Search Results - "KEITA, Sekouba"
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Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial
Published in The Lancet infectious diseases (01-06-2018)“…Primaquine and methylene blue are gametocytocidal compounds that could prevent Plasmodium falciparum transmission to mosquitoes. We aimed to assess the…”
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Primaquine to reduce transmission of Plasmodium falciparum malaria in Mali: a single-blind, dose-ranging, adaptive randomised phase 2 trial
Published in The Lancet infectious diseases (01-06-2016)“…Summary Background Single low doses of primaquine, when added to artemisinin-based combination therapy, might prevent transmission of Plasmodium falciparum…”
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Effect of Seasonal Malaria Chemoprevention on Immune Markers of Exhaustion and Regulation
Published in The Journal of infectious diseases (01-01-2020)“…Abstract Background Seasonal malaria chemoprevention (SMC) is a novel strategy to reduce malaria infections in children. Infection with Plasmodium falciparum…”
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Acquisition of antibodies that block Plasmodium falciparum adhesion to placental receptor chondroitin sulfate A with increasing gravidity in Malian women
Published in Frontiers in immunology (11-01-2024)“…In malaria-endemic areas, pregnant women are more susceptible to infection, especially primigravidae. During pregnancy, parasites sequester in the placenta and…”
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Host factors that modify Plasmodium falciparum adhesion to endothelial receptors
Published in Scientific reports (24-10-2017)“…P. falciparum virulence is related to adhesion and sequestration of infected erythrocytes (IE) in deep vascular beds, but the endothelial receptors involved in…”
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Higher platelet counts and platelet factors are associated with a reduction in Plasmodium falciparum parasite density in young Malian children
Published in International journal of infectious diseases (01-02-2024)“…The association between thrombocytopenia and parasite density or disease severity is described in numerous studies. In recent years, several studies described…”
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Persistence of Plasmodium falciparum HRP-2 antigenaemia after artemisinin combination therapy is not associated with gametocytes
Published in Malaria journal (06-12-2022)“…In some settings, sensitive field diagnostic tools may be needed to achieve elimination of falciparum malaria. To this end, rapid diagnostic tests (RDTs) based…”
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Antibody levels to recombinant VAR2CSA domains vary with Plasmodium falciparum parasitaemia, gestational age, and gravidity, but do not predict pregnancy outcomes
Published in Malaria journal (09-03-2018)“…Maternal malaria is a tropical scourge associated with poor pregnancy outcomes. Women become resistant to Plasmodium falciparum pregnancy malaria as they…”
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Efficacy of artemether-lumefantrine in relation to drug exposure in children with and without severe acute malnutrition: an open comparative intervention study in Mali and Niger
Published in BMC medicine (24-10-2016)“…Severe acute malnutrition (SAM) affects almost all organs and has been associated with reduced intestinal absorption of medicines. However, very limited…”
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Age-dependent increase in antibodies that inhibit Plasmodium falciparum adhesion to a subset of endothelial receptors
Published in Malaria journal (11-04-2019)“…Plasmodium falciparum-infected erythrocytes (IE) sequester in deep vascular beds where their adhesion is mediated by an array of endothelial surface receptors…”
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Effect of seasonal malaria chemoprevention on the acquisition of antibodies to Plasmodium falciparum antigens in Ouelessebougou, Mali
Published in Malaria journal (18-07-2017)“…Seasonal malaria chemoprevention (SMC) is a new strategy to reduce malaria burden in young children in Sahelian countries. It consists of the administration of…”
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Pyronaridine–artesunate or dihydroartemisinin–piperaquine combined with single low-dose primaquine to prevent Plasmodium falciparum malaria transmission in Ouélessébougou, Mali: a four-arm, single-blind, phase 2/3, randomised trial
Published in The Lancet. Microbe (01-01-2022)“…Pyronaridine–artesunate is the most recently licensed artemisinin-based combination therapy. WHO has recommended that a single low dose of primaquine could be…”
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Malaria Infection Is Common and Associated With Perinatal Mortality and Preterm Delivery Despite Widespread Use of Chemoprevention in Mali: An Observational Study 2010 to 2014
Published in Clinical infectious diseases (20-10-2021)“…In malaria-endemic areas, pregnant women and especially first-time mothers are more susceptible to Plasmodium falciparum. Malaria diagnosis is often missed…”
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Systemic Inflammatory Response to Malaria During Pregnancy Is Associated With Pregnancy Loss and Preterm Delivery
Published in Clinical infectious diseases (15-11-2017)“…Pregnancy malaria (PM) is associated with a proinflammatory immune response characterized by increased levels of cytokines and chemokines such as tumor…”
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Natural History of Malaria Infections During Early Childhood in Twins
Published in The Journal of infectious diseases (11-01-2023)“…Abstract Background The frequency and clinical presentation of malaria infections show marked heterogeneity in epidemiological studies. However, deeper…”
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Safety of Single-Dose Primaquine in G6PD-Deficient and G6PD-Normal Males in Mali Without Malaria: An Open-Label, Phase 1, Dose-Adjustment Trial
Published in The Journal of infectious diseases (28-03-2018)“…Abstract Background The World Health Organization recommendation on the use of a single low dose of primaquine (SLD-PQ) to reduce Plasmodium falciparum malaria…”
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Single low-dose tafenoquine combined with dihydroartemisinin–piperaquine to reduce Plasmodium falciparum transmission in Ouelessebougou, Mali: a phase 2, single-blind, randomised clinical trial
Published in The Lancet. Microbe (01-05-2022)“…Tafenoquine was recently approved as a prophylaxis and radical cure for Plasmodium vivax infection, but its Plasmodium falciparum transmission-blocking…”
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Artemether–lumefantrine with or without single-dose primaquine and sulfadoxine–pyrimethamine plus amodiaquine with or without single-dose tafenoquine to reduce Plasmodium falciparum transmission: a phase 2, single-blind, randomised clinical trial in Ouelessebougou, Mali
Published in The Lancet. Microbe (01-07-2024)“…Artemether–lumefantrine is widely used for uncomplicated Plasmodium falciparum malaria; sulfadoxine–pyrimethamine plus amodiaquine is used for seasonal malaria…”
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Malaria Infection and Gametocyte Carriage Rates in Preparation for Transmission Blocking Vaccine Trials in Bancoumana, Mali
Published in The American journal of tropical medicine and hygiene (01-07-2017)“…The epidemiological characterization of transmission reservoirs is a critical step in preparation for interventional trials for malaria…”
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Promoting Good Clinical Laboratory Practices and Laboratory Accreditation to Support Clinical Trials in Sub-Saharan Africa
Published in The American journal of tropical medicine and hygiene (01-04-2012)“…Laboratory capacity in the developing world frequently lacks quality management systems (QMS) such as good clinical laboratory practices, proper safety…”
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