Search Results - "KEIBLER, Mark A"

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer by Davidson, Shawn M., Papagiannakopoulos, Thales, Olenchock, Benjamin A., Heyman, Julia E., Keibler, Mark A., Luengo, Alba, Bauer, Matthew R., Jha, Abhishek K., O’Brien, James P., Pierce, Kerry A., Gui, Dan Y., Sullivan, Lucas B., Wasylenko, Thomas M., Subbaraj, Lakshmipriya, Chin, Christopher R., Stephanopolous, Gregory, Mott, Bryan T., Jacks, Tyler, Clish, Clary B., Vander Heiden, Matthew G.

“…Cultured cells convert glucose to lactate, and glutamine is the major source of tricarboxylic acid (TCA)-cycle carbon, but whether the same metabolic phenotype…”
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Review of metabolic pathways activated in cancer cells as determined through isotopic labeling and network analysis by Dong, Wentao, Keibler, Mark A., Stephanopoulos, Gregory

“…Cancer metabolism has emerged as an indispensable part of contemporary cancer research. During the past 10 years, the use of stable isotopic tracers and…”
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The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival by Wang, Haizhen, Nicolay, Brandon N., Chick, Joel M., Gao, Xueliang, Geng, Yan, Ren, Hong, Gao, Hui, Yang, Guizhi, Williams, Juliet A., Suski, Jan M., Keibler, Mark A., Sicinska, Ewa, Gerdemann, Ulrike, Haining, W. Nicholas, Roberts, Thomas M., Polyak, Kornelia, Gygi, Steven P., Dyson, Nicholas J., Sicinski, Piotr

“…The cyclin D3–CDK6 kinase complex, which is overactive in some cancers, inhibits two key glycolysis enzymes and thereby enhances the levels of antioxidants in…”
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Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors by Davidson, Shawn M, Jonas, Oliver, Keibler, Mark A, Hou, Han Wei, Luengo, Alba, Mayers, Jared R, Wyckoff, Jeffrey, Del Rosario, Amanda M, Whitman, Matthew, Chin, Christopher R, Condon, Kendall J, Lammers, Alex, Kellersberger, Katherine A, Stall, Brian K, Stephanopoulos, Gregory, Bar-Sagi, Dafna, Han, Jongyoon, Rabinowitz, Joshua D, Cima, Michael J, Langer, Robert, Vander Heiden, Matthew G

“…Using a device implanted in KRAS-driven pancreatic tumors, authors demonstrate that cancer cells incorporate proteins in their microenvironment as a source of…”
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A self-assembling hydrophobically modified chitosan capable of reversible hemostatic action by Dowling, Matthew B, Kumar, Rakesh, Keibler, Mark A, Hess, John R, Bochicchio, Grant V, Raghavan, Srinivasa R

“…Abstract Blood loss at the site of a wound in mammals is curtailed by the rapid formation of a hemostatic plug, i.e., a self-assembled network of the protein,…”
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Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation by Berrios, Christian, Padi, Megha, Keibler, Mark A, Park, Donglim Esther, Molla, Vadim, Cheng, Jingwei, Lee, Soo Mi, Stephanopoulos, Gregory, Quackenbush, John, DeCaprio, James A

“…Merkel cell polyomavirus (MCPyV) is an etiological agent of Merkel cell carcinoma (MCC), a highly aggressive skin cancer. The MCPyV small tumor antigen (ST) is…”
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Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism by FENDT, Sarah-Maria, BELL, Eric L, PATNAIK, Akash, BLOUIN, Marie Jose, CANTLEY, Lewis C, GUARENTE, Leonard, BLENIS, John, POLLAK, Michael N, OLUMI, Aria F, VANDER HEIDEN, Matthew G, STEPHANOPOULOS, Gregory, KEIBLER, Mark A, DAVIDSON, Shawn M, WIRTH, Gregory J, FISKE, Brian, MAYERS, Jared R, SCHWAB, Matthias, BELLINGER, Gary, CSIBI, Alfredo

“…Metformin inhibits cancer cell proliferation, and epidemiology studies suggest an association with increased survival in patients with cancer taking metformin;…”
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Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells by Hung, Yin P, Teragawa, Carolyn, Kosaisawe, Nont, Gillies, Taryn E, Pargett, Michael, Minguet, Marta, Distor, Kevin, Rocha-Gregg, Briana L, Coloff, Jonathan L, Keibler, Mark A, Stephanopoulos, Gregory, Yellen, Gary, Brugge, Joan S, Albeck, John G

“…Cells use multiple feedback controls to regulate metabolism in response to nutrient and signaling inputs. However, feedback creates the potential for unstable…”
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Elevated homocysteine is negatively correlated with plasma cystathionine β‐synthase activity in givosiran‐treated patients by Keibler, Mark A., Sridharan, Gautham V., Sweetser, Marianne T., Ticau, Simina

“…Givosiran is a subcutaneously administered, liver‐targeted RNA interference (RNAi) therapeutic that has been approved for treating acute hepatic porphyria…”
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Stable Isotope-Assisted Untargeted Metabolomics Identifies ALDH1A1-Driven Erythronate Accumulation in Lung Cancer Cells by Zhang, Jie, Keibler, Mark A, Dong, Wentao, Ghelfi, Jenny, Cordes, Thekla, Kanashova, Tamara, Pailot, Arnaud, Linster, Carole L, Dittmar, Gunnar, Metallo, Christian M, Lautenschlaeger, Tim, Hiller, Karsten, Stephanopoulos, Gregory

“…Using an untargeted stable isotope-assisted metabolomics approach, we identify erythronate as a metabolite that accumulates in several human cancer cell lines…”
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Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells by Fendt, Sarah-Maria, Bell, Eric L., Keibler, Mark A., Olenchock, Benjamin A., Mayers, Jared R., Wasylenko, Thomas M., Vokes, Natalie I., Guarente, Leonard, Heiden, Matthew G. Vander, Stephanopoulos, Gregory

“…Reductively metabolized glutamine is a major cellular carbon source for fatty acid synthesis during hypoxia or when mitochondrial respiration is impaired. Yet,…”
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Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers by Yusuf, Rushdia Zareen, Saez, Borja, Sharda, Azeem, van Gastel, Nick, Yu, Vionnie W.C., Baryawno, Ninib, Scadden, Elizabeth W., Acharya, Sanket, Chattophadhyay, Shrikanta, Huang, Cherrie, Viswanathan, Vasanthi, S'aulis, Dana, Cobert, Julien, Sykes, David B., Keibler, Mark A., Das, Sudeshna, Hutchinson, John N., Churchill, Michael, Mukherjee, Siddhartha, Lee, Dongjun, Mercier, Francois, Doench, John, Bullinger, Lars, Logan, David J., Schreiber, Stuart, Stephanopoulos, Gregory, Rizzo, William B., Scadden, David T.

“…Metabolic alterations in cancer represent convergent effects of oncogenic mutations. We hypothesized that a metabolism-restricted genetic screen, comparing…”
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Metabolic requirements for cancer cell proliferation by Keibler, Mark A, Wasylenko, Thomas M, Kelleher, Joanne K, Iliopoulos, Othon, Vander Heiden, Matthew G, Stephanopoulos, Gregory

“…The study of cancer metabolism has been largely dedicated to exploring the hypothesis that oncogenic transformation rewires cellular metabolism to sustain…”
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Differential substrate use in EGF‐ and oncogenic KRAS‐stimulated human mammary epithelial cells by Keibler, Mark A., Dong, Wentao, Korthauer, Keegan D., Hosios, Aaron M., Moon, Sun Jin, Sullivan, Lucas B., Liu, Nian, Abbott, Keene L., Arevalo, Orlando D., Ho, Kailing, Lee, Jennifer, Phanse, Aasavari S., Kelleher, Joanne K., Iliopoulos, Othon, Coloff, Jonathan L., Vander Heiden, Matthew G., Stephanopoulos, Gregory

“…Many metabolic phenotypes in cancer cells are also characteristic of proliferating nontransformed mammalian cells, and attempts to distinguish between…”
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Expanding the concepts and tools of metabolic engineering to elucidate cancer metabolism by Keibler, Mark A., Fendt, Sarah-Maria, Stephanopoulos, Gregory

“…The metabolic engineer's toolbox, comprising stable isotope tracers, flux estimation and analysis, pathway identification, and pathway kinetics and regulation,…”
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13C isotope-assisted methods for quantifying glutamine metabolism in cancer cells by Zhang, Jie, Ahn, Woo Suk, Gameiro, Paulo A, Keibler, Mark A, Zhang, Zhe, Stephanopoulos, Gregory

“…Glutamine has recently emerged as a key substrate to support cancer cell proliferation, and the quantification of its metabolic flux is essential to understand…”
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The metabolic function of cyclin D3CDK6 kinase in cancer cell survival by Wang, Haizhen, Nicolay, Brandon N, Chick, Joel M, Gao, Xueliang, Geng, Yan, Ren, Hong, Gao, Hui, Yang, Guizhi, Williams, Juliet A, Suski, Jan M, Keibler, Mark A, Sicinska, Ewa, Gerdemann, Ulrike, Haining, W. Nicholas, Roberts, Thomas M, Polyak, Kornelia, Gygi, Steven P, Dyson, Nicholas J, Sicinski, Piotr

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Abstract 3234: Metformin shifts prostate cancer metabolism towards a less malignant phenotype by Wirth, Gregory J., Fendt, Sarah-Maria, Bell, Eric L., Keibler, Mark A., Stephanopoulos, Gregory, Olumi, Aria F.

“…Abstract Introduction Excess nutrient metabolic states such as obesity and hyperinsulinemia are associated with prostate cancer progression. Metformin is the…”
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Reductive glutamine metabolism is a function of the [alpha]-ketoglutarate to citrate ratio in cells by Fendt, Sarah-maria, Bell, Eric L, Keibler, Mark A, Olenchock, Benjamin A, Mayers, Jared R, Wasylenko, Thomas M, Vokes, Natalie I, Guarente, Leonard, Heiden, Matthew G Vander, Stephanopoulos, Gregory

“…Reductively metabolized glutamine is a major cellular carbon source for fatty acid synthesis during hypoxia or when mitochondrial respiration is impaired. Yet,…”
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