Search Results - "KELSOE, JOHN R"

Polygenic Polarity in Bipolar Disorder by R Kelsoe, John

“…The polygenic risk score (PRS) was created in order to capture the overall polygenic contribution to genetic heritability. This is accomplished by summing all…”
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High Frequencies of De Novo CNVs in Bipolar Disorder and Schizophrenia by Malhotra, Dheeraj, McCarthy, Shane, Michaelson, Jacob J., Vacic, Vladimir, Burdick, Katherine E., Yoon, Seungtai, Cichon, Sven, Corvin, Aiden, Gary, Sydney, Gershon, Elliot S., Gill, Michael, Karayiorgou, Maria, Kelsoe, John R., Krastoshevsky, Olga, Krause, Verena, Leibenluft, Ellen, Levy, Deborah L., Makarov, Vladimir, Bhandari, Abhishek, Malhotra, Anil K., McMahon, Francis J., Nöthen, Markus M., Potash, James B., Rietschel, Marcella, Schulze, Thomas G., Sebat, Jonathan

“…While it is known that rare copy-number variants (CNVs) contribute to risk for some neuropsychiatric disorders, the role of CNVs in bipolar disorder is…”
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Toward a Valid Animal Model of Bipolar Disorder: How the Research Domain Criteria Help Bridge the Clinical-Basic Science Divide by Cosgrove, Victoria E, Kelsoe, John R, Suppes, Trisha

“…Abstract Bipolar disorder is a diagnostically heterogeneous disorder, although mania emerges as a distinct phenotype characterized by elevated mood and…”
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Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate by Andreassen, Ole A, Thompson, Wesley K, Schork, Andrew J, Ripke, Stephan, Mattingsdal, Morten, Kelsoe, John R, Kendler, Kenneth S, O'Donovan, Michael C, Rujescu, Dan, Werge, Thomas, Sklar, Pamela, Roddey, J Cooper, Chen, Chi-Hua, McEvoy, Linda, Desikan, Rahul S, Djurovic, Srdjan, Dale, Anders M

“…Several lines of evidence suggest that genome-wide association studies (GWAS) have the potential to explain more of the "missing heritability" of common…”
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A survey of genomic studies supports association of circadian clock genes with bipolar disorder spectrum illnesses and lithium response by McCarthy, Michael J, Nievergelt, Caroline M, Kelsoe, John R, Welsh, David K

“…Circadian rhythm abnormalities in bipolar disorder (BD) have led to a search for genetic abnormalities in circadian "clock genes" associated with BD. However,…”
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Circadian rhythms in bipolar disorder patient-derived neurons predict lithium response: preliminary studies by Mishra, Himanshu K., Ying, Noelle M., Luis, Angelica, Wei, Heather, Nguyen, Metta, Nakhla, Timothy, Vandenburgh, Sara, Alda, Martin, Berrettini, Wade H., Brennand, Kristen J., Calabrese, Joseph R., Coryell, William H., Frye, Mark A., Gage, Fred H., Gershon, Elliot S., McInnis, Melvin G., Nievergelt, Caroline M., Nurnberger, John I., Shilling, Paul D., Oedegaard, Ketil J., Zandi, Peter P., Kelsoe, John R., Welsh, David K., McCarthy, Michael J.

“…A bstract Bipolar disorder (BD) is a neuropsychiatric illness defined by recurrent episodes of mania/hypomania, depression and circadian rhythm abnormalities…”
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Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia by Sebat, Jonathan, Vacic, Vladimir, McCarthy, Shane, Malhotra, Dheeraj, Murray, Fiona, Chou, Hsun-Hua, Peoples, Aine, Makarov, Vladimir, Yoon, Seungtai, Bhandari, Abhishek, Corominas, Roser, Iakoucheva, Lilia M, Krastoshevsky, Olga, Krause, Verena, Larach-Walters, Verónica, Welsh, David K, Craig, David, Kelsoe, John R, Gershon, Elliot S, Leal, Suzanne M, Aquila, Marie Dell, Morris, Derek W, Gill, Michael, Corvin, Aiden, Insel, Paul A, McClellan, Jon, King, Mary-Claire, Karayiorgou, Maria, Levy, Deborah L, DeLisi, Lynn E

“…Rare copy number variants (CNVs) have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for…”
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All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs by Schork, Andrew J, Thompson, Wesley K, Pham, Phillip, Torkamani, Ali, Roddey, J Cooper, Sullivan, Patrick F, Kelsoe, John R, O'Donovan, Michael C, Furberg, Helena, Schork, Nicholas J, Andreassen, Ole A, Dale, Anders M

“…Recent results indicate that genome-wide association studies (GWAS) have the potential to explain much of the heritability of common complex phenotypes, but…”
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Analysis of 94 Candidate Genes and 12 Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia by Greenwood, Tiffany A, Lazzeroni, Laura C, Murray, Sarah S, Cadenhead, Kristin S, Calkins, Monica E, Dobie, Dorcas J, Green, Michael F, Gur, Raquel E, Gur, Ruben C, Hardiman, Gary, Kelsoe, John R, Leonard, Sherry, Light, Gregory A, Nuechterlein, Keith H, Olincy, Ann, Radant, Allen D, Schork, Nicholas J, Seidman, Larry J, Siever, Larry J, Silverman, Jeremy M, Stone, William S, Swerdlow, Neal R, Tsuang, Ming T, Tsuang, Debby W, Turetsky, Bruce I, Freedman, Robert, Braff, David L

“…Genes affecting glutamate neurotransmission featured prominently in associations between 94 genes and 12 inherited physiological or cognitive characteristics…”
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Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells by Santos, Renata, Vadodaria, Krishna C., Jaeger, Baptiste N., Mei, Arianna, Lefcochilos-Fogelquist, Sabrina, Mendes, Ana P.D., Erikson, Galina, Shokhirev, Maxim, Randolph-Moore, Lynne, Fredlender, Callie, Dave, Sonia, Oefner, Ruth, Fitzpatrick, Conor, Pena, Monique, Barron, Jerika J., Ku, Manching, Denli, Ahmet M., Kerman, Bilal E., Charnay, Patrick, Kelsoe, John R., Marchetto, Maria C., Gage, Fred H.

“…Astrocyte dysfunction and neuroinflammation are detrimental features in multiple pathologies of the CNS. Therefore, the development of methods that produce…”
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Ntrk1 mutation co-segregating with bipolar disorder and inherited kidney disease in a multiplex family causes defects in neuronal growth and depression-like behavior in mice by Nakajima, Kazuo, Miranda, Alannah, Craig, David W., Shekhtman, Tatyana, Kmoch, Stanislav, Bleyer, Anthony, Szelinger, Szabolcs, Kato, Tadafumi, Kelsoe, John R.

“…Previously, we reported a family in which bipolar disorder (BD) co-segregates with a Mendelian kidney disorder linked to 1q22. The causative renal gene was…”
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Common and rare variant analysis in early-onset bipolar disorder vulnerability by Jamain, Stéphane, Cichon, Sven, Etain, Bruno, Mühleisen, Thomas W, Georgi, Alexander, Zidane, Nora, Chevallier, Lucie, Deshommes, Jasmine, Nicolas, Aude, Henrion, Annabelle, Degenhardt, Franziska, Mattheisen, Manuel, Priebe, Lutz, Mathieu, Flavie, Kahn, Jean-Pierre, Henry, Chantal, Boland, Anne, Zelenika, Diana, Gut, Ivo, Heath, Simon, Lathrop, Mark, Maier, Wolfgang, Albus, Margot, Rietschel, Marcella, Schulze, Thomas G, McMahon, Francis J, Kelsoe, John R, Hamshere, Marian, Craddock, Nicholas, Nöthen, Markus M, Bellivier, Frank, Leboyer, Marion

“…Bipolar disorder is one of the most common and devastating psychiatric disorders whose mechanisms remain largely unknown. Despite a strong genetic contribution…”
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CRY2 is associated with depression by Lavebratt, Catharina, Sjöholm, Louise K, Soronen, Pia, Paunio, Tiina, Vawter, Marquis P, Bunney, William E, Adolfsson, Rolf, Forsell, Yvonne, Wu, Joseph C, Kelsoe, John R, Partonen, Timo, Schalling, Martin

“…Abnormalities in the circadian clockwork often characterize patients with major depressive and bipolar disorders. Circadian clock genes are targets of interest…”
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Pharmacogenetics of lithium response in bipolar disorder by McCarthy, Michael J, Leckband, Susan G, Kelsoe, John R

“…Bipolar disorder (BD) is a serious mental illness with well-established, but poorly characterized genetic risk. Lithium is among the best proven mood…”
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Effect of the Type and Number of Adverse Childhood Experiences and the Timing of Adverse Experiences on Clinical Outcomes in Individuals with Bipolar Disorder by Park, Young-Min, Shekhtman, Tatyana, Kelsoe, John R

“…Studies have reported an association between adverse childhood experiences (ACEs) and the clinical outcomes of bipolar disorder (BD). However, these studies…”
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Over-expression of XIST, the Master Gene for X Chromosome Inactivation, in Females With Major Affective Disorders by Ji, Baohu, Higa, Kerin K., Kelsoe, John R., Zhou, Xianjin

“…Psychiatric disorders are common mental disorders without a pathological biomarker. Classic genetic studies found that an extra X chromosome frequently causes…”
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TEMPS-A: validation of a short version of a self-rated instrument designed to measure variations in temperament by Akiskal, Hagop S., Mendlowicz, Mauro V., Jean-Louis, Girardin, Rapaport, Mark H., Kelsoe, John R., Gillin, J.Christian, Smith, Tom L.

“…Objective: To validate a short English-language version of the Temperament Evaluation of Memphis, Pisa, Paris and San Diego-autoquestionnaire version…”
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A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder by Lee, Heon-Jeong, Woo, Hyun Goo, Greenwood, Tiffany A, Kripke, Daniel F, Kelsoe, John R

“…Abstract Objective The use of subphenotypes may be an effective approach for genetic studies of complex diseases. Manic episodes with a seasonal pattern may…”
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RNA sequencing of transcriptomes in human brain regions: protein-coding and non-coding RNAs, isoforms and alleles by Webb, Amy, Papp, Audrey C, Curtis, Amanda, Newman, Leslie C, Pietrzak, Maciej, Seweryn, Michal, Handelman, Samuel K, Rempala, Grzegorz A, Wang, Daqing, Graziosa, Erica, Tyndale, Rachel F, Lerman, Caryn, Kelsoe, John R, Mash, Deborah C, Sadee, Wolfgang

“…We used RNA sequencing to analyze transcript profiles of ten autopsy brain regions from ten subjects. RNA sequencing techniques were designed to detect both…”
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Promoter and intronic variants affect the transcriptional regulation of the human dopamine transporter gene by Greenwood, Tiffany A, Kelsoe, John R

“…We have attempted to identify regions involved in the transcriptional regulation of the DAT1 (HUGO approved symbol SLC6A3) gene that may harbor functional…”
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