Search Results - "KAUFMAN, Dan S"

iPSC-Derived Natural Killer Cell Therapies - Expansion and Targeting by Goldenson, Benjamin H, Hor, Pooja, Kaufman, Dan S

“…Treatment of cancer with allogeneic natural killer (NK) cell therapies has seen rapid development, especially use against hematologic malignancies. Clinical…”
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Utilizing chimeric antigen receptors to direct natural killer cell activity by Hermanson, David L, Kaufman, Dan S

“…Natural killer (NK) cells represent an attractive lymphocyte population for cancer immunotherapy due to their ability to lyse tumor targets without prior…”
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Toward clinical therapies using hematopoietic cells derived from human pluripotent stem cells by Kaufman, Dan S.

“…Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) provide remarkable cellular platforms to better understand human hematopoiesis…”
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Cardiac Repair in a Porcine Model of Acute Myocardial Infarction with Human Induced Pluripotent Stem Cell-Derived Cardiovascular Cells by Ye, Lei, Chang, Ying-Hua, Xiong, Qiang, Zhang, Pengyuan, Zhang, Liying, Somasundaram, Porur, Lepley, Mike, Swingen, Cory, Su, Liping, Wendel, Jacqueline S., Guo, Jing, Jang, Albert, Rosenbush, Daniel, Greder, Lucas, Dutton, James R., Zhang, Jianhua, Kamp, Timothy J., Kaufman, Dan S., Ge, Ying, Zhang, Jianyi

“…Human induced pluripotent stem cells (hiPSCs) hold promise for myocardial repair following injury, but preclinical studies in large animal models are required…”
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Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity by Zhu, Huang, Blum, Robert H., Bernareggi, Davide, Ask, Eivind Heggernes, Wu, Zhengming, Hoel, Hanna Julie, Meng, Zhipeng, Wu, Chengsheng, Guan, Kun-Liang, Malmberg, Karl-Johan, Kaufman, Dan S.

“…Cytokine-inducible SH2-containing protein (CIS; encoded by the gene CISH) is a key negative regulator of interleukin-15 (IL-15) signaling in natural killer…”
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Induced Pluripotent Stem Cell‐Derived Natural Killer Cells for Treatment of Ovarian Cancer by Hermanson, David L., Bendzick, Laura, Pribyl, Lee, McCullar, Valarie, Vogel, Rachel Isaksson, Miller, Jeff S., Geller, Melissa A., Kaufman, Dan S.

“…Natural killer (NK) cells can provide effective immunotherapy for ovarian cancer. Here, we evaluated the ability of NK cells isolated from peripheral blood…”
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Identification of an ADAM17 cleavage region in human CD16 (FcγRIII) and the engineering of a non-cleavable version of the receptor in NK cells by Jing, Yawu, Ni, Zhenya, Wu, Jianming, Higgins, LeeAnn, Markowski, Todd W, Kaufman, Dan S, Walcheck, Bruce

“…CD16a and CD16b are IgG Fc receptors expressed by human natural killer (NK) cells and neutrophils, respectively. Both CD16 isoforms undergo a rapid…”
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Next-generation macrophages: repolarizing CAR-macrophages against cancer by Ebrahimabadi, Sima, Kaufman, Dan S

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CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity by Bernareggi, Davide, Xie, Qi, Prager, Briana C., Yun, Jiyoung, Cruz, Luisjesus S., Pham, Timothy V., Kim, William, Lee, Xiqing, Coffey, Michael, Zalfa, Cristina, Azmoon, Pardis, Zhu, Huang, Tamayo, Pablo, Rich, Jeremy N., Kaufman, Dan S.

“…Natural killer (NK) cells are known to mediate killing of various cancer types, but tumor cells can develop resistance mechanisms to escape NK cell-mediated…”
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Clinical‐Scale Derivation of Natural Killer Cells From Human Pluripotent Stem Cells for Cancer Therapy by Knorr, David A., Ni, Zhenya, Hermanson, David, Hexum, Melinda K., Bendzick, Laura, Cooper, Laurence J.N., Lee, Dean A., Kaufman, Dan S.

“…This study used a two‐stage culture system to efficiently produce natural killer (NK) cells from human embryonic stem cells (hESCs) and induced pluripotent…”
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Expression of a Recombinant High Affinity IgG Fc Receptor by Engineered NK Cells as a Docking Platform for Therapeutic mAbs to Target Cancer Cells by Snyder, Kristin M, Hullsiek, Robert, Mishra, Hemant K, Mendez, Daniel C, Li, Yunfang, Rogich, Allison, Kaufman, Dan S, Wu, Jianming, Walcheck, Bruce

“…Anti-tumor mAbs are the most widely used and characterized cancer immunotherapy. Despite having a significant impact on some malignancies, most cancer patients…”
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RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells by Ran, Dan, Shia, Wei-Jong, Lo, Miao-Chia, Fan, Jun-Bao, Knorr, David A., Ferrell, Patrick I., Ye, Zhaohui, Yan, Ming, Cheng, Linzhao, Kaufman, Dan S., Zhang, Dong-Er

“…Advancements in human pluripotent stem cell (hPSC) research have potential to revolutionize therapeutic transplantation. It has been demonstrated that…”
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Lineage‐specific differentiation of osteogenic progenitors from pluripotent stem cells reveals the FGF1‐RUNX2 association in neural crest‐derived osteoprogenitors by Kidwai, Fahad, Mui, Byron W. H., Arora, Deepika, Iqbal, Kulsum, Hockaday, Madison, Castro Diaz, Luis Fernandez, Cherman, Natasha, Martin, Daniel, Myneni, Vamsee D., Ahmad, Moaz, Futrega, Katarzyna, Ali, Sania, Merling, Randall K., Kaufman, Dan S., Lee, Janice, Robey, Pamela G.

“…Human pluripotent stem cells (hPSCs) can provide a platform to model bone organogenesis and disease. To reflect the developmental process of the human…”
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Umbilical Cord Blood and iPSC-Derived Natural Killer Cells Demonstrate Key Differences in Cytotoxic Activity and KIR Profiles by Goldenson, Benjamin H, Zhu, Huang, Wang, YunZu Michele, Heragu, Naveen, Bernareggi, Davide, Ruiz-Cisneros, Alessa, Bahena, Andres, Ask, Eivind Heggernes, Hoel, Hanna Julie, Malmberg, Karl-Johan, Kaufman, Dan S

“…Natural killer (NK) cells derived or isolated from different sources have been gaining in importance for cancer therapies. In this study, we evaluate and…”
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A Fibrin Patch‐Based Enhanced Delivery of Human Embryonic Stem Cell‐Derived Vascular Cell Transplantation in a Porcine Model of Postinfarction Left Ventricular Remodeling by Xiong, Qiang, Hill, Katherine L., Li, Qinglu, Suntharalingam, Piradeep, Mansoor, Abdul, Wang, Xiaohong, Jameel, Mohammad Nurulqadr, Zhang, Pengyuan, Swingen, Cory, Kaufman, Dan S., Zhang, Jianyi

“…It is unknown how to use human embryonic stem cell (hESC) to effectively treat hearts with postinfarction left ventricular (LV) remodeling. Using a porcine…”
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Engineered human pluripotent stem cell-derived natural killer cells: the next frontier for cancer immunotherapy by Zhu, Huang, Kaufman, Dan S.

“…Adoptive immunotherapy using immune effector cells has revolutionized cancer treatments with approval of two autologous chimeric antigen receptor (CAR) T cell…”
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Hematopoietic Engraftment of Human Embryonic Stem Cell‐Derived Cells Is Regulated by Recipient Innate Immunity by Tian, Xinghui, Woll, Petter S., Morris, Julie K., Linehan, Jonathan L., Kaufman, Dan S.

“…Human embryonic stem cells (hESCs) provide an important means to characterize early stages of hematopoietic development. However, the in vivo potential of…”
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Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity by Li, Ye, Hermanson, David L., Moriarity, Branden S., Kaufman, Dan S.

“…Chimeric antigen receptors (CARs) significantly enhance the anti-tumor activity of immune effector cells. Although most studies have evaluated CAR expression…”
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Human Pluripotent Stem Cells Produce Natural Killer Cells That Mediate Anti-HIV-1 Activity by Utilizing Diverse Cellular Mechanisms by ZHENYA NI, KNORR, David A, CLOUSER, Christine L, HEXUM, Melinda K, SOUTHERN, Peter, MANSKY, Louis M, PARK, In-Hyun, KAUFMAN, Dan S

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells by Woll, Petter S., Morris, Julie K., Painschab, Matt S., Marcus, Rebecca K., Kohn, Aimee D., Biechele, Travis L., Moon, Randall T., Kaufman, Dan S.

“…Human embryonic stem cells (hESCs) provide an important means to effectively study soluble and cell-bound mediators that regulate development of early blood…”
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