Search Results - "KENG, P. C"

hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress by Gehen, S C, Staversky, R J, Bambara, R A, Keng, P C, O'Reilly, M A

“…Genotoxic stress activates the phosphatidylinositol 3-kinase-like kinases (PIKKs) that phosphorylate proteins involved in cell cycle arrest, DNA repair and…”
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Sigma-2 receptors as a biomarker of proliferation in solid tumours by WHEELER, K. T, WANG, L.-M, WALLEN, C. A, CHILDERS, S. R, CLINE, J. M, KENG, P. C, MACH, R. H

“…Over the past several years, our group has provided considerable evidence that the expression of sigma-2 (sigma2) receptors may serve as a biomarker of tumour…”
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Effect of ploidy, recruitment, environmental factors, and tamoxifen treatment on the expression of sigma-2 receptors in proliferating and quiescent tumour cells by AL-NABULSI, MACH, R. H, WANG, L.-M, WALLEN, C. A, KENG, P. C, STEN, K, CHILDERS, S. R, WHEELER, K. T

“…Recently, we demonstrated that sigma-2 receptors may have the potential to be a biomarker of tumour cell proliferation (Mach et al (1997) Cancer Res 57:…”
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The Cyclin-Dependent Kinase Inhibitor p21 Protects the Lung from Oxidative Stress by O'Reilly, Michael A, Staversky, Rhonda J, Watkins, Richard H, Reed, Christina K, de Mesy Jensen, Karen L, Finkelstein, Jacob N, Keng, Peter C

“…The lung is a major target tissue for oxidative stress, including hyperoxia used to relieve tissue hypoxia. Unfortunately, severe hyperoxia damages DNA,…”
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Hypoxia significantly reduces aminolaevulinic acid-induced protoporphyrin IX synthesis in EMT6 cells by GEORGAKOUDI, I, KENG, P. C, FOSTER, T. H

“…We have studied the effects of hypoxia on aminolaevulinic acid (ALA)-induced protoporphyrin IX (PpIX) synthesis in EMT6 monolayer cultures characterized by…”
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Alteration of tumour response to radiation by interleukin-2 gene transfer by LEE, J, MORAN, J. P, FENTON, B. M, KOCH, C. J, FRELINGER, J. G, KENG, P. C, LORD, E. M

“…We have previously shown that BALB/c-derived EMT6 mammary tumours transfected with interleukin (IL)-2 have decreased hypoxia compared to parental tumours, due…”
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Toxicity of Cadmium in Human Trophoblast Cells (JAr Choriocarcinoma): Role of Calmodulin and the Calmodulin Inhibitor, Zaldaride Maleate by Powlin, Stephanie Schubach, Keng, Peter C., Miller, Richard K.

“…Cadmium (Cd), the heavy metal, is toxic to the placenta. The objectives of this study were to determine if Cd toxicity is due to inhibition of placental or…”
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Drug resistance in Chinese hamster ovary cells during recovery from severe hypoxia by Wilson, R E, Keng, P C, Sutherland, R M

“…Chinese hamster ovary cells exposed to hypoxia developed an 80-fold resistance to a subsequent 1-hour exposure to doxorubicin (ADR) in air. Recovery in air…”
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The effect of bcr-abl antisense oligonucleotide on DNA synthesis and apoptosis in K562 chronic myeloid leukemia cells by Rowley, Peter T., Keng, Peter C., Kosciolek, Barbara A.

“…Mutations in oncogenes have traditionally been viewed as inducing malignancy by causing excessive cell division. However, an additional possible tumorigenic…”
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Characterization of radiation resistant hypoxic cell subpopulations in KHT sarcomas. (ii) Cell sorting by SIEMANN, D. W, KENG, P. C

“…Hypoxic cells in KHT sarcomas were characterized using fluorescence activated cell sorting based on the diffusion properties of the fluorochrome Hoechst 33342…”
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Selective protection against cis-diamminedichloroplatinum(II)-induced toxicity in kidney, gut, and bone marrow by diethyldithiocarbamate by BODENNER, D. L, DEDON, P. C, KENG, P. C, KATZ, J. C, BORCH, R. F

“…Diethyldithiocarbamate (DDTC) has been shown to inhibit nephrotoxicity induced by cis-platinum (DDP) without inhibition of tumor response in the rat. We report…”
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Absence of Radiation-induced G1 Arrest in Two Closely Related Human Lymphoblast Cell Lines That Differ in p53 Status by Little, John B., Nagasawa, Hatsumi, Keng, Peter C., Yu, Yongjia, Li, Chuan-Yuan

“…In order to examine more precisely the role of p53 in the activation of the G1/S checkpoint by ionizing radiation, we examined two human lymphoblast cell lines…”
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Interactions of dimethyl sulfoxide and granulocyte-macrophage colony-stimulating factor on the cell cycle kinetics and phosphoproteins of G1-enriched HL-60 cells: evidence of early effects on lamin B phosphorylation by Brennan, J K, Lee, K S, Frazel, M A, Keng, P C, Young, D A

“…We have found that GM-CSF and DMSO have antagonistic effects on the proliferation but not maturation of asynchronously growing HL-60 cells such that growth in…”
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Potentiation of radiation cytotoxicity by recombinant interferons, a phenomenon associated with increased blockage at the G2-M phase of the cell cycle by CHANG, A. Y. C, KENG, P. C

“…Radiation sensitivity of human hypernephroma tumor cells, ACHN, was evaluated in the presence or absence of various recombinant interferons (IFNs): alpha D…”
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Diethyldithiocarbamate inhibition of murine bone marrow toxicity caused by cis-diamminedichloroplatinum(II) or diammine-(1,1-cyclobutanedicarboxylato)platinum(II) by GRINGERI, A, KENG, P. C, BORCH, R. F

“…We report here the effects of diethyldithiocarbamate (DDTC) rescue on myelotoxicity caused by carboplatin (CBDCA) and cisplatin (DDP) in C57BL/6 x DBA/2 F1…”
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Studying the effects of actin cytoskeletal destabilization on cell cycle by cofilin overexpression by LEE, Yi-Jang, KENG, Peter C

“…The significance of actin cytoskeleton on cell growth was historically studied using toxic drugs, such as cytochalasin. However, it is possible that…”
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Enhancement of radiosensitivity in H1299 cancer cells by actin-associated protein cofilin by Lee, Yi-Jang, Sheu, Tzong-Jen, Keng, Peter C.

“…Cofilin is an actin-associated protein that belongs to the actin depolymerization factor/cofilin family and is important for regulation of actin dynamics…”
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Changes in growth characteristics and macromolecular synthesis on recovery from severe hypoxia by WILSON, R. E, KENG, P. C, SUTHERLAND, R. M

“…Chinese hamster ovary cells subjected to severe hypoxia stop growing. When oxygen was reintroduced growth resumed, but at a slower rate. The longer the hypoxic…”
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The role of p21(CIP1/WAF1) in growth of epithelial cells exposed to hyperoxia by Rancourt, R C, Keng, P C, Helt, C E, O'Reilly, M A

“…Previous studies have shown that hyperoxia inhibits proliferation and increases the expression of the tumor suppressor p53 and its downstream target, the…”
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Cell cycle specific toxicity of the Hoechst 33342 stain in untreated or irradiated murine tumor cells by SIEMANN, D. W, KENG, P. C

“…Hoechst 33342 stain has been used previously in conjunction with fluorescence activated cell sorting to separate cell populations into the various phases of…”
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