Search Results - "KELLY, Mark J. S"

structural basis of yeast prion strain variants by Toyama, B.H, Kelly, M.J.S, Gross, J.D, Weissman, J.S

“…Among the many surprises to arise from studies of prion biology, perhaps the most unexpected is the strain phenomenon whereby a single protein can misfold into…”
Get full text

Allosteric N-WASP activation by an inter-SH3 domain linker in Nck by Okrut, Julia, Prakash, Sumit, Wu, Qiong, Kelly, Mark J. S., Taunton, Jack

“…Actin filament networks assemble on cellular membranes in response to signals that locally activate neural Wiskott–Aldrich-syndrome protein (N-WASP) and the…”
Get full text

The centrosomin CM2 domain is a multi-functional binding domain with distinct cell cycle roles by Citron, Y Rose, Fagerstrom, Carey J, Keszthelyi, Bettina, Huang, Bo, Rusan, Nasser M, Kelly, Mark J S, Agard, David A

“…The centrosome serves as the main microtubule-organizing center in metazoan cells, yet despite its functional importance, little is known mechanistically about…”
Get full text

Expanding the space of protein geometries by computational design of de novo fold families by Pan, Xingjie, Thompson, Michael C, Zhang, Yang, Liu, Lin, Fraser, James S, Kelly, Mark J S, Kortemme, Tanja

“…Naturally occurring proteins vary the precise geometries of structural elements to create distinct shapes optimal for function. We present a computational…”
Get full text

Recognition of Histone H3 Methylation States by the PHD1 Domain of Histone Demethylase KDM5A by Longbotham, James E., Kelly, Mark J. S., Fujimori, Danica Galonić

“…PHD reader domains are chromatin binding modules often responsible for the recruitment of large protein complexes that contain histone modifying enzymes,…”
Get full text

Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices by JIANYING ZENG, JIA LIU, YANG, Guo-Yuan, KELLY, Mark J. S, JAMES, Thomas L, LITT, Lawrence

“…Exogenous pyruvate and ethyl pyruvate (EP), the key ingredient in a new Ringer's solution in clinical trials, are antioxidants as well as metabolic substrates…”
Get full text

Elucidating the Mechanism of Substrate Recognition by the Bacterial Hsp90 Molecular Chaperone by Street, Timothy O., Zeng, Xiaohui, Pellarin, Riccardo, Bonomi, Massimiliano, Sali, Andrej, Kelly, Mark J.S., Chu, Feixia, Agard, David A.

“…Hsp90 is a conformationally dynamic molecular chaperone known to promote the folding and activation of a broad array of protein substrates (“clients”). Hsp90…”
Get full text

Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding by Frantz, Christian, Barreiro, Gabriela, Dominguez, Laura, Chen, Xiaoming, Eddy, Robert, Condeelis, John, Kelly, Mark J.S, Jacobson, Matthew P, Barber, Diane L

“…Newly generated actin free barbed ends at the front of motile cells provide sites for actin filament assembly driving membrane protrusion. Growth factors…”
Get full text

Identifying ligands for the PHD1 finger of KDM5A through high-throughput screening by Ortiz, Gloria, Longbotham, James E, Qin, Sophia L, Zhang, Meng Yao, Lee, Gregory M, Neitz, R. Jeffrey, Kelly, Mark J. S, Arkin, Michelle R, Fujimori, Danica Galoni

“…PHD fingers are a type of chromatin reader that primarily recognize chromatin as a function of lysine methylation state. Dysregulated PHD fingers are…”
Get full text

Metabolomics of oxidative stress in recent studies of endogenous and exogenously administered intermediate metabolites by Liu, Jia, Litt, Lawrence, Segal, Mark R, Kelly, Mark J S, Pelton, Jeffrey G, Kim, Myungwon

“…Aerobic metabolism occurs in a background of oxygen radicals and reactive oxygen species (ROS) that originate from the incomplete reduction of molecular oxygen…”
Get full text

Biophysical methods for identifying fragment-based inhibitors of protein-protein interactions by Pfaff, Samuel J, Chimenti, Michael S, Kelly, Mark J S, Arkin, Michelle R

“…Fragment-based lead discovery complements high-throughput screening and computer-aided drug design for the discovery of small-molecule inhibitors of…”
Get more information

13C NMR Metabolomic Evaluation of Immediate and Delayed Mild Hypothermia in Cerebrocortical Slices after Oxygen―Glucose Deprivation by JIA LIU, SEGAL, Mark R, KELLY, Mark J. S, PELTON, Jeffrey G, MYUNGWON KIM, JAMES, Thomas L, LITT, Lawrence

“…Mild brain hypothermia (32°-34°C) after human neonatal asphyxia improves neurodevelopmental outcomes. Astrocytes but not neurons have pyruvate carboxylase and…”
Get full text

Design of a Phosphorylatable PDZ Domain with Peptide-Specific Affinity Changes by Smith, Colin A., Shi, Catherine A., Chroust, Matthew K., Bliska, Thomas E., Kelly, Mark J.S., Jacobson, Matthew P., Kortemme, Tanja

“…Phosphorylation is one of the most common posttranslational modifications controlling cellular protein activity. Here, we describe a combined computational and…”
Get full text

Chromatin Sensing by the Auxiliary Domains of KDM5C Regulates Its Demethylase Activity and Is Disrupted by X-linked Intellectual Disability Mutations by Ugur, Fatima S., Kelly, Mark J.S., Fujimori, Danica Galonić

“…[Display omitted] •Dysregulation of KDM5C in X-linked intellectual disability is poorly understood.•ARID domain of KDM5C aids nucleosome demethylation, while…”
Get full text

A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain by Lin King, John V., Emrick, Joshua J., Kelly, Mark J.S., Herzig, Volker, King, Glenn F., Medzihradszky, Katalin F., Julius, David

“…TRPA1 is a chemosensory ion channel that functions as a sentinel for structurally diverse electrophilic irritants. Channel activation occurs through an unusual…”
Get full text

Computational design of a modular protein sense-response system by Glasgow, Anum A, Huang, Yao-Ming, Mandell, Daniel J, Thompson, Michael, Ritterson, Ryan, Loshbaugh, Amanda L, Pellegrino, Jenna, Krivacic, Cody, Pache, Roland A, Barlow, Kyle A, Ollikainen, Noah, Jeon, Deborah, Kelly, Mark J S, Fraser, James S, Kortemme, Tanja

“…Sensing and responding to signals is a fundamental ability of living systems, but despite substantial progress in the computational design of new protein…”
Get full text

Radically Different Amyloid Conformations Dictate the Seeding Specificity of a Chimeric Sup35 Prion by Foo, Catherine K., Ohhashi, Yumiko, Kelly, Mark J.S., Tanaka, Motomasa, Weissman, Jonathan S.

“…A remarkable feature of prion biology is that the same prion protein can misfold into more than one infectious conformation, and these conformations in turn…”
Get full text

Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism by Torres, Idelisse Ortiz, Kuchenbecker, Kristopher M., Nnadi, Chimno I., Fletterick, Robert J., Kelly, Mark J. S., Fujimori, Danica Galonić

“…The retinoblastoma binding protein KDM5A removes methyl marks from lysine 4 of histone H3 (H3K4). Misregulation of KDM5A contributes to the pathogenesis of…”
Get full text

Probing the KRas Switch II Groove by Fluorine NMR Spectroscopy by Peacock, D. Matthew, Kelly, Mark J. S., Shokat, Kevan M.

“…While there has been recent success in the development of KRasG12C inhibitors, unmet needs for selective inhibitors of KRasG12D and the remaining oncogenic…”
Get full text

A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells by Stöhr, Jan, Wu, Haifan, Nick, Mimi, Wu, Yibing, Bhate, Manasi, Condello, Carlo, Johnson, Noah, Rodgers, Jeffrey, Lemmin, Thomas, Acharya, Srabasti, Becker, Julia, Robinson, Kathleen, Kelly, Mark J. S., Gai, Feng, Stubbs, Gerald, Prusiner, Stanley B., DeGrado, William F.

“…The self-propagation of misfolded conformations of tau underlies neurodegenerative diseases, including Alzheimer's. There is considerable interest in…”
Get full text