Intraindividual variability in red blood cell thiopurine methyltransferase activity

Intraindividual variability in red blood cell thiopurine methyltransferase activity

Long-term (13 weeks) and circadian (24 hours) intraindividual variability in red blood cell (RBC) thiopurine methyltransferase (TPMT) activity in healthy subjects was studied. RBC TPMT activity was measured radiochemically. The variability in RBC TPMT activity was low and was only slightly higher th...

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Bibliographic Details
Published in:European journal of clinical pharmacology Vol. 50; no. 3; pp. 217 - 220
Main Authors: GIBERHAUG, T, KEMETSDAL, B, LYSAA, R, AARBAKKE, J
Format: Journal Article
Language:English
Published: Heidelberg Springer 1996
Berlin
Subjects:
Adult
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Circadian Rhythm
Enzymes and enzyme inhibitors
Erythrocytes - metabolism
Female
Fundamental and applied biological sciences. Psychology
Humans
Male
Methyltransferases - metabolism
Middle Aged
Reproducibility of Results
Transferases
Human
Methyltransferases
Enzymatic activity
Intraindividual comparison
Enzyme
Transferases
Red blood cell
Thiopurine S-methyltransferase
Circadian rhythm
Normal
Long term
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Summary:Long-term (13 weeks) and circadian (24 hours) intraindividual variability in red blood cell (RBC) thiopurine methyltransferase (TPMT) activity in healthy subjects was studied. RBC TPMT activity was measured radiochemically. The variability in RBC TPMT activity was low and was only slightly higher than the imprecision of he TPMT assay. Mean long-term intraindividual variability in RBC TPMT activity was 6.5% (CV) (n = 46). Mean intraindividual circadian variability in RBC TPMT activity was 6.4% (CV) (n = 18). In contrast to what has been observed in children with acute lymphoblastic leukaemia, the intraindividual variability in RBC TPMT activity in healthy subjects was low. The reported changes in baseline RBC TPMT activity in patients are probably therefore due to drugs, disease, assay variation or other, unidentified factors.
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ISSN:0031-6970
1432-1041
DOI:10.1007/s002280050095