Search Results - "KAUPMANN, K"

GABA(B)-receptor subtypes assemble into functional heteromeric complexes by Kaupmann, K, Malitschek, B, Schuler, V, Heid, J, Froestl, W, Beck, P, Mosbacher, J, Bischoff, S, Kulik, A, Shigemoto, R, Karschin, A, Bettler, B

“…B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G-protein-coupled second-messenger systems, which…”
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Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo‐66 receptor by Pignot, V., Hein, A. E., Barske, C., Wiessner, C., Walmsley, A. R., Kaupmann, K., Mayeur, H., Sommer, B., Mir, A. K., Frentzel, S.

“…Nogo‐66 receptor (NgR) has recently been identified as the neuronal receptor of the myelin‐associated proteins Nogo‐A, oligodendrocyte protein (OMgp) and…”
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Two amino acids, located in transmembrane domains VI and VII, determine the selectivity of the peptide agonist SMS 201‐995 for the SSTR2 somatostatin receptor by Kaupmann, K., Bruns, C., Raulf, F., Weber, H.P., Mattes, H., Lübbert, H.

“…Human somatostatin receptor subtypes (SSTR1‐5) bind their natural ligands SRIF‐14 and SRIF‐28 with high affinity. By contrast, short synthetic SRIF analogues…”
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Molecular structure and physiological functions of GABA(B) receptors by Bettler, Bernhard, Kaupmann, Klemens, Mosbacher, Johannes, Gassmann, Martin

“…GABA(B) receptors are broadly expressed in the nervous system and have been implicated in a wide variety of neurological and psychiatric disorders. The cloning…”
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Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression by Cryan, John F, Kaupmann, Klemens

“…GABA, the main inhibitory neurotransmitter in the brain, regulates many physiological and psychological processes. Thus, dysfunction of the GABA system is…”
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Localization of somatostatin (SRIF) SSTR-1, SSTR-2 and SSTR-3 receptor mRNA in rat brain by in situ hybridization by PEREZ, J, RIGO, M, KAUPMANN, K, BRUNS, C, YASUDA, K, BELL, G. I, LÜBBERT, H, HOYER, D

“…In situ hybridization histochemistry was performed to analyse the distribution of the messenger RNA (mRNA) of three putative somatostatin (SRIF) receptors in…”
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Metabotropic Glutamate 2/3 Receptors in the Ventral Tegmental Area and the Nucleus Accumbens Shell Are Involved in Behaviors Relating to Nicotine Dependence by Liechti, Matthias E, Lhuillier, Loic, Kaupmann, Klemens, Markou, Athina

“…The motivation to maintain nicotine self-administration and dependence may involve alterations in glutamatergic neurotransmission. Metabotropic glutamate…”
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Pharmacological identity between somatostatin SS-2 binding sites and SSTR-1 receptors by Hoyer, D., Pérez, J., Schoeffter, P., Langenegger, D., Schüpbach, E., Kaupmann, K., Lübbert, H., Bruns, C., Reubi, J.C.

“…Somatostatin (SRIF) SS-2 binding sites were originally defined in rat brain cerebral cortex membranes using [ 125I]Tyr 11-SRIF-14 in the presence of 120 mM…”
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Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501 by Urwyler, S, Mosbacher, J, Lingenhoehl, K, Heid, J, Hofstetter, K, Froestl, W, Bettler, B, Kaupmann, K

“…The compounds CGP7930 [2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol] and its close analog CGP13501 were identified as positive modulators of…”
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Genetic and Pharmacological Evidence of a Role for GABA Receptors in the Modulation of Anxiety- and Antidepressant-Like Behavior by Mombereau, Cedric, Kaupmann, Klemens, Froestl, Wolfgang, Sansig, Gilles, van der Putten, Herman, Cryan, John F

“…Although there is much evidence for a role of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the pathophysiology of anxiety and depression,…”
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Processing of GABABR1 in Heterologous Expression Systems by MOSBACHER, J., KAUPMANN, K., SCHULER, V., RISTIG, D., STRUCKMEYER, K., PFAFF, T., KARSCHIN, A., POZZA, M. F., BETTLER, B.

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Cloning and characterization of the gene encoding murine insulin-like growth factor-binding protein-2, mIGFBP-2 by Landwehr, J, Kaupmann, K, Heinrich, G, Schwander, J

“…We present a characterization of the single-copy gene, mIGFBP-2, encoding the murine insulin-like growth factor-binding protein-2 (mIGFBP-2). It consists of…”
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Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition by Cassasus, Guillaume, Barbieri, Samuel, van der Putten, Herman, Humeau, Yann, Ciocchi, Stephane, Shaban, Hamdy, Kaupmann, Klemens, Bettler, Bernhard, Lüthi, Andreas, Herry, Cyril, Shigemoto, Ryuichi

“…Pavlovian fear conditioning, a simple form of associative learning, is thought to involve the induction of associative, NMDA receptor-dependent long-term…”
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Nogo-A Inhibits Neurite Outgrowth and Cell Spreading with Three Discrete Regions by Oertle, Thomas, van der Haar, Marjan E, Bandtlow, Christine E, Robeva, Anna, Burfeind, Patricia, Buss, Armin, Huber, Andrea B, Simonen, Marjo, Schnell, Lisa, Brosamle, Christian, Kaupmann, Klemens, Vallon, Rudiger, Schwab, Martin E

“…Nogo-A is a potent neurite growth inhibitor in vitro and plays a role both in the restriction of axonal regeneration after injury and in structural plasticity…”
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Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)) by Schuler, V, Lüscher, C, Blanchet, C, Klix, N, Sansig, G, Klebs, K, Schmutz, M, Heid, J, Gentry, C, Urban, L, Fox, A, Spooren, W, Jaton, A L, Vigouret, J, Pozza, M, Kelly, P H, Mosbacher, J, Froestl, W, Käslin, E, Korn, R, Bischoff, S, Kaupmann, K, van der Putten, H, Bettler, B

“…GABA(B) (gamma-aminobutyric acid type B) receptors are important for keeping neuronal excitability under control. Cloned GABA(B) receptors do not show the…”
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Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice by Kaupmann, Klemens, Cryan, John F, Wellendorph, Petrine, Mombereau, Cedric, Sansig, Gilles, Klebs, Klaus, Schmutz, Markus, Froestl, Wolfgang, van der Putten, Herman, Mosbacher, Johannes, Bräuner-Osborne, Hans, Waldmeier, Peter, Bettler, Bernhard

“…gamma-Hydroxybutyrate (GHB), a metabolite of gamma-aminobutyric acid (GABA), is proposed to function as a neurotransmitter or neuromodulator…”
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C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABA(b) receptors by Pagano, A, Rovelli, G, Mosbacher, J, Lohmann, T, Duthey, B, Stauffer, D, Ristig, D, Schuler, V, Meigel, I, Lampert, C, Stein, T, Prezeau, L, Blahos, J, Pin, J, Froestl, W, Kuhn, R, Heid, J, Kaupmann, K, Bettler, B

“…Assembly of fully functional GABA(B) receptors requires heteromerization of the GABA(B(1)) and GABA(B(2)) subunits. It is thought that GABA(B(1)) and…”
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Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors by Kaupmann, K, Huggel, K, Heid, J, Flor, P J, Bischoff, S, Mickel, S J, McMaster, G, Angst, C, Bittiger, H, Froestl, W, Bettler, B

“…GABA (gamma-amino-butyric acid), the principal inhibitory neurotransmitter in the brain, signals through ionotropic (GABA(A)/ GABA(c)) and metabotropic…”
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Dolichos biflorus agglutinin receptors in mouse muscle. II. Biochemical properties in relation to molecular forms of acetylcholinesterase by Kaupmann, K, Jockusch, H

“…A biochemical analysis has been performed on the relationship between the receptors for Dolichos biflorus agglutinin (DBA) and collagen tailed…”
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Spatial distribution of GABA(B)R1 receptor mRNA and binding sites in the rat brain by Bischoff, S, Leonhard, S, Reymann, N, Schuler, V, Shigemoto, R, Kaupmann, K, Bettler, B

“…A gamma-aminobutyric acid (GABA)(B) receptor (named GABA(B)R1) has been recently cloned in the rat and human brain and two variants generated by alternative…”
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