Search Results - "KAUPPILA, SAILA"

Oxidative stress and counteracting mechanisms in hormone receptor positive, triple-negative and basal-like breast carcinomas by Karihtala, Peeter, Kauppila, Saila, Soini, Ylermi, Arja-Jukkola-Vuorinen

“…Triple-negative breast cancer (TNBC) and basal-like breast cancer (BLBC) are breast cancer subtypes with an especially poor prognosis. 8-Hydroxydeoxyguanosine…”
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Targeting collagen XVIII improves the efficiency of ErbB inhibitors in breast cancer models by Devarajan, Raman, Izzi, Valerio, Peltoketo, Hellevi, Rask, Gunilla, Kauppila, Saila, Väisänen, Marja-Riitta, Ruotsalainen, Heli, Martínez-Nieto, Guillermo, Karppinen, Sanna-Maria, Väisänen, Timo, Kaur, Inderjeet, Koivunen, Jussi, Sasaki, Takako, Winqvist, Robert, Manninen, Aki, Wärnberg, Fredrik, Sund, Malin, Pihlajaniemi, Taina, Heljasvaara, Ritva

“…The tumor extracellular matrix (ECM) critically regulates cancer progression and treatment response. Expression of the basement membrane component collagen…”
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Impact of central nervous system (CNS) prophylaxis on the incidence of CNS relapse in patients with high-risk diffuse large B cell/follicular grade 3B lymphoma by Kuitunen, Hanne, Kaprio, Elina, Karihtala, Peeter, Makkonen, Ville, Kauppila, Saila, Haapasaari, Kirsi-Maria, Kuusisto, Milla, Jantunen, Esa, Turpeenniemi-Hujanen, Taina, Kuittinen, Outi

“…Although overall survival in diffuse large B cell lymphomas (DLBCL) has improved, central nervous system (CNS) relapse is still a fatal complication of DLBCL…”
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Targeted Next-Generation Sequencing Identifies a Recurrent Mutation in MCPH1 Associating with Hereditary Breast Cancer Susceptibility by Mantere, Tuomo, Winqvist, Robert, Kauppila, Saila, Grip, Mervi, Jukkola-Vuorinen, Arja, Tervasmäki, Anna, Rapakko, Katrin, Pylkäs, Katri

“…Breast cancer is strongly influenced by hereditary risk factors, a majority of which still remain unknown. Here, we performed a targeted next-generation…”
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Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility by Mantere, Tuomo, Tervasmäki, Anna, Nurmi, Anna, Rapakko, Katrin, Kauppila, Saila, Tang, Jiangbo, Schleutker, Johanna, Kallioniemi, Anne, Hartikainen, Jaana M., Mannermaa, Arto, Nieminen, Pentti, Hanhisalo, Riitta, Lehto, Sini, Suvanto, Maija, Grip, Mervi, Jukkola-Vuorinen, Arja, Tengström, Maria, Auvinen, Päivi, Kvist, Anders, Borg, Åke, Blomqvist, Carl, Aittomäki, Kristiina, Greenberg, Roger A., Winqvist, Robert, Nevanlinna, Heli, Pylkäs, Katri

“…Several known breast cancer susceptibility genes encode proteins involved in DNA damage response (DDR) and are characterized by rare loss-of-function…”
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Tonsillar granuloma associated with hypogammaglobulinemia by Laajala, Aleksi, Kuismin, Outi, Tastula, Mikko, Tiitto, Leena, Kauppila, Saila, Salo, Anna, Åström, Pirjo, Nissinen, Antti, Glumoff, Virpi, Seppänen, Mikko R J, Hautala, Timo

“…Rare tonsillar granulomas may be caused for example by infections, malignancies or sarcoidosis. Granulomas also occur in inborn errors of immunity (IEI) such…”
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Absent Toll-like receptor-9 expression predicts poor prognosis in renal cell carcinoma by Ronkainen, Hanna, Hirvikoski, Pasi, Kauppila, Saila, Vuopala, Katri S, Paavonen, Timo K, Selander, Katri S, Vaarala, Markku H

“…Toll-like receptor 9 (TLR9) is a cellular DNA-receptor whose activation with cognate ligands triggers an immune reaction, with increased production of…”
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Eiger and its receptor, Wengen, comprise a TNF-like system in Drosophila by KAUPPILA, Saila, MAATY, Walid S. A, ABRAMS, John M, CHAUDHARY, Preet M, PO CHEN, TOMAR, Raghuvir S, EBY, Michael T, CHAPO, Joe, CHEW, Sukit, RATHORE, Nisha, ZACHARIAH, Sunny, SINHA, Suwan K

“…In mammals, members of the tumor necrosis factor (TNF) family play an important role in the regulation of cellular proliferation, differentiation and…”
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The effect of topical pimecrolimus on inflammatory infiltrate in vulvar lichen sclerosus by Kauppila, Saila, MD, PhD, Kotila, Vesa, Lic Sci (Tech.), Knuuti, Eila, MD, Väre, Päivi O., MD, Vittaniemi, Pia, MD, Nissi, Ritva, MD, PhD

“…Objective Lichen sclerosus (LS) is a relatively common chronic inflammatory disorder of the skin and mucosal surfaces. Study Design A total of 29 women with…”
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Evaluation of neuroendocrine markers in renal cell carcinoma by Ronkainen, Hanna, Soini, Ylermi, Vaarala, Markku H, Kauppila, Saila, Hirvikoski, Pasi

“…The purpose of the study was to examine serotonin, CD56, neurone-specific enolase (NSE), chromogranin A and synaptophysin by immunohistochemistry in renal cell…”
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Evaluation of myosin VI, E-cadherin and beta-catenin immunostaining in renal cell carcinoma by Ronkainen, Hanna, Kauppila, Saila, Hirvikoski, Pasi, Vaarala, Markku H

“…Renal cell carcinoma (RCC) is a cancer of increasing incidence and mortality. Currently, there are no immunohistochemical prognostic markers for RCCs in…”
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Prebiopsy Multiparametric Magnetic Resonance Imaging for Prostate Cancer Diagnosis in Biopsy-naive Men with Suspected Prostate Cancer Based on Elevated Prostate-specific Antigen Values: Results from a Randomized Prospective Blinded Controlled Trial by Tonttila, Panu P, Lantto, Juha, Pääkkö, Eija, Piippo, Ulla, Kauppila, Saila, Lammentausta, Eveliina, Ohtonen, Pasi, Vaarala, Markku H

“…Abstract Background Multiparametric magnetic resonance imaging (MP-MRI) may improve the detection of clinically significant prostate cancer (PCa). Objective To…”
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Vimentin, zeb1 and Sip1 are up-regulated in triple-negative and basal-like breast cancers: association with an aggressive tumour phenotype by Karihtala, Peeter, Auvinen, Päivi, Kauppila, Saila, Haapasaari, Kirsi-Maria, Jukkola-Vuorinen, Arja, Soini, Ylermi

“…In epithelial-to-mesenchymal transition (EMT) epithelial cancer cells achieve mesenchymal features, essentially helping them to metastasize. There is some…”
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Exome sequencing identifies a recurrent variant in SERPINA3 associating with hereditary susceptibility to breast cancer by Koivuluoma, Susanna, Tervasmäki, Anna, Kauppila, Saila, Winqvist, Robert, Kumpula, Timo, Kuismin, Outi, Moilanen, Jukka, Pylkäs, Katri

“…Breast cancer is strongly influenced by hereditary risk factors. Yet, the known susceptibility genes and genomic loci explain only about half of the familial…”
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Divergent behaviour of oxidative stress markers 8-hydroxydeoxyguanosine (8-OHdG) and 4-hydroxy-2-nonenal (HNE) in breast carcinogenesis by Karihtala, Peeter, Kauppila, Saila, Puistola, Ulla, Jukkola-Vuorinen, Arja

“…Karihtala P, Kauppila S, Puistola U & Jukkola‐Vuorinen A
(2011) Histopathology58, 854–862
Divergent behaviour of oxidative stress markers…”
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Incidence and clinicopathological features of Follicular T-cell lymphoma in Finland: a population-based immunohistochemical study by Kiiskilä, Jenni, Uotila, Pyry, Haapasaari, Kirsi-Maria, Kauppila, Saila, Teppo, Hanna-Riikka, Kuusisto, Milla E.L., Lemma, Siria, Turpeenniemi-Hujanen, Taina, Vornanen, Martine, Eray, Mine, Kuittinen, Outi

“…Follicular T-cell lymphoma (FTCL) is a rare subtype of mature T-cell lymphoma. It was recently recognized as a separate lymphoma entity in the 2017 revised…”
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Oxidative stress-induced antioxidant enzyme expression is an early phenomenon in ovarian carcinogenesis by Pylväs, Marjo, Puistola, Ulla, Kauppila, Saila, Soini, Ylermi, Karihtala, Peeter

“…Abstract Oxidative stress and antioxidant enzymes have been widely investigated in various carcinomas. However, there is only some information about their role…”
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Inflammation and prognosis in colorectal cancer by Klintrup, Kai, Mäkinen, Johanna M., Kauppila, Saila, Väre, Päivi O., Melkko, Jukka, Tuominen, Hannu, Tuppurainen, Karoliina, Mäkelä, Jyrki, Karttunen, Tuomo J., Mäkinen, Markus J.

“…Previous work has indicated that quantification of inflammatory cell reaction is of prognostic value in colorectal cancer. We evaluated the prognostic…”
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Rare missense mutations in RECQL and POLG associate with inherited predisposition to breast cancer by Tervasmäki, Anna, Mantere, Tuomo, Hartikainen, Jaana M., Kauppila, Saila, Lee, Hang‐Mao, Koivuluoma, Susanna, Grip, Mervi, Karihtala, Peeter, Jukkola‐Vuorinen, Arja, Mannermaa, Arto, Winqvist, Robert, Pylkäs, Katri

“…Several known breast cancer susceptibility genes with moderate‐to‐high risk alleles encode proteins involved in DNA damage response (DDR). As these explain…”
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Elevated serum 8-OHdG is associated with poor prognosis in epithelial ovarian cancer by Pylväs, Marjo, Puistola, Ulla, Laatio, Liisa, Kauppila, Saila, Karihtala, Peeter

“…8-Hydroxydeoxyguanosine (8-OHdG) is a marker of oxidative stress in DNA. This study was undertaken to reveal whether serum 8-OHdG could be a prognostic factor…”
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