Search Results - "KELEG, Shereen"

Chondroitin sulfate proteoglycan CSPG4 as a novel hypoxia-sensitive marker in pancreatic tumors by Keleg, Shereen, Titov, Alexandr, Heller, Anette, Giese, Thomas, Tjaden, Christine, Ahmad, Sufian S, Gaida, Matthias M, Bauer, Andrea S, Werner, Jens, Giese, Nathalia A

“…CSPG4 marks pericytes, undifferentiated precursors and tumor cells. We assessed whether the shed ectodomain of CSPG4 (sCSPG4) might circulate and reflect…”
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Invasion and metastasis in pancreatic cancer by Keleg, Shereen, Büchler, Peter, Ludwig, Roman, Büchler, Markus W, Friess, Helmut

“…Pancreatic cancer remains a challenging disease with an overall cumulative 5-year survival rate below 1%. The process of cancer initiation, progression and…”
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Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system by Fredebohm, Johannes, Boettcher, Michael, Eisen, Christian, Gaida, Matthias M, Heller, Anette, Keleg, Shereen, Tost, Jörg, Greulich-Bode, Karin M, Hotz-Wagenblatt, Agnes, Lathrop, Mark, Giese, Nathalia A, Hoheisel, Jörg D

“…Standard cancer cell lines do not model the intratumoural heterogeneity situation sufficiently. Clonal selection leads to a homogeneous population of cells by…”
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Actinin-4 expression in primary and metastasized pancreatic ductal adenocarcinoma by Welsch, Thilo, Keleg, Shereen, Bergmann, Frank, Bauer, Sonja, Hinz, Ulf, Schmidt, Jan

“…Actinin-4 is an actin-bundling protein that probably has a tumor-promoting potential in several solid tumors. The present study analyzed the expression of…”
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Tumor-Suppressor Function of SPARC-Like Protein 1/Hevin in Pancreatic Cancer by Esposito, Irene, Kayed, Hany, Keleg, Shereen, Giese, Thomas, Sage, E. Helene, Schirmacher, Peter, Friess, Helmut, Kleeff, Jörg

“…SPARC-like protein 1 (SPARCL1), a member of the SPARC family, is downregulated in various tumors. In the present study, the expression and localization of…”
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Indian hedgehog signaling pathway: Expression and regulation in pancreatic cancer by Kayed, Hany, Kleeff, Jörg, Keleg, Shereen, Guo, Junchau, Ketterer, Knut, Berberat, Pascal O., Giese, Nathalia, Esposito, Irene, Giese, Thomas, Büchler, Markus W., Friess, Helmut

“…Pancreatic cancer is an aggressive malignancy that exhibits a number of genetic and epigenetic alterations. Indian hedgehog (Ihh) and its 2 signaling…”
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Comparative analysis of tumorbiology and CD133 positivity in primary and recurrent pancreatic ductal adenocarcinoma by Welsch, Thilo, Keleg, Shereen, Bergmann, Frank, Degrate, Luca, Bauer, Sonja, Schmidt, Jan

“…In over 70% of the cases, patients with curative surgery and adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PDAC) develop recurrent tumors. The…”
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Silencing of X-linked Inhibitor of Apoptosis (XIAP) Decreases Gemcitabine Resistance of Pancreatic Cancer Cells by SHRIKHANDE, Shailesh V, KLEEFF, Jorg, KAYED, Hany, KELEG, Shereen, REISER, Carolin, GIESE, Thomas, BUCHLER, Markus W, ESPOSITO, Irene, FRIESS, Helmut

“…Background: The X-linked inhibitor of apoptosis (XIAP) belongs to a family of proteins that suppresses apoptosis by inhibition of caspases in some cancers. It…”
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Prognostic significance of erythropoietin in pancreatic adenocarcinoma by Welsch, Thilo, Zschäbitz, Stefanie, Becker, Verena, Giese, Thomas, Bergmann, Frank, Hinz, Ulf, Keleg, Shereen, Heller, Anette, Sipos, Bence, Klingmüller, Ursula, Büchler, Markus W, Werner, Jens, Giese, Nathalia A

“…Erythropoietin (Epo) administration has been reported to have tumor-promoting effects in anemic cancer patients. We investigated the prognostic impact of…”
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FXYD3 is overexpressed in pancreatic ductal adenocarcinoma and influences pancreatic cancer cell growth by Kayed, Hany, Kleeff, Jörg, Kolb, Armin, Ketterer, Knut, Keleg, Shereen, Felix, Klaus, Giese, Thomas, Penzel, Roland, Zentgraf, Hanswalter, Büchler, Markus W., Korc, Murray, Friess, Helmut

“…The expression and localization of FXYD domain containing ion transport regulator 3 (FXYD3), a transmembrane protein that acts as a chloride channel or…”
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BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion by Kayed, Hany, Bekasi, Sandor, Keleg, Shereen, Michalski, Christoph W, Giese, Thomas, Friess, Helmut, Kleeff, Jörg

“…Bone gamma-carboxyglutamate protein (BGLAP; osteocalcin) is a small, highly conserved molecule first identified in the mineralized matrix of bone. It has been…”
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Adrenomedullin is induced by hypoxia and enhances pancreatic cancer cell invasion by Keleg, Shereen, Kayed, Hany, Jiang, Xiaohua, Penzel, Roland, Giese, Thomas, Büchler, Markus W., Friess, Helmut, Kleeff, Jörg

“…Adrenomedullin (ADM) is synthesized by different types of cells and acts by binding calcitonin receptor‐like receptor (CRLR) and members of the receptor…”
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Hedgehog signaling in the normal and diseased pancreas by Kayed, Hany, Kleeff, Jörg, Osman, Tarek, Keleg, Shereen, Büchler, Markus W, Friess, Helmut

“…The hedgehog (Hh) family of genes, sonic hedgehog (Shh), Indian hedgehog (Ihh), and desert hedgehog (Dhh) encode signaling molecules that regulate multiple…”
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Correlation of glypican-1 expression with TGF-β, BMP, and activin receptors in pancreatic ductal adenocarcinoma by KAYED, Hany, KLEEFF, Jörg, KELEG, Shereen, XIAOHUA JIANG, PENZEL, Roland, GIESE, Thomas, ZENTGRAF, Hanswalter, BÜCHLER, Markus W, KORC, Murray, FRIESS, Helmut

“…Glypican1 (GPC1) is a cell surface heparan sulfate proteoglycan that acts as a co-receptor for heparin-binding growth factors as well as for members of the…”
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Effects of bone sialoprotein on pancreatic cancer cell growth, invasion and metastasis by Kayed, Hany, Kleeff, Jörg, Keleg, Shereen, Felix, Klaus, Giese, Thomas, Berger, Martin R, Büchler, Markus W, Friess, Helmut

“…Abstract Bone sialoprotein (BSP) is an acidic glycoprotein that plays an important role in cancer cell growth, migration and invasion. The expression,…”
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Localization of the human hedgehog-interacting protein (Hip) in the normal and diseased pancreas by Kayed, Hany, Kleeff, Jörg, Esposito, Irene, Giese, Thomas, Keleg, Shereen, Giese, Nathalia, Büchler, Markus W., Friess, Helmut

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor prognosis. Previously, it has been shown that Indian hedgehog (Ihh) and its two…”
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Expression of the Shwachman-Bodian-Diamond syndrome (SBDS) protein in human pancreatic cancer and chronic pancreatitis by Kayed, Hany, Bekasi, Sandor, Keleg, Shereen, Welsch, Thilo, Esposito, Irene, Shimamura, Akiko, Michalski, Christoph W, Friess, Helmut, Kleeff, Jörg

“…The Shwachman-Bodian-Diamond syndrome (SBDS) protein is a member of a highly conserved family which influences RNA activation and is associated with…”
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P10. Effects of bone sialoprotein on pancreatic cancer cell growth, invasion and metastasis by Kayed, Hany, Kleeff, Jörg, Keleg, Shereen, Felix, Klaus, Giese, Thomas, Berger, Martin R., Büchler, Markus W., Friess, Helmut

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