Search Results - "KAY, Michael S"

Synthesis and folding of a mirror-image enzyme reveals ambidextrous chaperone activity by Weinstock, Matthew T., Jacobsen, Michael T., Kay, Michael S.

“…Mirror-image proteins (composed of d -amino acids) are promising therapeutic agents and drug discovery tools, but as synthesis of larger d -proteins becomes…”
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A Helping Hand to Overcome Solubility Challenges in Chemical Protein Synthesis by Jacobsen, Michael T, Petersen, Mark E, Ye, Xiang, Galibert, Mathieu, Lorimer, George H, Aucagne, Vincent, Kay, Michael S

“…Although native chemical ligation (NCL) and related chemoselective ligation approaches provide an elegant method to stitch together unprotected peptides, the…”
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A glutamic acid-based traceless linker to address challenging chemical protein syntheses by Giesler, Riley J, Spaltenstein, Paul, Jacobsen, Michael T, Xu, Weiliang, Maqueda, Mercedes, Kay, Michael S

“…Native chemical ligation (NCL) enables the total chemical synthesis of proteins. However, poor peptide segment solubility remains a frequently encountered…”
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Aligator: A computational tool for optimizing total chemical synthesis of large proteins by Jacobsen, Michael T., Erickson, Patrick W., Kay, Michael S.

“…[Display omitted] The scope of chemical protein synthesis (CPS) continues to expand, driven primarily by advances in chemical ligation tools (e.g., reversible…”
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Electron tomography visualization of HIV-1 fusion with target cells using fusion inhibitors to trap the pre-hairpin intermediate by Ladinsky, Mark S, Gnanapragasam, Priyanthi Np, Yang, Zhi, West, Anthony P, Kay, Michael S, Bjorkman, Pamela J

“…Fusion of HIV-1 with the membrane of its target cell, an obligate first step in virus infectivity, is mediated by binding of the viral envelope (Env) spike…”
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Homogeneous surrogate virus neutralization assay to rapidly assess neutralization activity of anti-SARS-CoV-2 antibodies by Kim, Sun Jin, Yao, Zhong, Marsh, Morgan C., Eckert, Debra M., Kay, Michael S., Lyakisheva, Anna, Pasic, Maria, Bansal, Aiyush, Birnboim, Chaim, Jha, Prabhat, Galipeau, Yannick, Langlois, Marc-André, Delgado, Julio C., Elgort, Marc G., Campbell, Robert A., Middleton, Elizabeth A., Stagljar, Igor, Owen, Shawn C.

“…The COVID-19 pandemic triggered the development of numerous diagnostic tools to monitor infection and to determine immune response. Although assays to measure…”
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Potent D-peptide inhibitors of HIV-1 entry by Welch, Brett D, VanDemark, Andrew P, Heroux, Annie, Hill, Christopher P, Kay, Michael S

“…During HIV-1 entry, the highly conserved gp41 N-trimer pocket region becomes transiently exposed and vulnerable to inhibition. Using mirror-image phage display…”
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Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases by Han, Han, Fulcher, James M, Dandey, Venkata P, Iwasa, Janet H, Sundquist, Wesley I, Kay, Michael S, Shen, Peter S, Hill, Christopher P

“…Many AAA+ ATPases form hexamers that unfold protein substrates by translocating them through their central pore. Multiple structures have shown how a helical…”
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Design of a Potent d-Peptide HIV-1 Entry Inhibitor with a Strong Barrier to Resistance by WELCH, Brett D, FRANCIS, J. Nicholas, ROOT, Michael J, KAY, Michael S, REDMAN, Joseph S, PAUL, Suparna, WEINSTOCK, Matthew T, REEVES, Jacqueline D, LIE, Yolanda S, WHITBY, Frank G, ECKERT, Debra M, HILL, Christopher P

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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One Percent Tenofovir Applied Topically to Humanized BLT Mice and Used According to the CAPRISA 004 Experimental Design Demonstrates Partial Protection from Vaginal HIV Infection, Validating the BLT Model for Evaluation of New Microbicide Candidates by DENTON, Paul W, OTHIENO, Florence, WELCH, Brett D, KAY, Michael S, PAYNE, Deborah A, GALLAY, Philippe, APPELLA, Ettore, ESTES, Jacob D, MIN LU, VICTOR GARCIA, J, MARTINEZ-TORRES, Francisco, WEI ZOU, KRISKO, John F, FLEMING, Elisa, ZEIN, Sima, POWELL, Daniel A, WAHL, Angela, YOUN TAE KWAK

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Chemical synthesis of Shiga toxin subunit B using a next-generation traceless "helping hand" solubilizing tag by Fulcher, James M, Petersen, Mark E, Giesler, Riley J, Cruz, Zachary S, Eckert, Debra M, Francis, J Nicholas, Kawamoto, Eric M, Jacobsen, Michael T, Kay, Michael S

“…The application of solid-phase peptide synthesis and native chemical ligation in chemical protein synthesis (CPS) has enabled access to synthetic proteins that…”
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Virion stiffness regulates immature HIV-1 entry by Pang, Hong-Bo, Hevroni, Liron, Kol, Nitzan, Eckert, Debra M, Tsvitov, Marianna, Kay, Michael S, Rousso, Itay

“…Human immunodeficiency virus type 1 (HIV-1) undergoes a protease-mediated maturation process that is required for its infectivity. Little is known about how…”
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Corrigendum: Neonatal NET-Inhibitory Factor improves survival in the cecal ligation and puncture model of polymicrobial sepsis by inhibiting neutrophil extracellular traps by de Araujo, Claudia V, Denorme, Frederik, Stephens, W Zac, Li, Qing, Cody, Mark J, Crandell, Jacob L, Petrey, Aaron C, Queisser, Kimberly A, Rustad, John L, Fulcher, James M, Evangelista, Judah L, Kay, Michael S, Schiffman, Joshua D, Campbell, Robert A, Yost, Christian C

“…[This corrects the article DOI: 10.3389/fimmu.2022.1046574.]…”
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Characterization of resistance to a potent D-peptide HIV entry inhibitor by Smith, Amanda R, Weinstock, Matthew T, Siglin, Amanda E, Whitby, Frank G, Francis, J Nicholas, Hill, Christopher P, Eckert, Debra M, Root, Michael J, Kay, Michael S

“…PIE12-trimer is a highly potent D-peptide HIV-1 entry inhibitor that broadly targets group M isolates. It specifically binds the three identical conserved…”
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Neonatal NET-Inhibitory Factor improves survival in the cecal ligation and puncture model of polymicrobial sepsis by inhibiting neutrophil extracellular traps by de Araujo, Claudia V, Denorme, Frederik, Stephens, W Zac, Li, Qing, Cody, Mark J, Crandell, Jacob L, Petrey, Aaron C, Queisser, Kimberly A, Rustad, John L, Fulcher, James M, Evangelista, Judah L, Kay, Michael S, Schiffman, Joshua D, Campbell, Robert A, Yost, Christian C

“…Neutrophil extracellular traps (NETs) clear pathogens but may contribute Q8 pathogenically to host inflammatory tissue damage during sepsis. Innovative…”
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Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes by Koirala, Sajjan, Bui, Huyen T, Schubert, Heidi L, Eckert, Debra M, Hill, Christopher P, Kay, Michael S, Shaw, Janet M

“…Recruitment and assembly of some dynamin-related guanosine triphosphatases depends on adaptor proteins restricted to distinct cellular membranes. The yeast…”
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BracketMaker: Visualization and optimization of chemical protein synthesis by Evangelista, Judah L., Kay, Michael S.

“…Chemical protein synthesis (CPS), in which custom peptide segments of ~20–60 aa are produced by solid‐phase peptide synthesis and then stitched together…”
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Stalking influenza by Eckert, Debra M, Kay, Michael S

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Enhancing native chemical ligation for challenging chemical protein syntheses by Giesler, Riley J., Erickson, Patrick W., Kay, Michael S.

“…Native chemical ligation has enabled the chemical synthesis of proteins for a wide variety of applications (e.g., mirror-image proteins). However,…”
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Traceless Click-Assisted Native Chemical Ligation Enabled by Protecting Dibenzocyclooctyne from Acid-Mediated Rearrangement with Copper(I) by Erickson, Patrick W, Fulcher, James M, Spaltenstein, Paul, Kay, Michael S

“…The scope of proteins accessible to total chemical synthesis via native chemical ligation (NCL) is often limited by slow ligation kinetics. Here we describe…”
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