Search Results - "KAZEMIER, Geert"

Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9 by Rodriguez, Ernesto, Boelaars, Kelly, Brown, Kari, Eveline Li, R. J., Kruijssen, Laura, Bruijns, Sven C. M., van Ee, Thomas, Schetters, Sjoerd T. T., Crommentuijn, Matheus H. W., van der Horst, Joost C., van Grieken, Nicole C. T., van Vliet, Sandra J., Kazemier, Geert, Giovannetti, Elisa, Garcia-Vallejo, Juan J., van Kooyk, Yvette

“…Changes in glycosylation during tumour progression are a key hallmark of cancer. One of the glycan moieties generally overexpressed in cancer are sialic acids,…”
Get full text

Heterogeneity and plasticity of cancer-associated fibroblasts in the pancreatic tumor microenvironment by Boyd, Lenka N.C., Andini, Katarina D., Peters, Godefridus J., Kazemier, Geert, Giovannetti, Elisa

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a notably poor prognosis, in urgent need of improved treatment strategies. The…”
Get full text

FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer by Caparello, Chiara, Meijer, Laura L, Garajova, Ingrid, Falcone, Alfredo, Le Large, Tessa Y, Funel, Niccola, Kazemier, Geert, Peters, Godefridus J, Vasile, Enrico, Giovannetti, Elisa

“…Pancreatic cancer is an extremely aggressive disease; although progress has been made in the last few years, the prognosis of these patients remains dismal…”
Get full text

Plasma miR-181a-5p Downregulation Predicts Response and Improved Survival After FOLFIRINOX in Pancreatic Ductal Adenocarcinoma by Meijer, Laura L., Garajová, Ingrid, Caparello, Chiara, Le Large, Tessa Y. S., Frampton, Adam E., Vasile, Enrico, Funel, Niccola, Kazemier, Geert, Giovannetti, Elisa

“…OBJECTIVE:The aim of the study was to identify plasma microRNA (miRNA) biomarkers for stratifying and monitoring patients with locally advanced or metastatic…”
Get full text

Advanced analytics and artificial intelligence in gastrointestinal cancer: a systematic review of radiomics predicting response to treatment by Wesdorp, Nina J., Hellingman, Tessa, Jansma, Elise P., van Waesberghe, Jan-Hein T. M., Boellaard, Ronald, Punt, Cornelis J. A., Huiskens, Joost, Kazemier, Geert

“…Purpose Advanced medical image analytics is increasingly used to predict clinical outcome in patients diagnosed with gastrointestinal tumors. This review…”
Get full text

Factors that influence the pancreatic and duodenal microbiome in patients undergoing pancreatic surgery by Zwart, Eline S, Jeleniewski, Suzanne, Boyd, Lenka N C, Meijer, Laura L, Puik, Jisce R, Zonderhuis, Barbara M, Daams, Freek, Budding, Andries E, Mebius, Reina E, Kazemier, Geert

“…This study examined the correlation between pancreatic microbiome and patients characteristics. Furthermore, we compared different duodenal materials to…”
Get full text

Selective tumor antigen vaccine delivery to human CD169+ antigen-presenting cells using ganglioside-liposomes by Affandi, Alsya J., Grabowska, Joanna, Olesek, Katarzyna, Venegas, Miguel Lopez, Barbaria, Arnaud, Rodríguez, Ernesto, Mulder, Patrick P. G., Pijffers, Helen J., Ambrosini, Martino, Kalay, Hakan, O’Toole, Tom, Zwart, Eline S., Kazemier, Geert, Nazmi, Kamran, Bikker, Floris J., Stöckl, Johannes, van den Eertwegh, Alfons J. M., de Gruijl, Tanja D., Storm, Gert, van Kooyk, Yvette, den Haan, Joke M. M.

“…Priming of CD8⁺ T cells by dendritic cells (DCs) is crucial for the generation of effective antitumor immune responses. Here, we describe a liposomal vaccine…”
Get full text

Outcomes and Treatment Options for Duodenal Adenocarcinoma: A Systematic Review and Meta-Analysis by Meijer, Laura L., Alberga, Anna J., de Bakker, Jacob K., van der Vliet, Hans J., Le Large, Tessa Y. S., van Grieken, Nicole C. T., de Vries, Ralph, Daams, Freek, Zonderhuis, Barbara M., Kazemier, Geert

“…Background Duodenal adenocarcinoma (DA) is a rare tumor for which survival data per treatment modality and disease stage are unclear. This systematic review…”
Get full text

Irreversible electroporation of locally advanced pancreatic cancer transiently alleviates immune suppression and creates a window for antitumor T cell activation by Scheffer, Hester J., Stam, Anita G.M., Geboers, Bart, Vroomen, Laurien G.P.H., Ruarus, Alette, de Bruijn, Beaunelle, van den Tol, M. Petrousjka, Kazemier, Geert, Meijerink, Martijn R., de Gruijl, Tanja D.

“…Purpose: Local tumor ablation through irreversible electroporation (IRE) may offer a novel therapeutic option for locally advanced pancreatic cancer (LAPC). It…”
Get full text

The use of histopathological subtyping in patients with ampullary cancer: a nationwide analysis by de Bakker, Jacob, Sommeijer, Dirkje, Besselink, Marc, Kazemier, Geert, van Grieken, Nicole

“…Recent guidelines advise to subtype adenocarcinoma at the ampulla and papilla of Vater (here: ampullary cancer) as intestinal, pancreatobiliary, and mixed,…”
Get full text

NUC-1031 in biliary tract cancer: from bench to bedside and back? by Boyd, Lenka N. C., Peters, Godefridus J., Kazemier, Geert, Giovannetti, Elisa

“…In preclinical models of biliary tract cancer, NUC-1031 showed less potency than gemcitabine, no correlation with potential biomarkers and only moderate…”
Get full text

Biomarkers to assess graft quality during conventional and machine preservation in liver transplantation by Verhoeven, Cornelia J, Farid, Waqar R.R, de Jonge, Jeroen, Metselaar, Herold J, Kazemier, Geert, van der Laan, Luc J.W

“…Summary A global rising organ shortage necessitates the use of extended criteria donors (ECD) for liver transplantation (LT). However, poor preservation and…”
Get full text

CD169 Defines Activated CD14+ Monocytes With Enhanced CD8+ T Cell Activation Capacity by Affandi, Alsya J., Olesek, Katarzyna, Grabowska, Joanna, Nijen Twilhaar, Maarten K., Rodríguez, Ernesto, Saris, Anno, Zwart, Eline S., Nossent, Esther J., Kalay, Hakan, de Kok, Michael, Kazemier, Geert, Stöckl, Johannes, van den Eertwegh, Alfons J. M., de Gruijl, Tanja D., Garcia-Vallejo, Juan J., Storm, Gert, van Kooyk, Yvette, den Haan, Joke M. M.

“…Monocytes are antigen-presenting cells (APCs) that play diverse roles in promoting or regulating inflammatory responses, but their role in T cell stimulation…”
Get full text

Proteomic analysis of gemcitabine-resistant pancreatic cancer cells reveals that microtubule-associated protein 2 upregulation associates with taxane treatment by Le Large, Tessa Ya Sung, El Hassouni, Btissame, Funel, Niccola, Kok, Bart, Piersma, Sander R., Pham, Thang V., Olive, Kenneth P., Kazemier, Geert, van Laarhoven, Hanneke W.M., Jimenez, Connie R., Bijlsma, Maarten F., Giovannetti, Elisa

“…Background: Chemoresistance hampers the treatment of patients suffering from pancreatic ductal adenocarcinoma (PDAC). Here we aimed to evaluate the…”
Get full text

Outcome and long-term quality of life after total pancreatectomy (PANORAMA): a nationwide cohort study by Scholten, Lianne, Latenstein, Anouk E.J., van Eijck, Casper, Erdmann, Joris, van der Harst, Erwin, Mieog, J. Sven D., Molenaar, I. Quintus, van Santvoort, Hjalmar C., DeVries, J. Hans, Besselink, Marc G., van Hooft, Jeanin E., Bonsing, Bert A., Bosscha, Koop, Coene, Peter-Paul L.O., van Dam, Ronald M., van Dieren, Susan, Gerhards, Michael F., van Goor, Harry, de Hingh, Ignace H., Kazemier, Geert, Klaase, Joost M., Patijn, Gijs A., Scheepers, Joris J., van der Schelling, George P., Pranger, Bobby K., Busch, Olivier, Snoek, Frank

“…The threshold to perform total pancreatectomy is rather high, predominantly because of concerns for long-term consequences of brittle diabetes on patients’…”
Get full text

Detection of Circulating Tumor Cells Using the Attune NxT by Gruijs, Mandy, Zeelen, Carolien, Hellingman, Tessa, Smit, Jasper, Borm, Frank J, Kazemier, Geert, Dickhoff, Chris, Bahce, Idris, de Langen, Joop, Smit, Egbert F, Hartemink, Koen J, van Egmond, Marjolein

“…Circulating tumor cells (CTCs) have been detected in many patients with different solid malignancies. It has been reported that presence of CTCs correlates…”
Get full text

Hepatocyte‐derived microRNAs as serum biomarkers of hepatic injury and rejection after liver transplantation by Farid, Waqar R. R., Pan, Qiuwei, van der Meer, Adriaan J. P., de Ruiter, Petra E., Ramakrishnaiah, Vedashree, de Jonge, Jeroen, Kwekkeboom, Jaap, Janssen, Harry L. A., Metselaar, Herold J., Tilanus, Hugo W., Kazemier, Geert, van der Laan, Luc J.W.

“…Recent animal and human studies have highlighted the potential of hepatocyte‐derived microRNAs (HDmiRs) in serum as early, stable, sensitive, and specific…”
Get full text

Dedicated operating room for emergency surgery generates more utilization, less overtime, and less cancellations by van Veen-Berkx, Elizabeth, M.Sc, Elkhuizen, Sylvia G., Ph.D, Kuijper, Bart, M.Sc, Kazemier, Geert, M.D., Ph.D

“…Abstract Background Two approaches prevail for reserving operating room (OR) capacity for emergency surgery: (1) dedicated emergency ORs and (2) evenly…”
Get full text

Early and Late Complications After Surgery for MEN1-related Nonfunctioning Pancreatic Neuroendocrine Tumors by Nell, Sjoerd, Borel Rinkes, Inne H M, Verkooijen, Helena M, Bonsing, Bert A, van Eijck, Casper H, van Goor, Harry, de Kleine, Ruben H J, Kazemier, Geert, Nieveen van Dijkum, Elisabeth J, Dejong, Cornelis H C, Valk, Gerlof D, Vriens, Menno R

“…OBJECTIVE:To estimate short and long-term morbidity after pancreatic surgery for multiple endocrine neoplasia type 1 (MEN1)-related nonfunctioning pancreatic…”
Get full text

Functional Differences between Human NKp44(-) and NKp44(+) RORC(+) Innate Lymphoid Cells by Hoorweg, Kerim, Peters, Charlotte P, Cornelissen, Ferry, Aparicio-Domingo, Patricia, Papazian, Natalie, Kazemier, Geert, Mjösberg, Jenny M, Spits, Hergen, Cupedo, Tom

“…Human RORC(+) lymphoid tissue inducer cells are part of a rapidly expanding family of innate lymphoid cells (ILC) that participate in innate and adaptive…”
Get full text