Search Results - "KATSUBE, Nobuo"

Astrocytic Activation and Delayed Infarct Expansion After Permanent Focal Ischemia in Rats. Part II: Suppression of Astrocytic Activation by a Novel Agent (R)-(-)-2-propyloctanoic acid (ONO-2506) Leads to Mitigation of Delayed Infarct Expansion and Early Improvement of Neurologic Deficits by Tateishi, Narito, Mori, Takashi, Kagamiishi, Yoshifumi, Satoh, Souichi, Katsube, Nobuo, Morikawa, Eiharu, Morimoto, Tadashi, Matsui, Toru, Asano, Takao

“…A novel agent, (R)-(−)-2-propyloctanoic acid (ONO-2506), has a unique property in that it modulates functions of activated cultured astrocytes, including…”
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Lithium protects rat cerebellar granule cells against apoptosis induced by anticonvulsants, phenytoin and carbamazepine by Nonaka, S, Katsube, N, Chuang, D M

“…We have studied the neuroprotective actions of lithium against various insults in cultured cerebellar granule cells of rats. The anticonvulsants, phenytoin and…”
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Nuclear localization of overexpressed glyceraldehyde-3-phosphate dehydrogenase in cultured cerebellar neurons undergoing apoptosis by Ishitani, R, Tanaka, M, Sunaga, K, Katsube, N, Chuang, D M

“…We recently reported that overexpression of glyceraldehyde-3-phosphate dehydrogenase (GAPDH; EC 1.2.1.12) is directly involved in cytosine arabinonucleoside…”
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Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewy body-like inclusions by Tsuchiya, Katsumi, Tajima, Hisao, Kuwae, Toyoyasu, Takeshima, Takao, Nakano, Toshiya, Tanaka, Masaharu, Sunaga, Katsuyoshi, Fukuhara, Yoko, Nakashima, Kenji, Ohama, Eisaku, Mochizuki, Hideki, Mizuno, Yoshikuni, Katsube, Nobuo, Ishitani, Ryoichi

“…Glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) has long been recognized as a classical glycolytic protein; however, previous studies by our group and others…”
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Involvement of Cathepsin E in Exogenous Antigen Processing in Primary Cultured Murine Microglia by Nishioku, Tsuyoshi, Hashimoto, Koichi, Yamashita, Keizo, Liou, Shyh-Yuh, Kagamiishi, Yoshifumi, Maegawa, Hitoshi, Katsube, Nobuo, Peters, Christoph, von Figura, Kurt, Saftig, Paul, Katunuma, Nobuhiko, Yamamoto, Kenji, Nakanishi, Hiroshi

“…We have attempted to elucidate an involvement of cathepsin E (CE) in major histocompatibility complex class II-mediated antigen presentation by microglia. In…”
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Thromboxane A2 Up-Regulates Neutrophil Elastase Release in Syrian Hamsters With Trinitrobenzene Sulfonic Acid-Induced Colitis by Hirota, Yasushi, Suzuki, Mikie, Katsube, Nobuo

“…Neutrophil elastase (NE) is a factor that aggravates colitis. We investigated the influence of thromboxane A2 (TXA2) and leukotriene B4 (LTB4) on NE release in…”
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Attenuation of a delayed increase in the extracellular glutamate level in the peri-infarct area following focal cerebral ischemia by a novel agent ONO-2506 by Mori, Takashi, Tateishi, Narito, Kagamiishi, Yoshifumi, Shimoda, Taiji, Satoh, Souichi, Ono, Sakiko, Katsube, Nobuo, Asano, Takao

“…A novel agent, ONO-2506 [( R)-(−)-2-propyloctanoic acid, ONO Pharmaceutical Co. Ltd.] was previously shown to mitigate delayed infarct expansion through…”
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Disclosure of a pro-apoptotic glyceraldehyde-3-phosphate dehydrogenase promoter: anti-dementia drugs depress its activation in apoptosis by Tsuchiya, Katsumi, Tajima, Hisao, Yamada, Mitsunori, Takahashi, Hitoshi, Kuwae, Toyoyasu, Sunaga, Katsuyoshi, Katsube, Nobuo, Ishitani, Ryoichi

“…Overexpression and subsequent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is involved in neuronal apoptosis induced by several…”
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Proapoptotic protein glyceraldehyde-3-phosphate dehydrogenase: a possible site of action of antiapoptotic drugs by Ishitani, Ryoichi, Tajima, Hisao, Takata, Hiroyuki, Tsuchiya, Katsumi, Kuwae, Toyoyasu, Yamada, Mitsunori, Takahashi, Hitoshi, Tatton, Nadine A., Katsube, Nobuo

“…Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has long been recognized as a classical glycolytic protein and has been used as a “housekeeping” gene in…”
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ONO-1603, a potential antidementia drug, delays age-induced apoptosis and suppresses overexpression of glyceraldehyde-3-phosphate dehydrogenase in cultured central nervous system neurons by Katsube, N, Sunaga, K, Aishita, H, Chuang, D M, Ishitani, R

“…Primary cultures of rat cerebral cortical cells and cerebellar granule cells die by an apoptotic mechanism after more than 2 weeks in cultures in the absence…”
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Induction of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Expression in Rat Brain After Focal Ischemia/Reperfusion by Tanaka, Ryota, Mochizuki, Hideki, Suzuki, Asuka, Katsube, Nobuo, Ishitani, Ryoichi, Mizuno, Yoshikuni, Urabe, Takao

“…Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a glycolytic enzyme, has been recently identified to be involved in the initiation of neuronal apoptosis. To…”
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Model of neuropathic intermittent claudication in the rat: methodology and application by Takenobu, Yoshifumi, Katsube, Nobuo, Marsala, Martin, Kondo, Kigen

“…In the present study we characterize a rat neurogenic intermittent claudication model which was accomplished by placing two pieces of silicone rubber of…”
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Overexpression of Glyceraldehyde-3-phospahe Dehydrogenase Is Not Involved in 5-Hydroxytryptamine (5-HT)-Induced Necrosis in Cultured Cerebrocortical Neurons by Tajima, Hisao, Sunaga, Katsuyoshi, Tanaka, Masaharu, Kuwae, Toyoyasu, Katsube, Nobuo

“…Cerebrocortical cell cultures were prepared from 1-d-old rats. On post-culture day 6, 5-hydroxytryptamine (5-HT) was added to the medium and cells were exposed…”
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Effects of a Selective Inhibitor of Inducible Nitric Oxide Synthase, ONO-1714, on Experimental Hemodialysis-Related Hypotension in Renal Dysfunctional Dogs by Komeno, Masaharu, Akimoto, Akira, Fujita, Tsuneo, Katsube, Nobuo

“…The effect of a selective inducible nitric oxide synthase inhibitor, ONO-1714 ((1S,5S,6R,7R)-7-chloro-3-imino-5-methyl-2-azabicyclo[4.1.0]heptane…”
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l-Cysteine based N-type calcium channel blockers: structure–activity relationships of the C-terminal lipophilic moiety, and oral analgesic efficacy in rat pain models by Seko, Takuya, Kato, Masashi, Kohno, Hiroshi, Ono, Shizuka, Hashimura, Kazuya, Takenobu, Yoshifumi, Takimizu, Hideyuki, Nakai, Katsuhiko, Maegawa, Hitoshi, Katsube, Nobuo, Toda, Masaaki

“…This study was performed to determine the structure–activity relationships (SAR) of l-cysteine based N-type calcium channel blockers. Basic nitrogen was…”
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Structure-activity study of L-cysteine-based N-type calcium channel blockers: Optimization of N- and C-terminal substituents by SEKO, Takuya, KATO, Masashi, KOHNO, Hiroshi, ONO, Shizuka, HASHIMURA, Kazuya, TAKIMIZU, Hideyuki, NAKAI, Katsuhiko, MAEGAWA, Hitoshi, KATSUBE, Nobuo, TODA, Masaaki

“…Synthesis and structure-activity relationship (SAR) studies of L-cysteine-based N-type calcium channel blockers are described. In the course of exploring SAR…”
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Vasopressin-Stimulated Release of Atriopeptin: Endocrine Antagonists in Fluid Homeostasis by Manning, Pamela T., Schwartz, David, Katsube, Nobuo C., Holmberg, Sandra W., Needleman, Philip

“…Administration of pharmacological doses of arginine-vasopressin, related peptides, and other pressor agents induced a profound release of atriopeptin…”
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Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters by Hirota, Y. (Ono Pharmaceutical Co. Ltd., Mikuni, Fukui (Japan)), Suzuki, M, Yamaguchi, K, Fujita, T, Katsube, N

“…Neutrophil elastase (NE) released from neutrophils during inflammation is related to tissue disturbance and organ failure. We investigated the effects of an…”
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Colonic Ulceration and Increase of Neutrophil Elastase Activity in the Acetic Acid-Induced Colitis Model in Syrian Hamsters by HIROTA, Yasushi, SUZUKI, Mikie, YAMAGUCHI, Kojiro, FUJITA, Tsuneo, KATSUBE, Nobuo

“…A novel colitis model using Syrian hamsters was developed. Colitis was induced by intracolonic administration of 1% acetic acid, and the ulcer area, tissue…”
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Overexpression of Glyceraldehyde-3-phospahe Dehydrogenase Is Not Involved in 5-Hydroxytryptamine (5-HT)-Induced Necrosis in Cultured Cerebrocortical Neurons by Hisao TAJIMA, Katsuyoshi SUNAGA, Masaharu TANAKA, Toyoyasu KUWAE, Nobuo KATSUBE

“…Cerebrocortical cell cultures were prepared from 1-d-old rats. On post-culture day 6, 5-hydroxytryptamine (5-HT) was added to the medium and cells were exposed…”
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