Search Results - "KEHL, Timo"

Investigation of Schwann cells at neoplastic cell sites before the onset of cancer invasion by Demir, Ihsan Ekin, Boldis, Alexandra, Pfitzinger, Paulo L, Teller, Steffen, Brunner, Eva, Klose, Natascha, Kehl, Timo, Maak, Matthias, Lesina, Marina, Laschinger, Melanie, Janssen, Klaus-Peter, Algül, Hana, Friess, Helmut, Ceyhan, Güralp O

“…In neural invasion (NI), cancer cells are classically assumed to actively invade nerves and to cause local recurrence and pain. However, the opposite…”
Get full text

The neurotrophic factor neurturin contributes toward an aggressive cancer cell phenotype, neuropathic pain and neuronal plasticity in pancreatic cancer by Wang, Kun, Demir, Ihsan Ekin, D'Haese, Jan G, Tieftrunk, Elke, Kujundzic, Kristina, Schorn, Stephan, Xing, Baocai, Kehl, Timo, Friess, Helmut, Ceyhan, Güralp O

“…Neurotrophic factors possess an emerging role in the pathophysiology of several gastrointestinal disorders, regulating innervation, pain sensation and…”
Get full text

Identification of novel, highly expressed retroviral microRNAs in cells infected by bovine foamy virus by Whisnant, Adam W, Kehl, Timo, Bao, Qiuying, Materniak, Magdalena, Kuzmak, Jacek, Löchelt, Martin, Cullen, Bryan R

“…While numerous viral microRNAs (miRNAs) expressed by DNA viruses, especially herpesvirus family members, have been reported, there have been very few reports…”
Get full text

Non-simian foamy viruses: molecular virology, tropism and prevalence and zoonotic/interspecies transmission by Kehl, Timo, Tan, Juan, Materniak, Magdalena

“…Within the field of retrovirus, our knowledge of foamy viruses (FV) is still limited. Their unique replication strategy and mechanism of viral persistency…”
Get full text

Perineural mast cells are specifically enriched in pancreatic neuritis and neuropathic pain in pancreatic cancer and chronic pancreatitis by Demir, Ihsan Ekin, Schorn, Stephan, Schremmer-Danninger, Elisabeth, Wang, Kun, Kehl, Timo, Giese, Nathalia A, Algül, Hana, Friess, Helmut, Ceyhan, Güralp O

“…Pancreatic neuritis is a histopathological hallmark of pancreatic neuropathy and correlates to abdominal neuropathic pain sensation in pancreatic…”
Get full text

Complete Genome Sequences of Two Novel European Clade Bovine Foamy Viruses from Germany and Poland by HECHLER, Torsten, MATERNIAK, Magdalena, KEHL, Timo, KUZMAK, Jacek, LÖCHELT, Martin

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

In Vitro Evolution of Bovine Foamy Virus Variants with Enhanced Cell-Free Virus Titers and Transmission by Bao, Qiuying, Hipp, Michaela, Hugo, Annette, Lei, Janet, Liu, Yang, Kehl, Timo, Hechler, Torsten, Löchelt, Martin

“…Virus transmission is essential for spreading viral infections and is a highly coordinated process which occurs by cell-free transmission or cell-cell contact…”
Get full text

15-Lipoxygenase-1 Production is Lost in Pancreatic Cancer and Overexpression of the Gene Inhibits Tumor Cell Growth by Hennig, René, Kehl, Timo, Noor, Seema, Ding, Xian-Zhong, Rao, Sambasiva M., Bergmann, Frank, Fürstenberger, Gerhard, Büchler, Markus W., Friess, Helmut, Krieg, Peter, Adrian, Thomas E.

“…Pancreatic cancer patients have an abysmal prognosis because of late diagnosis and lack of therapeutic options. Pancreatic intraepithelial neoplasias (PaniNs),…”
Get full text

Feline foamy virus-based vectors: advantages of an authentic animal model by Liu, Weibin, Lei, Janet, Liu, Yang, Lukic, Dragana Slavkovic, Räthe, Ann-Mareen, Bao, Qiuying, Kehl, Timo, Bleiholder, Anne, Hechler, Torsten, Löchelt, Martin

“…New-generation retroviral vectors have potential applications in vaccination and gene therapy. Foamy viruses are particularly interesting as vectors, because…”
Get full text

The impact of MFG-E8 in chronic pancreatitis: potential for future immunotherapy? by D'Haese, Jan G, Demir, Ihsan Ekin, Kehl, Timo, Winckler, Jannik, Giese, Nathalia A, Bergmann, Frank, Giese, Thomas, Büchler, Markus W, Friess, Helmut, Hartel, Mark, Ceyhan, Güralp O

“…The glycoprotein MFG-E8 mediates phagocytic clearance of apoptotic cells and influences the pathogenesis and progression of inflammatory diseases. MFG-E8 was…”
Get full text

The chromatin binding domain, including the QPQRYG motif, of feline foamy virus Gag is required for viral DNA integration and nuclear accumulation of Gag and the viral genome by Wei, Guochao, Kehl, Timo, Bao, Qiuying, Benner, Axel, Lei, Janet, Löchelt, Martin

“…The retroviral Gag protein, the major component of released particles, plays different roles in particle assembly, maturation or infection of new host cells…”
Get full text

RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis by Lesina, Marina, Wörmann, Sonja Maria, Morton, Jennifer, Diakopoulos, Kalliope Nina, Korneeva, Olga, Wimmer, Margit, Einwächter, Henrik, Sperveslage, Jan, Demir, Ihsan Ekin, Kehl, Timo, Saur, Dieter, Sipos, Bence, Heikenwälder, Mathias, Steiner, Jörg Manfred, Wang, Timothy Cragin, Sansom, Owen J, Schmid, Roland Michael, Algül, Hana

“…Tumor suppression that is mediated by oncogene-induced senescence (OIS) is considered to function as a safeguard during development of pancreatic ductal…”
Get full text

Targeted Enrichment for Pathogen Detection and Characterization in Three Felid Species by Lee, Justin S, Mackie, Ryan S, Harrison, Thomas, Shariat, Basir, Kind, Trey, Kehl, Timo, Löchelt, Martin, Boucher, Christina, VandeWoude, Sue

“…Traditional diagnostic assays often lack sensitivity and can be difficult to multiplex across many pathogens. Next-generation sequencing (NGS) can overcome…”
Get full text

Early pancreatic cancer lesions suppress pain through CXCL12-mediated chemoattraction of Schwann cells by Demir, Ihsan Ekin, Kujundzic, Kristina, Pfitzinger, Paulo L., Saricaoglu, Ömer Cemil, Teller, Steffen, Kehl, Timo, Reyes, Carmen Mota, Ertl, Linda S., Miao, Zhenhua, Schall, Thomas J., Tieftrunk, Elke, Haller, Bernhard, Diakopoulos, Kalliope Nina, Kurkowski, Magdalena U., Lesina, Marina, Krüger, Achim, Algül, Hana, Friess, Helmut, Ceyhan, Güralp O.

“…Pancreatic ductal adenocarcinoma (PDAC) cells (PCC) have an exceptional propensity to metastasize early into intratumoral, chemokine-secreting nerves. However,…”
Get full text

Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia by Demir, Ihsan Ekin, Tieftrunk, Elke, Schorn, Stephan, Saricaoglu, Ömer Cemil, Pfitzinger, Paulo L, Teller, Steffen, Wang, Kun, Waldbaur, Christine, Kurkowski, Magdalena U, Wörmann, Sonja Maria, Shaw, Victoria E, Kehl, Timo, Laschinger, Melanie, Costello, Eithne, Algül, Hana, Friess, Helmut, Ceyhan, Güralp O

“…The impact of glia cells during GI carcinogenesis and in cancer pain is unknown. Here, we demonstrate a novel mechanism how Schwann cells (SCs) become…”
Get more information

The Severity of Neural Invasion Is Associated with Shortened Survival in Colon Cancer by LIEBL, Florian, EKIN DEMIR, Ihsan, BECKER, Karen, LANGER, Rupert, LASCHINGER, Melanie, FRIESS, Helmut, CEYHAN, Güralp O, ROSENBERG, Robert, BOLDIS, Alexandra, YILDIZ, Esra, KUJUNDZIC, Kristina, KEHL, Timo, DISCHL, Dominic, SCHUSTER, Tibor, MAAK, Matthias

“…Neural invasion (NI) is a histopathologic feature of colon cancer that receives little consideration. Therefore, we conducted a morphologic and functional…”
Get full text

Myeloid, but Not Pancreatic, RelA/p65 Is Required for Fibrosis in a Mouse Model of Chronic Pancreatitis by Treiber, Matthias, Neuhöfer, Patrick, Anetsberger, Elisabeth, Einwächter, Henrik, Lesina, Marina, Rickmann, Mariana, Liang, Song, Kehl, Timo, Nakhai, Hassan, Schmid, Roland M, Algül, Hana

“…Background & Aims Little is known about how transcription factors might regulate pathogenesis of chronic pancreatitis (CP). We analyzed the in vivo role of…”
Get full text

Neuronal plasticity in chronic pancreatitis is mediated via the neurturin/GFRα2 axis by Demir, Ihsan Ekin, Wang, Kun, Tieftrunk, Elke, Giese, Nathalia A, Xing, Baocai, Friess, Helmut, Kehl, Timo, Ceyhan, Güralp O

“…The glial cell line-derived neurotrophic factor (GDNF) family member neurturin (NRTN) and its receptor GFRα2 play a deciding role in the normal development of…”
Get more information

Mutagenesis of N-terminal residues of feline foamy virus Gag reveals entirely distinct functions during capsid formation, particle assembly, Gag processing and budding by Liu, Yang, Betts, Matthew J, Lei, Janet, Wei, Guochao, Bao, Qiuying, Kehl, Timo, Russell, Robert B, Löchelt, Martin

“…Foamy viruses (FVs) of the Spumaretrovirinae subfamily are distinct retroviruses, with many features of their molecular biology and replication strategy…”
Get full text

RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis by Lesina, Marina, Wörmann, Sonja Maria, Morton, Jennifer, Diakopoulos, Kalliope Nina, Korneeva, Olga, Wimmer, Margit, Einwächter, Henrik, Sperveslage, Jan, Demir, Ihsan Ekin, Kehl, Timo, Saur, Dieter, Sipos, Bence, Heikenwälder, Mathias, Steiner, Jörg Manfred, Wang, Timothy Cragin, Sansom, Owen J, Schmid, Roland Michael, Algül, Hana

“…Tumor suppression that is mediated by oncogene-induced senescence (OIS) is considered to function as a safeguard during development of pancreatic ductal…”
Get full text