Search Results - "KENNER, Lukas"

The Implications of PDK1-4 on Tumor Energy Metabolism, Aggressiveness and Therapy Resistance by Atas, Emine, Oberhuber, Monika, Kenner, Lukas

“…A metabolic shift from oxidative phosphorylation (OXPHOS) to glycolysis-known as the Warburg effect-is characteristic for many cancers. It gives the cancer…”
Get full text

Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT-mTOR-S6K signaling and drug responses by Riedl, Angelika, Schlederer, Michaela, Pudelko, Karoline, Stadler, Mira, Walter, Stefanie, Unterleuthner, Daniela, Unger, Christine, Kramer, Nina, Hengstschläger, Markus, Kenner, Lukas, Pfeiffer, Dagmar, Krupitza, Georg, Dolznig, Helmut

“…Three-dimensional (3D) cancer models are used as preclinical systems to mimic physiologic drug responses. We provide evidence for strong changes of…”
Get full text

A modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces potent antitumor immunity by Das, Krishna, Belnoue, Elodie, Rossi, Matteo, Hofer, Tamara, Danklmaier, Sarah, Nolden, Tobias, Schreiber, Liesa-Marie, Angerer, Katharina, Kimpel, Janine, Hoegler, Sandra, Spiesschaert, Bart, Kenner, Lukas, von Laer, Dorothee, Elbers, Knut, Derouazi, Madiha, Wollmann, Guido

“…Functional tumor-specific cytotoxic T cells elicited by therapeutic cancer vaccination in combination with oncolytic viruses offer opportunities to address…”
Get full text

A dual role for autophagy in a murine model of lung cancer by Rao, Shuan, Tortola, Luigi, Perlot, Thomas, Wirnsberger, Gerald, Novatchkova, Maria, Nitsch, Roberto, Sykacek, Peter, Frank, Lukas, Schramek, Daniel, Komnenovic, Vukoslav, Sigl, Verena, Aumayr, Karin, Schmauss, Gerald, Fellner, Nicole, Handschuh, Stephan, Glösmann, Martin, Pasierbek, Pawel, Schlederer, Michaela, Resch, Guenter P., Ma, Yuting, Yang, Heng, Popper, Helmuth, Kenner, Lukas, Kroemer, Guido, Penninger, Josef M.

“…Autophagy is a mechanism by which starving cells can control their energy requirements and metabolic states, thus facilitating the survival of cells in…”
Get full text

Targeting Androgen, Thyroid Hormone, and Vitamin A and D Receptors to Treat Prostate Cancer by Hantusch, Brigitte, Kenner, Lukas, Stanulović, Vesna S, Hoogenkamp, Maarten, Brown, Geoffrey

“…The nuclear hormone family of receptors regulates gene expression. The androgen receptor (AR), upon ligand binding and homodimerization, shuttles from the…”
Get full text

TGF-β IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer by Yao, Zhan, Fenoglio, Silvia, Gao, Ding Cheng, Camiolo, Matthew, Stiles, Brendon, Lindsted, Trine, Schlederer, Michaela, Johns, Chris, Altorki, Nasser, Mittal, Vivek, Kenner, Lukas, Sordella, Raffaella

“…The epidermal growth-factor receptor (EGFR) tyrosine kinase inhibitor erlotinib has been proven to be highly effective in the treatment of nonsmall cell lung…”
Get full text

PD‐1 and PD‐L1 expression in HNSCC primary cancer and related lymph node metastasis – impact on clinical outcome by Schneider, Sven, Kadletz, Lorenz, Wiebringhaus, Robert, Kenner, Lukas, Selzer, Edgar, Füreder, Thorsten, Rajky, Orsolya, Berghoff, Anna S, Preusser, Matthias, Heiduschka, Gregor

“…Aims Expression profiles and clinical impact of programmed cell death ligand 1 (PD‐L1) and programmed cell death 1 (PD‐1) expressing tumour infiltrating…”
Get full text

Epigenetic Alterations Affecting Transcription Factors and Signaling Pathways in Stromal Cells of Endometriosis by Yotova, Iveta, Hsu, Emily, Do, Catherine, Gaba, Aulona, Sczabolcs, Matthias, Dekan, Sabine, Kenner, Lukas, Wenzl, Rene, Tycko, Benjamin

“…Endometriosis is characterized by growth of endometrial-like tissue outside the uterine cavity. Since its pathogenesis may involve epigenetic changes, we used…”
Get full text

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer by Kenner, Lukas, Khokha, Rama, Lee, Heather J, Schramek, Daniel, Widschwendter, Martin, Joshi, Purna A, Hanada, Reiko, Leibbrandt, Andreas, Glimcher, Laurie, Sigl, Verena, Penninger, Josef M, Schett, Georg, Pospisilik, John A, Pasparakis, Manolis, Aliprantis, Antonios, Ormandy, Christopher J

“…Breast cancer is one of the most common cancers in humans and will on average affect up to one in eight women in their lifetime in the United States and…”
Get full text

Micro- and Nanoplastics Breach the Blood-Brain Barrier (BBB): Biomolecular Corona's Role Revealed by Kopatz, Verena, Wen, Kevin, Kovács, Tibor, Keimowitz, Alison S, Pichler, Verena, Widder, Joachim, Vethaak, A Dick, Hollóczki, Oldamur, Kenner, Lukas

“…Humans are continuously exposed to polymeric materials such as in textiles, car tires and packaging. Unfortunately, their break down products pollute our…”
Get full text

STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway by Swoboda, Alexander, Soukup, Robert, Eckel, Oliver, Kinslechner, Katharina, Wingelhofer, Bettina, Schörghofer, David, Sternberg, Christina, Pham, Ha T. T., Vallianou, Maria, Horvath, Jaqueline, Stoiber, Dagmar, Kenner, Lukas, Larue, Lionel, Poli, Valeria, Beermann, Friedrich, Yokota, Takashi, Kubicek, Stefan, Krausgruber, Thomas, Rendeiro, André F., Bock, Christoph, Zenz, Rainer, Kovacic, Boris, Aberger, Fritz, Hengstschläger, Markus, Petzelbauer, Peter, Mikula, Mario, Moriggl, Richard

“…Metastatic melanoma is hallmarked by its ability of phenotype switching to more slowly proliferating, but highly invasive cells. Here, we tested the impact of…”
Get full text

Phylotype-level 16S rRNA analysis reveals new bacterial indicators of health state in acute murine colitis by Berry, David, Schwab, Clarissa, Milinovich, Gabriel, Reichert, Jochen, Ben Mahfoudh, Karim, Decker, Thomas, Engel, Marion, Hai, Brigitte, Hainzl, Eva, Heider, Susanne, Kenner, Lukas, Müller, Mathias, Rauch, Isabella, Strobl, Birgit, Wagner, Michael, Schleper, Christa, Urich, Tim, Loy, Alexander

“…Human inflammatory bowel disease and experimental colitis models in mice are associated with shifts in intestinal microbiota composition, but it is unclear at…”
Get full text

When the guardian sleeps: Reactivation of the p53 pathway in cancer by Merkel, Olaf, Taylor, Ninon, Prutsch, Nicole, Staber, Philipp B., Moriggl, Richard, Turner, Suzanne D., Kenner, Lukas

“…The p53 tumor suppressor is inactivated in most cancers, thus suggesting that loss of p53 is a prerequisite for tumor growth. Therefore, its reintroduction…”
Get full text

The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas by Garces de Los Fayos Alonso, Ines, Liang, Huan-Chang, Turner, Suzanne D, Lagger, Sabine, Merkel, Olaf, Kenner, Lukas

“…The Activator Protein-1 (AP-1) transcription factor (TF) family, composed of a variety of members including c-JUN, c-FOS and ATF, is involved in mediating many…”
Get full text

Screening for oncogenic AF1q expression predicts disease recurrence in gastric cancer patients by Gruber, Elisabeth S., Oberhuber, Georg, Schlederer, Michaela, Birner, Peter, Jomrich, Gerd, Schoppmann, Sebastian F., Tse, William, Kenner, Lukas

“…AF1q associates with tumor progression and metastases upon WNT signaling. The downstream WNT target CD44 has demonstrated prognostic significance in gastric…”
Get full text

The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection by Ebner, Florian, Sedlyarov, Vitaly, Tasciyan, Saren, Ivin, Masa, Kratochvill, Franz, Gratz, Nina, Kenner, Lukas, Villunger, Andreas, Sixt, Michael, Kovarik, Pavel

“…Protective responses against pathogens require a rapid mobilization of resting neutrophils and the timely removal of activated ones. Neutrophils are…”
Get full text

YAP–IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis by Taniguchi, Koji, Moroishi, Toshiro, de Jong, Petrus R., Krawczyk, Michal, Grebbin, Britta Moyo, Luo, Huiyan, Xu, Rui-hua, Golob-Schwarzl, Nicole, Schweiger, Caroline, Wang, Kepeng, Di Caro, Giuseppe, Feng, Ying, Fearon, Eric R., Raz, Eyal, Kenner, Lukas, Farin, Henner F., Guan, Kun-Liang, Haybaeck, Johannes, Datz, Christian, Zhang, Kang, Karin, Michael

“…Loss of tumor suppressor adenomatous polyposis coli (APC) activates β-catenin to initiate colorectal tumorigenesis. However, β-catenin (CTNNB1) activating…”
Get full text

Is breast implant-associated anaplastic large cell lymphoma a hazard of breast implant surgery? by Fitzal, Florian, Turner, Suzanne D, Kenner, Lukas

“…Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) may occur after reconstructive or aesthetic breast surgery. Worldwide, approximately 1.7…”
Get full text

The adsorption of drugs on nanoplastics has severe biological impact by Dick, Leonard, Batista, Patrick R., Zaby, Paul, Manhart, Gabriele, Kopatz, Verena, Kogler, Lukas, Pichler, Verena, Grebien, Florian, Bakos, Vince, Plósz, Benedek G., Kolev, Nikola Zlatkov, Kenner, Lukas, Kirchner, Barbara, Hollóczki, Oldamur

“…Micro- and nanoplastics can interact with various biologically active compounds forming aggregates of which the effects have yet to be understood. To this end,…”
Get full text

Radiogenomic markers enable risk stratification and inference of mutational pathway states in head and neck cancer by Spielvogel, Clemens P., Stoiber, Stefan, Papp, Laszlo, Krajnc, Denis, Grahovac, Marko, Gurnhofer, Elisabeth, Trachtova, Karolina, Bystry, Vojtech, Leisser, Asha, Jank, Bernhard, Schnoell, Julia, Kadletz, Lorenz, Heiduschka, Gregor, Beyer, Thomas, Hacker, Marcus, Kenner, Lukas, Haug, Alexander R.

“…Purpose Head and neck squamous cell carcinomas (HNSCCs) are a molecularly, histologically, and clinically heterogeneous set of tumors originating from the…”
Get full text