Search Results - "KE-QIN XIN"

Atg5-Atg12 conjugate associates with innate antiviral immune responses by Jounai, Nao, Takeshita, Fumihiko, Kobiyama, Kouji, Sawano, Asako, Miyawaki, Atsushi, Xin, Ke-Qin, Ishii, Ken J, Kawai, Taro, Akira, Shizuo, Suzuki, Koichi, Okuda, Kenji

“…Autophagy is an essential process for physiological homeostasis, but its role in viral infection is only beginning to be elucidated. We show here that the…”
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Induction of Robust Immune Responses against Human Immunodeficiency Virus Is Supported by the Inherent Tropism of Adeno-Associated Virus Type 5 for Dendritic Cells by XIN, Ke-Qin, MIZUKAMI, Hiroaki, OZAWA, Keiya, OKUDA, Kenji, URABE, Masashi, TODA, Yoshihiko, SHINODA, Kaori, YOSHIDA, Atsushi, OOMURA, Kenji, KOJIMA, Yoshitsugu, ICHINO, Motohide, KLINMAN, Dennis

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Scalable Generation of High-Titer Recombinant Adeno-Associated Virus Type 5 in Insect Cells by URABE, Masashi, NAKAKURA, Takayo, XIN, Ke-Qin, OBARA, Yoko, MIZUKAMI, Hiroaki, KUME, Akihiro, KOTIN, Robert M, OZAWA, Keiva

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Removal of Empty Capsids from Type 1 Adeno-Associated Virus Vector Stocks by Anion-Exchange Chromatography Potentiates Transgene Expression by Urabe, Masashi, Xin, Ke-Qin, Obara, Yoko, Nakakura, Takayo, Mizukami, Hiroaki, Kume, Akihiro, Okuda, Kenji, Ozawa, Keiya

“…Production of recombinant adeno-associated virus (rAAV) results in substantial quantities of empty capsids or virus-like particles (VLPs), virus protein shells…”
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Immunogenicity and protective efficacy of orally administered recombinant Lactococcus lactis expressing surface-bound HIV Env by Xin, Ke-Qin, Hoshino, Yuka, Toda, Yoshihiko, Igimi, Shizunobu, Kojima, Yoshitsugu, Jounai, Nao, Ohba, Kenji, Kushiro, Akira, Kiwaki, Mayumi, Hamajima, Kenji, Klinman, Dennis, Okuda, Kenji

“…This study investigates whether genetically modified orally administered Lactococcus lactis (L lactis) could be used as an HIV vaccine. L lactis is immunogenic…”
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Tendon Healing In Vitro: bFGF Gene Transfer to Tenocytes by Adeno-Associated Viral Vectors Promotes Expression of Collagen Genes by Wang, Xiao Tian, Liu, Paul Y., Xin, Ke-Qin, Tang, Jin Bo

“…Adeno-associated virus-mediated gene transfer is promising in the delivery of genes to tendons because this vector stimulates few adverse tissue reactions…”
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Blocking of the TLR5 Activation Domain Hampers Protective Potential of Flagellin DNA Vaccine by Saha, Sukumar, Takeshita, Fumihiko, Matsuda, Tomoko, Jounai, Nao, Kobiyama, Kouji, Matsumoto, Tetsuya, Sasaki, Shin, Yoshida, Atsushi, Xin, Ke-Qin, Klinman, Dennis M, Uematsu, Satoshi, Ishii, Ken J, Akira, Shizuo, Okuda, Kenji

“…Flagellin is a key component of the flagella of many pathogens, including Pseudomonas aeruginosa. Flagellin is an attractive vaccine candidate because it is…”
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Management of ovarian cysts in infants by Xue-qiang, Yan, Nan-nan, Zheng, Lei, Yu, Wei, Lu, Hong-qiang, Bian, Jun, Yang, Xu-fei, Duan, Xin-ke, Qin

“…Background: To discuss the experience of diagnosis and treatment of ovarian cyst in infants. Materials and Methods: A retrospective review was conducted on 20…”
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The F(ab′) 2 fragment of an Aβ-specific monoclonal antibody reduces Aβ deposits in the brain by Tamura, Yuichi, Hamajima, Kenji, Matsui, Kiyohiko, Yanoma, Shunsuke, Narita, Masato, Tajima, NobuyoshiI, Xin, Ke-Qin, Klinman, Dennis, Okuda, Kenji

“…This work examines whether administering the F(ab´) 2 fragment of an IgG1 monoclonal antibody (mAb) targeting the N-terminal 1–13 amino acids of the β-amyloid…”
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Designed recombinant adenovirus type 5 vector induced envelope-specific CD8+ cytotoxic T lymphocytes and cross-reactive neutralizing antibodies against human immunodeficiency virus type 1 by Ura, Takehiro, Yoshida, Atsushi, Xin, Ke-Qin, Yoshizaki, Shinji, Yashima, Sayaka, Abe, Shinya, Mizuguchi, Hiroyuki, Okuda, Kenji

“…Background A monoclonal antibody (mAb) 2F5 binds to the membrane‐proximal external region (MPER) of the transmembrane subunit gp41 of human immunodeficiency…”
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The Timing of GM-CSF Expression Plasmid Administration Influences the Th1/Th2 Response Induced by an HIV-1-Specific DNA Vaccine by Kusakabe, Ken-ichi, Xin, Ke-Qin, Katoh, Hidenori, Sumino, Kaharu, Hagiwara, Eri, Kawamoto, Susumu, Okuda, Katsuji, Miyagi, Yohei, Aoki, Ichiro, Nishioka, Kusuya, Klinman, Dennis, Okuda, Kenji

“…The mechanism of immune activation induced by a plasmid-encoding GM-CSF (pGM-CSF), administered in combination with a DNA vaccine encoding the envelope of HIV,…”
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Chimeric adenovirus 5/35 vector containing the clade C HIV gag gene induces a cross-reactive immune response against HIV by Xin, Ke-Qin, Sekimoto, Yuka, Takahashi, Toru, Mizuguchi, Hiroyuki, Ichino, Motohide, Yoshida, Atsushi, Okuda, Kenji

“…Abstract Most of the recent HIV studies have focused on the clade B virus subtype. However, it is estimated that half the HIV patients in developing countries…”
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Isolation and identification of adenovirus from conjunctival scrapings over a two-year period (between 2001 and 2003) in Yokohama, Japan by Matsui, Kiyohiko, Saha, Sukumar, Saitoh, Masaaki, Mizuki, Nobuhisa, Itoh, Norihiko, Okada, Eiichi, Yoshida, Atsushi, Xin, Ke-Qin, Nishio, Osamu, Okuda, Kenji

“…Over a 2‐year period between 2001 and 2003, a total of 115 conjunctival scrapings were collected from patients with keratoconjuctivitis from several hospitals…”
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Protection against influenza virus challenge by topical application of influenza DNA vaccine by Watabe, Setsuko, Xin, Ke-Qin, Ihata, Atsushi, Liu, Li-Juan, Honsho, Akiko, Aoki, Ichiro, Hamajima, Kenji, Wahren, Britta, Okuda, Kenji

“…We studied the use of a DNA vaccine expressing the matrix (M) gene of the influenza virus A/PR/8/34. Mice were immunized by painting the DNA vaccine three…”
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Tissue Reactions of Adenoviral, Adeno-Associated Viral, and Liposome–Plasmid Vectors in Tendons and Comparison With Early-Stage Healing Responses of Injured Flexor Tendons by Zhu, Bei, Cao, Yi, Xin, Ke-Qin, Wang, Xiao Tian, Summerhayes, Ian C., Liu, Paul Y., Tang, Jin Bo

“…Delivery of growth factor genes that may substantially increase the healing rate of injured digital flexor tendons is a new application of gene therapy…”
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Adeno-Associated Virus-2-Mediated bFGF Gene Transfer to Digital Flexor Tendons Significantly Increases Healing Strength: An in Vivo Study by Tang, Jin Bo, Cao, Yi, Zhu, Bei, Xin, Ke-Qin, Wang, Xiao Tian, Liu, Paul Y

“…BackgroundTreatment of the disrupted intrasynovial flexor tendon is troublesome and can be complicated by the rupture of weak repairs and the formation of…”
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A Consecutive Priming-Boosting Vaccination of Mice with Simian Immunodeficiency Virus (SIV) gag/pol DNA and Recombinant Vaccinia Virus Strain DIs Elicits Effective Anti-SIV Immunity by SOMEYA, Kenji, XIN, Ke-Qin, MATSUO, Kazuhiro, OKUDA, Kenji, YAMAMOTO, Naoki, HONDA, Mitsuo

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Contribution of the rev gene to the immunogenicity of DNA vaccines targeting the envelope glycoprotein of HIV by Jounai, Nao, Okuda, Kenji, Kojima, Yoshitsugu, Toda, Yoshihiko, Hamajima, Kenji, Ohba, Kenji, Klinman, Dennis, Xin, Ke-Qin

“…Background The Rev protein of HIV plays a critical role in the export of viral mRNA from the nucleus to the cytoplasm of infected cells. This work examines the…”
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Oral administration of recombinant adeno-associated virus elicits human immunodeficiency virus-specific immune responses by Xin, Ke-Qin, Ooki, Takaaki, Mizukami, Hiroaki, Hamajima, Kenji, Okudela, Koji, Hashimoto, Kumiko, Kojima, Yoshitsugu, Jounai, Nao, Kumamoto, Yasuko, Sasaki, Shin, Klinman, Dennis, Ozawa, Keiya, Okuda, Kenji

“…Oral vaccines can induce both systemic and mucosal immunity. Mucosal immunity, especially regional cell-mediated immunity, plays an important role in…”
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Cross-reactive protection against influenza A virus by a topically applied DNA vaccine encoding M gene with adjuvant by Ozaki, Tomomi, Yauchi, Masaomi, Xin, Ke-Qin, Hirahara, Fumiki, Okuda, Kenji

“…The skin is rich with immunocompetent cells and therefore immunization through the skin is an attractive alternative to the invasive vaccination methods…”
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