Search Results - "KERN, Earl R"

Virucidal activity of polysaccharide extracts from four algal species against herpes simplex virus by Harden, Emma A., Falshaw, Ruth, Carnachan, Susan M., Kern, Earl R., Prichard, Mark N.

“…Herpes simplex virus types 1 and 2 (HSV-1, HSV-2) infections are common, but can cause serious infections in neonates and the immunocompromised. Drugs…”
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The search for new therapies for human cytomegalovirus infections by Prichard, Mark N., Kern, Earl R.

“…Ganciclovir (GCV), the therapy of choice for human cytomegalovirus (CMV) infections and foscarnet, a drug used to treat GCV-resistant CMV infections was…”
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Efficacy of CMX001 against Herpes Simplex Virus Infections in Mice and Correlations with Drug Distribution Studies by Quenelle, Debra C., Lampert, Bernhardt, Collins, Deborah J., Rice, Terri L., Painter, George R., Kern, Earl R.

“…CMX001, an orally active lipid conjugate of cidofovir, is 50 times more active in vitro against herpes simplex virus (HSV) replication than acyclovir or…”
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Synergistic Efficacy of the Combination of ST-246 with CMX001 against Orthopoxviruses by QUENELLE, Debra C, PRICHARD, Mark N, KEITH, Kathy A, HRUBY, Dennis E, JORDAN, Robert, PAINTER, George R, ROBERTSON, Alice, KERN, Earl R

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CMX001 Potentiates the Efficacy of Acyclovir in Herpes Simplex Virus Infections by Prichard, Mark N, Kern, Earl R, Hartline, Caroll B, Lanier, E. Randall, Quenelle, Debra C

“…Although acyclovir (ACV) has proven to be of value in the therapy of certain herpes simplex virus (HSV) infections, there is a need for more effective…”
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Efficacy of Delayed Treatment with ST-246 Given Orally against Systemic Orthopoxvirus Infections in Mice by QUENELLE, Debra C, BULLER, R. M. L, PARKER, Scott, KEITH, Kathy A, HRUBY, Dennis E, JORDAN, Robert, KERN, Earl R

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Preclinical Evaluation of a Genetically Engineered Herpes Simplex Virus Expressing Interleukin-12 by MARKERT, James M, CODY, James J, CARTNER, Samuel C, YANCEY GILLESPIE, G, WHITLEY, Richard J, PARKER, Jacqueline N, COLEMAN, Jennifer M, PRICE, Kathleen H, KERN, Earl R, QUENELLE, Debra C, LAKEMAN, Alfred D, SCHOEB, Trenton R, PALMER, Cheryl A

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Pivotal role of animal models in the development of new therapies for cytomegalovirus infections by Kern, Earl R.

“…Since human cytomegalovirus (CMV) is extremely species specific and does not replicate in experimental animal tissues, animal models for the evaluation of…”
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Human Cytomegalovirus UL97 Kinase Activity Is Required for the Hyperphosphorylation of Retinoblastoma Protein and Inhibits the Formation of Nuclear Aggresomes by PRICHARD, Mark N, SZTUL, Elizabeth, KERN, Earl R, DAILY, Shannon L, PERRY, Amie L, FREDERICK, Samuel L, GILL, Rachel B, HARTLINE, Caroll B, STREBLOW, Daniel N, VARNUM, Susan M, SMITH, Richard D

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Ether Lipid-Ester Prodrugs of Acyclic Nucleoside Phosphonates: Activity against Adenovirus Replication In Vitro by Hartline, Caroll B., Gustin, Kortney M., Wan, William B., Ciesla, Stephanie L., Beadle, James R., Hostetler, Karl Y., Kern, Earl R

“…The acyclic nucleoside phosphonate cidofovir (CDV) and its closely related analogue (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)-adenine ([S]-HPMPA) have been…”
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Human Cytomegalovirus UL97 Kinase Is Required for the Normal Intranuclear Distribution of pp65 and Virion Morphogenesis by PRICHARD, Mark N, BRITT, William J, DAILY, Shannon L, HARTLINE, Caroll B, KERN, Earl R

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Cyclopropavir Inhibits the Normal Function of the Human Cytomegalovirus UL97 Kinase by James, Scott H, Hartline, Caroll B, Harden, Emma A, Driebe, Elizabeth M, Schupp, James M, Engelthaler, David M, Keim, Paul S, Bowlin, Terry L, Kern, Earl R, Prichard, Mark N

“…Cyclopropavir (CPV) is active against human cytomegalovirus (CMV), as well as both variants of human herpesvirus 6 and human herpesvirus 8. The mechanism of…”
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Enhanced Inhibition of Orthopoxvirus Replication In Vitro by Alkoxyalkyl Esters of Cidofovir and Cyclic Cidofovir by KERN, Earl R, HARTLINE, Caroll, HARDEN, Emma, KEITH, Kathy, RODRIGUEZ, Natalie, BEADLE, James R, HOSTETLER, Karl Y

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Oral Treatment of Cowpox and Vaccinia Virus Infections in Mice with Ether Lipid Esters of Cidofovir by Quenelle, Debra C, Collins, Deborah J, Wan, W Brad, Beadle, James R, Hostetler, Karl Y, Kern, Earl R

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Comparative Activities of Lipid Esters of Cidofovir and Cyclic Cidofovir against Replication of Herpesviruses In Vitro by WILLIAMS-AZIZ, Stephanie L, HARTLINE, Caroll B, HARDEN, Emma A, DAILY, Shannon L, PRICHARD, Mark N, KUSHNER, Nicole L, BEADLE, James R, WAN, W. Brad, HOSTETLER, Karl Y, KERN, Earl R

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Alkoxyalkyl Esters of Cidofovir and Cyclic Cidofovir Exhibit Multiple-Log Enhancement of Antiviral Activity against Cytomegalovirus and Herpesvirus Replication In Vitro by BEADLE, James R, HARTLINE, Caroll, ALDERN, Kathy A, RODRIGUEZ, Natalie, HARDEN, Emma, KERN, Earl R, HOSTETLER, Karl Y

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In vitro activity of potential anti-poxvirus agents by Kern, Earl R

“…The potential use of variola or another orthopoxvirus such as monkeypox as a weapon of bioterrorism has stimulated efforts to develop new drugs for treatment…”
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Inhibition of Herpesvirus Replication by 5-Substituted 4′-Thiopyrimidine Nucleosides by PRICHARD, Mark N, QUENELLE, Debra C, SECRIST, John A, KERN, Earl R, HARTLINE, Caroll B, HARDEN, Emma A, JEFFERSON, Geraldine, FREDERICK, Samuel L, DAILY, Shannon L, WHITLEY, Richard J, TIWARI, Kamal N, MADDRY, Joseph A

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Benzimidazole Analogs Inhibit Human Herpesvirus 6 by PRICHARD, Mark N, FREDERICK, Samuel L, DAILY, Shannon, BORYSKO, Katherine Z, TOWNSEND, Leroy B, DRACH, John C, KERN, Earl R

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Amphipathic DNA Polymers Exhibit Antiherpetic Activity In Vitro and In Vivo by BERNSTEIN, David I, GOYETTE, Nathalie, CARDIN, Rhonda, KERN, Earl R, BOIVIN, Guy, IRELAND, James, JUTEAU, Jean-Marc, VAILLANT, Andrew

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