Search Results - "KAWAS, C. H."

Prevalence of dementia after age 90 : Results from The 90+ Study by CORRADA, M. M, BROOKMEYER, R, BERLAU, D, PAGANINI-HILL, A, KAWAS, C. H

“…Although the prevalence of dementia increases with age from ages 65 to 85, whether this increase continues after age 90 is unclear. Most studies reporting on…”
Get full text

Visual memory predicts Alzheimer's disease more than a decade before diagnosis by KAWAS, C. H, CORRADA, M. M, BROOKMEYER, R, MORRISON, A, RESNICK, S. M, ZONDERMAN, A. B, ARENBERG, D

“…Recent studies have suggested that AD may reflect a chronic process that begins many years before the clinical expression of dementia. The current study…”
Get full text

The CA1 Region of the Human Hippocampus Is a Hot Spot in Alzheimer's Disease by WEST, M. J., KAWAS, C. H., MARTIN, L. J., TRONCOSO, J. C.

“…: Data from an ongoing study of differences in the total number of neurons in the five major subdivisions of the hippocampal regions of the brains of patients…”
Get full text

Microtransplantation of Functional Receptors and Channels from the Alzheimer's Brain to Frog Oocytes by Miledi, R., Dueñas, Z., Martinez-Torres, A., Kawas, C. H., Eusebi, F.

“…About a decade ago, cell membranes from the electric organ of Torpedo and from the rat brain were transplanted to frog oocytes, which thus acquired functional…”
Get full text

APOE genotype and survival in men and women with Alzheimer's disease by DAL FORNO, G, CARSON, K. A, BROOKMEYER, R, TRONCOSO, J, KAWAS, C. H, BRANDT, J

“…The epsilon 4 allele of the APOE gene (APOE) is more frequent in patients with AD than in the general population, but studies are inconclusive as to whether it…”
Get full text

Prior endogenous and exogenous estrogen and incident dementia in the 10th decade of life: The 90+ Study by Paganini-Hill, A, Corrada, M M, Kawas, C H

“…This study aimed to investigate the association of endogenous and exogenous estrogen exposure with risk of incident dementia in the oldest-old (age 90+ years)…”
Get full text

Activities and mortality in the elderly: the Leisure World cohort study by Paganini-Hill, Annlia, Kawas, Claudia H, Corrada, María M

“…Although physical activity has substantial health benefits and reduces mortality, few studies have examined its impact on survival beyond age 75. Using the…”
Get full text

Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease by Behan, Dominic P, Heinrichs, Stephen C, Troncoso, Juan C, Liu, Xin-Jun, Kawas, Claudia H, Ling, Nicholas, De Souza, Errol B

“…In Alzheimer's disease (AD) there are dramatic reductions in the content of corticotropin releasing factor (CRF), reciprocal increases in CRF receptors, and…”
Get full text

Neuropathology in controls and demented subjects from the Baltimore longitudinal study of aging by Troncoso, Juan C., Martin, Lee J., Dal Forno, Gloria, Kawas, Claudia H.

“…To establish correlations among cognitive states and neuropathology, we have examined 22 subjects (69–97 years of age) from the Baltimore Longitudinal Study of…”
Get full text

Neuropathology of preclinical and clinical late-onset Alzheimer's disease by Troncoso, J C, Cataldo, A M, Nixon, R A, Barnett, J L, Lee, M K, Checler, F, Fowler, D R, Smialek, J E, Crain, B, Martin, L J, Kawas, C H

“…We report on the neuropathological examinations of a 74-year-old woman with Alzheimer's disease (AD) and of her 47-year-old nondemented daughter. The brain of…”
Get more information

In Situ Labeling of Dying Cortical Neurons in Normal Aging and in Alzheimer’s Disease: Correlations with Senile Plaques and Disease Progression by Troncoso, Juan C, Sukhov, Renat R, Kawas, Claudia H, Koliatsos, Vassilis E

“…We examined the degeneration of neocortical neurons in normal aging and Alzheimerʼs disease (AD) using terminal transferase (TdT)-mediated deoxyuridine…”
Get full text

Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway by Kang, D E, Pietrzik, C U, Baum, L, Chevallier, N, Merriam, D E, Kounnas, M Z, Wagner, S L, Troncoso, J C, Kawas, C H, Katzman, R, Koo, E H

“…Susceptibility to Alzheimer's disease (AD) is governed by multiple genetic factors. Remarkably, the LDL receptor-related protein (LRP) and its ligands, apoE…”
Get full text

Lack of relation between race and cognitive test performance in Alzheimer's disease by CARLSON, M. C, BRANDT, J, CARSON, K. A, KAWAS, C. H

“…This study evaluated cognitive test performance in African-American and European-American Alzheimer's disease patients with equivalent years of education…”
Get full text

Clinical trials in Alzheimer disease: debate on the use of placebo controls by Kawas, C H, Clark, C M, Farlow, M R, Knopman, D S, Marson, D, Morris, J C, Thal, L J, Whitehouse, P J

“…During the past 10 years, there has been a rapidly growing number of pharmaceutical industry-sponsored drug trials for treatment of Alzheimer disease (AD) and…”
Get more information

Cognitive problems in the elderly by Dal Forno, G, Kawas, C H

“…We have summarized the literature on cognitive changes in normal aging. The concepts of normal aging, age-associated memory impairment, and their possible…”
Get more information

Lack of association of the apoE4 allele with hippocampal sclerosis dementia by Troncoso, Juan C., Kawas, Claudia H., Chang, Craig K., Folstein, Marshal F., Hedreen, John C.

“…We determined the apolipoprotein E4 (apoE) genotype in 12 cases of autopsy-confirmed hippocampal sclerosis dementia (HSD), a disorder characterized…”
Get full text

No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies by Szekely, C A, Green, R C, Breitner, J C S, Østbye, T, Beiser, A S, Corrada, M M, Dodge, H H, Ganguli, M, Kawas, C H, Kuller, L H, Psaty, B M, Resnick, S M, Wolf, P A, Zonderman, A B, Welsh-Bohmer, K A, Zandi, P P

“…Observational studies show reduced incidence of Alzheimer dementia (AD) in users of nonsteroidal anti-inflammatory drugs (NSAIDs). One hypothesis holds that…”
Get full text

Aging and the Public Health Effects of Dementia by Kawas, Claudia H, Brookmeyer, Ron

“…Dementia, and Alzheimer's disease in particular, is one of the principal causes of disability and decreased quality of life among the elderly and a leading…”
Get full text

Apolipoprotein E genotype and rate of decline in probable Alzheimer's disease by Dal Forno, G, Rasmusson, D X, Brandt, J, Carson, K A, Brookmeyer, R, Troncoso, J, Kawas, C H

“…The risk of Alzheimer's disease (AD) appears to increase, and the age at onset to decrease, with the number of epsilon 4 alleles. If this relationship is due…”
Get more information

A Double-Blind, Placebo-Controlled Multicenter Study of Tacrine for Alzheimer's Disease by Davis, Kenneth L, Davis, Charles S, Thal, Leon J, Gamzu, Elkan R, Woolson, Robert F, Gracon, Stephen I, Drachman, David A, Schneider, Lon S, Whitehouse, Peter J, Hoover, Toni M, Morris, John C, Kawas, Claudia H, Knopman, David S, Earl, Nancy L, Kumar, Vinod, Doody, Rachelle S

“…IN Alzheimer's disease the brain has a variety of neurotransmitter deficits, and the most striking and consistent change is a marked decrease in the activity…”
Get full text