Search Results - "KAVATHAS, P"

A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers by Gettinger, S. N., Choi, J., Mani, N., Sanmamed, M. F., Datar, I., Sowell, Ryan, Du, Victor Y., Kaftan, E., Goldberg, S., Dong, W., Zelterman, D., Politi, K., Kavathas, P., Kaech, S., Yu, X., Zhao, H., Schlessinger, J., Lifton, R., Rimm, D. L., Chen, L., Herbst, R. S., Schalper, K. A.

“…The biological determinants of sensitivity and resistance to immune checkpoint blockers are not completely understood. To elucidate the role of intratumoral…”
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Nod1, but not the ASC inflammasome, contributes to induction of IL-1β secretion in human trophoblasts after sensing of Chlamydia trachomatis by Kavathas, P B, Boeras, C M, Mulla, M J, Abrahams, V M

“…Chlamydia trachomatis (Ct) is an obligate intracellular bacterial pathogen. Previously, we showed that infection of human trophoblast cells by Ct triggers the…”
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Direct Detection and Magnetic Isolation of Chlamydia trachomatis Major Outer Membrane Protein-Specific CD8+ CTLs with HLA Class I Tetramers by Kim, Seon-Kyeong, Devine, Lesley, Angevine, Mark, DeMars, Robert, Kavathas, Paula B

“…We recently identified HLA class I-presented epitopes in the major outer membrane protein (MOMP) of Chlamydia trachomatis that elicit CTL responses in human…”
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A Non-class I MHC Intestinal Epithelial Surface Glycoprotein, gp180, Binds to CD8 by Campbell, N.A., Park, M.S., Toy, L.S., Yio, X.Y., Devine, L., Kavathas, P., Mayer, L.

“…The activation of CD8+ T cells by normal intestinal epithelial cells in antigen-specific or allogeneic mixed cell culture systems has significant implications…”
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Identification and characterization of an Alu-containing, T-cell-specific enhancer located in the last intron of the human CD8 alpha gene by HAMBOR, J. E, MENNONE, J, COON, M. E, HANKE, J. H, KAVATHAS, P

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Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase by SHAW, A. S, CHALUPNY, J, WHITNEY, J. A, HAMMOND, C, AMREIN, K. E, KAVATHAS, P, SEFTON, B. M, ROSE, J. K

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Epstein-Barr virus shuttle vector for stable episomal replication of cDNA expression libraries in human cells by MARGOLSKEE, R. F, KAVATHAS, P, BERG, P

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Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a nonclassical major histocompatibility complex class 1 molecule on cytotrophoblasts by SANDERS, S. K, GIBLIN, P. A, KAVATHAS, P

“…The lymphocyte differentiation marker CD8 acts as a coreceptor with the T cell receptor (TCR) during recognition of peptide presented by major…”
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The Role of Charge and Multiple Faces of the CD8α/α Homodimer in Binding to Major Histocompatibility Complex Class I Molecules: Support for a Bivalent Model by Giblin, Patricia A., Leahy, Daniel J., Mennone, John, Kavathas, Paula B.

“…The CD8 dimer interacts with the α 3 domain of major histocompatibility complex class I molecules through two immunoglobulin variable-like domains. In this…”
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Interaction between CD8 and major histocompatibility complex (MHC) class I mediated by multiple contact surfaces that include the alpha 2 and alpha 3 domains of MHC class I by Sun, J, Leahy, D J, Kavathas, P B

“…The cell surface glycoprotein CD8 functions as a coreceptor with the TCR on cytotoxic T lymphocytes. Mutational analysis of the binding site of CD8 for MHC…”
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A modified cell surface marker gene for transgenic animal studies by Kieffer, Lynda, Kavathas, Paula B.

“…We developed a marker gene encoding a human cell surface molecule called CD8 for use in transgenic animal studies. The CD8 cDNA contains three mutations: one…”
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Human CD8 beta, but not mouse CD8 beta, can be expressed in the absence of CD8 alpha as a beta beta homodimer by Devine, L, Kieffer, L J, Aitken, V, Kavathas, P B

“…The T cell coreceptor CD8 exists on mature T cells as disulfide-linked homodimers of CD8 alpha polypeptide chains and heterodimers of CD8 alpha- and CD8…”
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Orientation of the Ig domains of CD8 alpha beta relative to MHC class I by Devine, L, Sun, J, Barr, M R, Kavathas, P B

“…The cell surface glycoprotein CD8 functions as a coreceptor with the TCR for interaction with MHC class I. The cocrystal structure of the CD8 alpha alpha-MHC…”
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Association of CD8 with p56lck is required for early T cell signalling events by Chalupny, N. J., Ledbetter, J. A., Kavathas, P.

“…The human CD8 glycoprotein functions as a co‐receptor during T cell activation by both binding to MHC class I and transducing a transmembrane signal. The…”
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Stable transformation of mouse L cells for human membrane T-cell differentiation antigens, HLA and beta 2-microglobulin: selection by fluorescence-activated cell sorting by Kavathas, P, Herzenberg, L A

“…We isolated stable transformants of mouse L cells expressing human cell surface differentiation antigens by using immunofluorescence with monoclonal antibodies…”
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Identification of a Candidate Regulatory Region in the Human CD8 Gene Complex by Colocalization of DNase I Hypersensitive Sites and Matrix Attachment Regions Which Bind SATB1 and GATA-3 by Kieffer, Lynda J, Greally, John M, Landres, Inna, Nag, Shanta, Nakajima, Yuko, Kohwi-Shigematsu, Terumi, Kavathas, Paula B

“…To locate elements regulating the human CD8 gene complex, we mapped nuclear matrix attachment regions (MARs) and DNase I hypersensitive (HS) sites over a…”
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Comparison of the roles of CD8 alpha alpha and CD8 alpha beta in interaction with MHC class I by Sun, J, Kavathas, PB

“…The CD8 molecule is expressed either as an alpha/alpha homodimer or an alpha/beta heterodimer on thymocytes and cytotoxic T cells, and functions as a…”
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Mutations in CD8 that affect interactions with HLA class I and monoclonal anti-CD8 antibodies by SANDERS, S. K, FOX, R. O, KAVATHAS, P

“…The T cell co-receptor, CD8, binds to the alpha 3 domain of HLA class I (Salter, R.D., R.J. Benjamin, P.K. Wesley, S.E. Buxton, T.P.J. Garrett, C. Clayberger,…”
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Gamma Ray-Induced Loss of Expression of HLA and Glyoxalase I Alleles in Lymphoblastoid Cells by Kavathas, Paula, Bach, Fritz H., DeMars, Robert

“…Gamma rays from a cesium source were used to generate human lymphoblastoid cell line variants that had lost expression of all major histocompatibility complex…”
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Increased efficiency of folding and peptide loading of mutant MHC class I molecules by Beißbarth, Tim, Sun, Jiaren, Kavathas, Paula B., Ortmann, Bodo

“…Class I molecules, encoded by diverse alleles at several loci of the major histocompatibility complex (MHC) are assembled in the endoplasmic reticulum (ER)…”
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