Search Results - "KATSUKI, Motoya"

Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells by Yana, Ikuo, Sagara, Hiroshi, Takaki, Satoshi, Takatsu, Kiyoshi, Nakamura, Kenji, Nakao, Kazuki, Katsuki, Motoya, Taniguchi, Shun-ichiro, Aoki, Takanori, Sato, Hiroshi, Weiss, Stephen J, Seiki, Motoharu

“…The membrane-anchored matrix metalloproteinase MT1-MMP (also known as Mmp14) plays a key role in the angiogenic process, but the mechanisms underlying its…”
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Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice by Takao, Keizo, Tanda, Koichi, Nakamura, Kenji, Kasahara, Jiro, Nakao, Kazuki, Katsuki, Motoya, Nakanishi, Kazuo, Yamasaki, Nobuyuki, Toyama, Keiko, Adachi, Minami, Umeda, Masahiro, Araki, Tsutomu, Fukunaga, Kohji, Kondo, Hisatake, Sakagami, Hiroyuki, Miyakawa, Tsuyoshi

“…Calcium-calmodulin dependent protein kinase IV (CaMKIV) is a protein kinase that activates the transcription factor CREB, the cyclic AMP-response element…”
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Targeted disruption of oncostatin M receptor results in altered hematopoiesis by Tanaka, Minoru, Hirabayashi, Yoko, Sekiguchi, Takashi, Inoue, Tohru, Katsuki, Motoya, Miyajima, Atsushi

“…Oncostatin M (OSM) is a multifunctional cytokine that belongs to the interleukin 6 (IL-6) family. As OSM is expressed in adult as well as embryonic…”
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mGluR1 in Cerebellar Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor Coordination by Ichise, Taeko, Kano, Masanobu, Hashimoto, Kouichi, Yanagihara, Dai, Nakao, Kazuki, Shigemoto, Ryuichi, Katsuki, Motoya, Aiba, Atsu

“…Targeted deletion of metabotropic glutamate receptor-subtype 1 (mGluR1) gene can cause defects in development and function in the cerebellum. We introduced the…”
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Cardiac Fibrosis in Mice Lacking Brain Natriuretic Peptide by Tamura, Naohisa, Ogawa, Yoshihiro, Chusho, Hideki, Nakamura, Kenji, Nakao, Kazuki, Suda, Michio, Kasahara, Masato, Hashimoto, Ryuju, Katsuura, Goro, Mukoyama, Masashi, Itoh, Hiroshi, Saito, Yoshihiko, Tanaka, Issei, Otani, Hiroki, Katsuki, Motoya, Nakao, Kazuwa

“…Cardiac fibrosis, defined as a proliferation of interstitial fibroblasts and biosynthesis of extracellular matrix components in the ventricles of the heart, is…”
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Dwarfism and Early Death in Mice Lacking C-Type Natriuretic Peptide by Chusho, Hideki, Tamura, Naohisa, Ogawa, Yoshihiro, Yasoda, Akihiro, Suda, Michio, Miyazawa, Takashi, Nakamura, Kenji, Nakao, Kazuki, Kurihara, Tatsuya, Komatsu, Yasato, Itoh, Hiroshi, Tanaka, Kiyoshi, Saito, Yoshihiko, Katsuki, Motoya, Nakao, Kazuwa

“…Longitudinal bone growth is determined by endochondral ossification that occurs as chondrocytes in the cartilaginous growth plate undergo proliferation,…”
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Overlapping Roles for Homeodomain-Interacting Protein Kinases Hipk1 and Hipk2 in the Mediation of Cell Growth in Response to Morphogenetic and Genotoxic Signals by Isono, Kyoichi, Nemoto, Kazumi, Li, Yuanyuan, Takada, Yuki, Suzuki, Rie, Katsuki, Motoya, Nakagawara, Akira, Koseki, Haruhiko

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Rac1 is required for the formation of three germ layers during gastrulation by SUGIHARA, K, NAKATSUJI, N, KATSUKI, M, NAKAMURA, K, NAKAO, K, HASHIMOTO, R, OTANI, H, SAKAGAMI, H, KONDO, H, NOZAWA, S, AIBA, A

“…The Rac1, a member of the Rho family proteins, regulates actin organization of cytoskeleton and cell adhesion. We used genetic analysis to elucidate the role…”
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Spontaneous Tumorigenesis in Mice Defective in the MTH1 Gene Encoding 8-Oxo-dGTPase by Tsuzuki, Teruhisa, Egashira, Akinori, Igarashi, Hisato, Iwakuma, Tomoo, Nakatsuru, Yoko, Tominaga, Yohei, Kawate, Hisaya, Nakao, Kazuki, Nakamura, Kenji, Ide, Fumio, Kura, Shinobu, Nakabeppu, Yusaku, Katsuki, Motoya, Ishikawa, Takatoshi, Sekiguchi, Mutsuo

“…Oxygen radicals, which can be produced through normal cellular metabolism, are thought to play an important role in mutagenesis and tumorigenesis. Among…”
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Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development by Nishinakamura, R, Matsumoto, Y, Nakao, K, Nakamura, K, Sato, A, Copeland, N G, Gilbert, D J, Jenkins, N A, Scully, S, Lacey, D L, Katsuki, M, Asashima, M, Yokota, T

“…SALL1 is a mammalian homolog of the Drosophila region-specific homeotic gene spalt ( sal ); heterozygous mutations in SALL1 in humans lead to Townes-Brocks…”
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Ras signaling directs endothelial specification of VEGFR2⁺ vascular progenitor cells by Kawasaki, Kyoko, Watabe, Tetsuro, Sase, Hitoshi, Hirashima, Masanori, Koide, Hiroshi, Morishita, Yasuyuki, Yuki, Keiko, Sasaoka, Toshikuni, Suda, Toshio, Katsuki, Motoya, Miyazono, Kohei, Miyazawa, Keiji

“…Vascular endothelial growth factor receptor 2 (VEGFR2) transmits signals of crucial importance to vasculogenesis, including proliferation, migration, and…”
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Membrane Fixation of Vascular Endothelial Growth Factor Receptor 1 Ligand-Binding Domain Is Important for Vasculogenesis and Angiogenesis in Mice by Hiratsuka, Sachie, Nakao, Kazuki, Nakamura, Kenji, Katsuki, Motoya, Maru, Yoshiro, Shibuya, Masabumi

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Decreased c‐kit function inhibits enhanced skin carcinogenesis in c‐Ha‐ras protooncogene transgenic mice by Muto, Satoru, Katsuki, Motoya, Horie, Shigeo

“…We previously showed that rasH2 transgenic mice carrying the human c‐Ha‐ras protooncogene are highly susceptible to chemical skin carcinogenesis. In the dermis…”
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Requirement of Phospholipase Cδ4 for the Zona Pellucida-Induced Acrosome Reaction by Fukami, Kiyoko, Nakao, Kazuki, Inoue, Takafumi, Kataoka, Yuki, Kurokawa, Manabu, Fissore, Rafael A., Nakamura, Kenji, Katsuki, Motoya, Mikoshiba, Katsuhiko, Yoshida, Nobuaki, Takenawa, Tadaomi

“…Several phospholipase C (PLC) isoforms have been found in male and female mammalian gametes, and splicing isoforms of PLCδ4 are predominantly expressed in…”
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Loss of teratogenic response to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) in mice lacking the Ah (dioxin) receptor by Mimura, Junsei, Yamashita, Keisuke, Nakamura, Kenji, Morita, Masanobu, Takagi, Toshio N., Nakao, Kazuki, Ema, Masatsugu, Sogawa, Kazuhiro, Yasuda, Mineo, Katsuki, Motoya, Fujii‐Kuriyama, Yoshiaki

“…Background: The aryl hydrocarbon receptor (AhR or dioxin receptor) is a ligand‐activated transcription factor that is considered to mediate pleiotropic…”
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K-ras is essential for the development of the mouse embryo by KOERA, K, NAKAMURA, K, NAKAO, K, MIYOSHI, J, TOYOSHIMA, K, HATTA, T, OTANI, H, AIBA, A, KATSUKI, M

“…ras genes encode members of the small GTP-binding proteins. Ras protein in highly conserved in various species from yeast to humans and plays a key role in…”
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Dopamine D1 Receptors Involved in Locomotor Activity and Accumbens Neural Responses to Prediction of Reward Associated with Place by Tran, Anh Hai, Tamura, Ryoi, Uwano, Teruko, Kobayashi, Tsuneyuki, Katsuki, Motoya, Ono, Taketoshi, Bureš, Jan

“…Predicting reward is essential in learning approach behaviors. Dopaminergic activity has been implicated in reward, movement, and cognitive processes, all…”
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Vascular Endothelial Growth Factor A (VEGF-A) Is Involved in Guidance of VEGF Receptor-Positive Cells to the Anterior Portion of Early Embryos by Hiratsuka, Sachie, Kataoka, Yuki, Nakao, Kazuki, Nakamura, Kenji, Morikawa, Shunichi, Tanaka, Satoshi, Katsuki, Motoya, Maru, Yoshiro, Shibuya, Masabumi

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Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis by ISE, K, NAKAMURA, K, KATSUKI, M, NAKAO, K, SHIMIZU, S, HARADA, H, ICHISE, T, MIYOSHI, J, GONDO, Y, ISHIKAWA, T, AIBA, A

“…To clarify the role of the H-Ras in vivo, we generated H-ras null mutant mice by gene targeting. In spite of the importance of the Ras in cell proliferation…”
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Rapid induction of skin tumors in human but not mouse c‐Ha‐ras proto‐oncogene transgenic mice by chemical carcinogenesis by Muto, Satoru, Katsuki, Motoya, Horie, Shigeo

“…The rasH2 transgenic mice carry human c‐Ha‐ras proto‐oncogene, and are highly susceptible to chemical carcinogenesis. Previous studies showed that the mutation…”
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