Search Results - "KC, Shekhar"

Strategies toward Dicarbofunctionalization of Unactivated Olefins by Combined Heck Carbometalation and Cross-Coupling by Giri, Ramesh, KC, Shekhar

“…The use of combined Heck carbometalation and cross-coupling remains one of the most powerful ways for the difunctionalization of unactivated olefins with…”
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Clinical Scenario of Venerophobia in Patients Presenting in Outpatient Department by KC, Shekhar, Adhikary, Manoj, Karn, Dharmendra

“…Background: Venereophobia is fear of getting sexually transmitted disease after first or repeated unprotected sexual activities with unsafe or safe partners…”
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Transition Metal‐Catalyzed Dicarbofunctionalization of Unactivated Olefins by Dhungana, Roshan K., KC, Shekhar, Basnet, Prakash, Giri, Ramesh

“…Transition metal (TM)‐catalyzed difunctionalization of unactivated olefins with two carbon‐based entities is a powerful method to construct complex molecular…”
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Nickel‐Catalyzed α‐Carbonylalkylarylation of Vinylarenes: Expedient Access to γ,γ‐Diarylcarbonyl and Aryltetralone Derivatives by KC, Shekhar, Dhungana, Roshan K., Khanal, Namrata, Giri, Ramesh

“…We report a Ni‐catalyzed regioselective α‐carbonylalkylarylation of vinylarenes with α‐halocarbonyl compounds and arylzinc reagents. The reaction works with…”
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Ni-Catalyzed Regioselective Alkylarylation of Vinylarenes via C(sp3)–C(sp3)/C(sp3)–C(sp2) Bond Formation and Mechanistic Studies by KC, Shekhar, Dhungana, Roshan K, Shrestha, Bijay, Thapa, Surendra, Khanal, Namrata, Basnet, Prakash, Lebrun, Robert W, Giri, Ramesh

“…We report a Ni-catalyzed regioselective alkylarylation of vinylarenes with alkyl halides and arylzinc reagents to generate 1,1-diarylalkanes. The reaction…”
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Ni-Catalyzed Regioselective 1,2-Dicarbofunctionalization of Olefins by Intercepting Heck Intermediates as Imine-Stabilized Transient Metallacycles by Shrestha, Bijay, Basnet, Prakash, Dhungana, Roshan K, KC, Shekhar, Thapa, Surendra, Sears, Jeremiah M, Giri, Ramesh

“…We disclose a strategy for Ni-catalyzed dicarbofunctionalization of olefins in styrenes by intercepting Heck C­(sp3)–NiX intermediates with arylzinc reagents…”
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Ni-Catalyzed Regioselective Dicarbofunctionalization of Unactivated Olefins by Tandem Cyclization/Cross-Coupling and Application to the Concise Synthesis of Lignan Natural Products by KC, Shekhar, Basnet, Prakash, Thapa, Surendra, Shrestha, Bijay, Giri, Ramesh

“…We disclose a (terpy)­NiBr2-catalyzed reaction protocol that regioselectively difunctionalizes unactivated olefins with tethered alkyl halides and arylzinc…”
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Ni-catalysed regioselective 1,2-diarylation of unactivated olefins by stabilizing Heck intermediates as pyridylsilyl-coordinated transient metallacycles by Thapa, Surendra, Dhungana, Roshan K, Magar, Rajani Thapa, Shrestha, Bijay, Kc, Shekhar, Giri, Ramesh

“…We report a Ni-catalysed diarylation of unactivated olefins in dimethylpyridylvinylsilane by intercepting Heck C(sp )-NiX intermediates, derived from aryl…”
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K 2 CO 3 -Catalyzed Synthesis of 2,5-Dialkyl-4,6,7-tricyano-Decorated Indoles via Carbon-Carbon Bond Cleavage by Pike, Ryan A S, Sapkota, Rishi R, Shrestha, Bijay, Dhungana, Roshan K, Kc, Shekhar, Dickie, Diane A, Giri, Ramesh

“…We describe a novel method to synthesize 2,5-dialkyl-4,6,7-tricyanoindole derivatives from a base-catalyzed reaction of 1,3-diketones with fumaronitrile. The…”
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Clinical Outcome of Autologous Serum Therapy in Chronic Idiopathic Urticaria by Dharmendra Karn, Shekhar KC

“…Background: Quality of life in chronic idiopathic urticaria is hampered as efficacy of H1-antihistamines is limited. Autologous serum containing…”
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Comparative Efficacy of Fexofenadine Versus Levocetrizine Versus Desloratadine via 1% Histamine Wheal Suppression Test by Kc, S, Aryal, A, Adhikary, M, Karn, D

“…Background Urticaria and allergic dermatoses remains a great challenge to treating dermatologist. Histamine is the major mediator in such disorders…”
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Ni-Catalyzed Regioselective β,δ-Diarylation of Unactivated Olefins in Ketimines via Ligand-Enabled Contraction of Transient Nickellacycles: Rapid Access to Remotely Diarylated Ketones by Basnet, Prakash, Dhungana, Roshan K, Thapa, Surendra, Shrestha, Bijay, KC, Shekhar, Sears, Jeremiah M, Giri, Ramesh

“…We disclose a [(PhO)3P]/NiBr2-catalyzed regioselective β,δ-diarylation of unactivated olefins in ketimines with aryl halides and arylzinc reagents. This…”
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Synergistic Bimetallic Ni/Ag and Ni/Cu Catalysis for Regioselective γ,δ-Diarylation of Alkenyl Ketimines: Addressing β‑H Elimination by in Situ Generation of Cationic Ni(II) Catalysts by Basnet, Prakash, KC, Shekhar, Dhungana, Roshan K, Shrestha, Bijay, Boyle, Timothy J, Giri, Ramesh

“…We disclose unprecedented synergistic bimetallic Ni/Ag and Ni/Cu catalysts for regioselective γ,δ-diarylation of unactivated alkenes in simple ketimines with…”
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Ni(I)-Catalyzed β,δ-Vinylarylation of γ,δ-Alkenyl α‑Cyanocarboxylic Esters via Contraction of Transient Nickellacycles by Dhungana, Roshan K, KC, Shekhar, Basnet, Prakash, Aryal, Vivek, Chesley, Lucas J, Giri, Ramesh

“…We disclose a transmetalation-initiated Ni­(I)-catalyzed regioselective β,δ-vinylarylation of γ,δ-alkenyl α-cyanocarboxylic esters with vinyl triflates and…”
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Concise Synthesis of a Potential 5‑Lipoxygenase Activating Protein (FLAP) Inhibitor and Its Analogs through Late-Stage Alkene Dicarbofunctionalization by KC, Shekhar, Dhungana, Roshan K, Aryal, Vivek, Giri, Ramesh

“…We report a five-step synthesis of the biologically important 1,1-diarylalkane 1, a potential 5-lipoxygenase activating protein (FLAP) inhibitor that was…”
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Schistosomiasis drug therapy and treatment considerations by Shekhar, K C

“…Schistosomiasis, a grave and debilitating disease of socioeconomic importance, is increasing in incidence despite concerted efforts to control and contain the…”
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K2CO3‑Catalyzed Synthesis of 2,5-Dialkyl-4,6,7-tricyano-Decorated Indoles via Carbon–Carbon Bond Cleavage by Pike, Ryan A. S, Sapkota, Rishi R, Shrestha, Bijay, Dhungana, Roshan K, KC, Shekhar, Dickie, Diane A, Giri, Ramesh

“…We describe a novel method to synthesize 2,5-dialkyl-4,6,7-tricyanoindole derivatives from a base-catalyzed reaction of 1,3-diketones with fumaronitrile. The…”
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Ni-catalysed regioselective 1,2-diarylation of unactivated olefins by stabilizing Heck intermediates as pyridylsilyl-coordinated transient metallacyclesElectronic supplementary information (ESI) available: Experimental procedures and characterization, and the 1H and 13C NMR spectra of new compounds. See DOI: 10.1039/c7sc04351a by Thapa, Surendra, Dhungana, Roshan K, Magar, Rajani Thapa, Shrestha, Bijay, KC, Shekhar, Giri, Ramesh

“…We report a Ni-catalysed diarylation of unactivated olefins in dimethylpyridylvinylsilane by intercepting Heck C(sp 3 )-NiX intermediates, derived from aryl…”
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Ni-catalysed regioselective 1,2-diarylation of unactivated olefins by stabilizing Heck intermediates as pyridylsilyl-coordinated transient metallacycles† †Electronic supplementary information (ESI) available: Experimental procedures and characterization, and the 1H and 13C NMR spectra of new compounds. See DOI: 10.1039/c7sc04351a by Thapa, Surendra, Dhungana, Roshan K., Magar, Rajani Thapa, Shrestha, Bijay, KC, Shekhar, Giri, Ramesh

“…Ni-catalysed diarylation of vinylpyridylsilanes with arylzinc reagents and aryl halides is reported by stabilizing Heck intermediates as…”
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Development of Ni-Catalyzed Alkene Dicarbofunctionalization Reactions by KC, Shekhar

“…Alkenes serve as one of the most important feedstocks for organic synthesis, having two vicinal sites for bond formation. In alkenes, both vicinal sites can be…”
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