Search Results - "KENSLER, Thomas W"

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis by Yamamoto, Masayuki, Kensler, Thomas W, Motohashi, Hozumi

“…The Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) system forms the major node of cellular and organismal defense against oxidative…”
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Broccoli or Sulforaphane: Is It the Source or Dose That Matters? by Yagishita, Yoko, Fahey, Jed W, Dinkova-Kostova, Albena T, Kensler, Thomas W

“…There is robust epidemiological evidence for the beneficial effects of broccoli consumption on health, many of them clearly mediated by the isothiocyanate…”
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Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway by KENSLER, Thomas W, WAKABAYASHI, Nobunao, BISWAL, Shyam

“…Keap1-Nrf2-ARE signaling plays a significant role in protecting cells from endogenous and exogenous stresses. The development of Nrf2 knockout mice has…”
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Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases by Cuadrado, Antonio, Rojo, Ana I., Wells, Geoffrey, Hayes, John D., Cousin, Sharon P., Rumsey, William L., Attucks, Otis C., Franklin, Stephen, Levonen, Anna-Liisa, Kensler, Thomas W., Dinkova-Kostova, Albena T.

“…The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2 ) and its principal negative regulator, the E3 ligase adaptor Kelch-like…”
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Transcriptional Regulation of Math1 by Aryl Hydrocarbon Receptor: Effect on Math1+ Progenitor Cells in Mouse Small Intestine by Yagishita, Yoko, Joshi, Tanvi, Kensler, Thomas W., Wakabayashi, Nobunao

“…The physiological roles of aryl hydrocarbon receptor (AhR) in the small intestine have been revealed as immunomodulatory and barrier functions. However, its…”
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Isothiocyanates: Translating the Power of Plants to People by Palliyaguru, Dushani L., Yuan, Jian‐Min, Kensler, Thomas W., Fahey, Jed W.

“…Isothiocyanates from cruciferous vegetables have been studied extensively in cells and in animals for their disease preventive and therapeutic effects…”
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Nrf2 in liver toxicology by Taguchi, Keiko, Kensler, Thomas W.

“…Liver plays essential roles in the metabolism of many endogenous chemicals and exogenous toxicants. Mechanistic studies in liver have been at the forefront of…”
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The Keap1-Nrf2 System Prevents Onset of Diabetes Mellitus by Uruno, Akira, Furusawa, Yuki, Yagishita, Yoko, Fukutomi, Toshiaki, Muramatsu, Hiroyuki, Negishi, Takaaki, Sugawara, Akira, Kensler, Thomas W., Yamamoto, Masayuki

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism by Chartoumpekis, Dionysios V, Wakabayashi, Nobunao, Kensler, Thomas W

“…Cancer cells adapt their metabolism to their increased needs for energy and substrates for protein, lipid and nucleic acid synthesis. Nuclear erythroid factor…”
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Novel NRF2‐activated cancer treatments utilizing synthetic lethality by Baird, Liam, Kensler, Thomas W., Yamamoto, Masayuki

“…The KEAP1‐NRF2 pathway regulates the main inducible cellular response to oxidative and electrophilic stresses. Activating mutations in the KEAP1‐NRF2 pathway…”
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dynamin-related GTPase Drp1 is required for embryonic and brain development in mice by Wakabayashi, Junko, Zhang, Zhongyan, Wakabayashi, Nobunao, Tamura, Yasushi, Fukaya, Masahiro, Kensler, Thomas W, Iijima, Miho, Sesaki, Hiromi

“…The dynamin-related guanosine triphosphatase Drp1 mediates the division of mitochondria and peroxisomes. To understand the in vivo function of Drp1, complete…”
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Validation of the multiple sensor mechanism of the Keap1-Nrf2 system by Takaya, Kai, Suzuki, Takafumi, Motohashi, Hozumi, Onodera, Ko, Satomi, Susumu, Kensler, Thomas W., Yamamoto, Masayuki

“…The Keap1-Nrf2 system plays a critical role in cellular defense against electrophiles and reactive oxygen species. Keap1 possesses a number of cysteine…”
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Nrf2: control of sensitivity to carcinogens by Slocum, Stephen L., Kensler, Thomas W.

“…Induction of enzymes that enhance the detoxication of chemical carcinogens has been a broadly effective strategy for chemoprevention of experimental…”
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NRF2 and the Moirai: Life and Death Decisions on Cell Fates by Yagishita, Yoko, Chartoumpekis, Dionysios V, Kensler, Thomas W, Wakabayashi, Nobunao

“…The transcription factor NRF2 (NF-E2-related factor 2) plays an important role as a master regulator of the cellular defense system by activating…”
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NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress-Induced DPP3-KEAP1 Interaction by Lu, Kevin, Alcivar, Allen L, Ma, Jianglin, Foo, Tzeh Keong, Zywea, Susan, Mahdi, Amar, Huo, Yanying, Kensler, Thomas W, Gatza, Michael L, Xia, Bing

“…NRF2 is a transcription factor serving as a master regulator of the expression of many genes involved in cellular responses to oxidative and other stresses. In…”
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Forced Hepatic Expression of NRF2 or NQO1 Impedes Hepatocyte Lipid Accumulation in a Lipodystrophy Mouse Model by Wakabayashi, Nobunao, Yagishita, Yoko, Joshi, Tanvi, Kensler, Thomas W

“…Lipodystrophy is a disorder featuring loss of normal adipose tissue depots due to impaired production of normal adipocytes. It leads to a gain of fat…”
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Dual Deletion of Keap1 and Rbpjκ Genes in Liver Leads to Hepatomegaly and Hypercholesterolemia by Wakabayashi, Nobunao, Yagishita, Yoko, Joshi, Tanvi, Kensler, Thomas W

“…The hepatic deletion of Rbpjκ ( ) in the mouse leads to exhibition of the Alagille syndrome phenotype during early postnatal liver development with…”
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Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage by Kageyama, Yusuke, Zhang, Zhongyan, Roda, Ricardo, Fukaya, Masahiro, Wakabayashi, Junko, Wakabayashi, Nobunao, Kensler, Thomas W, Reddy, P Hemachandra, Iijima, Miho, Sesaki, Hiromi

“…Mitochondria divide and fuse continuously, and the balance between these two processes regulates mitochondrial shape. Alterations in mitochondrial dynamics are…”
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Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanisms by Palliyaguru, Dushani L., Chartoumpekis, Dionysios V., Wakabayashi, Nobunao, Skoko, John J., Yagishita, Yoko, Singh, Shivendra V., Kensler, Thomas W.

“…Small molecules of plant origin offer presumptively safe opportunities to prevent carcinogenesis, mutagenesis and other forms of toxicity in humans. However,…”
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Genetic or pharmacologic Nrf2 activation increases proteinuria in chronic kidney disease in mice by Rush, Brittney M, Bondi, Corry D, Stocker, Sean D, Barry, Kacie M, Small, Sarah A, Ong, Jason, Jobbagy, Soma, Stolz, Donna B, Bastacky, Sheldon I, Chartoumpekis, Dionysios V, Kensler, Thomas W, Tan, Roderick J

“…The nuclear factor erythroid 2-related factor 2 (Nrf2) pathway upregulates key cellular defenses. Clinical trials are utilizing pharmacologic Nrf2 inducers…”
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