Search Results - "KAWAI, Toshinao"

Elevated Soluble PD-L1 in Pregnant Women's Serum Suppresses the Immune Reaction by Okuyama, Mai, Mezawa, Hidetoshi, Kawai, Toshinao, Urashima, Mitsuyoshi

“…Programmed death-ligand 1 (PD-L1) is expressed not only on some cancer cells, but also on the outer surface of placental syncytiotrophoblasts, which is assumed…”
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Hepcidin in Kawasaki disease: upregulation by acute inflammation in patients having resistance to intravenous immunoglobulin therapy by Ishikawa, Takashi, Wada, Yasuyuki, Namba, Hiroyuki, Kawai, Toshinao

“…Hepcidin is an iron metabolism inhibitor that increases with chronic inflammation. However, it is unclear whether hepcidin indicates acute inflammatory…”
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Bacillus Calmette-Guérin (BCG) Infections at High Frequency in Both AR-CGD and X-CGD Patients Following BCG Vaccination by Ishikawa, Takashi, Okai, Masashi, Mochizuki, Emi, Uchiyama, Toru, Onodera, Masafumi, Kawai, Toshinao

“…Abstract Background Patients with chronic granulomatous disease (CGD) develop severe infections, including Bacillus Calmette-Guérin (BCG). Although the…”
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STAT6 gain-of-function variant exacerbates multiple allergic symptoms by Takeuchi, Ichiro, Yanagi, Kumiko, Takada, Shuji, Uchiyama, Toru, Igarashi, Arisa, Motomura, Kenichiro, Hayashi, Yuka, Nagano, Naoko, Matsuoka, Ryo, Sugiyama, Hiroki, Yoshioka, Takako, Saito, Hirohisa, Kawai, Toshinao, Miyaji, Yumiko, Inuzuka, Yusuke, Matsubara, Yoichi, Ohya, Yukihiro, Shimizu, Toshiaki, Matsumoto, Kenji, Arai, Katsuhiro, Nomura, Ichiro, Kaname, Tadashi, Morita, Hideaki

“…Allergic diseases were long considered to be complex multifactorial disorders. However, recent findings indicate that severe allergic inflammation can be…”
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Patient-reported outcomes in patients with primary immunodeficiency diseases in Japan: baseline results from a prospective observational study by Kanegane, Hirokazu, Ishimura, Masataka, Kawai, Toshinao, Okada, Satoshi, Okamatsu, Nobuaki, Go, Madoka, Noto, Shinichi

“…IntroductionPrimary immunodeficiency diseases (PIDs) are rare inherited diseases resulting in impaired immunity. People with PID experience lower…”
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Haploinsufficiency of A20 caused by a novel nonsense variant or entire deletion of TNFAIP3 is clinically distinct from Behçet's disease by Tsuchida, Naomi, Kirino, Yohei, Soejima, Yutaro, Onodera, Masafumi, Arai, Katsuhiro, Tamura, Eiichiro, Ishikawa, Takashi, Kawai, Toshinao, Uchiyama, Toru, Nomura, Shigeru, Kobayashi, Daisuke, Taguri, Masataka, Mitsuhashi, Satomi, Mizuguchi, Takeshi, Takata, Atsushi, Miyake, Noriko, Nakajima, Hideaki, Miyatake, Satoko, Matsumoto, Naomichi

“…Haploinsufficiency of A20 (HA20) is caused by loss-of-function TNFAIP3 variants. Phenotypic and genetic features of HA20 remain uncertain; therefore, the…”
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Autoimmune hemolytic anemia associated with Takenouchi–Kosaki syndrome by Ishikawa, Kotaro, Uchiyama, Toru, Kaname, Tadashi, Kawai, Toshinao, Ishiguro, Akira

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Vedolizumab therapy for pediatric steroid-refractory gastrointestinal acute graft-versus-host disease by Isshiki, Kyohei, Kamiya, Takahiro, Endo, Akifumi, Okamoto, Kentaro, Osumi, Tomoo, Kawai, Toshinao, Arai, Katsuhiro, Tomizawa, Daisuke, Ohtsuka, Kazuo, Nagahori, Masakazu, Imai, Kohsuke, Kato, Motohiro, Kanegane, Hirokazu

“…Vedolizumab, an immunosuppressive drug that acts locally on the gastrointestinal tract, is mainly used for the treatment of inflammatory bowel disease, and has…”
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Prospective study of live attenuated vaccines for patients receiving immunosuppressive agents by Kamei, Koichi, Miyairi, Isao, Ishikura, Kenji, Ogura, Masao, Shoji, Kensuke, Arai, Katsuhiro, Ito, Reiko, Kawai, Toshinao, Ito, Shuichi

“…Patients receiving immunosuppressive agents are at risk of life-threatening infections. However, live vaccines are generally contraindicated in them. We…”
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A mycobacterium fortuitum infection in chronic mucocutaneous candidiasis by Hoshina, Yuta, Okai, Masashi, Shoji, Kensuke, Ishikawa, Takashi, Kawai, Toshinao

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Bronchial stenosis associated with non‐tuberculous mycobacterial infection by Ishikawa, Takashi, Okai, Masashi, Funata, Keiko, Miyazaki, Osamu, Kawai, Toshinao

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Purulent lymphadenitis caused by Staphylococcus argenteus, representing the first Japanese case of Staphylococcus argenteus (multilocus sequence type 2250) infection in a 12-year-old boy by Ohnishi, Takuma, Shinjoh, Masayoshi, Ohara, Hirotoshi, Kawai, Toshinao, Kamimaki, Isamu, Mizushima, Ryo, Kamada, Keisuke, Itakura, Yasutomo, Iguchi, Shigekazu, Uzawa, Yutaka, Yoshida, Atsushi, Kikuchi, Ken

“…Staphylococcus argenteus is a novel species separated from a strain of coagulase-positive, non-pigmented S. aureus. Although S. argenteus has been reported to…”
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Two novel gain-of-function mutations of STAT1 responsible for chronic mucocutaneous candidiasis disease: impaired production of IL-17A and IL-22, and the presence of anti-IL-17F autoantibody by Yamazaki, Yasuhiro, Yamada, Masafumi, Kawai, Toshinao, Morio, Tomohiro, Onodera, Masafumi, Ueki, Masahiro, Watanabe, Nobuyuki, Takada, Hidetoshi, Takezaki, Shunichiro, Chida, Natsuko, Kobayashi, Ichiro, Ariga, Tadashi

“…Heterozygous gain-of-function (GOF) mutations of STAT1 are responsible for chronic mucocutaneous candidiasis disease (CMCD), one of the primary…”
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Ecthyma gangrenosum in an infant with neutropenia by Kikuchi, Nanae, Nakao, Hiro, Matsumoto, Yukio, Yoshida, Kazue, Okai, Masashi, Kawai, Toshinao, Kubota, Mitsuru, Ishiguro, Akira

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Severe Liver Disorder Following Liver Transplantation in STING-Associated Vasculopathy with Onset in Infancy by Ishikawa, Takashi, Tamura, Eiichiro, Kasahara, Mureo, Uchida, Hajime, Higuchi, Masataka, Kobayashi, Hisato, Shimizu, Hirotaka, Ogawa, Eiki, Yotani, Nobuyuki, Irie, Rie, Kosaki, Rika, Kosaki, Kenjiro, Uchiyama, Toru, Onodera, Masafumi, Kawai, Toshinao

“…Purpose STING-associated vasculopathy with onset in infancy (SAVI) is a type-I interferonopathy, characterized by systemic inflammation, peripheral vascular…”
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A pregnant woman with thymoma-associated pure red cell aplasia by Shibata, Megumi, Kaneko, Kayoko, Umehara, Nagayoshi, Matsui, Hitoshi, Kawai, Toshinao, Nakadate, Hisaya, Murashimia, Atsuko, Sago, Haruhiko

“…Background Pure red cell aplasia (PRCA) is a hematological disorder characterized by anemia with severe reticulocytopenia caused by a marked reduction in…”
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A novel STAT3 mutation associated with hyper immunoglobulin E syndrome with a paucity of connective tissue signs by Yoshida, Yoichiro, Nagamori, Tsunehisa, Takahashi, Hironori, Ishibazawa, Emi, Shimada, Sorachi, Kawai, Toshinao, Azuma, Hiroshi

“…Background A heterozygous mutation of STAT3 causes autosomal dominant hyper immunoglobulin E (IgE) syndrome; however, there are still many unclear points…”
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X‐linked agammaglobulinemia complicated with pulmonary aspergillosis by Nishi, Kentaro, Kawai, Toshinao, Kubota, Mitsuru, Ishiguro, Akira, Onodera, Masafumi

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Thymitis in chronic granulomatous disease by Kanamori, Keita, Tamura, Eiichiro, Onodera, Masafumi, Ishiguro, Akira, Kawai, Toshinao

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Clinical features of very early-onset inflammatory bowel disease in Japan: a retrospective single-center study by Usami, Masaaki, Takeuchi, Ichiro, Kyodo, Reiko, Hirano, Yuri, Kashiwagi, Kosuke, Fujikawa, Hiroki, Shimizu, Hirotaka, Kawai, Toshinao, Arai, Katsuhiro

“…Background/Aims: Very early-onset inflammatory bowel disease (VEO-IBD), defined as IBD diagnosed in patients younger than 6 years, is a challenge for pediatric…”
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