Search Results - "KEENAN, Kevin P"

Nature via Nurture: Effect of Diet on Health, Obesity, and Safety Assessment by Keenan, Kevin P., Wallig, Matthew A., Haschek, Wanda M.

“…Food is not only vital for the health and well-being of any living being, but it is a potential source of harmful chemicals, both natural and man-made. Further…”
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Longevity and Age-Related Pathology of Mice Deficient in Pregnancy-Associated Plasma Protein-A by Conover, Cheryl A., Bale, Laurie K., Mader, Jessica R., Mason, Megan A., Keenan, Kevin P., Marler, Ronald J.

“…The pregnancy-associated plasma protein-A knockout (PAPP-A KO) mouse is a model of reduced local insulin-like growth factor (IGF)-I activity with normal…”
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Chronic Nephropathy in Ad Libitum Overfed Sprague-Dawley Rats and Its Early Attenuation by Increasing Degrees of Dietary (Caloric) Restriction to Control Growth by Keenan, Kevin P., Coleman, John B., Mccoy, Carol L., Hoe, Chao-Min, Soper, Keith A., Laroque, Philippe

“…The early development and progression of chronic nephropathy and its amelioration by moderate and marked dietary restriction (DR) was determined in…”
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The Relative Protective Effects of Moderate Dietary Restriction versus Dietary Modification on Spontaneous Cardiomyopathy in Male Sprague-Dawley Rats by Kemi, Masayuki, Keenan, Kevin P., Mccoy, Carol, Hoe, Chao-Min, Soper, Keith A., Ballam, Gordon C., Van Zwieten, Matthew J.

“…The relative protective effects of modifying dietary protein, fat, fiber, and energy content vs moderate food or dietary restriction (DR) on spontaneous…”
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The Effects of Ad Libitum Overfeeding and Moderate and Marked Dietary Restriction on Age-Related Spontaneous Pituitary Gland Pathology in Sprague—Dawley Rats by Molon-Noblot, Sylvain, Laroque, Philippe, Coleman, John B., Hoe, Chao-Min, Keenan, Kevin P.

“…This study compared the effects of ad libitum (AL) overfeeding and moderate or marked dietary restriction (DR) on the pathogenesis of aged-related pituitary…”
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Society of Toxicologic Pathology Position Paper: Diet as a Variable in Rodent Toxicology and Carcinogenicity Studies by Nold, James B., Keenan, Kevin P., Nyska, Abraham, Cartwright, Mark E.

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The effects of diet, ad libitum overfeeding, and moderate dietary restriction on the rodent bioassay: the uncontrolled variable in safety assessment by Keenan, K P, Laroque, P, Ballam, G C, Soper, K A, Dixit, R, Mattson, B A, Adams, S P, Coleman, J B

“…Ad libitum (AL) overfeeding is the most significant, uncontrolled variable affecting the outcome of the current rodent bioassay. There is a highly significant…”
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Diet, overfeeding, and moderate dietary restriction in control Sprague-Dawley rats: I. Effects on spontaneous neoplasms by Keenan, K P, Soper, K A, Smith, P F, Ballam, G C, Clark, R L

“…This study was designed to compare the effects of ad libitum (AL) overfeeding and moderate dietary restriction (DR) of two different diets on Sprague-Dawley…”
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The effects of diet, ad libitum feeding, and moderate and severe dietary restriction on body weight, survival, clinical pathology parameters, and cause of death in control Sprague-Dawley rats by HUBERT, Marie-Francoise, LAROQUE, Philippe, GILLET, Jean-Pierre, KEENAN, Kevin P

“…A 2-year study was conducted in Sprague-Dawley rats to compare the effects of ad libitum (AL) feeding and dietary restriction (DR) on body weight, survival,…”
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HPLC-MS/MS determination of a peptide conjugate prodrug of doxorubicin, and its active metabolites, leucine-doxorubicin and doxorubicin, in dog and rat plasma by Mazuel, Claude, Grove, Jeffrey, Gerin, Geneviève, Keenan, Kevin P.

“…A HPLC-MS/MS Electrospray (ESI) method was developed and validated to quantify a peptide conjugate prodrug of doxorubicin (Dox-Con) and its active metabolites…”
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Diabesity: A Polygenic Model of Dietary-Induced Obesity from Ad Libitum Overfeeding of Sprague–Dawley Rats and Its Modulation by Moderate and Marked Dietary Restriction by Keenan, Kevin P., Hoe, Chao-Min, Mixson, Lori, Mccoy, Carol L., Coleman, John B., Mattson, Britta A., Ballam, Gordon A., Gumprecht, Laura A., Soper, Keith A.

“…This study compared the effects of ad libitum (AL) overfeeding and moderate or marked dietary restriction (DR) on the pathogenesis of a metabolic syndrome of…”
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The morphology of juxtaglomerular cell hyperplasia and hypertrophy in normotensive rats and monkeys given an angiotensin II receptor antagonist by Owen, R A, Molon-Noblot, S, Hubert, M F, Kindt, M V, Keenan, K P, Eydelloth, R S

“…L-694,492 (DUP 532), an angiotensin II (AII) receptor antagonist, was given orally at 125 mg/kg/day to rats and monkeys for up to 6 mo to assess the effects of…”
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The morphology of juxtaglomerular cell hyperplasia and hypertrophy in normotensive rats and monkeys given an angiotensin II receptor antagonist by Owen, R A, Molon-Noblot, S, Hubert, M F, Kindt, M V, Keenan, K P, Eydelloth, R S

“…L-694,492 (DUP 532), an angiotensin II (AII) receptor antagonist, was given orally at 125 mg/kh/day to rats and monkeys for up to 6 mo to assess the effects of…”
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Need for dietary control by caloric restriction in rodent toxicology and carcinogenicity studies by Keenan, Kevin P., Laroque, Philippe, Dixit, Rakesh

“…The conditions under which laboratory animals are maintained can powerfully influence the results of toxicological studies utilized for risk assessment…”
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The effects of overfeeding and dietary restriction on Sprague-Dawley rat survival and early pathology biomarkers of aging by Keenan, K P, Smith, P F, Hertzog, P, Soper, K, Ballam, G C, Clark, R L

“…A significant correlation exists between average daily food consumption and 2-yr survival in control ad libitum (AL)-fed Sprague-Dawley (SD) rats. SD rats were…”
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The Effects of Ad Libitum Overfeeding and Moderate and Marked Dietary Restriction on Age-Related Spontaneous Pancreatic Islet Pathology in Sprague—Dawley Rats by Molon-Noblot, Sylvain, Keenan, Kevin P., Coleman, John B., Hoe, Chao-Min, Laroque, Philippe

“…This study compared the effects of ad libitum (AL) overfeeding and moderate or marked dietary restriction (DR) on aged-related degenerative and proliferative…”
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Commentary. The uncontrolled variable in risk assessment: ad libitum overfed rodents--fat, facts and fiction by Keenan, K P

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Diet, overfeeding, and moderate dietary restriction in control Sprague-Dawley rats: II. Effects on age-related proliferative and degenerative lesions by Keenan, K P, Soper, K A, Hertzog, P R, Gumprecht, L A, Smith, P F, Mattson, B A, Ballam, G C, Clark, R L

“…This study compared the effects of ad libitum (AL) overfeeding and moderate dietary restriction (DR) of 2 different diets on Sprague-Dawley (SD) rat survival…”
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Effect of food restriction on risk assessment by Keenan, K P

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Induction of emphysema and bronchial mucus cell hyperplasia by intratracheal instillation of lipopolysaccharide in the hamster by Stolk, J, Rudolphus, A, Davies, P, Osinga, D, Dijkman, J H, Agarwal, L, Keenan, K P, Fletcher, D, Kramps, J A

“…The aim of this study was to determine whether lipopolysaccharide-induced elastase release from recruited neutrophils in the hamster lung would induce…”
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