Search Results - "KEITHLEY, E. M"

GDNF protects the cochlea against noise damage by Keithley, E M, Ma, C L, Ryan, A F, Louis, J-C, Magal, E

“…GLIAL-DERIVED neurotrophic factor (GDNF) was tested for its ability to prevent hearing and sensory cell loss in guinea pigs exposed to acoustic trauma. Hearing…”
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Role of transcription factors a Brn-3.1 and Brn-3.2 in auditory and visual system development by Erkman, Linda, McEvilly, Robert J, Luo, Lin, Ryan, Aimee K, Hooshmand, Farideh, O'Connell, Shawn M, Keithley, Elizabeth M, Rapaport, David H, Ryan, Alien F, Rosenfeld, Michael G

“…The neurally expressed genes Brn-3.1 and Brn-3.2 (refs 1-6) are mammalian orthologues of the Caenorhabditis elegans unc-86 gene that constitute, with Brn-3.0…”
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Characterization of an Experimentally Induced Inner Ear Immune Response by Ma, Chun-lei, Billings, Peter, Harris, Jeffrey P., Keithley, Elizabeth M.

“…Objective To determine the effects of a sterile immune response on the structure and function of the cochlea. Methods An immune response was created in guinea…”
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Assessment of serum antibodies in patients with rapidly progressive sensorineural hearing loss and Menière's disease by Gottschlich, S, Billings, P B, Keithley, E M, Weisman, M H, Harris, J P

“…The immunoreactivity of sera from patients with rapidly progressive sensorineural hearing loss (SNHL) or Menière's disease with bovine inner ear material was…”
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Evidence linking the 68 kilodalton antigen identified in progressive sensorineural hearing loss patient sera with heat shock protein 70 by Billings, P B, Keithley, E M, Harris, J P

“…Immunoblotting against bovine inner ear extracts has previously identified a 68 kd antigen reactive with 22% to 58% of sera of patients with rapidly…”
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Clinical Diagnoses Associated With Histologic Findings of Fibrotic Tissue and New Bone in the Inner Ear by Keithley, Elizabeth M., Chen, Mien-Chi, Linthicum, Fred

“…Fibrotic tissue or new bone occurs following inner ear inflammation, fracture, or surgery. The prevalence is unknown and was investigated using the National…”
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Effects of a hair cell transcription factor, Brn-3.1, gene deletion on homozygous and heterozygous mouse cochleas in adulthood and aging by Keithley, Elizabeth M., Erkman, Linda, Bennett, Thecla, Lou, Lin, Ryan, Allen F.

“…The transcription factor Brn-3.1, is expressed in the inner ear hair cells throughout life and is necessary for the development of these cells. Mutant mice in…”
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Comparison of Anti-Heat Shock Protein 70 (Anti-hsp70) and Anti-68-kDa Inner Ear Protein in the Sera of Patients with Meniere's Disease by Shin, See-Ok, Billings, Peter B., Keithley, Elizabeth M., Harris, Jeffrey P.

“…The 68‐kDa antigen detected in the sera of patients with autoimmune inner ear disease is known to represent the highly inducible heat shock protein 70 (hsp70)…”
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Immunohistochemical Analysis of Proliferating Cells in a Sterile Labyrinthitis Animal Model by Chen, Mien-Chi, Harris, Jeffrey P., Keithley, Elizabeth M.

“…Inflammatory reactions within the cochlea lead to the formation of fibrotic tissue and bone. To determine which cells are involved in the proliferation of the…”
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Late sequelae of cochlear infection by Keithley, E M, Harris, J P

“…Inflammatory reactions within the inner ear are deleterious to cochlear function and can result in server hearing loss that does not recover. This study…”
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Intratympanic immunosuppressives for prevention of immune-mediated sensorineural hearing loss by YANG, G. S. Y, SONG, H.-T, KEITHLEY, E. M, HARRIS, J. P

“…Round window membrane application of immunosuppressives reduces cochlear inflammation and hearing loss in a guinea pig model of sterile labyrinthitis. Systemic…”
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Development of high endothelial venule-like characteristics in the spiral modiolar vein induced by viral labyrinthitis by Stearns, G S, Keithley, E M, Harris, J P

“…The postcapillary venule is known to be the preferred site of lymphocyte migration into the extravascular compartment. In this study, induction of these high…”
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Antigen diffusion from the perilymphatic space of the cochlea by Yeo, S W, Gottschlich, S, Harris, J P, Keithley, E M

“…The diffusion pattern of horseradish peroxidase (HRP) injected into the scala tympani of the cochlear basal turn of guinea pigs was studied to test whether…”
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Reduction of endotoxin-induced inflammation of the middle ear by polymyxin B by Darrow, D H, Keithley, E M

“…Endotoxin (ET) is an aggregate of lipo-oligosaccharide and protein found in the cell wall of gram-negative bacteria. A potent mediator of inflammatory…”
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Application of Labeling Techniques to Archival Temporal Bone Sections by Tian, Qing, Linthicum, Fred H., Keithley, Elizabeth M.

“…Pathology of the human inner ear has traditionally been studied in celloidin-embedded, hematoxylin and eosin-stained sections of the temporal bone. Although…”
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Na,K-ATPase in the cochlear lateral wall of human temporal bones with endolymphatic hydrops by Keithley, E M, Horowitz, S, Ruckenstein, M J

“…Meniere's disease has traditionally been thought to arise from a disruption in longitudinal endolymphatic flow. This view has been brought into question by…”
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2-Deoxyglucose uptake patterns in response to pure tone stimuli in the aged rat inferior colliculus by Keithley, E M, Lo, J, Ryan, A F

“…The tonotopic map of the inferior colliculus (IC) of aged rats (25 months old) was examined to determine whether age-related changes known to occur in the…”
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Development of morphological and physiological changes in the cochlea induced by cytomegalovirus by Keithley, E M, Woolf, N K, Harris, J P

“…The effect of viral infection in the cochlea was investigated by inoculation of live cytomegalovirus or inactivated virus. Auditory thresholds were measured on…”
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Fibronectin-like immunoreactivity of the basilar membrane of celloidin-embedded human temporal bone sections by Keithley, E M, Tian, Q, Robins-Browne, R

“…Dysfunction of the mechanical properties of the basilar membrane is a potential cause of presbycusis. In cases of minimal sensorineural or strial degeneration…”
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The spatial representation of frequency in the rat dorsal cochlear nucleus and inferior colliculus by Ryan, A F, Furlow, Z, Woolf, N K, Keithley, E M

“…The spatial distribution of neural activity produced by tones was assessed in the rat dorsal cochlear nucleus (DCN) and inferior colliculus (IC), using the…”
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