Search Results - "KAYE, Frederic J"

Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial by Creelan, Benjamin C., Wang, Chao, Teer, Jamie K., Toloza, Eric M., Yao, Jiqiang, Kim, Sungjune, Landin, Ana M., Mullinax, John E., Saller, James J., Saltos, Andreas N., Noyes, David R., Montoya, Leighann B., Curry, Wesley, Pilon-Thomas, Shari A., Chiappori, Alberto A., Tanvetyanon, Tawee, Kaye, Frederic J., Thompson, Zachary J., Yoder, Sean J., Fang, Bin, Koomen, John M., Sarnaik, Amod A., Chen, Dung-Tsa, Conejo-Garcia, Jose R., Haura, Eric B., Antonia, Scott J.

“…Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown activity in melanoma, but has not been previously evaluated in metastatic non-small…”
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cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth by Chen, Zirong, Li, Jian-Liang, Lin, Shuibin, Cao, Chunxia, Gimbrone, Nicholas T, Yang, Rongqiang, Fu, Dongtao A, Carper, Miranda B, Haura, Eric B, Schabath, Matthew B, Lu, Jianrong, Amelio, Antonio L, Cress, W Douglas, Kaye, Frederic J, Wu, Lizi

“…The LKB1 tumor suppressor gene is frequently mutated and inactivated in non-small cell lung cancer (NSCLC). Loss of LKB1 promotes cancer progression and…”
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TYMS promotes genomic instability and tumor progression in Ink4a/Arf null background by Guijarro, Maria V., Nawab, Akbar, Dib, Peter, Burkett, Sandra, Luo, Xiaoping, Feely, Michael, Nasri, Elham, Seifert, Robert P., Kaye, Frederic J., Zajac-Kaye, Maria

“…We previously showed that elevated TYMS exhibits oncogenic properties and promotes tumorigenesis after a long latency, suggesting cooperation with sequential…”
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Co-occurring Alterations in the RAS-MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer by Rotow, Julia K, Gui, Philippe, Wu, Wei, Raymond, Victoria M, Lanman, Richard B, Kaye, Frederic J, Peled, Nir, Fece de la Cruz, Ferran, Nadres, Brandon, Corcoran, Ryan B, Yeh, Iwei, Bastian, Boris C, Starostik, Petr, Newsom, Kimberly, Olivas, Victor R, Wolff, Alexander M, Fraser, James S, Collisson, Eric A, McCoach, Caroline E, Camidge, D Ross, Pacheco, Jose, Bazhenova, Lyudmila, Li, Tianhong, Bivona, Trever G, Blakely, Collin M

“…Although patients with advanced-stage non-small cell lung cancers (NSCLC) harboring exon 14 skipping mutations ( ex14) often benefit from MET tyrosine kinase…”
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Mutation-associated fusion cancer genes in solid tumors by Kaye, Frederic J

“…Chromosomal translocations and fusion oncogenes serve as the ultimate biomarker for clinicians as they show specificity for distinct histopathologic…”
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Targeting Focal Adhesion Kinase and Resistance to mTOR Inhibition in Pancreatic Neuroendocrine Tumors by François, Rony A, Maeng, Kyungah, Nawab, Akbar, Kaye, Frederic J, Hochwald, Steven N, Zajac-Kaye, Maria

“…Focal adhesion kinase (FAK) mediates survival of normal pancreatic islets through activation of AKT. Upon malignant transformation of islet cells into…”
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PROTAC-Mediated Dual Degradation of BCL-xL and BCL-2 Is a Highly Effective Therapeutic Strategy in Small-Cell Lung Cancer by Khan, Sajid, Cao, Lin, Wiegand, Janet, Zhang, Peiyi, Zajac-Kaye, Maria, Kaye, Frederic J, Zheng, Guangrong, Zhou, Daohong

“…BCL-xL and BCL-2 are validated therapeutic targets in small-cell lung cancer (SCLC). Targeting these proteins with navitoclax (formerly ABT263, a dual BCL-xL/2…”
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Cetuximab‐associated pulmonary toxicity in concurrent chemoradiation for the treatment of a squamous cell carcinoma of the head and neck by Mayfield, John D., Mercado, Catherine E., Kaye, Frederic J., Mendenhall, William M.

“…Background Cetuximab is a common EGFR monoclonal antibody used with radiotherapy to treat head‐and‐neck cancer. Severe pulmonary toxicity, including…”
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Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation by Zhou, Xin, Li, Jennifer W, Chen, Zirong, Ni, Wei, Li, Xuehui, Yang, Rongqiang, Shen, Huangxuan, Liu, Jian, DeMayo, Francesco J, Lu, Jianrong, Kaye, Frederic J, Wu, Lizi

“…Lung cancer with loss-of-function of the LKB1 tumor suppressor is a common aggressive subgroup with no effective therapies. LKB1 - deficiency induces…”
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Proof-of-Concept of an Integrated Yoga and Psychological Intervention in Mitigating Distress Among Diverse Women With Gynecologic, Gastrointestinal, and Thoracic Cancers by Hanvey, Grace Ann, Kacel, Elizabeth L, Bacharz, Kelsey C, Wilborn, Adaixa Padrón, Mesa, Sonia, McCracken, Halle, Estores, Irene M, Markham, Merry-Jennifer, Kaye, Frederic J, Jones, Jr, Dennie, George, Thomas J, Pereira, Deidre B

“…Fear of cancer recurrence (FCR), cancer-distress, depression, and anxiety are prevalent concerns among women with gynecologic and other understudied cancers,…”
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The CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma by Chen, Zirong, Ni, Wei, Li, Jian-Liang, Lin, Shuibin, Zhou, Xin, Sun, Yuping, Li, Jennifer W, Leon, Marino E, Hurtado, Maria D, Zolotukhin, Sergei, Liu, Chen, Lu, Jianrong, Griffin, James D, Kaye, Frederic J, Wu, Lizi

“…No effective systemic treatment is available for patients with unresectable, recurrent, or metastatic mucoepidermoid carcinoma (MEC), the most common salivary…”
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CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: Implications for histogenesis and biologic behavior by Tirado, Yamilet, Williams, Michelle D., Hanna, Ehab Y., Kaye, Frederic J., Batsakis, John G., El-Naggar, Adel K.

“…We analyzed 55 primary salivary gland tumors including 22 mucoepidermoid carcinomas (MECs) to determine the association of MECT1/TORC1/CRTC1‐MAML2 fusion…”
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RB and cyclin dependent kinase pathways: defining a distinction between RB and p16 loss in lung cancer: Lung cancer by KAYE, Frederic J

“…The genetic components of the RB:CDK:cyclin:p16 tumor suppressor pathway undergo mutational and epigenetic alterations in a wide range of human cancers and…”
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Targeting Notch and EGFR signaling in human mucoepidermoid carcinoma by Ni, Wei, Chen, Zirong, Zhou, Xin, Yang, Rongqiang, Yu, Mu, Lu, Jianrong, Kaye, Frederic J., Wu, Lizi

“…Mucoepidermoid carcinoma (MEC) is the most common type of salivary gland cancers and patients with advanced, metastatic, and recurrent MECs have limited…”
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Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice by Khan, Sajid, Kellish, Patrick, Connis, Nick, Thummuri, Dinesh, Wiegand, Janet, Zhang, Peiyi, Zhang, Xuan, Budamagunta, Vivekananda, Hua, Nan, Yang, Yang, De, Umasankar, Jin, Lingtao, Zhang, Weizhou, Zheng, Guangrong, Hromas, Robert, Hann, Christine, Zajac-Kaye, Maria, Kaye, Frederic J., Zhou, Daohong

“…Small-cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic options. The dismal prognosis in SCLC is in part associated with an…”
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Personalised Lung Cancer Screening (PLuS) study to assess the importance of coexisting chronic conditions to clinical practice and policy: protocol for a multicentre observational study by Braithwaite, Dejana, Karanth, Shama D, Slatore, Christopher G, Zhang, Dongyu, Bian, Jiang, Meza, Rafael, Jeon, Jihyoun, Tammemagi, Martin, Schabath, Mattthew, Wheeler, Meghann, Guo, Yi, Hochhegger, Bruno, Kaye, Frederic J, Silvestri, Gerard A, Gould, Michael K

“…IntroductionLung cancer is the leading cause of cancer death in the USA and worldwide, and lung cancer screening (LCS) with low-dose CT (LDCT) has the…”
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BCL-XL PROTAC degrader DT2216 synergizes with sotorasib in preclinical models of KRASG12C-mutated cancers by Khan, Sajid, Wiegand, Janet, Zhang, Peiyi, Hu, Wanyi, Thummuri, Dinesh, Budamagunta, Vivekananda, Hua, Nan, Jin, Lingtao, Allegra, Carmen J, Kopetz, Scott E, Zajac-Kaye, Maria, Kaye, Frederic J, Zheng, Guangrong, Zhou, Daohong

“…KRAS mutations are the most common oncogenic drivers. Sotorasib (AMG510), a covalent inhibitor of KRAS G12C , was recently approved for the treatment of KRAS…”
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Characterization of tumorigenic cell lines from the recurrence and lymph node metastasis of a human salivary mucoepidermoid carcinoma by Warner, Kristy A, Adams, April, Bernardi, Lisiane, Nor, Carolina, Finkel, Kelsey A, Zhang, Zhaocheng, McLean, Scott A, Helman, Joseph, Wolf, Gregory T, Divi, Vasu, Queimado, Lurdes, Kaye, Frederic J, Castilho, Rogerio M, Nör, Jacques E

“…Summary The long-term outcome of patients with mucoepidermoid carcinoma is poor. Limited availability of cell lines and lack of xenograft models is considered…”
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Nivolumab monotherapy or combination with ipilimumab with or without cobimetinib in previously treated patients with pancreatic adenocarcinoma (CheckMate 032) by Callahan, Margaret, Amin, Asim, Kaye, Frederic J, Morse, Michael A, Taylor, Matthew H, Peltola, Katriina J, Sharma, Padmanee, O'Reilly, Eileen M, Meadows Shropshire, Stephanie, O'Brien, Shaun, Tschaika, Marina, Le, Dung T

“…BackgroundPancreatic cancer is one of the deadliest cancer types and represents a major unmet medical need. CheckMate 032 investigated safety and efficacy of…”
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CRTC1/MAML2 gain-of-function interactions with MYC create a gene signature predictive of cancers with CREB–MYC involvement by Amelio, Antonio L, Fallahi, Mohammad, Schaub, Franz X, Zhang, Min, Lawani, Mariam B, Alperstein, Adam S, Southern, Mark R, Young, Brandon M, Wu, Lizi, Zajac-Kaye, Maria, Kaye, Frederic J, Cleveland, John L, Conkright, Michael D

“…Chimeric oncoproteins created by chromosomal translocations are among the most common genetic mutations associated with tumorigenesis. Malignant mucoepidermoid…”
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