Search Results - "KAUFMANN, Jörg"

Delivery of Therapeutic siRNA to the Lung Endothelium via Novel Lipoplex Formulation DACC by Fehring, V, Schaeper, U, Ahrens, K, Santel, A, Keil, O, Eisermann, M, Giese, K, Kaufmann, Jörg

“…Posttranscriptional gene silencing by RNA interference can be therapeutically exploited to inhibit pathophysiological gene expression. However, in contrast to…”
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mitochondrial protein MTP18 contributes to mitochondrial fission in mammalian cells by Tondera, Daniel, Czauderna, Frank, Paulick, Katharina, Schwarzer, Rolf, Kaufmann, Jörg, Santel, Ansgar

“…Mitochondria are dynamic organelles that change morphology by controlled fission and fusion events. Mitochondrial fission is regulated by a conserved protein…”
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Atu027 Prevents Pulmonary Metastasis in Experimental and Spontaneous Mouse Metastasis Models by SANTEL, Ansgar, ALEKU, Manuela, EISERMANN, Mona, LÖFFLER, Kathrin, FECHTNER, Melanie, FISCH, Gerald, VANK, Christiane, SCHAEPER, Ute, GIESE, Klaus, KAUFMANN, Jörg, RÖDER, Nadine, MÖPERT, Kristin, DURIEUX, Birgit, JANKE, Oliver, KEIL, Oliver, ENDRUSCHAT, Jens, DAMES, Sibylle, LANGE, Christian

“…Atu027, a novel RNA interference therapeutic, has been shown to inhibit lymph node metastasis in orthotopic prostate cancer mouse models. The aim of this study…”
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Fibre reinforced polymers in the sports industry - Life Cycle Engineering methodology applied to a snowboard using anisotropic layer design by Ribeiro, Inês, Kaufmann, Jörg, Götze, Uwe, Peças, Paulo, Henriques, Elsa

“…Technological development has had huge impacts in sports performance throughout the years, fostering the development of specific materials and manufacturing…”
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Cationic LNP-formulated mRNA expressing Tie2-agonist in the lung endothelium prevents pulmonary vascular leakage by Radloff, Katrin, Gutbier, Birgitt, Dunne, Charlotte Maeve, Moradian, Hanieh, Schwestka, Marko, Gossen, Manfred, Ahrens, Katharina, Kneller, Laura, Wang, Yadong, Moga, Akanksha, Gkionis, Leonidas, Keil, Oliver, Fehring, Volker, Tondera, Daniel, Giese, Klaus, Santel, Ansgar, Kaufmann, Jörg, Witzenrath, Martin

“…Dysfunction of endothelial cells (ECs) lining the inner surface of blood vessels are causative for a number of diseases. Hence, the ability to therapeutically…”
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Loss of Drp1 function alters OPA1 processing and changes mitochondrial membrane organization by Möpert, Kristin, Hajek, Petr, Frank, Stephan, Chen, Christiane, Kaufmann, Jörg, Santel, Ansgar

“…RNAi mediated loss of Drp1 function changes mitochondrial morphology in cultured HeLa and HUVEC cells by shifting the balance of mitochondrial fission and…”
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Inducible shRNA expression for application in a prostate cancer mouse model by Czauderna, Frank, Santel, Ansgar, Hinz, Michael, Fechtner, Melanie, Durieux, Birgit, Fisch, Gerald, Leenders, Frauke, Arnold, Wolfgang, Giese, Klaus, Klippel, Anke, Kaufmann, Jörg

“…RNA interference (RNAi) is a powerful tool to induce loss‐of‐function phenotypes by inhibiting gene expression post‐transcriptionally. Synthetic short…”
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Depletion of protein kinase N3 (PKN3) impairs actin and adherens junctions dynamics and attenuates endothelial cell activation by Möpert, Kristin, Löffler, Kathrin, Röder, Nadine, Kaufmann, Jörg, Santel, Ansgar

“…Several pathways are involved in the control of endothelial cell morphology, endothelial permeability and function in order to maintain vascular homeostasis…”
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Knockdown of MTP18, a Novel Phosphatidylinositol 3-Kinase-dependent Protein, Affects Mitochondrial Morphology and Induces Apoptosis by Tondera, Daniel, Santel, Ansgar, Schwarzer, Rolf, Dames, Sybille, Giese, Klaus, Klippel, Anke, Kaufmann, Jörg

“…We identified a novel human cDNA encoding a mitochondrial protein, MTP18 (mitochondrial protein, 18 kDa) as a transcriptional downstream target of…”
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RNAi-mediated suppression of constitutive pulmonary gene expression by small interfering RNA in mice by Gutbier, Birgitt, Kube, Stefanie M, Reppe, Katrin, Santel, Ansgar, Lange, Christian, Kaufmann, Jörg, Suttorp, Norbert, Witzenrath, Martin

“…Abstract The ability of synthetic small interfering RNA (siRNA) to silence gene expression makes it a useful tool in biomedical research. However, effective…”
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Biceps Femoris Injury a Rarity: A Case Report by Strasser, Roland, Wein, Thomas, Wieder, Marc, Erhardt, Johannes, Kaufmann, Jörg

“…Isolated biceps femoris rupture is a rare injury associated with limitation in the function of the knee. We present a 65-year-old man who sustained an isolated…”
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First-in-human phase I study of the liposomal RNA interference therapeutic Atu027 in patients with advanced solid tumors by Schultheis, Beate, Strumberg, Dirk, Santel, Ansgar, Vank, Christiane, Gebhardt, Frank, Keil, Oliver, Lange, Christian, Giese, Klaus, Kaufmann, Jörg, Khan, Michael, Drevs, Joachim

“…Atu027 is a novel liposomal RNA interference therapeutic that includes a short-interfering RNA (siRNA), which silences expression of protein kinase N3 in the…”
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Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3, inhibits cancer progression by Aleku, Manuela, Schulz, Petra, Keil, Oliver, Santel, Ansgar, Schaeper, Ute, Dieckhoff, Britta, Janke, Oliver, Endruschat, Jens, Durieux, Birgit, Röder, Nadine, Löffler, Kathrin, Lange, Christian, Fechtner, Melanie, Möpert, Kristin, Fisch, Gerald, Dames, Sibylle, Arnold, Wolfgang, Jochims, Karin, Giese, Klaus, Wiedenmann, Bertram, Scholz, Arne, Kaufmann, Jörg

“…We have previously described a small interfering RNA (siRNA) delivery system (AtuPLEX) for RNA interference (RNAi) in the vasculature of mice. Here we report…”
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Intracellular localization of lipoplexed siRNA in vascular endothelial cells of different mouse tissues by Aleku, Manuela, Fisch, Gerald, Möpert, Kristin, Keil, Oliver, Arnold, Wolfgang, Kaufmann, Jörg, Santel, Ansgar

“…Liposomally formulated siRNA can be used for RNAi applications in vivo. Intravenous bolus administration of lipoplexed siRNA has been shown to reduce gene…”
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Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells by Czauderna, Frank, Fechtner, Melanie, Dames, Sibylle, Aygün, Hüseyin, Klippel, Anke, Pronk, Gijsbertus J., Giese, Klaus, Kaufmann, Jörg

“…Double‐stranded short interfering RNAs (siRNA) induce post‐transcriptional silencing in a variety of biological systems. In the present study we have…”
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Mechanism of Nanoparticle-Enhanced Turbidimetric Assays Applying Nanoparticles of Different Size and Immunoreactivity by Cölfen, Helmut, Völkel, Antje, Eda, Shinichi, Kobold, Uwe, Kaufmann, Jörg, Puhlmann, Angela, Göltner, Christine, Wachernig, Hanno

“…The mechanism of a novel assay technique for nanoparticle-enhanced immunoturbidimetric assays is investigated. In a mixture of latex particles of two different…”
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CIF150, a Human Cofactor for Transcription Factor IID-Dependent Initiator Function by Kaufmann, Jörg, Ahrens, Katharina, Koop, Ronald, Smale, Stephen T., Müller, Rolf

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase by SCHWARZER, Rolf, TONDERA, Daniel, ARNOLD, Wolfgang, GIESE, Klaus, KLIPPEL, Anke, KAUFMANN, Jörg

“…Cancer cells frequently evade apoptosis during tumorigenesis by acquiring mutations in apoptotic regulators. Chronic activation of the PI 3-kinase-Akt pathway…”
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Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia by Gutbier, Birgitt, Neuhauß, Anne-Kathrin, Reppe, Katrin, Ehrler, Carolin, Santel, Ansgar, Kaufmann, Jörg, Scholz, Markus, Weissmann, Norbert, Morawietz, Lars, Mitchell, Timothy J, Aliberti, Stefano, Hippenstiel, Stefan, Suttorp, Norbert, Witzenrath, Martin

“…During pneumonia, pathogen-host interaction evokes inflammation and lung barrier dysfunction. Tie2 activation by angiopoietin-1 reduces, whereas Tie2 blockade…”
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Phase I clinical development of Atu027, a siRNA formulation targeting PKN3 in patients with advanced solid tumors by Strumberg, Dirk, Schultheis, Beate, Traugott, Ulrich, Vank, Christiane, Santel, Ansgar, Keil, Oliver, Giese, Klaus, Kaufmann, Jörg, Drevs, Joachim

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