Search Results - "KEREN, Gad"

Potential roles in cardiac physiology and pathology of the cation channel TRPV2 expressed in cardiac cells and cardiac macrophages: a mini-review by Entin-Meer, Michal, Keren, Gad

“…TRPV2 is a well-conserved channel protein expressed in almost all tissues. Cardiomyocyte TRPV2 is expressed in the intercalated disks of the cardiac…”
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Tricuspid regurgitation and long-term clinical outcomes by Chorin, Ehud, Rozenbaum, Zach, Topilsky, Yan, Konigstein, Maayan, Ziv-Baran, Tomer, Richert, Eyal, Keren, Gad, Banai, Shmuel

“…Abstract Aims Tricuspid regurgitation (TR) is a frequent echocardiographic finding; however, its effect on outcome is unclear. The objectives of current study…”
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Neutrophil/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients undergoing angiography by Arbel, Yaron, Finkelstein, Ariel, Halkin, Amir, Birati, Edo Y, Revivo, Miri, Zuzut, Meital, Shevach, Ayala, Berliner, Shlomo, Herz, Itzhak, Keren, Gad, Banai, Shmuel

“…Abstract Background White blood cell count is an independent predictor of cardiovascular events and mortality. Neutrophil/lymphocyte ratio (NLR) is a biomarker…”
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Impact of Right Ventricular Dysfunction and Tricuspid Regurgitation on Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement by Schwartz, Lorin Arie, MD, Rozenbaum, Zach, MD, Ghantous, Ehab, MD, Kramarz, Judith, MD, Biner, Simon, MD, Ghermezi, Michael, MD, Shimiaie, Jason, MD, Finkelstein, Ariel, MD, Banai, Shmuel, MD, Aviram, Galit, MD, Ingbir, Meirav, MD, Keren, Gad, MD, Topilsky, Yan, MD

“…Background Right ventricular (RV) dysfunction and tricuspid regurgitation (TR) may coexist with aortic stenosis. The aim of this study was to assess the…”
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Usefulness of Global Longitudinal Strain for Early Identification of Subclinical Left Ventricular Dysfunction in Patients With Active Cancer by Laufer-Perl, Michal, Derakhshesh, Matthew, Milwidsky, Assi, Mor, Liat, Ravid, Dor, Amrami, Nadav, Sherez, Jack, Keren, Gad, Topilsky, Yan, Arbel, Yaron

“…Cardiotoxicity from cancer therapy has become a leading cause of morbidity and mortality in cancer survivors. The most commonly used definition is cancer…”
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Prognostic Implications of Mid-Range Left Ventricular Ejection Fraction on Patients Presenting With ST- Segment Elevation Myocardial Infarction by Margolis, Gilad, MD, Khoury, Shafik, MD, Ben-Shoshan, Jeremy, MD, PhD, Letourneau-Shesaf, Sevan, MD, Flint, Nir, MD, Keren, Gad, MD, Shacham, Yacov, MD

“…Abstract The new European Society of Cardiology guidelines reclassified heart failure according to left ventricular ejection fraction (LVEF), recognizing…”
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Comparison of the Edwards SAPIEN S3 Versus Medtronic Evolut-R Devices for Transcatheter Aortic Valve Implantation by Ben-Shoshan, Jeremy, MD, PhD, Konigstein, Maayan, MD, Zahler, David, MD, Margolis, Gilad, MD, Chorin, Ehud, MD, PhD, Steinvil, Arie, MD, Arbel, Yaron, MD, Aviram, Galit, MD, Granot, Yoav, MD, Barkagan, Michael, MD, Keren, Gad, MD, Halkin, Amir, MD, Banai, Shmuel, MD, Finkelstein, Ariel, MD

“…New generation of the most widely used devices for transcatheter aortic valve implantation have been recently introduced into practice. We compare the…”
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Altered status of CD4(+)CD25(+) regulatory T cells in patients with acute coronary syndromes by Mor, Adi, Luboshits, Galia, Planer, David, Keren, Gad, George, Jacob

“…Considerable evidence supports the role of innate and adaptive immunity in the progression and destabilization of the atheromatous plaque. Naturally occurring…”
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Relation of lowering door-to-balloon time and mortality in ST segment elevation myocardial infarction patients undergoing percutaneous coronary intervention by Zahler, David, Lee-Rozenfeld, Keren, Ravid, Dor, Rozenbaum, Zach, Banai, Shmuel, Keren, Gad, Shacham, Yacov

“…Background Current guidelines for the treatment of ST-segment elevation myocardial infarction (STEMI) recommend a door-to-balloon time (DBT) of ≤ 90 min for…”
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Kynurenic acid, a key L-tryptophan-derived metabolite, protects the heart from an ischemic damage by Bigelman, Einat, Pasmanik-Chor, Metsada, Dassa, Bareket, Itkin, Maxim, Malitsky, Sergey, Dorot, Orly, Pichinuk, Edward, Kleinberg, Yuval, Keren, Gad, Entin-Meer, Michal

“…Background Renal injury induces major changes in plasma and cardiac metabolites. Using a small- animal in vivo model, we sought to identify a key metabolite…”
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Comparison of 30-Day and Long-Term Outcomes and Hospital Complications Among Patients Aged <75 Versus ≥75 Years With ST-Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention by Topaz, Guy, Finkelstein, Ariel, Flint, Nir, Shacham, Yacov, Banai, Shmuel, Steinvil, Arie, Arbel, Yaron, Keren, Gad, Yankelson, Lior

“…Our aim was to evaluate the mortality rate and occurrence of complications in patients aged <75 versus ≥75 years with ST-elevation myocardial infarction…”
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TRPV2 knockout mice demonstrate an improved cardiac performance following myocardial infarction due to attenuated activity of peri-infarct macrophages by Entin-Meer, Michal, Cohen, Lena, Hertzberg-Bigelman, Einat, Levy, Ran, Ben-Shoshan, Jeremy, Keren, Gad

“…We have recently shown that the expression of the transient receptor potential vanilloid 2 channel, TRPV2, is upregulated in the peri-infarct zone 3-5 days…”
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Relation of Clinical Presentation of Aortic Stenosis and Survival Following Transcatheter Aortic Valve Implantation by Ben-Shoshan, Jeremy, Zahler, David, Margolis, Gilad, Arbel, Yaron, Konigstein, Maayan, Chorin, Ehud, Steinvil, Arie, Keren, Gad, Banai, Shmuel, Finkelstein, Ariel

“…Although the natural history of aortic stenosis (AS) depends on the severity of symptoms, the prognostic significance of AS clinical progression in patients…”
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Cardiac remodeling secondary to chronic volume overload is attenuated by a novel MMP9/2 blocking antibody by Cohen, Lena, Sagi, Irit, Bigelman, Einat, Solomonov, Inna, Aloshin, Anna, Ben-Shoshan, Jeremy, Rozenbaum, Zach, Keren, Gad, Entin-Meer, Michal

“…Monoclonal antibody derivatives are promising drugs for the treatment of various diseases due to their high matrix metalloproteinases (MMP) active site…”
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Pathological presentation of cardiac mitochondria in a rat model for chronic kidney disease by Bigelman, Einat, Cohen, Lena, Aharon-Hananel, Genya, Levy, Ran, Rozenbaum, Zach, Saada, Ann, Keren, Gad, Entin-Meer, Michal

“…Mitochondria hold crucial importance in organs with high energy demand especially the heart. We investigated whether chronic kidney disease (CKD), which…”
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Experimental myocardial infarction induces altered regulatory T cell hemostasis, and adoptive transfer attenuates subsequent remodeling by Sharir, Rinat, Semo, Jonathan, Shimoni, Sara, Ben-Mordechai, Tamar, Landa-Rouben, Natalie, Maysel-Auslender, Sofia, Shaish, Aviv, Entin-Meer, Michal, Keren, Gad, George, Jacob

“…Ischemic cardiac damage is associated with upregulation of cardiac pro-inflammatory cytokines, as well as invasion of lymphocytes into the heart. Regulatory T…”
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Red blood cell distribution width as a prognostic factor in patients undergoing transcatheter aortic valve implantation by Szekely, Yishay, Finkelstein, Ariel, Bazan, Samuel, Halkin, Amir, Abbas Younis, Maria, Erez, Johnathan, Keren, Gad, Banai, Shmuel, Arbel, Yaron

“…•Transcatheter aortic valve implantation (TAVI) patients with elevated red blood cell distribution width (RDW) had a twofold higher 1-year mortality rate.•TAVI…”
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Long-term renal outcomes and mortality following renal injury among myocardial infarction patients treated by primary percutaneous intervention by Kofman, Natalia, Margolis, Gilad, Gal-Oz, Amir, Letourneau-Shesaf, Sevan, Keren, Gad, Rozenbaum, Zach, Shacham, Yacov

“…OBJECTIVESLimited data are present on persistent renal impairment following acute kidney injury (AKI) among ST elevation myocardial infarction (STEMI) patients…”
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Decline in serum cholinesterase activities predicts 2-year major adverse cardiac events by Arbel, Yaron, Shenhar-Tsarfaty, Shani, Waiskopf, Nir, Finkelstein, Ariel, Halkin, Amir, Revivo, Miri, Berliner, Shlomo, Herz, Itzhak, Shapira, Itzhak, Keren, Gad, Soreq, Hermona, Banai, Shmuel

“…Parasympathetic activity influences long-term outcome in patients with cardiovascular disease, but the underlying mechanism(s) linking parasympathetic activity…”
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The transient receptor potential vanilloid 2 cation channel is abundant in macrophages accumulating at the peri-infarct zone and may enhance their migration capacity towards injured cardiomyocytes following myocardial infarction by Entin-Meer, Michal, Levy, Ran, Goryainov, Pavel, Landa, Natalie, Barshack, Iris, Avivi, Camila, Semo, Jonathan, Keren, Gad

“…A novel family of transient receptor potential (TRP) channels, that may hold a role in calcium homeostasis, has recently been described. By employing a…”
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