Search Results - "KEIRSTEAD, Hans S"

Human Embryonic Stem Cell‐Derived Oligodendrocyte Progenitor Cell Transplants Improve Recovery after Cervical Spinal Cord Injury by Sharp, Jason, Frame, Jennifer, Siegenthaler, Monica, Nistor, Gabriel, Keirstead, Hans S.

“…Evidence that cell transplants can improve recovery outcomes in spinal cord injury (SCI) models substantiates treatment strategies involving cell replacement…”
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Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ESCs and iPSCs during Reprogramming and Time in Culture by Laurent, Louise C., Ulitsky, Igor, Slavin, Ileana, Tran, Ha, Schork, Andrew, Morey, Robert, Lynch, Candace, Harness, Julie V., Lee, Sunray, Barrero, Maria J., Ku, Sherman, Martynova, Marina, Semechkin, Ruslan, Galat, Vasiliy, Gottesfeld, Joel, Belmonte, Juan Carlos Izpisua, Murry, Chuck, Keirstead, Hans S., Park, Hyun-Sook, Schmidt, Uli, Laslett, Andrew L., Muller, Franz-Josef, Nievergelt, Caroline M., Shamir, Ron, Loring, Jeanne F.

“…Genomic stability is critical for the clinical use of human embryonic and induced pluripotent stem cells. We performed high-resolution SNP (single-nucleotide…”
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Recurrent Variations in DNA Methylation in Human Pluripotent Stem Cells and Their Differentiated Derivatives by Nazor, Kristopher L., Altun, Gulsah, Lynch, Candace, Tran, Ha, Harness, Julie V., Slavin, Ileana, Garitaonandia, Ibon, Müller, Franz-Josef, Wang, Yu-Chieh, Boscolo, Francesca S., Fakunle, Eyitayo, Dumevska, Biljana, Lee, Sunray, Park, Hyun Sook, Olee, Tsaiwei, D'Lima, Darryl D., Semechkin, Ruslan, Parast, Mana M., Galat, Vasiliy, Laslett, Andrew L., Schmidt, Uli, Keirstead, Hans S., Loring, Jeanne F., Laurent, Louise C.

“…Human pluripotent stem cells (hPSCs) are potential sources of cells for modeling disease and development, drug discovery, and regenerative medicine. However,…”
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Autologous dendritic cells loaded with antigens from self-renewing autologous tumor cells as patient-specific therapeutic cancer vaccines by Dillman, Robert O., Nistor, Gabriel I., Keirstead, Hans S.

“…A promising personal immunotherapy is autologous dendritic cells (DC) loaded ex vivo with autologous tumor antigens (ATA) derived from self-renewing autologous…”
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Spinal cord injury is accompanied by chronic progressive demyelination by Totoiu, Minodora O., Keirstead, Hans S.

“…Preceding the development of therapeutic strategies for spinal cord injury is an identification of those pathological processes that might serve as therapeutic…”
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Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Transplants Remyelinate and Restore Locomotion after Spinal Cord Injury by Keirstead, Hans S, Nistor, Gabriel, Bernal, Giovanna, Totoiu, Minodora, Cloutier, Frank, Sharp, Kelly, Steward, Oswald

“…Demyelination contributes to loss of function after spinal cord injury, and thus a potential therapeutic strategy involves replacing myelin-forming cells…”
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Co-grafts of Human Embryonic Stem Cell Derived Retina Organoids and Retinal Pigment Epithelium for Retinal Reconstruction in Immunodeficient Retinal Degenerate Royal College of Surgeons Rats by Thomas, Biju B, Lin, Bin, Martinez-Camarillo, Juan Carlos, Zhu, Danhong, McLelland, Bryce T, Nistor, Gabriel, Keirstead, Hans S, Humayun, Mark S, Seiler, Magdalene J

“…End-stage age-related macular degeneration (AMD) and retinitis pigmentosa (RP) are two major retinal degenerative (RD) conditions that result in irreversible…”
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PTEN inhibition enhances neurite outgrowth in human embryonic stem cell-derived neuronal progenitor cells by Wyatt, Lindsey A., Filbin, Marie T., Keirstead, Hans S.

“…ABSTRACT We investigated the role of PTEN (phosphatase and tensin homolog deleted on chromosome 10) during neurite outgrowth of human embryonic stem cell…”
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Phase 2 study of AV-GBM-1 (a tumor-initiating cell targeted dendritic cell vaccine) in newly diagnosed Glioblastoma patients: safety and efficacy assessment by Bota, Daniela A, Taylor, Thomas H, Piccioni, David E, Duma, Christopher M, LaRocca, Renato V, Kesari, Santosh, Carrillo, Jose A, Abedi, Mehrdad, Aiken, Robert D, Hsu, Frank P K, Kong, Xiao-Tang, Hsieh, Candace, Bota, Peter G, Nistor, Gabriel I, Keirstead, Hans S, Dillman, Robert O

“…Vaccine immunotherapy may improve survival in Glioblastoma (GBM). A multicenter phase II trial was designed to determine: (1) the success rate of manufacturing…”
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Retinal Organoids Long-Term Functional Characterization Using Two-Photon Fluorescence Lifetime and Hyperspectral Microscopy by Xue, Yuntian, Browne, Andrew W, Tang, William C, Delgado, Jeffrey, McLelland, Bryce T, Nistor, Gabriel, Chen, Jacqueline T, Chew, Kaylee, Lee, Nicolas, Keirstead, Hans S, Seiler, Magdalene J

“…Pluripotent stem cell-derived organoid technologies have opened avenues to preclinical basic science research, drug discovery, and transplantation therapy in…”
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Histological and functional benefit following transplantation of motor neuron progenitors to the injured rat spinal cord by Rossi, Sharyn L, Nistor, Gabriel, Wyatt, Tanya, Yin, Hong Zhen, Poole, Aleksandra J, Weiss, John H, Gardener, Matthew J, Dijkstra, Sipke, Fischer, David F, Keirstead, Hans S

“…Motor neuron loss is characteristic of cervical spinal cord injury (SCI) and contributes to functional deficit. In order to investigate the amenability of the…”
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The extent of myelin pathology differs following contusion and transection spinal cord injury by Siegenthaler, Monica M, Tu, Michelle K, Keirstead, Hans S

“…Demyelination is a prominent feature of spinal cord injury (SCI) and is followed by incomplete remyelination, which may contribute to physiological impairment…”
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Therapeutic applications of oligodendrocyte precursors derived from human embryonic stem cells by Sharp, Jason, Keirstead, Hans S

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A personal COVID-19 dendritic cell vaccine made at point-of-care: Feasibility, safety, and antigen-specific cellular immune responses by Nistor, Gabriel I., Dillman, Robert O., Robles, Rockelle M., Langford, James L., Poole, Aleksandra J., Sofro, Muchlis A. U., Nency, Yetty M., Jonny, Jonny, Yana, Martina L., Karyana, Mahammad, Lestari, Endang S., Triwardhani, Ria, Mujahidah, Mujahidah, Sari, Retty K., Soetojo, Nur A., Wibisono, Djoko, Tjen, Daniel, Ikrar, Taruna, Sarkissian, Gregory, Winarta, Haryono, Putranto, Terawan A., Keirstead, Hans S.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a world-wide pandemic. Internationally, because of availability, accessibility, and…”
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Derivation of high purity neuronal progenitors from human embryonic stem cells by Nistor, Gabriel, Siegenthaler, Monica M, Poirier, Stephane N, Rossi, Sharyn, Poole, Aleksandra J, Charlton, Maura E, McNeish, John D, Airriess, Chris N, Keirstead, Hans S

“…The availability of human neuronal progenitors (hNPs) in high purity would greatly facilitate neuronal drug discovery and developmental studies, as well as…”
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Myelin pathogenesis and functional deficits following SCI are age-associated by Siegenthaler, Monica M., Ammon, Denise L., Keirstead, Hans S.

“…Most spinal cord injuries (SCI) occur in young adults. In the past few decades however, the average age at time of SCI and the percentage of injuries in…”
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Neutralization of the Chemokine CXCL10 Reduces Inflammatory Cell Invasion and Demyelination and Improves Neurological Function in a Viral Model of Multiple Sclerosis by Liu, Michael T, Keirstead, Hans S, Lane, Thomas E

“…Intracerebral infection of mice with mouse hepatitis virus (MHV) results in an acute encephalomyelitis followed by a chronic demyelinating disease with…”
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Restricted ethnic diversity in human embryonic stem cell lines by Laurent, Louise C, Nievergelt, Caroline M, Lynch, Candace, Fakunle, Eyitayo, Harness, Julie V, Schmidt, Uli, Galat, Vasiliy, Laslett, Andrew L, Otonkoski, Timo, Keirstead, Hans S, Schork, Andrew, Park, Hyun-Sook, Loring, Jeanne F

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Equivalence of conventionally-derived and parthenote-derived human embryonic stem cells by Harness, Julie V, Turovets, Nikolay A, Seiler, Magdalene J, Nistor, Gabriel, Altun, Gulsah, Agapova, Larissa S, Ferguson, David, Laurent, Louise C, Loring, Jeanne F, Keirstead, Hans S

“…As human embryonic stem cell (hESC) lines can be derived via multiple means, it is important to determine particular characteristics of individual lines that…”
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Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats by McLelland, Bryce T, Lin, Bin, Mathur, Anuradha, Aramant, Robert B, Thomas, Biju B, Nistor, Gabriel, Keirstead, Hans S, Seiler, Magdalene J

“…To investigate whether sheets of retina organoids derived from human embryonic stem cells (hESCs) can differentiate, integrate, and improve visual function in…”
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