Search Results - "KATZ, A B"

Efficiency of signalling through cytokine receptors depends critically on receptor orientation by Syed, Rashid S, Reid, Scott W, Li, Cuiwei, Cheetham, Janet C, Aoki, Kenneth H, Liu, Beishan, Zhan, Hangjun, Osslund, Timothy D, Chirino, Arthur J, Zhang, Jiandong, Finer-Moore, Janet, Elliott, Steven, Sitney, Karen, Katz, Bradley A, Matthews, David J, Wendoloski, John J, Egrie, Joan, Stroud, Robert M

“…Human erythropoietin is a haematopoietic cytokine required for the differentiation and proliferation of precursor cells into red blood cells. It activates…”
Get full text

Development of Serine Protease Inhibitors Displaying a Multicentered Short (<2.3 Å) Hydrogen Bond Binding Mode:  Inhibitors of Urokinase-Type Plasminogen Activator and Factor Xa by Verner, Erik, Katz, Bradley A, Spencer, Jeffrey R, Allen, Darin, Hataye, Jason, Hruzewicz, Witold, Hui, Hon C, Kolesnikov, Aleksandr, Li, Yong, Luong, Christine, Martelli, Arnold, Radika, Kesavan, Rai, Roopa, She, Miles, Shrader, William, Sprengeler, Paul A, Trapp, Sean, Wang, Jing, Young, Wendy B, Mackman, Richard L

“…Novel scaffolds that bind to serine proteases through a unique network of short hydrogen bonds to the catalytic Ser195 have been developed. The resulting…”
Get full text

Exploiting Subsite S1 of Trypsin-Like Serine Proteases for Selectivity:  Potent and Selective Inhibitors of Urokinase-Type Plasminogen Activator by Mackman, Richard L, Katz, Bradley A, Breitenbucher, J. Guy, Hui, Hon C, Verner, Erik, Luong, Christine, Liu, Liang, Sprengeler, Paul A

“…A nonselective inhibitor of trypsin-like serine proteases, 2-(2-hydroxybiphenyl-3-yl)-1H-indole-5-carboxamidine (1) (Verner, E.; Katz, B. A.; Spencer, J.;…”
Get full text

A Partial Catalog of Proteins Secreted by Epidermal Keratinocytes in Culture by Katz, Anne B., Taichman, Lorne B.

“…Proteins secreted by epidermal keratinocytes are known to engage in functions other than those directly associated with barrier formation. We have used a…”
Get full text

Design of potent selective zinc-mediated serine protease inhibitors by Katz, Bradley A, Clark, James M, Finer-Moore, Janet S, Jenkins, Thomas E, Johnson, Charles R, Ross, Michael J, Luong, Christine, Moore, William R, Stroud, Robert M

“…Many serine proteases are targets for therapeutic intervention because they often play key roles in disease. Small molecule inhibitors of serine proteases with…”
Get full text

The crystallographically determined structures of atypical strained disulfides engineered into subtilisin by Katz, B A, Kossiakoff, A

“…The geometries of two disulfide bridges genetically engineered into subtilisin have been characterized by x-ray crystallography to determine the structural and…”
Get full text

Expression of human cathepsin K in Pichia pastoris and preliminary crystallographic studies of an inhibitor complex by Linnevers, Christopher J., Mcgrath, Mary E., Armstrong, Andy, Mistry, Firoz R., Barnes, Michael G., Klaus, Jeffrey L., Palmer, James T., Katz, Bradley A., Brömme, Dieter

“…Cathepsin K is a cysteine protease of the papain family, which is predominantly expressed in osteoclasts, and is regarded as a key protease in bone remodeling…”
Get full text

Epidermis as a Secretory Tissue: An In Vitro Tissue Model to Study Keratinocyte Secretion by Katz, Anne B., Taichman, Lorne B.

“…In addition to protective functions, keratinocytes secrete a variety of effector molecules that may have local or distant effects. To explore the secretory…”
Get full text

Retrovirus-Mediated Transduction of Cultured Epidermal Keratinocytes by Garlick, Jonathan A., Katz, Anne B., Fenjves, Elizabeth S., Taichman, Lorne B.

“…Retrovirus-mediated gene transfer is an efficient means of introducing and expressing exogenous gene(s) in many cell types including keratinocytes. However,…”
Get full text

Binding to Protein Targets of Peptidic Leads Discovered by Phage Display: Crystal Structures of Streptavidin-Bound Linear and Cyclic Peptide Ligands Containing the HPQ Sequence by Katz, Bradley A

“…The streptavidin-bound crystal structures of two disulfide-bridge cyclic peptides (cyclo-Ac-[CHPQGPPC]-NH2 and cyclo-Ac-[CHPQFC]-NH2) and of a linear peptide…”
Get full text

Crystal structure of recombinant human tissue kallikrein at 2.0 Å resolution by Katz, Bradley A., Liu, Beishan, Barnes, Micael, Springman, Eric B.

“…Human tissue kallikrein, a trypsin‐like serine protease involved in blood pressure regulation and inflammation processes, was expressed in a deglycosylated…”
Get full text

Binding of biotin to streptavidin stabilizes intersubunit salt bridges between Asp61 and His87 at low pH by Katz, Bradley A

“…The remarkable stability of the streptavidin tetramer towards subunit dissociation becomes even greater upon binding of biotin. At two equivalent extensive…”
Get full text

A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site by Katz, Bradley A, Elrod, Kyle, Luong, Christine, Rice, Mark J, Mackman, Richard L, Sprengeler, Paul A, Spencer, Jeffrey, Hataye, Jason, Janc, James, Link, John, Litvak, Joane, Rai, Roopa, Rice, Ken, Sideris, Steve, Verner, Erik, Young, Wendy

“…We describe a new serine protease inhibition motif in which binding is mediated by a cluster of very short hydrogen bonds (<2.3 Å) at the active site. This…”
Get full text

Recruiting Zn2+to Mediate Potent, Specific Inhibition of Serine Proteases by Katz, Bradley A., Luong, Christine

“…As regulators of ubiquitous biological processes, serine proteases can cause disease states when inappropriately expressed or regulated, and are thus rational…”
Get full text

Inhibitors of tryptase for the treatment of mast cell-mediated diseases by Rice, K D, Tanaka, R D, Katz, B A, Numerof, R P, Moore, W R

“…Human tryptase is a structurally unique and mast cell specific trypsin-like serine protease. Recent biological and immunological investigations have implicated…”
Get more information

A Novel Approach to Serine Protease Inhibition:  Kinetic Characterization of Inhibitors Whose Potencies and Selectivities Are Dramatically Enhanced by Zinc(II) by Janc, James W, Clark, James M, Warne, Robert L, Elrod, Kyle C, Katz, Bradley A, Moore, William R

“…Serine proteases play a role in a variety of disease states and thus are attractive targets for therapeutic intervention. We report the kinetic…”
Get full text

Development of potent and selective factor Xa inhibitors by RAI, Roopa, KOLESNIKOV, Aleksandr, ALLEN, Darin, CHEN, Xi, KATZ, Bradley A, LUONG, Christine, ELROD, Kyle, CREGAR, Lynne, YONG LI, YOUNG, Wendy B, LEAHY, Ellen, SPRENGELER, Paul A, VERNER, Erik, SHRADER, William D, BURGESS-HENRY, Jana, SANGALANG, Joan C

“…The development of potent and selective small molecule inhibitors of factor Xa is described…”
Get full text

Engineering a soluble extracellular erythropoietin receptor (EPObp) in Pichia pastoris to eliminate microheterogeneity, and its complex with erythropoietin by Zhan, Hangjun, Liu, Beishan, Reid, Scott W., Aoki, Kenneth H., Li, Cuiwei, Syed, Rashid S., Karkaria, Cyrus, Koe, Gary, Sitney, Karen, Hayenga, Kirk, Mistry, Firoz, Savel, Laura, Dreyer, Mark, Katz, Bradley A., Schreurs, Jolanda, Matthews, David J., Cheetham, Janet C., Egrie, Joan, Giebel, Lutz B., Stroud, Robert M.

“…The extracellular ligand-binding domain (EPObp) of the human EPO receptor (EPOR) was expressed both in CHO (Chinese Hamster Ovary) cells and in Pichia…”
Get full text

MMR Vaccination: A Potential Strategy to Reduce Severity and Mortality of COVID-19 Illness by Ashford, J. Wesson, Gold, Jeffrey E., Huenergardt, MaryJane A., Katz, Ronit B.A., Strand, Susanne E., Bolanos, Joe, Wheeler, Christopher J., Perry, George, Smith, Carr J., Steinman, Lawrence, Chen, Mike Y., Wang, Jeffrey C., Ashford, Clinton B., Roth, Walton T., Cheng, Jauhtai Joseph, Chao, Steven, Jennings, Jennifer, Sipple, Daniel, Yamamoto, Vicky, Kateb, Babak, Earnest, David L.

Get full text

Gastro-intestinal manifestations of urinary tract disease by KATZ, A B

Get more information