Search Results - "KERBEL, Robert"

Tumor Angiogenesis by Kerbel, Robert S

“…The dependency of the growth of tumors on blood vessels, once considered a doubtful proposition, has become a major avenue of research and drug development…”
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Improving immunotherapy outcomes with anti-angiogenic treatments and vice versa by Khan, Kabir A., Kerbel, Robert S.

“…Key Points Proteins with major roles in angiogenesis can also have direct or indirect effects on components of the immune system, most often resulting in…”
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Pharmacokinetics of metronomic chemotherapy: a neglected but crucial aspect by Bocci, Guido, Kerbel, Robert S.

“…Key Points Metronomic chemotherapy is the frequent, regular administration of drug doses designed to maintain low, but active, concentrations of…”
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Antiangiogenic therapy in oncology: current status and future directions by Jayson, Gordon C, Prof, Kerbel, Robert, Prof, Ellis, Lee M, Prof, Harris, Adrian L, Prof

“…Summary Angiogenesis, the formation of new blood vessels from pre-existing vessels, has been validated as a target in several tumour types through randomised…”
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Antiangiogenic Therapy: A Universal Chemosensitization Strategy for Cancer? by Kerbel, Robert S

“…For more than 50 years, a major goal of research in cancer therapeutics has been to develop universally effective agents that render cancer cells more…”
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Vessel co-option in cancer by Kuczynski, Elizabeth A., Vermeulen, Peter B., Pezzella, Francesco, Kerbel, Robert S., Reynolds, Andrew R.

“…All solid tumours require a vascular supply in order to progress. Although the ability to induce angiogenesis (new blood vessel growth) has long been regarded…”
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The Potential Clinical Promise of ‘Multimodality’ Metronomic Chemotherapy Revealed by Preclinical Studies of Metastatic Disease by Kerbel, Robert S, Shaked, Yuval

“…Abstract We present a rationale for further clinical development and assessment of metronomic chemotherapy on the basis of unexpected results obtained in…”
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Adjuvant metronomic chemotherapy for locoregionally advanced nasopharyngeal carcinoma by Kerbel, Robert S, Andre, Nicolas

“…[...]previous phase 2 studies in patients with advanced nasopharyngeal carcinoma indicated potential activity and clinical benefit,10,11 and fourth, there is…”
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Mouse models of advanced spontaneous metastasis for experimental therapeutics by Francia, Giulio, Kerbel, Robert S, Cruz-Munoz, William, Man, Shan, Xu, Ping

“…The successful systemic therapy of advanced visceral metastatic disease remains a daunting challenge, but this therapeutic circumstance has rarely been…”
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A Decade of Experience in Developing Preclinical Models of Advanced- or Early-Stage Spontaneous Metastasis to Study Antiangiogenic Drugs, Metronomic Chemotherapy, and the Tumor Microenvironment by Kerbel, Robert S

“…The clinical circumstance of treating spontaneous metastatic disease, after resection of primary tumors, whether advanced/overt or microscopic in nature, is…”
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Angiogenesis as a therapeutic target by Ferrara, Napoleone, Kerbel, Robert S

“…Inhibiting angiogenesis is a promising strategy for treatment of cancer and several other disorders, including age-related macular degeneration. Major progress…”
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Antiangiogenic therapy: impact on invasion, disease progression, and metastasis by Ebos, John M. L, Kerbel, Robert S

“…The progression-free survival benefits from approved antiangiogenic drugs are modest and are frequently not accompanied by overall survival improvements…”
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Drug rechallenge and treatment beyond progression—implications for drug resistance by Kuczynski, Elizabeth A., Sargent, Daniel J., Grothey, Axel, Kerbel, Robert S.

“…Key Points Reuse of the same anticancer therapy following disease progression is often considered to be futile owing to drug resistance; however, many cancers…”
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On coalescent angiogenesis and the remarkable flexibility of blood vessels by Pezzella, Francesco, Kerbel, Robert S.

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Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR by Al-Nedawi, Khalid, Meehan, Brian, Kerbel, Robert S, Allison, Anthony C, Rak, Janusz

“…Activated EGF receptor (EGFR) plays an oncogenic role in several human malignancies. Although the intracellular effects of EGFR are well studied, its ability…”
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Non-angiogenic tumours and their influence on cancer biology by Donnem, Tom, Reynolds, Andrew R., Kuczynski, Elizabeth A., Gatter, Kevin, Vermeulen, Peter B., Kerbel, Robert S., Harris, Adrian L., Pezzella, Francesco

“…In this Opinion article, Donnem et al . outline the evidence for non-angiogenic tumours, which use pre-existing blood vessels to support tumour growth, and…”
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miR-30b/30d Regulation of GalNAc Transferases Enhances Invasion and Immunosuppression during Metastasis by Gaziel-Sovran, Avital, Segura, Miguel F., Di Micco, Raffaella, Collins, Mary K., Hanniford, Douglas, Vega-Saenz de Miera, Eleazar, Rakus, John F., Dankert, John F., Shang, Shulian, Kerbel, Robert S., Bhardwaj, Nina, Shao, Yongzhao, Darvishian, Farbod, Zavadil, Jiri, Erlebacher, Adrian, Mahal, Lara K., Osman, Iman, Hernando, Eva

“…To metastasize, a tumor cell must acquire abilities such as the capacity to colonize new tissue and evade immune surveillance. Recent evidence suggests that…”
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The multifaceted circulating endothelial cell in cancer: towards marker and target identification by Bertolini, Francesco, Shaked, Yuval, Mancuso, Patrizia, Kerbel, Robert S

“…Increases in the number of circulating endothelial cells (CECs) and progenitors (CEPs) have been reported in various pathological conditions including cancer…”
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Antiangiogenic–immune-checkpoint inhibitor combinations: lessons from phase III clinical trials by Kuo, Hung-Yang, Khan, Kabir A., Kerbel, Robert S.

“…Antiangiogenic agents, generally antibodies or tyrosine-kinase inhibitors that target the VEGF–VEGFR pathway, are currently among the few combination partners…”
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Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis by Ebos, John M.L., Lee, Christina R., Cruz-Munoz, William, Bjarnason, Georg A., Christensen, James G., Kerbel, Robert S.

“…Herein we report that the VEGFR/PDGFR kinase inhibitor sunitinib/SU11248 can accelerate metastatic tumor growth and decrease overall survival in mice receiving…”
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