Search Results - "KELLY, PAUL A T"

Chronic Activation of Corticotropin-Releasing Factor Type 2 Receptors Reveals a Key Role for 5-HT1A Receptor Responsiveness in Mediating Behavioral and Serotonergic Responses to Stressful Challenge by Neufeld-Cohen, Adi, Kelly, Paul A.T, Paul, Evan D, Carter, Roderick N, Skinner, Elizabeth, Olverman, Henry J, Vaughan, Joan M, Issler, Orna, Kuperman, Yael, Lowry, Christopher A, Vale, Wylie W, Seckl, Jonathan R, Chen, Alon, Jamieson, Pauline M

“…Background The corticotropin-releasing factor type 2 receptor (CRFR2) is suggested to play an important role in aiding recovery from acute stress, but any…”
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Acute SSRI-induced anxiogenic and brain metabolic effects are attenuated 6 months after initial MDMA-induced depletion by Andó, Rómeó D., Ádori, Csaba, Kirilly, Eszter, Molnár, Eszter, Kovács, Gábor G., Ferrington, Linda, Kelly, Paul A.T., Bagdy, György

“…To assess the functional state of the serotonergic system, the acute behavioural and brain metabolic effect of SSRI antidepressants were studied during the…”
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Elevated BDNF protein level in cortex but not in hippocampus of MDMA-treated Dark Agouti rats: A potential link to the long-term recovery of serotonergic axons by Ádori, Csaba, Andó, Rómeó D., Ferrington, Linda, Szekeres, Mária, Vas, Szilvia, Kelly, Paul A.T., Hunyady, László, Bagdy, György

“…3,4-Methylenedioxymethamphetamine (MDMA, “ecstasy”) is a widely used recreational drug known to cause selective long-term serotonergic damage. In this study,…”
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Memory Reconsolidation: Sensitivity of Spatial Memory to Inhibition of Protein Synthesis in Dorsal Hippocampus during Encoding and Retrieval by Morris, Richard G.M., Inglis, Jennifer, Ainge, James A., Olverman, Henry J., Tulloch, Jane, Dudai, Yadin, Kelly, Paul A.T.

“…Reconsolidation is a putative neuronal process in which the retrieval of a previously consolidated memory returns it to a labile state that is once again…”
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Phosphodiesterase Inhibitors Enhance Object Memory Independent of Cerebral Blood Flow and Glucose Utilization in Rats by RUTTEN, Kris, VAN DONKELAAR, Eva L, FERRINGTON, Linda, BLOKLAND, Arjan, POLLEN, Eva, STEINBUSCH, Harry W. M, KELLY, Paul A. T, PRICKAERTS, Jos H. H. J

“…Phosphodiesterase (PDE) inhibitors prevent the breakdown of the second messengers, cyclic AMP (cAMP) and cyclic GMP (cGMP), and are currently studied as…”
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Frailty or frailties: exploring frailty index subdimensions in the English Longitudinal Study of Ageing by Johnson, Lara, Guthrie, Bruce, Kelly, Paul A T, Anand, Atul, Marshall, Alan, Seth, Sohan

“…Frailty, a state of increased vulnerability to adverse health outcomes, has garnered significant attention in research and clinical practice. Existing…”
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Programming of Rat Muscle and Fat Metabolism by in Utero Overexposure to Glucocorticoids by Cleasby, Mark E, Kelly, Paul A. T, Walker, Brian R, Seckl, Jonathan R

“…In utero overexposure to glucocorticoids may explain the association between low birth weight and subsequent development of the metabolic syndrome. We…”
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Acute tryptophan depletion in C57BL/6 mice does not induce central serotonin reduction or affective behavioural changes by van Donkelaar, Eva L., Blokland, Arjan, Lieben, Cindy K.J., Kenis, Gunter, Ferrington, Linda, Kelly, Paul A.T., Steinbusch, Harry W.M., Prickaerts, Jos

“…Acute tryptophan depletion is extensively used to investigate the implication of serotonin in the onset of depressive disorders. In rats, it lowers peripheral…”
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Partial lesion of the serotonergic system by a single dose of MDMA results in behavioural disinhibition and enhances acute MDMA-induced social behaviour on the social interaction test by Ando, Romeo D., Benko, Anita, Ferrington, Linda, Kirilly, Eszter, Kelly, Paul A.T., Bagdy, Gyorgy

“…The acute effects of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) on anxiety-related behaviours were studied using indices of social interaction in Dark…”
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Sex influences the effect of a lifelong increase in serotonin transporter function on cerebral metabolism by Dawson, Neil, Ferrington, Linda, Olverman, Henry J., Harmar, Anthony J., Kelly, Paul A. T.

“…Polymorphic variation in the human serotonin transporter (SERT; 5‐HTT) gene resulting in a lifelong increase in SERT expression is associated with reduced…”
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Novel analysis for improved validity in semi-quantitative 2-deoxyglucose autoradiographic imaging by Dawson, Neil, Ferrington, Linda, Olverman, Henry J., Kelly, Paul A.T.

“…The original [ 14C]-2-deoxyglucose autoradiographic imaging technique allows for the quantitative determination of local cerebral glucose utilisation (LCMRglu)…”
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Acute tryptophan depletion potentiates 3,4-methylenedioxymethamphetamine-induced cerebrovascular hyperperfusion in adult male wistar rats by van Donkelaar, Eva L., Kelly, Paul A.T., Dawson, Neil, Blokland, Arjan, Prickaerts, Jos, Steinbusch, Harry W.M., Ferrington, Linda

“…The serotonergic (5‐hydroxytryptamine; 5‐HT) dysfunction found in depression may affect not only brain function (mood) but also cerebrovascular control…”
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Persistent cerebrovascular effects of MDMA and acute responses to the drug by Ferrington, Linda, Kirilly, Eszter, McBean, Douglas E., Olverman, Henry J., Bagdy, György, Kelly, Paul A. T.

“…Acutely, 3,4,‐methylenedioxymethamphetamine (MDMA) induces cerebrovascular dysfunction [Quate et al., (2004)Psychopharmacol., 173, 287–295]. In the longer term…”
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Cerebral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression by Dawson, Neil, Ferrington, Linda, Lesch, Klaus-Peter, Kelly, Paul A.T

“…Abstract Variation in the human serotonin transporter gene ( h SERT; 5-HTT) resulting in a life-long alteration in SERT function influences anxiety and the…”
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Effects of a single dose of 3,4-methylenedioxymethamphetamine on circadian patterns, motor activity and sleep in drug-naive rats and rats previously exposed to MDMA by Balogh, Brigitta, Molnar, Eszter, Jakus, Rita, Quate, Linda, Olverman, Henry J, Kelly, Paul A T, Kantor, Sandor, Bagdy, Gyorgy

“…Despite the well documented neurochemical actions of 3,4-methylenedioxymethamphetamine (MDMA), acute effects in rats previously exposed to the drug have not…”
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Acute and long-term effects of a single dose of MDMA on aggression in Dark Agouti rats by Kirilly, Eszter, Benko, Anita, Ferrington, Linda, Ando, Romeo D., Kelly, Paul A. T., Bagdy, Gyorgy

“…MDMA causes selective depletion of serotonergic terminals in experimental animals and the consequent decrease in synaptic 5-HT may, inter alia, increase…”
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Acute methylenedioxymethamphetamine administration: effects on local cerebral blood flow and glucose utilisation in the Dark Agouti rat by Quate, Linda, McBean, Douglas E, Ritchie, Isobel M, Olverman, Henry J, Kelly, Paul A T

“…Clinical reports indicate that acute exposure to 3,4-methylenedioxymethamphetamine (MDMA; "Ecstasy") may induce pathological cerebrovascular responses in human…”
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Functional consequences of perinatal exposure to 3,4-methylenedioxymethamphetamine in rat brain by KELLY, Paul A. T, RITCHIE, Isobel M, QUATE, Linda, MCBEAN, Douglas E, OLVERMAN, Henry J

“…1. In this study we have examined methylenedioxymethamphetamine (MDMA)-induced toxicity in perinatal rat brain, related this to normal development of serotonin…”
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Intrahippocampal Septal Grafts Ameliorate Learning Impairments in Aged Rats by Gage, Fred H., Björklund, Anders, Stenevi, Ulf, Dunnett, Stephen B., Paul A. T. Kelly

“…Grafts of fetal septal tissue rich in cholinergic neurons were implanted as a dissociated cell suspension into the depth of the hippocampal formation in aged…”
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Cerebrovascular effects of nitric oxide manipulation in spontaneously hypertensive rats by Fouyas, Ioannis P, Kelly, Paul A T, Ritchie, Isobel M, Whittle, Ian R

“…Evidence that nitric oxide (NO) bioactivity is altered in chronic hypertension is conflicting, possibly as a result of heterogeneity in both the nature of the…”
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