Search Results - "KATSOYANNIS, P. G"

Hierarchical Protein Folding:  Asymmetric Unfolding of an Insulin Analogue Lacking the A7−B7 Interchain Disulfide Bridge by Hua, Qing-Xin, Nakagawa, Satoe H, Jia, Wenhua, Hu, Shi-Quan, Chu, Ying-Chi, Katsoyannis, Panayotis G, Weiss, Michael A

“…The landscape paradigm of protein folding can enable preferred pathways on a funnel-like energy surface. Hierarchical preferences may be manifest as a…”
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Hierarchical Protein “Un-Design”:  Insulin's Intrachain Disulfide Bridge Tethers a Recognition α-Helix by Weiss, Michael A, Hua, Qing-Xin, Jia, Wenhua, Chu, Ying-Chi, Wang, Run-Ying, Katsoyannis, Panayotis G

“…A hierarchical pathway of protein folding can enable segmental unfolding by design. A monomeric insulin analogue containing pairwise substitution of internal…”
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Isotope-Edited Raman Spectroscopy of Proteins:  A General Strategy To Probe Individual Peptide Bonds with Application to Insulin by Dong, Jian, Wan, Zhu-Li, Chu, Ying-Chi, Nakagawa, Satoe N, Katsoyannis, Panayotis G, Weiss, Michael A, Carey, Paul R

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Cross-linking of a B25 azidophenylalanine insulin derivative to the carboxyl-terminal region of the alpha-subunit of the insulin receptor. Identification of a new insulin-binding domain in the insulin receptor by Kurose, T, Pashmforoush, M, Yoshimasa, Y, Carroll, R, Schwartz, G P, Burke, G T, Katsoyannis, P G, Steiner, D F

“…To identify a site within the insulin receptor ectodomain which forms a binding pocket for B25 Phe and is responsible for initiating conformational changes…”
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A Superactive Insulin: [B 10-aspartic Acid]Insulin(Human) by Schwartz, Gerald P., Burke, G. Thompson, Katsoyannis, Panayotis G.

“…The genetic basis for a case of familial hyperproinsulinemia has been elucidated recently. It involves a single point mutation in the proinsulin gene resulting…”
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Modulation of insulinlike growth factor I binding to human fibroblast monolayer cultures by insulinlike. Growth factor carrier proteins released to the incubation media by DE VROEDE, M. A, TSENG, L. Y.-H, KATSOYANNIS, P. G, NISSLEY, S. P, RECHLER, M. M

“…The relative contributions of type I and type II insulinlike growth factor (IGF) receptors and IGF carrier proteins to the binding of IGF-I tracer to cultured…”
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A Highly Potent Insulin: Des-(B26-B30)-[AspB10,Tyr$^{\text{B}25}$< /latex>-NH2]insulin(human) by Schwartz, Gerald P., Burke, G. Thompson, Katsoyannis, Panayotis G.

“…An insulin analogue that embodies two distinct structural modifications, each of which independently increases insulin activity, has been synthesized and…”
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Diabetes-Associated Mutations in Insulin:  Consecutive Residues in the B Chain Contact Distinct Domains of the Insulin Receptor by Xu, Bin, Hu, Shi-Quan, Chu, Ying-Chi, Huang, Kun, Nakagawa, Satoe H, Whittaker, Jonathan, Katsoyannis, Panayotis G, Weiss, Michael A

“…How insulin binds to and activates the insulin receptor has long been the subject of speculation. Of particular interest are invariant phenylalanine residues…”
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Steric requirements at position B12 for high biological activity in insulin by Hu, Shi Quan, Burke, G. Thompson, Schwartz, Gerald P, Ferderigos, Nicolaos, Ross, J. B. Alexander, Katsoyannis, Panayotis G

“…The alpha-helix formed by the amino acid residues 9-19 of the B-chain of insulin is involved in the stabilization of its three-dimensional structure. We have…”
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Hybrid Molecules Containing the B-Domain of Insulin-Like Growth Factor I are Recognized by Carrier Proteins of the Growth Factor by De Vroede, Monique A., Rechler, Matthew M., Nissley, S. Peter, Joshi, Satish, Burke, G. Thompson, Katsoyannis, Panayotis G.

“…The insulin-like growth factors (IGFs) are polypeptides in plasma that are chemically related to insulin and have mitogenic and insulin-like activity. Unlike…”
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Superactive insulins by Burke, G T, Hu, S Q, Ohta, N, Schwartz, G P, Zong, L, Katsoyannis, P G

“…The substitution of aspartic acid for the naturally-occurring histidine residue in position B10 in human insulin results in an insulin analogue which displays…”
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Mapping the Functional Surface of Insulin by Design: Structure and Function of a Novel A-Chain Analogue by Hua, Qing-Xin, Hu, Shi-Quan, Frank, Bruce H., Jia, Wenhua, Chu, Ying-Chi, Wang, Shu-Hua, Burke, G.Thompson, Katsoyannis, Panayotis G., Weiss, Michael A.

“…Functional surfaces of a protein are often mapped by combination of X-ray crystallography and mutagenesis. Such studies of insulin have yielded paradoxical…”
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Activities of Monomeric Insulin Analogs at Position A8 Are Uncorrelated with Their Thermodynamic Stabilities by Weiss, Michael A., Hua, Qing-Xin, Jia, Wenhua, Nakagawa, Satoe H., Chu, Ying-Chi, Hu, Shi-Quan, Katsoyannis, Panayotis G.

“…Previous studies have demonstrated that the potency and thermodynamic stability of human insulin are enhanced in concert by substitution of ThrA8 by arginine…”
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Synthesis of Insulin by Katsoyannis, P G

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Insulin Synthesis by Recombination of A and B Chains: A Highly Efficient Method by Katsoyannis, Panayotis G., Tometsko, Andrew

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Elongation of the interchain disulfide bridges of insulin. A synthetic analog by Cosmatos, A, Katsoyannis, P G

“…The sythesis and isolation in purified form of an analog of insulin with the interchain disulfide bridges elongated by a methylene group is described. This…”
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Synthesis of an insulin-like compound consisting of the A chain of insulin and a B chain corresponding to the B domain of human insulin-like growth factor I by Joshi, Satish, Burke, G. Thompson, Katsoyannis, Panayotis G.

“…An insulin-like hybrid molecule consisting of the A chain of insulin and a B chain corresponding to the B domain of human insulin-like growth factor I (growth…”
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Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures by Hua, Qing-Xin, Hu, Shi-Quan, Jia, Wenhua, Chu, Ying-Chi, Burke, G.Thompson, Wang, Shu-Hua, Wang, Run-Ying, Katsoyannis, Panayotis G., Weiss, Michael A.

“…Protein minimization highlights essential determinants of structure and function. Minimal models of proinsulin and insulin-like growth factor I contain…”
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Determinants of growth-promoting activity reside in the A-domain of insulin-like growth factor I by Chen, Zhen Zhen, Schwartz, Gerald P, Zong, Lin, Burke, G. Thompson, Chanley, Jacob D, Katsoyannis, Panayotis G

“…A two-chain, disulfide linked, insulin-like compound embodying the A-domain of insulin-like growth factor I (IGF-I) and the B-chain of insulin has been…”
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Mitogenic activity and receptor reactivity of hybrid molecules containing portions of the insulin-like growth factor I (IGF-I), IGF-II, and insulin molecules by De Vroede, M. A., Rechler, M. M., Nissley, S. P., Ogawa, H., Joshi, S., Burke, G. T., Katsoyannis, P. G.

“…Mitogenic activity and receptor reactivity of hybrid molecules containing portions of the insulin-like growth factor I (IGF-I), IGF-II, and insulin molecules…”
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