Search Results - "KENDALL, Richard L"

Biochemical characterization of AMG 102: a neutralizing, fully human monoclonal antibody to human and nonhuman primate hepatocyte growth factor by Burgess, Teresa L, Sun, Jan, Meyer, Susanne, Tsuruda, Trace S, Sun, Jilin, Elliott, Gary, Chen, Qing, Haniu, Mitsuru, Barron, Will F, Juan, Todd, Zhang, Ke, Coxon, Angela, Kendall, Richard L

“…AMG 102 is a fully human monoclonal antibody that selectively targets and neutralizes hepatocyte growth factor/scatter factor (HGF/SF). A detailed biochemical…”
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HER2 and HLA-A02 dual CAR-T cells utilize LOH in a NOT logic gate to address on-target off-tumor toxicity by Bassan, David, Weinberger, Leehee, Yi, Jason, Kim, Tanya, Weist, Michael R, Adams, Gregor B, Foord, Orit, Chaim, Neta, Tabak, Sarit, Bujanover, Nir, Lopesco, Yael, Vucci, Kristina, Schnair, Caitlin, Levy-Knafo, Limor, Kendall, Richard L, Calzone, Frank J, Sharbi-Yunger, Adi

“…BackgroundOne of the major challenges in chimeric antigen receptor (CAR)-T cell therapy for solid tumors is the potential for on-target off-tumor toxicity due…”
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Paracrine Expression of a Native Soluble Vascular Endothelial Growth Factor Receptor Inhibits Tumor Growth, Metastasis, and Mortality Rate by Goldman, Corey K., Kendall, Richard L., Cabrera, Gustavo, Soroceanu, Liliana, Heike, Yuji, Gillespie, G. Yancey, Siegal, Gene P., Mao, Xianzhi, Bett, Andrew J., Huckle, William R., Thomas, Kenneth A., Curiel, David T.

“…Vascular endothelial growth factor (VEGF) is a potent and selective vascular endothelial cell mitogen and angiogenic factor. VEGF expression is elevated in a…”
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Kinetic Mechanism of AKT/PKB Enzyme Family by Zhang, Xiaoling, Zhang, Shiwen, Yamane, Harvey, Wahl, Robert, Ali, Arisha, Lofgren, Julie A., Kendall, Richard L.

“…AKT/PKB is a phosphoinositide-dependent serine/threonine protein kinase that plays a critical role in the signal transduction of receptors. It also serves as…”
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Preclinical Evaluation of AMG 900, a Novel Potent and Highly Selective Pan-Aurora Kinase Inhibitor with Activity in Taxane-Resistant Tumor Cell Lines by PAYTON, Marc, BUSH, Tammy L, NHO NGUYEN, Hanh, OLIVIERI, Philip R, ROMERO, Karina, SCHENKEL, Laurie B, BAK, Annette, STANTON, Mary, DUSSAULT, Isabelle, PATEL, Vinod F, GEUNS-MEYER, Stephanie, RADINSKY, Robert, CHUNG, Grace, KENDALL, Richard L, ZIEGLER, Beth, EDEN, Patrick, MCELROY, Patricia, ROSS, Sandra, CEE, Victor J, DEAK, Holly L, HODOUS, Brian L

“…In mammalian cells, the aurora kinases (aurora-A, -B, and -C) play essential roles in regulating cell division. The expression of aurora-A and -B is elevated…”
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AMG 900, a small-molecule inhibitor of aurora kinases, potentiates the activity of microtubule-targeting agents in human metastatic breast cancer models by Bush, Tammy L, Payton, Marc, Heller, Scott, Chung, Grace, Hanestad, Kelly, Rottman, James B, Loberg, Robert, Friberg, Gregory, Kendall, Richard L, Saffran, Douglas, Radinsky, Robert

“…Breast cancer is the most prevalent malignancy affecting women and ranks second in cancer-related deaths, in which death occurs primarily from metastatic…”
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Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor by KENDALL, R. L, THOMAS, K. A

“…Vascular endothelial cell growth factor, a mitogen selective for vascular endothelial cells in vitro that promotes angiogenesis in vivo, functions through…”
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Discovery of a Potent, Selective, and Orally Bioavailable Pyridinyl-Pyrimidine Phthalazine Aurora Kinase Inhibitor by Cee, Victor J, Schenkel, Laurie B, Hodous, Brian L, Deak, Holly L, Nguyen, Hanh N, Olivieri, Philip R, Romero, Karina, Bak, Annette, Be, Xuhai, Bellon, Steve, Bush, Tammy L, Cheng, Alan C, Chung, Grace, Coats, Steve, Eden, Patrick M, Hanestad, Kelly, Gallant, Paul L, Gu, Yan, Huang, Xin, Kendall, Richard L, Lin, Min-Hwa Jasmine, Morrison, Michael J, Patel, Vinod F, Radinsky, Robert, Rose, Paul E, Ross, Sandra, Sun, Ji-Rong, Tang, Jin, Zhao, Huilin, Payton, Marc, Geuns-Meyer, Stephanie D

“…The discovery of aurora kinases as essential regulators of cell division has led to intense interest in identifying small molecule aurora kinase inhibitors for…”
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Discovery of a Small Molecule Insulin Mimetic with Antidiabetic Activity in Mice by Zhang, Bei, Salituro, Gino, Szalkowski, Deborah, Li, Zhihua, Zhang, Yan, Royo, Inmaculada, Vilella, Dolores, Díez, Maria Teresa, Pelaez, Fernando, Ruby, Caroline, Kendall, Richard L., Mao, Xianzhi, Griffin, Patrick, Calaycay, Jimmy, Zierath, Juleen R., Heck, James V., Smith, Roy G., Moller, David E.

“…Insulin elicits a spectrum of biological responses by binding to its cell surface receptor. In a screen for small molecules that activate the human insulin…”
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Synthesis and Initial SAR Studies of 3,6-Disubstituted Pyrazolo[1,5- a]pyrimidines: A New Class of KDR Kinase Inhibitors by Fraley, Mark E., Hoffman, William F., Rubino, Robert S., Hungate, Randall W., Tebben, Andrew J., Rutledge, Ruth Z., McFall, Rosemary C., Huckle, William R., Kendall, Richard L., Coll, Kathleen E., Thomas, Kenneth A.

“…Graphic We have synthesized and evaluated the activity of 3,6-disubstituted pyrazolo[1,5- a]pyrimidines as a new class of KDR kinase inhibitors. Starting with…”
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Optimization of a pyrazolo[1,5- a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics by Fraley, Mark E., Rubino, Robert S., Hoffman, William F., Hambaugh, Scott R., Arrington, Kenneth L., Hungate, Randall W., Bilodeau, Mark T., Tebben, Andrew J., Rutledge, Ruth Z., Kendall, Richard L., McFall, Rosemary C., Huckle, William R., Coll, Kathleen E., Thomas, Kenneth A.

“…We have introduced solubilizing functionality to a 3,6-disubstituted pyrazolo[1,5- a]pyrimidine series of KDR kinase inhibitors to improve the physical…”
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Eukaryotic Methionyl Aminopeptidases: Two Classes of Cobalt-Dependent Enzymes by Arfin, Stuart M., Kendall, Richard L., Hall, Linda, Weaver, Larry H., Stewart, Albert E., Matthews, Brian W., Bradshaw, Ralph A.

“…Using partial amino acid sequence data derived from porcine methionyl aminopeptidase (MetAP; methionine aminopeptidase, peptidase M; EC 3.4.11.18), a…”
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Vascular Endothelial Growth Factor Receptor KDR Tyrosine Kinase Activity Is Increased by Autophosphorylation of Two Activation Loop Tyrosine Residues by Kendall, R L, Rutledge, R Z, Mao, X, Tebben, A J, Hungate, R W, Thomas, K A

“…Vascular endothelial growth factor is an important physiological regulator of angiogenesis. The function of this endothelial cell selective growth factor is…”
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The discovery of N-(1,3-thiazol-2-yl)pyridin-2-amines as potent inhibitors of KDR kinase by Bilodeau, Mark T., Rodman, Leonard D., McGaughey, Georgia B., Coll, Kathleen E., Koester, Timothy J., Hoffman, William F., Hungate, Randall W., Kendall, Richard L., McFall, Rosemary C., Rickert, Keith W., Rutledge, Ruth Z., Thomas, Kenneth A.

“…Graphic An azo-dye lead was modified to a novel N-(1,3-thiazol-2-yl)pyridin-2-amine series of KDR kinase inhibitors through the use of rapid analog libraries…”
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Design and synthesis of 1,5-diarylbenzimidazoles as inhibitors of the VEGF-receptor KDR by Bilodeau, Mark T., Cunningham, April M., Koester, Timothy J., Ciecko, Patrice A., Coll, Kathleen E., Huckle, William R., Hungate, Randall W., Kendall, Richard L., McFall, Rosemary C., Mao, Xianzhi, Rutledge, Ruth Z., Thomas, Kenneth A.

“…1,5-Diarylbenzimidazoles have been identified as potent inhibitors of KDR kinase activity. The series was developed with a goal of finding compounds with…”
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Discovery and evaluation of 3-(5-thien-3-ylpyridin-3-yl)-1H-indoles as a novel class of KDR kinase inhibitors by Fraley, Mark E, Arrington, Kenneth L, Hambaugh, Scott R, Hoffman, William F, Cunningham, April M, Young, Mary Beth, Hungate, Randall W, Tebben, Andrew J, Rutledge, Ruth Z, Kendall, Richard L, Huckle, William R, McFall, Rosemary C, Coll, Kathleen E, Thomas, Kenneth A

“…We have discovered 3-(5-thien-3-ylpyridin-3-yl)-1H-indoles as potent inhibitors of KDR kinase activity. This communication details the evolution of this novel…”
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Abstract 5797: Next generation antibody drug conjugates: Multi-payload conjugates targeting multiple mechanisms of cell killing by Kendall, Richard L., Lobba, Marco, Johri, Saurabh, Symister, Chanez, Trinter, Devin, Nguyen, Maxwell, Gutierrez, Daniel, Brady, Samantha, Lau, Andrew, Francis, Matthew B.

“…Abstract Introduction: ADCs have had tremendous impact on patient outcomes in breast cancer and are now second line therapy for stage IV HER2 positive…”
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Identification of a Natural Soluble Form of the Vascular Endothelial Growth Factor Receptor, FLT-1, and Its Heterodimerization with KDR by Kendall, Richard L., Wang, Guan, Thomas, Kenneth A.

“…A soluble form of the vascular endothelial growth factor (VEGF) receptor FLT-1 was identified in conditioned culture medium of human umbilical vein endothelial…”
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AMG 900, a Potent and Highly Selective Aurora Kinase Inhibitor Shows Promising Preclinical Activity Against Acute Myeloid Leukemia Cell Lines In Vitro and In Vivo by Cheung, Kam, Juan, Gloria, Wayne, William, Hanestad, Kelly, Keegan, Kathleen, Huard, Justin, McElroy, Patricia, Stanton, Mary K, Bush, Tammy L, Kendall, Richard L, Radinsky, Robert, Abella, Steve, Pieslor, Peter C, Friberg, Gregory, Coxon, Angela, Gamelin, Erick, Payton, Marc

“…Aurora kinases A and B play essential roles in multiple stages of mitosis and are frequently overexpressed in a subset of human cancers, including acute…”
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Specificity of vascular endothelial cell growth factor receptor ligand binding domains by Kendall, R L, Wang, G, DiSalvo, J, Thomas, K A

“…Vascular endothelial cell growth factor binds with high affinity to FLT and KDR, two homologous tyrosine kinase receptors expressed on vascular endothelial…”
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