Search Results - "KAY, Kevin R"

Differential central pathology and cognitive impairment in pre-diabetic and diabetic mice by Ramos-Rodriguez, Juan Jose, Ortiz, Oscar, Jimenez-Palomares, Margarita, Kay, Kevin R, Berrocoso, Esther, Murillo-Carretero, Maria Isabel, Perdomo, German, Spires-Jones, Tara, Cozar-Castellano, Irene, Lechuga-Sancho, Alfonso Maria, Garcia-Alloza, Monica

“…Summary Although age remains the main risk factor to suffer Alzheimer's disease (AD) and vascular dementia (VD), type 2 diabetes (T2D) has turned up as a…”
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Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β by KOFFIE, Robert M, HASHIMOTO, Tadafumi, HOLTZMAN, David M, HYMAN, Bradley T, SPIRES-JONES, Tara L, TAI, Hwan-Ching, KAY, Kevin R, SERRANO-POZO, Alberto, JOYNER, Daniel, HOU, Steven, KOPEIKINA, Katherine J, FROSCH, Matthew P, LEE, Virginia M

“…The apolipoprotein E ε4 gene is the most important genetic risk factor for sporadic Alzheimer's disease, but the link between this gene and neurodegeneration…”
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Non-Fibrillar Oligomeric Amyloid-β within Synapses by Pickett, Eleanor K, Koffie, Robert M, Wegmann, Susanne, Henstridge, Christopher M, Herrmann, Abigail G, Colom-Cadena, Marti, Lleo, Alberto, Kay, Kevin R, Vaught, Melissa, Soberman, Roy, Walsh, Dominic M, Hyman, Bradley T, Spires-Jones, Tara L

“…Alzheimer's disease (AD) is characterized by memory loss, insidious cognitive decline, profound neurodegeneration, and the extracellular accumulation of…”
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Studying synapses in human brain with array tomography and electron microscopy by Kay, Kevin R, Smith, Colin, Wright, Ann K, Serrano-Pozo, Alberto, Pooler, Amy M, Koffie, Robert, Bastin, Mark E, Bak, Thomas H, Abrahams, Sharon, Kopeikina, Katherine J, McGuone, Declan, Frosch, Matthew P, Gillingwater, Thomas H, Hyman, Bradley T, Spires-Jones, Tara L

“…Postmortem studies of synapses in human brain are problematic because of the axial resolution limit of light microscopy and the difficulty in preserving and…”
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Real-life consequences of cognitive dysfunction in Parkinson's disease by Kay, Kevin R, Uc, Ergun Y

“…While motor symptoms are the most recognized features of Parkinson's disease (PD), cognitive dysfunction is a key determinant of consequences of PD in…”
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Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes by Saidi, Laiq-Jan, Polydoro, Manuela, Kay, Kevin R, Sanchez, Laura, Mandelkow, Eva-Maria, Hyman, Bradley T, Spires-Jones, Tara L

“…One of the hallmarks of Alzheimer's disease is the formation of neurofibrillary tangles, intracellular aggregates of hyperphosphorylated, mislocalized tau…”
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Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer's disease by Polydoro, Manuela, de Calignon, Alix, Suárez-Calvet, Marc, Sanchez, Laura, Kay, Kevin R, Nicholls, Samantha B, Roe, Allyson D, Pitstick, Rose, Carlson, George A, Gómez-Isla, Teresa, Spires-Jones, Tara L, Hyman, Bradley T

“…Neurofibrillary tangles (NFTs), a marker of neuronal alterations in Alzheimer's disease (AD) and other tauopathies, are comprised of aggregates of…”
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Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology by Pooler, Amy M., Polydoro, Manuela, Wegmann, Susanne K., Pitstick, Rose, Kay, Kevin R., Sanchez, Laura, Carlson, George A., Gomez-Isla, Teresa, Albers, Mark W., Spires-Jones, Tara L., Hyman, Bradley T.

“…ABSTRACT Early observations of the patterns of neurofibrillary tangles and amyloid plaques in Alzheimer's disease suggested a hierarchical vulnerability of…”
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