Search Results - "KAZLAUSKAS, Egidijus"

Standard operating procedure for fluorescent thermal shift assay (FTSA) for determination of protein–ligand binding and protein stability by Kazlauskas, Egidijus, Petrauskas, Vytautas, Paketurytė, Vaida, Matulis, Daumantas

“…A standard operating procedure for a fluorescence-based thermal shift assay (FTSA) is provided describing its typical applications, advantages and limitations…”
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Improving the Hsp90 Inhibitors Containing 4-(2,4-Dihydroxyphenyl)-1,2,3-thiadiazole Scaffold: Synthesis, Affinity and Effect on Cancer Cells by Kazlauskas, Egidijus, Brukstus, Algirdas, Petrikas, Herkus, Petrikaite, Vilma, Cikotiene, Inga, Matulis, Daumantas

“…Human Hsp90 chaperone inhibitors are known to be potential anticancer drugs. Previously we have shown a couple of…”
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Thermodynamics of aryl-dihydroxyphenyl-thiadiazole binding to human Hsp90 by Kazlauskas, Egidijus, Petrikaitė, Vilma, Michailovienė, Vilma, Revuckienė, Jurgita, Matulienė, Jurgita, Grinius, Leonas, Matulis, Daumantas

“…The design of specific inhibitors against the Hsp90 chaperone and other enzyme relies on the detailed and correct understanding of both the thermodynamics of…”
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Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors by Sharp, Swee Y, Roe, S Mark, Kazlauskas, Egidijus, Cikotienė, Inga, Workman, Paul, Matulis, Daumantas, Prodromou, Chrisostomos

“…A potential therapeutic strategy for targeting cancer that has gained much interest is the inhibition of the ATP binding and ATPase activity of the molecular…”
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Correction: Thermodynamics of Aryl-Dihydroxyphenyl-Thiadiazole Binding to Human Hsp90 by Kazlauskas, Egidijus, Petrikaitė, Vilma, Michailovienė, Vilma, Revuckienė, Jurgita, Matulienė, Jurgita, Grinius, Leonas, Matulis, Daumantas

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Binding affinity in drug design: experimental and computational techniques by Kairys, Visvaldas, Baranauskiene, Lina, Kazlauskiene, Migle, Matulis, Daumantas, Kazlauskas, Egidijus

“…: In pharmaceutical design where future drugs are developed by targeting a specific chosen protein, the evaluation of ligand affinity is crucial. For this very…”
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Thermott: A comprehensive online tool for protein–ligand binding constant determination by Gedgaudas, Marius, Baronas, Denis, Kazlauskas, Egidijus, Petrauskas, Vytautas, Matulis, Daumantas

“…[Display omitted] •An online tool for the protein–compound binding constant from thermal shift data.•Provides estimates of the thermodynamic data on target…”
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Thermal shift assay for protein–ligand dissociation constant determination by Petrauskas, Vytautas, Kazlauskas, Egidijus, Gedgaudas, Marius, Baranauskienė, Lina, Zubrienė, Asta, Matulis, Daumantas

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Comprehensive analysis of resorcinyl-imidazole Hsp90 inhibitor design by Gedgaudas, Marius, Kaziukonytė, Paulina, Kairys, Visvaldas, Mickevičiūtė, Aurelija, Zubrienė, Asta, Brukštus, Algirdas, Matulis, Daumantas, Kazlauskas, Egidijus

“…Human Hsp90 chaperones are implicated in various aspects of cancer. Due to this, Hsp90 has been explored as potential target in cancer treatment. Initial…”
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Heat Shock Protein 90 Inhibitor Effects on Pancreatic Cancer Cell Cultures by Gulla, Aistė, Kazlauskas, Egidijus, Liang, Hong, Strupas, Kestutis, Petrauskas, Vytautas, Matulis, Daumantas, Eshleman, James R.

“…Pancreatic ductal adenocarcinoma is one of the deadliest cancers for which few curative therapies are available to date. Heat shock protein 90 (Hsp90)…”
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Discovery and Characterization of Novel Selective Inhibitors of Carbonic Anhydrase IX by Dudutienė, Virginija, Matulienė, Jurgita, Smirnov, Alexey, Timm, David D, Zubrienė, Asta, Baranauskienė, Lina, Morku̅naitė, Vaida, Smirnovienė, Joana, Michailovienė, Vilma, Juozapaitienė, Vaida, Mickevičiu̅tė, Aurelija, Kazokaitė, Justina, Bakšytė, Sandra, Kasiliauskaitė, Aistė, Jachno, Jelena, Revuckienė, Jurgita, Kišonaitė, Miglė, Pilipuitytė, Vilma, Ivanauskaitė, Eglė, Milinavičiu̅tė, Goda, Smirnovas, Vytautas, Petrikaitė, Vilma, Kairys, Visvaldas, Petrauskas, Vytautas, Norvaišas, Povilas, Lingė, Darius, Gibieža, Paulius, Čapkauskaitė, Edita, Zakšauskas, Audrius, Kazlauskas, Egidijus, Manakova, Elena, Gražulis, Saulius, Ladbury, John E, Matulis, Daumantas

“…Human carbonic anhydrase IX (CA IX) is highly expressed in tumor tissues, and its selective inhibition provides a potential target for the treatment of…”
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Interaction of the middle domains stabilizes Hsp90α dimer in a closed conformation with high affinity for p23 by Synoradzki, Kamil, Miszta, Przemyslaw, Kazlauskas, Egidijus, Mickevičiūtė, Aurelija, Michailovienė, Vilma, Matulis, Daumantas, Filipek, Slawomir, Bieganowski, Pawel

“…The human genome encodes two highly similar cytosolic Hsp90 proteins called isoforms Hsp90α and Hsp90β. Of the 300 client proteins for Hsp90 identified so far…”
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5-Aryl-4-(5-substituted-2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone by Cikotiene, Inga, Kazlauskas, Egidijus, Matuliene, Jurgita, Michailoviene, Vilma, Torresan, Jolanta, Jachno, Jelena, Matulis, Daumantas

“…The synthesis and in vitro binding of the thiadiazole inhibitors of Hsp90 with K ds up to 5 nM. A series of…”
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PLBD: protein–ligand binding database of thermodynamic and kinetic intrinsic parameters by Lingė, Darius, Gedgaudas, Marius, Merkys, Andrius, Petrauskas, Vytautas, Vaitkus, Antanas, Grybauskas, Algirdas, Paketurytė, Vaida, Zubrienė, Asta, Zakšauskas, Audrius, Mickevičiūtė, Aurelija, Smirnovienė, Joana, Baranauskienė, Lina, Čapkauskaitė, Edita, Dudutienė, Virginija, Urniežius, Ernestas, Konovalovas, Aleksandras, Kazlauskas, Egidijus, Shubin, Kirill, Schiöth, Helgi B, Chen, Wen-Yih, Ladbury, John E, Gražulis, Saulius, Matulis, Daumantas

“…Abstract We introduce a protein–ligand binding database (PLBD) that presents thermodynamic and kinetic data of reversible protein interactions with small…”
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Co-Crystalization and In Vitro Biological Characterization of 5-Aryl-4 by Sharp, Swee Y, Roe, S. Mark, Kazlauskas, Egidijus, CikotienÄ, Inga, Workman, Paul, Matulis, Daumantas, Prodromou, Chrisostomos

“…A potential therapeutic strategy for targeting cancer that has gained much interest is the inhibition of the ATP binding and ATPase activity of the molecular…”
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Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells by GIESSRIG, Benedikt, KRIEGER, Sigurd, KOPF, Sabine, KAZLAUSKAS, Egidijus, MAZAL, Peter, SZEKERES, Thomas, HENGSTSCHLÄGER, Markus, MATULIS, Daumantas, JÄGER, Walter, KRUPITZA, Georg, ROSNER, Margit, HUTTARY, Nicole, SAIKO, Philipp, ALAMI, Mouad, MESSAOUDI, Samir, PEYRAT, Jean-François, MACIUK, Alexandre, GOLLINGER, Michaela

“…Pancreas cancer cells escape most treatment options. Heat shock protein (Hsp)90 is frequently over-expressed in pancreas carcinomas and protects a number of…”
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