Victor E, Kinzler, Kenneth W

“…There are currently few therapeutic options for patients with pancreatic cancer, and new insights into the pathogenesis of this lethal disease are urgently…”
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Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene by Jones, Siân, Hruban, Ralph H, Kamiyama, Mihoko, Borges, Michael, Zhang, Xiaosong, Parsons, D. Williams, Lin, Jimmy Cheng-Ho, Palmisano, Emily, Brune, Kieran, Jaffee, Elizabeth M, Iacobuzio-Donahue, Christine A, Maitra, Anirban, Parmigiani, Giovanni, Kern, Scott E, Velculescu, Victor E, Kinzler, Kenneth W, Vogelstein, Bert, Eshleman, James R, Goggins, Michael, Klein, Alison P

“…Through complete sequencing of the protein-coding genes in a patient with familial pancreatic cancer, we identified a germline, truncating mutation in PALB2…”
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Sodium boric acid: a Tris-free, cooler conductive medium for DNA electrophoresis by Brody, Jonathan R, Kern, Scott E

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Precursors to Pancreatic Cancer by Hruban, Ralph H., MD, Maitra, Anirban, MBBS, Kern, Scott E., MD, Goggins, Michael, MD

“…Infiltrating ductal adenocarcinoma of the pancreas is believed to arise from morphologically distinct noninvasive precursor lesions. These precursors include…”
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Pancreatic cancer pathology viewed in the light of evolution by Noë, Michaël, Hong, Seung-Mo, Wood, Laura D., Thompson, Elizabeth D., Roberts, Nicholas J., Goggins, Michael G., Klein, Alison P., Eshleman, James R., Kern, Scott E., Hruban, Ralph H.

“…One way to understand ductal adenocarcinoma of the pancreas (pancreatic cancer) is to view it as unimaginably large numbers of evolving living organisms…”
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complexity of pancreatic ductal cancers and multidimensional strategies for therapeutic targeting by Kern, Scott E, Shi, Chanjuan, Hruban, Ralph H

“…The directions of differentiation and the molecular features of ductal pancreatic cancer have by now been explored in reasonable detail. Already, diagnoses and…”
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Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer by BRUNE, Kieran, ABE, Tadayoshi, KERN, Scott E, GOGGINS, Michael, HRUBAN, Ralph H, CANTO, Marcia, O'MALLEY, Lauren, KLEIN, Alison P, MAITRA, Anirban, VOLKAN ADSAY, N, FISHMAN, Elliot K, CAMERON, John L, YEO, Charles J

“…We screened 116 patients with a strong family history of pancreatic cancer using a combination of endoscopic ultrasound and computed tomography. Ten of these…”
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Long-Term Treatment Patterns Among Patients With Psoriasis Treated With Ixekizumab or Adalimumab: A Real-World Study by Blauvelt, Andrew, Shi, Nianwen, Murage, Mwangi, Ridenour, Terri, Lew, Carolyn, Somani, Najwa, Zhu, Baojin, Zimmerman, Nicole, Kern, Scott, Burge, Russel

“…There is a paucity of long-term real-world evidence comparing the effectiveness of ixekizumab (IXE) and adalimumab (ADA). We compared real-world treatment…”
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Treatment patterns and health care costs among patients with psoriatic arthritis treated with biologic or targeted synthetic disease-modifying antirheumatic drugs by Murage, Mwangi J, Princic, Nicole, Park, Julie, Malatestinic, William N, Zhu, Baojin, Atiya, Bilal, Kern, Scott A, Stenger, Keri B, Sprabery, Aubrey Trevelin, Ogdie, Alexis

“…Biologic and targeted synthetic disease-modifying antirheumatic drug (tsDMARD) therapies are used in management of psoriatic arthritis (PsA). Although previous…”
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A Syngeneic Variance Library for Functional Annotation of Human Variation : Application to BRCA2 by HUCL, Tomas, RAGO, Carlo, GALLMEIER, Eike, BRODY, Jonathan R, GOROSPE, Myriam, KERN, Scott E

“…The enormous scope of natural human genetic variation is now becoming defined. To accurately annotate these variants, and to identify those with clinical…”
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Absence of E-Cadherin Expression Distinguishes Noncohesive from Cohesive Pancreatic Cancer by Winter, Jordan M, Ting, Angela H, Vilardell, Felip, Gallmeier, Eike, Baylin, Steve B, Hruban, Ralph H, Kern, Scott E, Iacobuzio-Donahue, Christine A

“…Purpose: The role of E-cadherin in carcinogenesis is of great interest, but few studies have examined its relevance to pancreatic carcinoma. Experimental…”
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Improved DNA electrophoresis in conditions favoring polyborates and lewis acid complexation by Singhal, Hari, Ren, Yunzhao R, Kern, Scott E

“…Spatial compression among the longer DNA fragments occurs during DNA electrophoresis in agarose and non-agarose gels when using certain ions in the conductive…”
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Genetic Progression in the Pancreatic Ducts by Hruban, Ralph H., Wilentz, Robb E., Kern, Scott E.

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Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds by KLEIN, Alison P, BRUNE, Kieran A, HRUBAN, Ralph H, PETERSEN, Gloria M, GOGGINS, Michael, TERSMETTE, Anne C, OFFERHAUS, G. Johan A, GRIFFIN, Constance, CAMERON, John L, YEA, Charles J, KERN, Scott

“…Individuals with a family history of pancreatic cancer have an increased risk of developing pancreatic cancer. Quantification of this risk provides a rational…”
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Exploration of Global Gene Expression Patterns in Pancreatic Adenocarcinoma Using cDNA Microarrays by Iacobuzio-Donahue, Christine A., Maitra, Anirban, Olsen, Mari, Lowe, Anson W., Van Heek, N. Tjarda, Rosty, Christophe, Walter, Kim, Sato, Norihiro, Parker, Antony, Ashfaq, Raheela, Jaffee, Elizabeth, Ryu, Byungwoo, Jones, Jessa, Eshleman, James R., Yeo, Charles J., Cameron, John L., Kern, Scott E., Hruban, Ralph H., Brown, Patrick O., Goggins, Michael

“…Pancreatic cancer is the fifth leading cause of cancer death in the United States. We used cDNA microarrays to analyze global gene expression patterns in 14…”
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