Search Results - "KEIL, UTA"

Mitochondrial dysfunction: the first domino in brain aging and Alzheimer's disease? by Leuner, Kristina, Hauptmann, Susanne, Abdel-Kader, Reham, Scherping, Isabel, Keil, Uta, Strosznajder, Johanna B, Eckert, Anne, Müller, Walter E

“…With the increasing average life span of humans and with decreasing cognitive function in elderly individuals, age-related cognitive disorders including…”
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Proteomic and Functional Analyses Reveal a Mitochondrial Dysfunction in P301L Tau Transgenic Mice by David, Della C., Hauptmann, Susanne, Scherping, Isabel, Schuessel, Katrin, Keil, Uta, Rizzu, Patrizia, Ravid, Rivka, Dröse, Stefan, Brandt, Ulrich, Müller, Walter E., Eckert, Anne, Götz, Jürgen

“…Transgenic mice overexpressing the P301L mutant human tau protein exhibit an accumulation of hyperphosphorylated tau and develop neurofibrillary tangles. The…”
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Mitochondrial dysfunction, apoptotic cell death, and Alzheimer’s disease by Eckert, Anne, Keil, Uta, Marques, Celio A., Bonert, Astrid, Frey, Claudia, Schüssel, Katrin, Müller, Walter E.

“…Being major sources of reactive oxygen species (ROS), mitochondrial structures are exposed to high concentrations of ROS and might therefore be particularly…”
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Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease by Hauptmann, Susanne, Keil, Uta, Scherping, Isabel, Bonert, Astrid, Eckert, Anne, Müller, Walter E.

“…Increasing evidence suggests an important role of mitochondrial dysfunction in the pathogenesis of many common age-related neurodegenerative diseases,…”
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Aging sensitizes toward ROS formation and lipid peroxidation in PS1M146L transgenic mice by Schuessel, Katrin, Frey, Claudia, Jourdan, Claudia, Keil, Uta, Weber, Claudia C., Müller-Spahn, Franz, Müller, Walter E., Eckert, Anne

“…Mutations in the presenilins (PS) account for the majority of familial Alzheimer disease (FAD) cases. To test the hypothesis that oxidative stress can underlie…”
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Piracetam improves mitochondrial dysfunction following oxidative stress by Keil, Uta, Scherping, Isabel, Hauptmann, Susanne, Schuessel, Katin, Eckert, Anne, Müller, Walter E

“…Mitochondrial dysfunction including decrease of mitochondrial membrane potential and reduced ATP production represents a common final pathway of many…”
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Increased Apoptotic Cell Death in Sporadic and Genetic Alzheimer's Disease by ECKERT, ANNE, MARQUES, CELIO A., KEIL, UTA, SCHÜSSEL, KATRIN, MÜLLER, WALTER E.

“…: Mounting evidence indicates increased susceptibility to cell death and increased oxidative damage as common features in neurons from sporadic Alzheimer's…”
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Neurotoxic Mechanisms Caused by the Alzheimer's Disease-linked Swedish Amyloid Precursor Protein Mutation by Marques, Celio A., Keil, Uta, Bonert, Astrid, Steiner, Barbara, Haass, Christian, Müller, Walter E., Eckert, Anne

“…Autosomal dominant forms of familial Alzheimer's disease (FAD) are caused by mutations of the amyloid precursor protein (APP) gene and by mutations of the…”
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Stabilization of mitochondrial function by Ginkgo biloba extract (EGb 761) by Abdel-Kader, Reham, Hauptmann, Susanne, Keil, Uta, Scherping, Isabel, Leuner, Kristina, Eckert, Anne, Müller, Walter E.

“…A large body of data emphasizes the central role of mitochondrial dysfunction during aging and as an early event in neurodegenerative diseases. In this study…”
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Amyloid β-induced Changes in Nitric Oxide Production and Mitochondrial Activity Lead to Apoptosis by Keil, Uta, Bonert, Astrid, Marques, Celio A., Scherping, Isabel, Weyermann, Jörg, Strosznajder, Joanna B., Müller-Spahn, Franz, Haass, Christian, Czech, Christian, Pradier, Laurent, Müller, Walter E., Eckert, Anne

“…Increasing evidence suggests an important role of mitochondrial dysfunction in the pathogenesis of Alzheimer's disease. Thus, we investigated the effects of…”
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Stabilization of Mitochondrial Membrane Potential and Improvement of Neuronal Energy Metabolism by Ginkgo Biloba Extract EGb 761 by ECKERT, ANNE, KEIL, UTA, SCHERPING, ISABEL, HAUPTMANN, SUSANNE, MÜLLER, WALTER E.

“…Ginkgo biloba extract EGb 761 has been used for many years to treat age‐related cognitive disorders including Alzheimer's disease. EGb 761 given shortly after…”
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Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway by Marques, Celio A, Keil, Uta, Bonert, Astrid, Steiner, Barbara, Haass, Christian, Muller, Walter E, Eckert, Anne

“…Autosomal dominant forms of familial Alzheimer's disease (FAD) are caused by mutations of the amyloid precursor protein (APP) gene and by mutations of the…”
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Mitochondrial dysfunction induced by disease relevant AbetaPP and tau protein mutations by Keil, Uta, Hauptmann, Susanne, Bonert, Astrid, Scherping, Isabel, Eckert, Anne, Müller, Walter E

“…Alzheimer's disease is characterized by two major pathological hallmarks: extracellular plaques consisting of amyloid beta peptide and neurofibrillary tangles…”
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P4-252 Impact of β-amyloid on mitochondrial failure in Alzheimer's disease by Eckert, Anne, Keil, Uta, Bonert, Astrid, Scherping, Isabel, Marques, Celio A., Haass, Christian, Czech, Christian, Pradier, Laurent, Müller, Walter E.

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Amyloid β-induced Changes in Nitric Oxide Production and Mitochondrial Activity Lead to Apoptosis by Uta Keil, Astrid Bonert, Celio A. Marques, Isabel Scherping, Jörg Weyermann, Joanna B. Strosznajder, Franz Müller-Spahn, Christian Haass, Christian Czech, Laurent Pradier, Walter E. Müller, Anne Eckert

“…Increasing evidence suggests an important role of mitochondrial dysfunction in the pathogenesis of Alzheimer's disease. Thus, we investigated the effects of…”
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Elevated nitric oxide production mediates beta-amyloid-induced mitochondria failure by Keil, U, Bonert, A, Marques, C A, Strosznajder, J B, Müller-Spahn, F, Müller, W E, Eckert, A

“…Mitochondrial dysfunction has been identified in a large proportion of neurodegenerative disorders including Alzheimer's disease (AD). In addition, the…”
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