Search Results - "KEHR, Jan"

Tailoring Enzyme Stringency Masks the Multispecificity of a Lyngbyatoxin (Indolactam Alkaloid) Nonribosomal Peptide Synthetase by Soeriyadi, Angela H., Ongley, Sarah E., Kehr, Jan‐Christoph, Pickford, Russel, Dittmann, Elke, Neilan, Brett A.

“…Indolactam alkaloids are activators of protein kinase C (PKC) and are of pharmacological interest for the treatment of pathologies involving PKC dysregulation…”
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The cyanobacterial hepatotoxin microcystin binds to proteins and increases the fitness of microcystis under oxidative stress conditions by Zilliges, Yvonne, Kehr, Jan-Christoph, Meissner, Sven, Ishida, Keishi, Mikkat, Stefan, Hagemann, Martin, Kaplan, Aaron, Börner, Thomas, Dittmann, Elke

“…Microcystins are cyanobacterial toxins that represent a serious threat to drinking water and recreational lakes worldwide. Here, we show that microcystin…”
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Biosynthesis and function of extracellular glycans in cyanobacteria by Kehr, Jan-Christoph, Dittmann, Elke

“…The cell surface of cyanobacteria is covered with glycans that confer versatility and adaptability to a multitude of environmental factors. The complex…”
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Functional assessment of mycosporine-like amino acids in Microcystis aeruginosa strain PCC 7806 by Hu, Chenlin, Völler, Ginka, Süßmuth, Roderich, Dittmann, Elke, Kehr, Jan-Christoph

“…Summary The biological role of the widespread mycosporine‐like amino acids (MAAs) in cyanobacteria is under debate. Here, we have constructed and characterized…”
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Biochemical Dissection of the Natural Diversification of Microcystin Provides Lessons for Synthetic Biology of NRPS by Meyer, Sabine, Kehr, Jan-Christoph, Mainz, Andi, Dehm, Daniel, Petras, Daniel, Süssmuth, Roderich D, Dittmann, Elke

“…The cyanobacterial hepatotoxin microcystin is assembled at a non-ribosomal peptide synthetase (NRPS) complex. The enormous structural diversity of this…”
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Microvirin, a Novel α(1,2)-Mannose-specific Lectin Isolated from Microcystis aeruginosa, Has Anti-HIV-1 Activity Comparable with That of Cyanovirin-N but a Much Higher Safety Profile by Huskens, Dana, Férir, Geoffrey, Vermeire, Kurt, Kehr, Jan-Christoph, Balzarini, Jan, Dittmann, Elke, Schols, Dominique

“…Microvirin (MVN), a recently isolated lectin from the cyanobacterium Microcystis aeruginosa PCC7806, shares 33% identity with the potent anti-human…”
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Harnessing the Evolvability of Tricyclic Microviridins To Dissect Protease-Inhibitor Interactions by Weiz, Annika R., Ishida, Keishi, Quitterer, Felix, Meyer, Sabine, Kehr, Jan-Christoph, Müller, Kristian M., Groll, Michael, Hertweck, Christian, Dittmann, Elke

“…Understanding and controlling proteolysis is an important goal in therapeutic chemistry. Among the natural products specifically inhibiting proteases…”
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Protective tunicate endosymbiont with extreme genome reduction by Kehr, Jan-Christoph, Dittmann, Elke

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Prerequisites of Isopeptide Bond Formation in Microcystin Biosynthesis by Meyer, Sabine, Mainz, Andi, Kehr, Jan‐Christoph, Süssmuth, Roderich D., Dittmann, Elke

“…The biosynthesis of the potent cyanobacterial hepatotoxin microcystin involves isopeptide bond formation through the carboxylic acid side chains of d‐glutamate…”
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Natural product biosyntheses in cyanobacteria: A treasure trove of unique enzymes by Kehr, Jan-Christoph, Gatte Picchi, Douglas, Dittmann, Elke

“…Cyanobacteria are prolific producers of natural products. Investigations into the biochemistry responsible for the formation of these compounds have revealed…”
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Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity by Kehr, Jan, Yoshitake, Takashi, Ichinose, Fumio, Yoshitake, Shimako, Kiss, Béla, Gyertyán, István, Adham, Nika

“…Rationale Aberrant glutamatergic, dopaminergic, and GABAergic neurotransmission has been implicated in schizophrenia. Cariprazine reverses the behavioral…”
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Editorial: Neuronopathic lysosomal storage diseases - specific neuronal characteristics and therapeutic approaches by Flunkert, Stefanie, Hutter-Paier, Birgit, Sun, Ying, Kehr, Jan

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The role of 5-HT1A receptors in learning and memory by Ögren, Sven Ove, Eriksson, Therese M., Elvander-Tottie, Elin, D’Addario, Claudio, Ekström, Joanna C., Svenningsson, Per, Meister, Björn, Kehr, Jan, Stiedl, Oliver

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Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons by Kadkhodaei, Banafsheh, Alvarsson, Alexandra, Schintu, Nicoletta, Ramsköld, Daniel, Volakakis, Nikolaos, Joodmardi, Eliza, Yoshitake, Takashi, Kehr, Jan, Decressac, Mickael, Björklund, Anders, Sandberg, Rickard, Svenningsson, Per, Perlmann, Thomas

“…Developmental transcription factors important in early neuron specification and differentiation often remain expressed in the adult brain. However, how these…”
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High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio by Ross, Jaime M., Öberg, Johanna, Brené, Stefan, Coppotelli, Giuseppe, Terzioglu, Mügen, Pernold, Karin, Goiny, Michel, Sitnikov, Rouslan, Kehr, Jan, Trifunovic, Aleksandra, Larsson, Nils-Göran, Hoffer, Barry J., Olson, Lars, Bloom, Floyd

“…At present, there are few means to track symptomatic stages of CNS aging. Thus, although metabolic changes are implicated in mtDNA mutation-driven aging, the…”
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Robust derivation of transplantable dopamine neurons from human pluripotent stem cells by timed retinoic acid delivery by Alekseenko, Zhanna, Dias, José M., Adler, Andrew F., Kozhevnikova, Mariya, van Lunteren, Josina Anna, Nolbrant, Sara, Jeggari, Ashwini, Vasylovska, Svitlana, Yoshitake, Takashi, Kehr, Jan, Carlén, Marie, Alexeyenko, Andrey, Parmar, Malin, Ericson, Johan

“…Stem cell therapies for Parkinson’s disease (PD) have entered first-in-human clinical trials using a set of technically related methods to produce…”
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Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents by He, Yachao, Kaya, Ibrahim, Shariatgorji, Reza, Lundkvist, Johan, Wahlberg, Lars U., Nilsson, Anna, Mamula, Dejan, Kehr, Jan, Zareba-Paslawska, Justyna, Biverstål, Henrik, Chergui, Karima, Zhang, Xiaoqun, Andren, Per E., Svenningsson, Per

“…Prosaposin (PSAP) modulates glycosphingolipid metabolism and variants have been linked to Parkinson’s disease (PD). Here, we find altered PSAP levels in the…”
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Sox6 and Otx2 Control the Specification of Substantia Nigra and Ventral Tegmental Area Dopamine Neurons by Panman, Lia, Papathanou, Maria, Laguna, Ariadna, Oosterveen, Tony, Volakakis, Nikolaos, Acampora, Dario, Kurtsdotter, Idha, Yoshitake, Takashi, Kehr, Jan, Joodmardi, Eliza, Muhr, Jonas, Simeone, Antonio, Ericson, Johan, Perlmann, Thomas

“…Distinct midbrain dopamine (mDA) neuron subtypes are found in the substantia nigra pars compacta (SNc) and the ventral tegmental area (VTA), but it is mainly…”
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Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease by Laguna, Ariadna, Schintu, Nicoletta, Nobre, André, Alvarsson, Alexandra, Volakakis, Nikolaos, Jacobsen, Jesper Kjaer, Gómez-Galán, Marta, Sopova, Elena, Joodmardi, Eliza, Yoshitake, Takashi, Deng, Qiaolin, Kehr, Jan, Ericson, Johan, Svenningsson, Per, Shupliakov, Oleg, Perlmann, Thomas

“…This study establishes a key role for the developmental transcription factors Lmx1a/b in the maintenance of midbrain dopamine neurons. The authors show that…”
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Neuropeptide and Small Transmitter Coexistence: Fundamental Studies and Relevance to Mental Illness by Hökfelt, Tomas, Barde, Swapnali, Xu, Zhi-Qing David, Kuteeva, Eugenia, Rüegg, Joelle, Le Maitre, Erwan, Risling, Mårten, Kehr, Jan, Ihnatko, Robert, Theodorsson, Elvar, Palkovits, Miklos, Deakin, William, Bagdy, Gyorgy, Juhasz, Gabriella, Prud'homme, H Josée, Mechawar, Naguib, Diaz-Heijtz, Rochellys, Ögren, Sven Ove

“…Neuropeptides are auxiliary messenger molecules that always co-exist in nerve cells with one or more small molecule (classic) neurotransmitters. Neuropeptides…”
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