Search Results - "KAWABATA, RUMI"

Acquired resistance to trastuzumab/pertuzumab or to T‐DM1 in vivo can be overcome by HER2 kinase inhibition with TAS0728 by Irie, Hiroki, Kawabata, Rumi, Fujioka, Yayoi, Nakagawa, Fumio, Itadani, Hiraku, Nagase, Hideki, Ito, Kimihiro, Uchida, Junji, Ohkubo, Shuichi, Matsuo, Kenichi

“…HER2‐targeting antibodies (trastuzumab, pertuzumab) and a HER2‐directed antibody‐drug conjugate (trastuzumab emtansine: T‐DM1) are used for the treatment of…”
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Activity of TAS4464, a novel NEDD8 activating enzyme E1 inhibitor, against multiple myeloma via inactivation of nuclear factor κB pathways by Muraoka, Hiromi, Yoshimura, Chihoko, Kawabata, Rumi, Tsuji, Shingo, Hashimoto, Akihiro, Ochiiwa, Hiroaki, Nakagawa, Fumio, Fujioka, Yayoi, Matsuo, Kenichi, Ohkubo, Shuichi

“…The ubiquitin proteasome pathway is essential for the proliferation and survival of multiple myeloma (MM) cells. TAS4464, a novel highly potent inhibitor of…”
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Dynamic modulation of thymidylate synthase gene expression and fluorouracil sensitivity in human colorectal cancer cells by Wakasa, Kentaro, Kawabata, Rumi, Nakao, Seiki, Hattori, Hiroyoshi, Taguchi, Kenichi, Uchida, Junji, Yamanaka, Takeharu, Maehara, Yoshihiko, Fukushima, Masakazu, Oda, Shinya

“…Biomarkers have revolutionized cancer chemotherapy. However, many biomarker candidates are still in debate. In addition to clinical studies, a priori…”
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Substitution of anti-androgens and tegafur-uracil combination therapy for castration-resistant prostate cancer: Results of a multi-center randomized phase II study by TAKAHASHI, MASAYUKI, KAWABATA, RUMI, KAWANO, AKIRA, MURAKAMI, YOSHIHIDE, SUTOU, YASUSHI, INAI, TOHRU, AKAZAWA, SEIJI, HAMAO, TAKUMI, HAYASHI, HIDEKI, FUKAWA, TOMOYA, TAKEMURA, MASAHIKO, YAMAMOTO, YASUYO, YAMAGUCHI, KUNIHISA, IZAKI, HIROFUMI, FUKUMORI, TOMOHARU, KANAYAMA, HIROOMI

“…We conducted this study to determine whether substitution with anti-androgen (SOA) and tegafur-uracil (a pro-drug of 5-FU) combination therapy is more…”
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Abstract A126: Acquired resistance to trastuzumab/pertuzumab, or to T-DM1 in vivo can be overcome by HER2 inhibition with TAS0728 by Irie, Hiroki, Kawabata, Rumi, Fujioka, Yayoi, Nakagawa, Fumio, Nagase, Hideki, Itadani, Hiraku, Ito, Kimihiro, Uchida, Junji, Ohkubo, Shuichi, Matsuo, Kenichi, Sagara, Takeshi, Utsugi, Teruhiro

“…Abstract Background: HER2-targeting antibodies (trastuzumab, pertuzumab) and an antibody-drug conjugate (trastuzumab emtansine: T-DM1) are available for the…”
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DLST as a method for detecting TS-1-induced allergy by Kawabata, Rumi, Koida, Masahiro, Kanie, Shohei, Tanaka, Gotaro, Ohuchida, Akinobu, Yoshida, Takemi

“…Drug-induced allergic adverse events including rash, interstitial pneumonia and hepatic injury are often observed in a few patients treated with anticancer…”
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Abstract B179: TAS0728, a HER2-selective covalent inhibitor, demonstrates potent antitumor effect as a single agent and in combination with anti-HER2 antibodies in HER2-overexpressed tumor models by Irie, Hiroki, Oguchi, Kei, Ito, Kimihiro, Fujioka, Yayoi, Kawai, Yuichi, Shimamura, Tadashi, Araki, Hikari, Fujioka, Akio, Nakagawa, Fumio, Kawabata, Rumi, Nagase, Hideki, Sagara, Takeshi, Uchida, Junji, Matsuo, Kenichi, Utsugi, Teruhiro, Iwasawa, Yoshikazu

“…Abstract Background: HER2 is a well-established therapeutic target in breast and gastric cancer. Although HER2-targeting therapies are available for…”
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Up-regulation of insulin-like growth factor-binding protein 3 by 5-fluorouracil (5-FU) leads to the potent anti-proliferative effect of androgen deprivation therapy combined with 5-FU in human prostate cancer cell lines by KAWABATA, Rumi, OIE, Shinji, TAKAHASHI, Masayuki, KANAYAMA, Hiroomi, OKA, Toshinori, ITOH, Kohji

“…In this study, we investigated the synergistic mechanism of anti-androgen and 5-fluorouracil (5-FU) combination therapy against castration-resistant prostate…”
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Abstract 2757: TAS-106, a newly synthesized RNA polymerase inhibitor, combined with cisplatin exhibits potent synergistic growth-inhibitory effect via Vaults dysfunction by Fukushima, Hiroto, Abe, Tetsuya, Tsujimoto, Akihiro, Kawabata, Rumi, Sakamoto, Kazuki, Oie, Shinji

“…Abstract TAS-106, 3′-C-ethynylcytidine, is a novel nucleoside analog that inhibits RNA polymerases I, II and III, and has been reported to exert potent…”
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Hydroxyflutamide enhances cellular sensitivity to 5-fluorouracil by suppressing thymidylate synthase expression in bicalutamide-resistant human prostate cancer cells by KAWABATA, Rumi, OIE, Shinji, OKA, Toshinori, TAKAHASHI, Masayuki, KANAYAMA, Hiroomi, ITOH, Kohji

“…We investigated the antitumor effects of combination therapy with anti-androgens and 5-fluorouracil (5-FU), and examined the underlying mechanism of the…”
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Dynamic Modulation of Thymidylate Synthase Gene Expression and Fluorouracil Sensitivity in Human Colorectal Cancer Cells: e0123076 by Wakasa, Kentaro, Kawabata, Rumi, Nakao, Seiki, Hattori, Hiroyoshi, Taguchi, Kenichi, Uchida, Junji, Yamanaka, Takeharu, Maehara, Yoshihiko, Fukushima, Masakazu, Oda, Shinya

“…Biomarkers have revolutionized cancer chemotherapy. However, many biomarker candidates are still in debate. In addition to clinical studies, a priori…”
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