Search Results - "KAWAI, Hidehiko"

Correction of monomeric enhanced green fluorescent protein (mEGFP) gene by short 5′-tailed duplexes by Kawai, Hidehiko, Kamitsubo, Ryotaro, Kamiya, Hiroyuki

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Correction of substitution, deletion, and insertion mutations by 5′-tailed duplexes by Kawai, Hidehiko, Sato, Kento, Kato, Taiki, Kamiya, Hiroyuki

“…Germline and somatic mutations cause various diseases, including cancer. Clinical applications of genome editing are keenly anticipated, since it can cure…”
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Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS-Activated TGFβ Signaling by Shimura, Tsutomu, Sasatani, Megumi, Kawai, Hidehiko, Kamiya, Kenji, Kobayashi, Junya, Komatsu, Kenshi, Kunugita, Naoki

“…Fibroblasts are a key stromal cell in the tumor microenvironment (TME) and promote tumor growth via release of various growth factors. Stromal fibroblasts in…”
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Preferential digestion of PCNA-ubiquitin and p53-ubiquitin linkages by USP7 to remove polyubiquitin chains from substrates by Masuda, Yuji, Kanao, Rie, Kawai, Hidehiko, Kukimoto, Iwao, Masutani, Chikahide

“…Ubiquitin-specific protease 7 (USP7) regulates various cellular pathways through its deubiquitination activity. Despite the identification of a growing number…”
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Gene correction by 5′-tailed duplexes with short editor oligodeoxyribonucleotides by Kawai, Hidehiko, Yazama, Kentaro, Yanai, Yuri, Kamitsubo, Ryotaro, Kamiya, Hiroyuki

“…Various diseases, including cancer, are caused by genetic mutations. A 5′-tailed duplex (TD) DNA, consisting of a long single-stranded (ss) editor DNA and a…”
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Spironolactone‐induced XPB degradation depends on CDK7 kinase and SCFFBXL18 E3 ligase by Ueda, Masanobu, Matsuura, Kenkyo, Kawai, Hidehiko, Wakasugi, Mitsuo, Matsunaga, Tsukasa

“…The multisubunit complex transcription factor IIH (TFIIH) has dual functions in transcriptional initiation and nucleotide excision repair (NER). TFIIH is…”
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Methylmercury Decreases AMPA Receptor Subunit GluA2 Levels in Cultured Rat Cortical Neurons by Ishida, Keishi, Takeda, Kazuki, Takehara, Yuki, Takabayashi, Tomoki, Miyara, Masatsugu, Sanoh, Seigo, Kawai, Hidehiko, Ohta, Shigeru, Kotake, Yaichiro

“…Methylmercury (MeHg) is a well-known environmental pollutant that has harmful effects on the central nervous systems of humans and animals. The molecular…”
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Stepwise multipolyubiquitination of p53 by the E6AP-E6 ubiquitin ligase complex by Masuda, Yuji, Saeki, Yasushi, Arai, Naoko, Kawai, Hidehiko, Kukimoto, Iwao, Tanaka, Keiji, Masutani, Chikahide

“…The human papillomavirus (HPV) oncoprotein E6 specifically binds to E6AP (E6-associated protein), a HECT (homologous to the E6AP C terminus)-type ubiquitin…”
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Development of a versatile high-throughput mutagenesis assay with multiplexed short-read NGS using DNA-barcoded supF shuttle vector library amplified in E. coli by Kawai, Hidehiko, Iwata, Ren, Ebi, Shungo, Sugihara, Ryusei, Masuda, Shogo, Fujiwara, Chiho, Kimura, Shingo, Kamiya, Hiroyuki

“…A forward mutagenesis assay using the gene has been widely employed for the last several decades in studies addressing mutation frequencies and mutation…”
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A comparison of radiation-induced mitochondrial damage between neural progenitor stem cells and differentiated cells by Shimura, Tsutomu, Sasatani, Megumi, Kawai, Hidehiko, Kamiya, Kenji, Kobayashi, Junya, Komatsu, Kenshi, Kunugita, Naoki

“…Mitochondria play a key role in maintaining cellular homeostasis during stress responses, and mitochondrial dysfunction contributes to carcinogenesis, aging,…”
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The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo by Huang, Lei, Yan, Zheng, Liao, Xiaodong, Li, Yuan, Yang, Jie, Wang, Zhu-Gang, Zuo, Yong, Kawai, Hidehiko, Shadfan, Miriam, Ganapathy, Suthakar, Yuan, Zhi-Min

“…There are currently two distinct models proposed to explain why both MDM2 and MDMX are required in p53 control, with a key difference centered on whether these…”
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DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells by Shinriki, Satoru, Hirayama, Mayumi, Nagamachi, Akiko, Yokoyama, Akihiko, Kawamura, Takeshi, Kanai, Akinori, Kawai, Hidehiko, Iwakiri, Junichi, Liu, Rin, Maeshiro, Manabu, Tungalag, Saruul, Tasaki, Masayoshi, Ueda, Mitsuharu, Tomizawa, Kazuhito, Kataoka, Naoyuki, Ideue, Takashi, Suzuki, Yutaka, Asai, Kiyoshi, Tani, Tokio, Inaba, Toshiya, Matsui, Hirotaka

“…Myeloid malignancies with DDX41 mutations are often associated with bone marrow failure and cytopenia before overt disease manifestation. However, the…”
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Mitochondrial reactive oxygen species perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of PP2A in lowdose irradiated human fibroblasts by Shimura, Tsutomu, Sasatani, Megumi, Kamiya, Kenji, Kawai, Hidehiko, Inaba, Yohei, Kunugita, Naoki

“…Here we investigated the cellular response of normal human fibroblasts to repeated exposure to low-dose radiation. In contrast to acute single radiation,…”
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Hypertension and diabetes mellitus are associated with high FIB-4 index in a health checkup examination cohort without known liver disease by Sato, Shunsuke, Kawai, Hidehiko, Sato, Sho, Iwasaki, Hirohiko, Omori, Masashi, Kita, Yuji, Ikeda, Yuji, Awatsu, Takahito, Murata, Ayato, Taniguchi, Gentaro, Shimada, Yuji, Genda, Takuya

“…Non-alcoholic fatty liver disease (NAFLD) is usually asymptomatic and lacks a specific biomarker; therefore, many individuals might remain undiagnosed even…”
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RFWD3 and translesion DNA polymerases contribute to PCNA modification-dependent DNA damage tolerance by Kanao, Rie, Kawai, Hidehiko, Taniguchi, Toshiyasu, Takata, Minoru, Masutani, Chikahide

“…DNA damage tolerance pathways are regulated by proliferating cell nuclear antigen (PCNA) modifications at lysine 164. Translesion DNA synthesis by DNA…”
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En bloc transfer of polyubiquitin chains to PCNA in vitro is mediated by two different human E2-E3 pairs by Masuda, Yuji, Suzuki, Miki, Kawai, Hidehiko, Hishiki, Asami, Hashimoto, Hiroshi, Masutani, Chikahide, Hishida, Takashi, Suzuki, Fumio, Kamiya, Kenji

“…Post-replication DNA repair in eukaryotes is regulated by ubiquitination of proliferating cell nuclear antigen (PCNA). Monoubiquitination catalyzed by…”
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Asymmetric nature of two subunits of RAD18, a RING-type ubiquitin ligase E3, in the human RAD6A-RAD18 ternary complex by Masuda, Yuji, Suzuki, Miki, Kawai, Hidehiko, Suzuki, Fumio, Kamiya, Kenji

“…RAD18, a RING-type ubiquitin ligase (E3) that plays an essential role in post-replication repair, possesses distinct domains named RING, UBZ, SAP and the…”
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RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity by KAWAI, Hidehiko, LOPEZ-PAJARES, Vanessa, KIM, Mihee M, WIEDERSCHAIN, Dmitri, YUAN, Zhi-Min

“…The RING domain of MDM2 that is essential for its E3 ligase activity mediates binding to itself and its structural homologue MDMX. Whereas it has been reported…”
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Periostin promotes invasion and anchorage-independent growth in the metastatic process of head and neck cancer by KUDO, Yasusei, OGAWA, Ikuko, KITAJIMA, Shojiro, KITAGAWA, Masae, KAWAI, Hidehiko, GAFFNEY, Patrick M, MIYAUCHI, Mutsumi, TAKATA, Takashi

“…Head and neck squamous cell carcinoma (HNSCC) is one of the most common types of human cancer. Typically, HNSCC cells show persistent invasion that frequently…”
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Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53 by Sen, Subrata, Katayama, Hiroshi, Sasai, Kaori, Kawai, Hidehiko, Yuan, Zhi-Min, Bondaruk, Jolanta, Suzuki, Fumio, Fujii, Satoshi, Arlinghaus, Ralph B, Czerniak, Bogdan A

“…Aurora kinase A (also called STK15 and BTAK) is overexpressed in many human cancers. Ectopic overexpression of aurora kinase A in mammalian cells induces…”
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