Search Results - "KEEN, Judith C"

The Role of HuR in Gemcitabine Efficacy in Pancreatic Cancer: HuR Up-regulates the Expression of the Gemcitabine Metabolizing Enzyme Deoxycytidine Kinase by COSTANTINO, Christina L, WITKIEWICZ, Agnieszka K, KUWANO, Yuki, COZZITORTO, Joseph A, KENNEDY, Eugene P, DASGUPTA, Abhijit, KEEN, Judith C, YEO, Charles J, GOROSPE, Myriam, BRODY, Jonathan R

“…RNA-binding protein HuR binds U- or AU-rich sequences in the 3'-untranslated regions of target mRNAs, stabilizing them and/or modulating their translation…”
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Genome-wide SNP assay reveals structural genomic variation, extended homozygosity and cell-line induced alterations in normal individuals by Simon-Sanchez, Javier, Scholz, Sonja, Fung, Hon-Chung, Matarin, Mar, Hernandez, Dena, Gibbs, J. Raphael, Britton, Angela, de Vrieze, Fabienne Wavrant, Peckham, Elizabeth, Gwinn-Hardy, Katrina, Crawley, Anthony, Keen, Judith C., Nash, Josefina, Borgaonkar, Digamber, Hardy, John, Singleton, Andrew

“…The recent hapmap effort has placed focus on the application of genome-wide SNP analysis to assess the contribution of genetic variability, particularly SNPs,…”
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pp32 (ANP32A) expression inhibits pancreatic cancer cell growth and induces gemcitabine resistance by disrupting HuR binding to mRNAs by Williams, Timothy K, Costantino, Christina L, Bildzukewicz, Nikolai A, Richards, Nathan G, Rittenhouse, David W, Einstein, Lisa, Cozzitorto, Joseph A, Keen, Judith C, Dasgupta, Abhijit, Gorospe, Myriam, Gonye, Gregory E, Yeo, Charles J, Witkiewicz, Agnieszka K, Brody, Jonathan R

“…The expression of protein phosphatase 32 (PP32, ANP32A) is low in poorly differentiated pancreatic cancers and is linked to the levels of HuR (ELAV1), a…”
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Epigenetic regulation of protein phosphatase 2A (PP2A), Lymphotactin (XCL1) and estrogen receptor alpha (ER) expression in human breast cancer cells by Keen, Judith C., Garrett-Mayer, Elizabeth, Pettit, Catherine, Mack, Kelly M., Manning, Jasper, Herman, James G., Davidson, Nancy E.

“…Absence of the estrogen receptor alpha (ER) in human breast cancer cells is an indicator of poor prognosis, and predictive of lack of response to hormonal…”
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Responses to the 2017 “1 Million Gray Question”: ASTRO Membership's Opinions on the Most Important Research Question Facing Radiation Oncology by Dominello, Michael M., Keen, Judith C., Beck, Tyler F., Bayouth, John, Knisely, Jonathan, Carlson, David J., Mendonca, Marc S., Mian, Omar, Brock, Kristy K., Anscher, Mitchell, Hugo, Geoffrey, Moros, Eduardo G., Singh, Anurag K., Yu, James B.

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Analysis of the 2017 American Society for Radiation Oncology (ASTRO) Research Portfolio by Yu, James B., Beck, Tyler F., Anscher, Mitchell S., Baschnagel, Andrew M., Brock, Kristy K., Carlson, David J., Dominello, Michael M., Kimple, Randall J., Knisely, Jonathan P., Mendonca, Marc S., Mian, Omar Y., Singh, Anurag K., Moros, Eduardo G., Keen, Judith C.

“…Research in radiation oncology (RO) is imperative to support the discovery of new uses of radiation and improvement of current approaches to radiation delivery…”
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The ASTRO Research Portfolio: Where Do We Go From Here? by Yu, James B., Beck, Tyler F., Anscher, Mitchell S., Baschnagel, Andrew M., Brock, Kristy K., Carlson, David J., Dominello, Michael M., Kimple, Randall J., Knisely, Jonathan P.S., Mendonca, Marc S., Mian, Omar Y., Singh, Anurag K., Moros, Eduardo G., Keen, Judith C.

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Assessing the Training and Research Environment for Genomics, Bioinformatics, and Immunology in Radiation Oncology by Mouw, Kent W, Beck, Tyler F, Keen, Judith C, Dicker, Adam P

“…To assess radiation oncologists' perceptions of training and research opportunities in the fields of genomics, bioinformatics, and immunology. A 13-item…”
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A step towards a new targeted nanotherapy for pancreatic cancer by Keen, Judith C.

“…Commentary to: Nanoparticulate delivery of diphtheria toxin DNA effectively kills mesothelin expressing pancreatic cancer cells SL Showalter, Y-H Huang, A…”
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Polyamine Analogues Down-regulate Estrogen Receptor α Expression in Human Breast Cancer Cells by Huang, Yi, Keen, Judith C., Pledgie, Allison, Marton, Laurence J., Zhu, Tao, Sukumar, Saraswati, Park, Ben Ho, Blair, Brian, Brenner, Keith, Casero, Robert A., Davidson, Nancy E.

“…The critical role of polyamines in cell growth has led to the development of a number of agents that interfere with polyamine metabolism including a novel…”
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Protein phosphatase 2A regulates estrogen receptor alpha (ER) expression through modulation of ER mRNA stability by Keen, Judith C, Zhou, Qun, Park, Ben Ho, Pettit, Catherine, Mack, Kelly M, Blair, Brian, Brenner, Keith, Davidson, Nancy E

“…Protein phosphatase 2A (PP2A) is a ubiquitously expressed member of the serine-threonine phosphatase family that is involved in regulation of many cellular…”
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The 'RNA-binding ome': future implications for chemotherapeutic efficacy by Brody, Jonathan R, Witkiewicz, Agnieszka K, Yeo, Charles J, Gorospe, Myriam, Keen, Judith C

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Characterization of a novel PMA‐inducible pathway of interleukin‐13 gene expression in T cells by Keen, Judith C., Cianferoni, Antonella, Florio, Giovanni, Guo, Jia, Chen, Rongbing, Roman, Jessica, Wills‐Karp, Marsha, Casolaro, Vincenzo, Georas, Steve N.

“…Summary Although interleukin 13 (IL‐13) is an important mediator of asthma and allergic diseases, the molecular mechanisms regulating IL‐13 gene expression are…”
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Regulation of polyamine analogue cytotoxicity by c-Jun in human MDA-MB-435 cancer cells by Huang, Yi, Keen, Judith C, Hager, Erin, Smith, Renee, Hacker, Amy, Frydman, Benjamin, Valasinas, Aldonia L, Reddy, Venodhar K, Marton, Laurence J, Casero, Jr, Robert A, Davidson, Nancy E

“…Several polyamine analogues have efficacy against a variety of epithelial tumor models including breast cancer. Recently, a novel class of polyamine analogues…”
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Abstract 4063: Estrogen receptor alpha functions as an RNA binding protein to regulate GATA3 protein levels: a novel role for ER by Joyce, Karen, Hostetter, Christine, Chamoun, George, Keen, Judith C.

“…Abstract The role of estrogen receptor alpha (ER) as a transcription factor has been well established. ER transcriptionally activates genes by binding to DNA…”
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Abstract 3078: CD44 mRNA stability is regulated by RNA binding protein HuR in ovarian cancer cells by Miletti-Gonzalez, Karl E., Hostetter, Christine L., Ravindranath, Abhilash K., Muthukumaran, Neelakandan, Keen, Judith C., Rodriguez-Rodriguez, Lorna

“…Abstract CD44, a major hyaluronic acid (HA) receptor, is involved in cell migration, metastasis and tumor progression. While in normal ovarian epithelium CD44…”
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pp32 by Williams, Timothy K, Costantino, Christina L, Bildzukewicz, Nikolai A, Richards, Nathan G, Rittenhouse, David W, Einstein, Lisa, Cozzitorto, Joseph A, Keen, Judith C, Dasgupta, Abhijit, Gorospe, Myriam, Gonye, Gregory E, Yeo, Charles J, Witkiewicz, Agnieszka K, Brody, Jonathan R

“…The expression of protein phosphatase 32 (PP32, ANP32A) is low in poorly differentiated pancreatic cancers and is linked to the levels of HuR (ELAV1), a…”
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HuR’s role in gemcitabine efficacy in pancreatic cancer: HuR upregulates the expression of the gemcitabine metabolizing enzyme, deoxycytidine kinase by Costantino, Christina L., Witkiewicz, Agnieszka K., Y, Yuki Kuwano, Cozzitorto, Joseph A., Kennedy, Eugene P., Dasgupta, Abhijit, Keen, Judith C., Yeo, Charles J., Gorospe, Myriam, Brody, Jonathan R.

“…RNA-binding protein HuR binds U- or AU-rich sequences in the 3′-untranslated regions (UTRs) of target mRNAs, stabilizing them and/or modulating their…”
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Protein Phosphatase 2A Regulates Estrogen Receptor α (ER) Expression through Modulation of ER mRNA Stability by Judith C. Keen, Qun Zhou, Ben Ho Park, Catherine Pettit, Kelly M. Mack, Brian Blair, Keith Brenner, Nancy E. Davidson

“…Protein phosphatase 2A (PP2A) is a ubiquitously expressed member of the serine-threonine phosphatase family that is involved in regulation of many cellular…”
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Polyamine Analogues Down-regulate Estrogen Receptor α Expression in Human Breast Cancer Cells by Yi Huang, Judith C. Keen, Allison Pledgie, Laurence J. Marton, Tao Zhu, Saraswati Sukumar, Ben Ho Park, Brian Blair, Keith Brenner, Robert A. Casero, Jr, Nancy E. Davidson

“…The critical role of polyamines in cell growth has led to the development of a number of agents that interfere with polyamine metabolism including a novel…”
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