Search Results - "KELLER, Jeffrey N"

Oxidative stress and cerebral endothelial cells: Regulation of the blood–brain-barrier and antioxidant based interventions by Freeman, Linnea R., Keller, Jeffrey N.

“…While numerous lines of evidence point to increased levels of oxidative stress playing a causal role in a number of neurodegenerative conditions, our current…”
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Saturated long-chain fatty acids activate inflammatory signaling in astrocytes by Gupta, Sunita, Knight, Alecia G., Gupta, Shruti, Keller, Jeffrey N., Bruce-Keller, Annadora J.

“…J. Neurochem. (2012) 120, 1060–1071. This study describes the effects of long‐chain fatty acids on inflammatory signaling in cultured astrocytes. Data show…”
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Feasibility, reliability, and validity of a smartphone based application for the assessment of cognitive function in the elderly by Brouillette, Robert M, Foil, Heather, Fontenot, Stephanie, Correro, Anthony, Allen, Ray, Martin, Corby K, Bruce-Keller, Annadora J, Keller, Jeffrey N

“…While considerable knowledge has been gained through the use of established cognitive and motor assessment tools, there is a considerable interest and need for…”
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Chronic exercise modulates RAS components and improves balance between pro- and anti-inflammatory cytokines in the brain of SHR by Agarwal, Deepmala, Welsch, Michael A., Keller, Jeffrey N., Francis, Joseph

“…Recently, exercise has been recommended as a part of lifestyle modification for all hypertensive patients; however, the precise mechanisms of its effects on…”
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High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling by Morrison, Christopher D, Pistell, Paul J, Ingram, Donald K, Johnson, William D, Liu, Ying, Fernandez-Kim, Sun Ok, White, Christy L, Purpera, Megan N, Uranga, Romina M, Bruce-Keller, Annadora J, Keller, Jeffrey N

“…J. Neurochem. (2010) 114, 1581-1589. Long term consumption of a high fat diet (HFD) contributes to increased morbidity and mortality. Yet the specific effects…”
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Feasibility and validation of a web-based platform for the self-administered patient collection of demographics, health status, anxiety, depression, and cognition in community dwelling elderly by Calamia, Matthew, Weitzner, Daniel S, De Vito, Alyssa N, Bernstein, John P K, Allen, Ray, Keller, Jeffrey N

“…The coronavirus disease pandemic has brought a new urgency for the development and deployment of web-based applications which complement, and offer…”
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Obesity increases cerebrocortical reactive oxygen species and impairs brainfunction by Freeman, Linnea R., Zhang, Le, Nair, Anand, Dasuri, Kalavathi, Francis, Joseph, Fernandez-Kim, Sun-Ok, Bruce-Keller, Annadora J., Keller, Jeffrey N.

“…Nearly two-thirds of the population in the United States is overweight or obese, and this unprecedented level of obesity will undoubtedly have a profound…”
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Protein oxidation and cellular homeostasis: Emphasis on metabolism by Cecarini, Valentina, Gee, Jillian, Fioretti, Evandro, Amici, Manila, Angeletti, Mauro, Eleuteri, Anna Maria, Keller, Jeffrey N.

“…Reactive oxygen species (ROS) are generated as the result of a number of physiological and pathological processes. Once formed ROS can promote multiple forms…”
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Ribosome Dysfunction Is an Early Event in Alzheimer's Disease by Ding, Qunxing, Markesbery, William R, Chen, Qinghua, Li, Feng, Keller, Jeffrey N

“…Alzheimer's disease (AD) is a progressive and devastating disorder that is often preceded by mild cognitive impairment (MCI). In the present study, we report…”
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Apolipoprotein E Genotype Linked to Spatial Gait Characteristics: Predictors of Cognitive Dual Task Gait Change by MacAulay, Rebecca K, Allaire, Ted, Brouillette, Robert, Foil, Heather, Bruce-Keller, Annadora J, Keller, Jeffrey N

“…Developing measures to detect preclinical Alzheimer's Disease is vital, as prodromal stage interventions may prove more efficacious in altering the disease's…”
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Effects of Ghrelin on the Proteolytic Pathways of Alzheimer’s Disease Neuronal Cells by Cecarini, Valentina, Bonfili, Laura, Cuccioloni, Massimiliano, Keller, Jeffrey N., Bruce-Keller, Annadora J., Eleuteri, Anna Maria

“…Ghrelin is an orexigenic hormone with a role in the onset and progression of neurodegenerative disorders. It has been recently associated to Alzheimer’s…”
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High-Throughput Screening for Identification of Blood-Brain Barrier Integrity Enhancers: A Drug Repurposing Opportunity to Rectify Vascular Amyloid Toxicity by Qosa, Hisham, Mohamed, Loqman A, Al Rihani, Sweilem B, Batarseh, Yazan S, Duong, Quoc-Viet, Keller, Jeffrey N, Kaddoumi, Amal

“…The blood-brain barrier (BBB) is a dynamic interface that maintains brain homeostasis and protects it from free entry of chemicals, toxins, and drugs. The…”
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Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: Contributions of maternal diet by White, Christy L, Pistell, Paul J, Purpera, Megan N, Gupta, Sunita, Fernandez-Kim, Sun-Ok, Hise, Taylor L, Keller, Jeffrey N, Ingram, Donald K, Morrison, Christopher D, Bruce-Keller, Annadora J

“…Abstract This study was undertaken to investigate the effects of prenatal and postnatal exposure to high fat diet on the brain. Female rats were divided into…”
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I'd Do Anything for Research, But I Won't Do That: Interest in Pharmacological Interventions in Older Adults Enrolled in a Longitudinal Aging Study by Calamia, Matthew, Bernstein, John P K, Keller, Jeffrey N

“…Alzheimer's disease (AD) ranks as the 6th leading cause of death in the United States, yet unlike other diseases in this category, there are no…”
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The fine-tuning of proteolytic pathways in Alzheimer’s disease by Cecarini, Valentina, Bonfili, Laura, Cuccioloni, Massimiliano, Mozzicafreddo, Matteo, Angeletti, Mauro, Keller, Jeffrey N., Eleuteri, Anna Maria

“…Several integrated proteolytic systems contribute to the maintenance of cellular homeostasis through the continuous removal of misfolded, aggregated or…”
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A longitudinal study on dual-tasking effects on gait: cognitive change predicts gait variance in the elderly by MacAulay, Rebecca K, Brouillette, Robert M, Foil, Heather C, Bruce-Keller, Annadora J, Keller, Jeffrey N

“…Neuropsychological abilities have found to explain a large proportion of variance in objective measures of walking gait that predict both dementia and falling…”
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Evaluation of noise regression techniques in resting-state fMRI studies using data of 434 older adults by Scheel, Norman, Keller, Jeffrey N, Binder, Ellen F, Vidoni, Eric D, Burns, Jeffrey M, Thomas, Binu P, Stowe, Ann M, Hynan, Linda S, Kerwin, Diana R, Vongpatanasin, Wanpen, Rossetti, Heidi, Cullum, C Munro, Zhang, Rong, Zhu, David C

“…Subject motion is a well-known confound in resting-state functional MRI (rs-fMRI) and the analysis of functional connectivity. Consequently, several clean-up…”
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Safety and Tolerability of Whole Soybean Products: A Dose-Escalating Clinical Trial in Older Adults with Obesity by Rebello, Candida J, Boué, Stephen, Levy, Jr, Ronald J, Puyau, Renée, Beyl, Robbie A, Greenway, Frank L, Heiman, Mark L, Keller, Jeffrey N, Reynolds, 3rd, Charles F, Kirwan, John P

“…Soybean products have nutrients, dietary fiber, and phytoalexins beneficial for cardiovascular and overall health. Despite their high consumption in Asian…”
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Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain by Keller, Jeffrey N., Dimayuga, Edgardo, Chen, Qinghua, Thorpe, Jeffrey, Gee, Jillian, Ding, Qunxing

“…In order to successfully respond to stress all cells rely on the ability of the proteasomal and lysosomal proteolytic pathways to continually maintain protein…”
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Examining Relationships between Multiple Self-Reported Sleep Measures and Gait Domains in Cognitively Healthy Older Adults by Bernstein, John P K, De Vito, Alyssa, Weitzner, Daniel S, MacAulay, Rebecca, Calamia, Matthew, Brouillette, Robert, Foil, Heather, Carmichael, Owen T, Keller, Jeffrey N

“…Gait-related changes in older adulthood may be related to changes in cognition (e.g., executive functioning), and recent work suggests that different…”
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