Search Results - "KELLY, J. W"

Current and future treatment of amyloid diseases by Ankarcrona, M., Winblad, B., Monteiro, C., Fearns, C., Powers, E. T., Johansson, J., Westermark, G. T., Presto, J., Ericzon, B.‐G., Kelly, J. W.

“…There are more than 30 human proteins whose aggregation appears to cause degenerative maladies referred to as amyloid diseases or amyloidoses. These disorders…”
Get full text

Light interception efficiency explained by two simple variables: a test using a diversity of small‐ to medium‐sized woody plants by Duursma, R. A, Falster, D. S, Valladares, F, Sterck, F. J, Pearcy, R. W, Lusk, C. H, Sendall, K. M, Nordenstahl, M, Houter, N. C, Atwell, B. J, Kelly, N, Kelly, J. W. G, Liberloo, M, Tissue, D. T, Medlyn, B. E, Ellsworth, D. S

“…• Plant light interception efficiency is a crucial determinant of carbon uptake by individual plants and by vegetation. Our aim was to identify whole‐plant…”
Get full text

Therapeutic strategies to ameliorate lysosomal storage disorders--a focus on Gaucher disease by Sawkar, A R, D'Haeze, W, Kelly, J W

“…The lysosomal storage disorders encompass more than 40 distinct diseases, most of which are caused by the deficient activity of a lysosomal hydrolase leading…”
Get full text

Clinical and dermoscopic characteristics of Merkel cell carcinoma by Jalilian, C., Chamberlain, A.J., Haskett, M., Rosendahl, C., Goh, M., Beck, H., Keir, J., Varghese, P., Mar, A., Hosking, S., Hussain, I., Rich, M., McLean, C., Kelly, J.W.

“…Summary Background Merkel cell carcinoma (MCC) is an aggressive cutaneous malignancy with a high mortality rate. Diagnosis is often delayed. Objectives To…”
Get full text

Postexcisional melanocytic regrowth extending beyond the initial scar: a novel clinical sign of melanoma by Kelly, J.W., Shen, S., Pan, Y., Dowling, J., McLean, C.A.

“…Summary Background Recurrent naevi are widely recognized to occur commonly following incomplete removal of melanocytic lesions. These lesions have been…”
Get full text

Mechanisms of amyloidogenesis by Kelly, Jeffery W

Get full text

Amyloid Diseases: Abnormal Protein Aggregation in Neurodegeneration by Koo, Edward H., Lansbury, Peter T., Kelly, Jeffery W.

“…Koo et al focus on biophysical studies of protein aggregation in Alzheimer's disease and familial amyloid polyneuropathy. Mechanistic models connecting…”
Get full text

Trans-Suppression of Misfolding in an Amyloid Disease by Hammarström, Per, Schneider, Frank, Kelly, Jeffery W.

“…The transthyretin (TTR) amyloid diseases, representative of numerous misfolding disorders, are of considerable interest because there are mutations that cause…”
Get full text

Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosis by Lindquist, Susan L, Kelly, Jeffery W

“…Maintaining the proteome to preserve the health of an organism in the face of developmental changes, environmental insults, infectious diseases, and rigors of…”
Get full text

The Environmental Dependency of Protein Folding Best Explains Prion and Amyloid Diseases by Kelly, Jeffery W.

“…The amyloid and prion diseases appear to result from the conversion of one of about 20 normally soluble and functional proteins into a beta-sheet-rich…”
Get full text

An Engineered Transthyretin Monomer that Is Nonamyloidogenic, Unless It Is Partially Denatured by Jiang, Xin, Smith, Craig S, Petrassi, H. Michael, Hammarström, Per, White, Joleen T, Sacchettini, James C, Kelly, Jeffery W

“…Transthyretin (TTR) is a soluble human plasma protein that can be converted into amyloid by acid-mediated dissociation of the homotetramer into monomers. The…”
Get full text

Support for the Multigenic Hypothesis of Amyloidosis: The Binding Stoichiometry of Retinol-Binding Protein, Vitamin A, and Thyroid Hormone Influences Transthyretin Amyloidogenicity in vitro by White, Joleen T., Kelly, Jeffery W.

“…The amyloidoses are a large group of protein misfolding diseases. Genetic and biochemical evidence support the hypothesis that amyloid formation from wild-type…”
Get full text

Rumen microbial (meta)genomics and its application to ruminant production by Morgavi, D. P., Kelly, W. J., Janssen, P. H., Attwood, G. T.

“…Meat and milk produced by ruminants are important agricultural products and are major sources of protein for humans. Ruminant production is of considerable…”
Get full text

Not all melanomas are created equal: a review and call for more research into nodular melanoma by Dessinioti, C., Geller, A.C., Whiteman, D.C., Garbe, C., Grob, J.J., Kelly, J.W., Scolyer, R.A., Rawson, R.V., Lallas, A., Pellacani, G., Stratigos, A.J.

“…Summary Among the histogenic subtypes of melanoma, nodular melanoma (NM) is the major contributor for thicker and fatal melanomas and it has been associated…”
Get full text

Rapid analysis of a plasmid by hydrophobic-interaction chromatography with a non-porous resin by Iuliano, S, Fisher, J.R, Chen, M, Kelly, W.J

“…A HPLC technique has been developed, based on hydrophobic-interaction Chromatography with a non-porous packing (TSKgel Butyl-NPR, Tosoh Biosep LLC), that…”
Get full text

Clinicopathological characteristics and prognosis of patients with multiple primary melanomas by Adler, N.R., Kelly, J.W., Haydon, A., McLean, C.A., Mar, V.J.

“…Respond to this article…”
Get full text

Anion Shielding of Electrostatic Repulsions in Transthyretin Modulates Stability and Amyloidosis:  Insight into the Chaotrope Unfolding Dichotomy by Hammarström, Per, Jiang, Xin, Deechongkit, Songpon, Kelly, Jeffery W

“…The balance between stabilizing forces and the localized electrostatic repulsions destabilizing the transthyretin (TTR) tetramer is tunable via anion…”
Get full text

Differences between pure desmoplastic melanoma and superficial spreading melanoma in terms of survival, distribution and other clinicopathologic features by Howard, M.D., Wee, E., Wolfe, R., McLean, C.A., Kelly, J.W., Pan, Y.

“…Background Pure desmoplastic melanoma (pDM) is an uncommon subtype of malignant melanoma with comparative high rates of local recurrence and low rates of…”
Get full text

Acral lentiginous melanoma: differences in survival compared with other subtypes by Howard, M.D., Xie, C., Wee, E., Wolfe, R., McLean, C.A., Kelly, J.W., Pan, Y.

Get full text

Desmoplastic melanoma: a review of its pathology and clinical behaviour, and of management recommendations in published guidelines by Hughes, T.M., Williams, G.J., Gyorki, D.E., Kelly, J.W., Stretch, J.R., Varey, A.H.R., Hong, A.M., Scolyer, R.A., Thompson, J.F.

“…Desmoplastic melanomas are uncommon. Their behaviour differs from that of other melanoma subtypes; therefore, management guidelines for non‐desmoplastic…”
Get full text