Search Results - "KENNY, Hilary"

Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum by Lee, WonJae, Ko, Song Yi, Mohamed, Muhaned S, Kenny, Hilary A, Lengyel, Ernst, Naora, Honami

“…Ovarian cancer preferentially metastasizes to the omentum, a fatty tissue characterized by immune structures called milky spots, but the cellular dynamics that…”
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Unsaturated Fatty Acids Maintain Cancer Cell Stemness by Mukherjee, Abir, Kenny, Hilary A., Lengyel, Ernst

“…Investigation of the metabolic regulation of cancer stem cells is an emerging field that offers promising approaches for identifying and targeting recalcitrant…”
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Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis by Curtis, Marion, Kenny, Hilary A., Ashcroft, Bradley, Mukherjee, Abir, Johnson, Alyssa, Zhang, Yilin, Helou, Ynes, Batlle, Raquel, Liu, Xiaojing, Gutierrez, Nuria, Gao, Xia, Yamada, S. Diane, Lastra, Ricardo, Montag, Anthony, Ahsan, Nagib, Locasale, Jason W., Salomon, Arthur R., Nebreda, Angel R., Lengyel, Ernst

“…Successful metastasis requires the co-evolution of stromal and cancer cells. We used stable isotope labeling of amino acids in cell culture coupled with…”
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Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis by Ladanyi, Andras, Mukherjee, Abir, Kenny, Hilary A., Johnson, Alyssa, Mitra, Anirban K., Sundaresan, Sinju, Nieman, Kristin M., Pascual, Gloria, Benitah, Salvador Aznar, Montag, Anthony, Yamada, S. Diane, Abumrad, Nada A., Lengyel, Ernst

“…Ovarian cancer (OvCa) is characterized by widespread and rapid metastasis in the peritoneal cavity. Visceral adipocytes promote this process by providing fatty…”
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Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis by Cui, Chang, Chakraborty, Kasturi, Tang, Xu Anna, Zhou, Guolin, Schoenfelt, Kelly Q., Becker, Kristen M., Hoffman, Alexandria, Chang, Ya-Fang, Blank, Ariane, Reardon, Catherine A., Kenny, Hilary A., Vaisar, Tomas, Lengyel, Ernst, Greene, Geoffrey, Becker, Lev

“…Cancer cell genetic variability and similarity to host cells have stymied development of broad anti-cancer therapeutics. Our innate immune system evolved to…”
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Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth by Nieman, Kristin M, Kenny, Hilary A, Penicka, Carla V, Ladanyi, Andras, Buell-Gutbrod, Rebecca, Zillhardt, Marion R, Romero, Iris L, Carey, Mark S, Mills, Gordon B, Hotamisligil, Gökhan S, Yamada, S Diane, Peter, Marcus E, Gwin, Katja, Lengyel, Ernst

“…Ovarian tumors preferentially metastasize to the omentum, a peritoneal fat layer. This report proposes that the reasons for this predilection stem from the…”
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The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin by Kenny, Hilary A, Kaur, Swayamjot, Coussens, Lisa M, Lengyel, Ernst

“…Most patients (80%) with ovarian cancer (OvCa) present with metastatic disease. Attachment of OvCa cells to peritoneum and omentum represents the first…”
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Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion by Kenny, Hilary A, Chiang, Chun-Yi, White, Erin A, Schryver, Elizabeth M, Habis, Mohammed, Romero, Iris L, Ladanyi, Andras, Penicka, Carla V, George, Joshy, Matlin, Karl, Montag, Anthony, Wroblewski, Kristen, Yamada, S Diane, Mazar, Andrew P, Bowtell, David, Lengyel, Ernst

“…Ovarian cancer (OvCa) metastasizes to organs in the abdominal cavity, such as the omentum, which are covered by a single layer of mesothelial cells…”
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Three-dimensional modeling of ovarian cancer by White, Erin A., Kenny, Hilary A., Lengyel, Ernst

“…New models for epithelial ovarian cancer initiation and metastasis are required to obtain a mechanistic understanding of the disease and to develop new…”
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Reversal of Chemoresistance in Ovarian Cancer by Co-Delivery of a P-Glycoprotein Inhibitor and Paclitaxel in a Liposomal Platform by Zhang, Yilin, Sriraman, Shravan Kumar, Kenny, Hilary A, Luther, Ed, Torchilin, Vladimir, Lengyel, Ernst

“…The overexpression of permeability-glycoprotein (P-gp), an ABC transporter involved in the cellular exclusion of chemotherapeutic drugs, is a major factor in…”
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MMP-2 functions as an early response protein in ovarian cancer metastasis by Kenny, Hilary A., Lengyel, Ernst

“…The most common site (80%) of ovarian cancer metastasis is the omentum, a large (15x10x2cm) peritoneal fold covering the small bowel. Because of the absence of…”
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Molecular pathways: trafficking of metabolic resources in the tumor microenvironment by Romero, Iris L, Mukherjee, Abir, Kenny, Hilary A, Litchfield, Lacey M, Lengyel, Ernst

“…A model of tumor metabolism is proposed that describes how the complementary metabolic functions of the local stroma and the tumor cells contribute to cancer…”
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Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy by Kenny, Hilary A., Lal-Nag, Madhu, White, Erin A., Shen, Min, Chiang, Chun-Yi, Mitra, Anirban K., Zhang, Yilin, Curtis, Marion, Schryver, Elizabeth M., Bettis, Sam, Jadhav, Ajit, Boxer, Matthew B., Li, Zhuyin, Ferrer, Marc, Lengyel, Ernst

“…The tumour microenvironment contributes to cancer metastasis and drug resistance. However, most high throughput screening (HTS) assays for drug discovery use…”
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Use of a novel 3D culture model to elucidate the role of mesothelial cells, fibroblasts and extra‐cellular matrices on adhesion and invasion of ovarian cancer cells to the omentum by Kenny, Hilary A., Krausz, Thomas, Yamada, Seiko D., Lengyel, Ernst

“…The omentum is a major site of ovarian cancer metastasis. Our goal was to establish a three‐dimensional (3D) model of the key components of the omental…”
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Organotypic 3D Models of the Ovarian Cancer Tumor Microenvironment by Watters, Karen M, Bajwa, Preety, Kenny, Hilary A

“…Ovarian cancer progression involves multifaceted and variable tumor microenvironments (TMEs), from the in situ carcinoma in the fallopian tube or ovary to…”
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Cancer-derived small extracellular vesicles promote angiogenesis by heparin-bound, bevacizumab-insensitive VEGF, independent of vesicle uptake by Ko, Song Yi, Lee, WonJae, Kenny, Hilary A., Dang, Long H., Ellis, Lee M., Jonasch, Eric, Lengyel, Ernst, Naora, Honami

“…Cancer-derived small extracellular vesicles (sEVs) induce stromal cells to become permissive for tumor growth. However, it is unclear whether this induction…”
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Inhibition of fascin in cancer and stromal cells blocks ovarian cancer metastasis by McGuire, Sean, Kara, Betul, Hart, Peter C., Montag, Anthony, Wroblewski, Kristen, Fazal, Sarah, Huang, Xin-Yun, Lengyel, Ernst, Kenny, Hilary A.

“…Ovarian cancer (OvCa) metastasis requires the coordinated motility of both cancer and stromal cells. Cellular movement is a dynamic process that involves the…”
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Loss of E-Cadherin Promotes Ovarian Cancer Metastasis via α5-Integrin, which Is a Therapeutic Target by SAWADA, Kenjiro, MITRA, Anirban K, PETER, Marcus E, RAMAKRISHNAN, Vanitha, YAMADA, S. Diane, LENGYEL, Ernst, REZA RADJABI, A, BHASKAR, Vinay, KISTNER, Emily O, TRETIAKOVA, Maria, JAGADEESWARAN, Sujatha, MONTAG, Anthony, BECKER, Amy, KENNY, Hilary A

“…Abstract E-cadherin loss is frequently associated with ovarian cancer metastasis. Given that adhesion to the abdominal peritoneum is the first step in ovarian…”
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Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk by Hart, Peter C., Kenny, Hilary A., Grassl, Niklas, Watters, Karen M., Litchfield, Lacey M., Coscia, Fabian, Blaženović, Ivana, Ploetzky, Lisa, Fiehn, Oliver, Mann, Matthias, Lengyel, Ernst, Romero, Iris L.

“…The tumor microenvironment (TME) plays a pivotal role in cancer progression, and, in ovarian cancer (OvCa), the primary TME is the omentum. Here, we show that…”
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Tumor microenvironment-induced FOXM1 regulates ovarian cancer stemness by Battistini, Chiara, Kenny, Hilary A., Zambuto, Melissa, Nieddu, Valentina, Melocchi, Valentina, Decio, Alessandra, Lo Riso, Pietro, Villa, Carlo Emanuele, Gatto, Alessia, Ghioni, Mariacristina, Porta, Francesca M., Testa, Giuseppe, Giavazzi, Raffaella, Colombo, Nicoletta, Bianchi, Fabrizio, Lengyel, Ernst, Cavallaro, Ugo

“…In ovarian tumors, the omental microenvironment profoundly influences the behavior of cancer cells and sustains the acquisition of stem-like traits, with major…”
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