Search Results - "KAWAMURA, KUNIO"

HPLC Retention Behavior of Oligonucleotides on an Anion-Exchange HPLC with a High Concentration of Urea by Kawamura, Kunio, Maruoka, Yoshimi

“…Roles of short RNA molecules in the emergence process of primitive life-like system and physiological activities have been extensively studied from the…”
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Hydrothermal Microflow Technology as a Research Tool for Origin-of-Life Studies in Extreme Earth Environments by Kawamura, Kunio

“…Although studies about the origin of life are a frontier in science and a number of effective approaches have been developed, drawbacks still exist. Examples…”
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Drawbacks of the ancient RNA-based life-like system under primitive earth conditions by Kawamura, Kunio

“…Following the discovery of ribozymes, the “RNA world” hypothesis has become the most accepted hypothesis concerning the origin of life and genetic information…”
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Simple extraction and analysis of environmental DNA using glass fibers in suspension form by Suzuki, Ryoji, Kawamura, Kunio, Mizukami, Yuko

“…A simple environmental DNA (eDNA) filtration and extraction method that can be implemented on-site from water sampling to analysis was developed. In suspended…”
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A Hypothesis: Life Initiated from Two Genes, as Deduced from the RNA World Hypothesis and the Characteristics of Life-Like Systems by Kawamura, Kunio

“…RNA played a central role in the emergence of the first life-like system on primitive Earth since RNA molecules contain both genetic information and catalytic…”
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Multiple therapeutic effects of progranulin on experimental acute ischaemic stroke by Kanazawa, Masato, Kawamura, Kunio, Takahashi, Tetsuya, Miura, Minami, Tanaka, Yoshinori, Koyama, Misaki, Toriyabe, Masafumi, Igarashi, Hironaka, Nakada, Tsutomu, Nishihara, Masugi, Nishizawa, Masatoyo, Shimohata, Takayoshi

“…In the central nervous system, progranulin, a glycoprotein growth factor, plays a crucial role in maintaining physiological functions, and progranulin gene…”
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Development of Micro-Flow Hydrothermal Monitoring Systems and Their Applications to the Origin of Life Study on Earth by KAWAMURA, Kunio

“…Continuous extensive studies on thermophilic organisms have suggested that life emerged on hydrothermal systems on primitive Earth. Thus, it is well known that…”
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In situ UV–VIS spectrophotometry within the second time scale as a research tool for solid-state catalyst and liquid-phase reactions at high temperatures: Its application to the formation of HMF from glucose and cellulose by Kawamura, Kunio, Yasuda, Tomoko, Hatanaka, Tsubasa, Hamahiga, Kazuhiro, Matsuda, Nami, Ueshima, Michio, Nakai, Kazuyuki

“…[Display omitted] •UV–VIS absorption spectroscopy within the second time scale for hydrothermal reactions.•In situ monitoring for solid-liquid two-phase…”
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Inhibition of VEGF signaling pathway attenuates hemorrhage after tPA treatment by Kanazawa, Masato, Igarashi, Hironaka, Kawamura, Kunio, Takahashi, Tetsuya, Kakita, Akiyoshi, Takahashi, Hitoshi, Nakada, Tsutomu, Nishizawa, Masatoyo, Shimohata, Takayoshi

“…An angiogenic factor, vascular endothelial growth factor (VEGF), might be associated with the blood-brain barrier (BBB) disruption after focal cerebral…”
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Effects of angiopoietin-1 on hemorrhagic transformation and cerebral edema after tissue plasminogen activator treatment for ischemic stroke in rats by Kawamura, Kunio, Takahashi, Tetsuya, Kanazawa, Masato, Igarashi, Hironaka, Nakada, Tsutomu, Nishizawa, Masatoyo, Shimohata, Takayoshi

“…An angiogenesis factor, angiopoietin-1 (Ang1), is associated with the blood-brain barrier (BBB) disruption after focal cerebral ischemia. However, whether…”
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In situ UV–VIS–NIR spectrophotometric detection system as a research tool for environment-friendly chemical processes by Kawamura, Kunio, Hatanaka, Tsubasa, Hamahiga, Kazuhiro, Ueshima, Michio, Nakai, Kazuyuki

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Life on Minerals: Binding Behaviors of Oligonucleotides on Zirconium Silicate and Its Inhibitory Activity for the Self-Cleavage of Hammerhead Ribozyme by Kawamura, Kunio, Lambert, Jean-François, Ter-Ovanessian, Louis M. P, Vergne, Jacques, Hervé, Guy, Maurel, Marie-Christine

“…The role of minerals in the chemical evolution of RNA molecules is an important issue when considering the early stage of the Hadean Earth. In particular, the…”
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A High-Pressure, High-Temperature Flow Reactor Simulating the Hadean Earth Environment, with Application to the Pressure Dependence of the Cleavage of Avocado Viroid Hammerhead Ribozyme by Kawamura, Kunio, Ogawa, Mari, Konagaya, Noriko, Maruoka, Yoshimi, Lambert, Jean-François, Ter-Ovanessian, Louis M. P., Vergne, Jacques, Hervé, Guy, Maurel, Marie-Christine

“…The RNA world hypothesis suggests that chemical networks consisting of functional RNA molecules could have constructed a primitive life-like system leading a…”
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Biochemical and histopathological alterations in TAR DNA-binding protein-43 after acute ischemic stroke in rats by Kanazawa, Masato, Kakita, Akiyoshi, Igarashi, Hironaka, Takahashi, Tetsuya, Kawamura, Kunio, Takahashi, Hitoshi, Nakada, Tsutomu, Nishizawa, Masatoyo, Shimohata, Takayoshi

“…J. Neurochem. (2011) 116, 957-965. ABSTRACT: Nuclear factor TAR DNA-binding protein-43 (TDP-43) is considered to play roles in pathogenesis of human…”
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Combinable poly(dimethyl siloxane) capillary sensor array for single-step and multiple enzyme inhibitor assays by Uchiyama, Yosuke, Okubo, Fumito, Akai, Kozo, Fujii, Yuji, Henares, Terence G, Kawamura, Kunio, Yao, Toshio, Endo, Tatsuro, Hisamoto, Hideaki

“…We describe a new method for fabricating a capillary-type sensor, called a combinable poly(dimethyl siloxane) (PDMS) capillary (CPC) sensor. The method for…”
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Civilization as a biosystem examined by the comparative analysis of biosystems by Kawamura, Kunio

“…Darwinian evolutionary theory has played a central role in the life sciences. However, this principle is rarely applied to exceptional life-like systems such…”
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Mineral-enhanced hydrothermal oligopeptide formation at the second time scale by Kawamura, Kunio, Takeya, Hitoshi, Kushibe, Takao, Koizumi, Yuka

“…Accumulation of biopolymers should have been an essential step for the emergence of life on primitive Earth. However, experimental simulations for submarine…”
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Kinetic Analysis of the Cleavage of the Ribose Phosphodiester Bond within Guanine and Cytosine-Rich Oligonucleotides and Dinucleotides at 65–200 °C and Its Implications Concerning the Chemical Evolution of RNA by Kawamura, Kunio

“…A monitoring method of rapid hydrothermal reactions was successfully applied to a kinetic analysis of the cleavage of a ribose phosphodiester bond within…”
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Single-step ELISA capillary sensor based on surface-bonded glucose oxidase, antibody, and physically-adsorbed PEG membrane containing peroxidase-labeled antibody by Henares, Terence G., Tsutsumi, Erina, Yoshimura, Hiromi, Kawamura, Kunio, Yao, Toshio, Hisamoto, Hideaki

“…A single-step enzyme-linked immunosorbent assay (ELISA) capillary immunosensor that exploits the combination of surface-bonded glucose oxidase (GOD), antibody…”
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VEGF-A therapeutic target against hemorrhagic transformation after t-PA treatment by Kanazawa, Masato, Takahashi, Tetsuya, Kawamura, Kunio, Shimohata, Takayoshi

“…Tissue plasminogen activator (t-PA) treatment is beneficial for patients with ischemic stroke within 4.5 h of stroke onset, because the risk of intracerebral…”
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