Search Results - "KATSETOS, Christos D"

Tubulins as therapeutic targets in cancer: from bench to bedside by Katsetos, Christos D, Dráber, Pavel

“…Tubulin is the target of some of the most widely used and time-honored anticancer tubulin-binding agents (TBAs). The clinical usefulness of many TBAs has been…”
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Astrocyte senescence as a component of Alzheimer's disease by Bhat, Rekha, Crowe, Elizabeth P, Bitto, Alessandro, Moh, Michelle, Katsetos, Christos D, Garcia, Fernando U, Johnson, Frederick Bradley, Trojanowski, John Q, Sell, Christian, Torres, Claudio

“…Aging is the main risk factor for Alzheimer's disease (AD); however, the aspects of the aging process that predispose the brain to the development of AD are…”
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Mitochondrial Dysfunction in Neuromuscular Disorders by Katsetos, Christos D., MD, PhD, FRCPath, Koutzaki, Sirma, MS, Melvin, Joseph J., DO

“…This review deciphers aspects of mitochondrial (mt) dysfunction among nosologically, pathologically, and genetically diverse diseases of the skeletal muscle,…”
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Experimental Studies in Epilepsy: Immunologic and Inflammatory Mechanisms by Legido, Agustín, MD, PhD, MBA, Katsetos, Christos D., MD, PhD, FRCPath

“…In this article, we review the literature based on experimental studies lending credence to a relationship between epilepsy and immune-mediated mechanisms…”
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Theiler's Virus Infection: a Model for Multiple Sclerosis by OLESZAK, Emilia L, CHANG, J. Robert, FRIEDMAN, Herman, KATSETOS, Christos D, PLATSOUCAS, Chris D

“…Classifications Services CMR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Targeting βIII-tubulin in glioblastoma multiforme: from cell biology and histopathology to cancer therapeutics by Katsetos, Christos D, Draber, Pavel, Kavallaris, Maria

“…Glioblastoma multiforme (GBM) is the most common, aggressive, and chemorefractory brain tumor in human adults. Notwithstanding significant discoveries in the…”
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Mitochondrial Dysfunction in Gliomas by Katsetos, Christos D., MD, PhD, FRCPath, Anni, Helen, PhD, Dráber, Pavel, PhD

“…Mitochondrial (mt) dysfunction in gliomas has been linked to abnormalities of mt energy metabolism, marked by a metabolic shift from oxidative phosphorylation…”
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Emerging Microtubule Targets in Glioma Therapy by Katsetos, Christos D., MD, PhD, FRCPath, FRCP Edin, Reginato, Mauricio J., PhD, Baas, Peter W., PhD, D’Agostino, Luca, PhD, Legido, Agustin, MD, PhD, Tuszyn´ski, Jack A., PhD, Dráberová, Eduarda, PhD, Dráber, Pavel, PhD

“…Major advances in the genomics and epigenomics of diffuse gliomas and glioblastoma to date have not been translated into effective therapy, necessitating…”
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Microtubule-Severing ATPase Spastin in Glioblastoma: Increased Expression in Human Glioblastoma Cell Lines and Inverse Roles in Cell Motility and Proliferation by Dráberová, Eduarda, Vinopal, Stanislav, Morfini, Gerardo, Liu, Pei S, Sládková, Vladimíra, Sulimenko, Tetyana, Burns, Matthew R, Solowska, Joanna, Kulandaivel, Kandan, de Chadarévian, Jean-Pierre, Legido, Agustin, Mörk, Sverre J, Janáček, Jiří, Baas, Peter W, Dráber, Pavel, Katsetos, Christos D

“…We studied the expression and distribution of the microtubule-severing enzyme spastin in 3 human glioblastoma cell lines (U87MG, U138MG, and T98G) and in…”
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Childhood Primary Angiitis of the Central Nervous System With Metachronous Hemorrhagic Infarcts: A Postmortem Study With Clinicopathologic Correlation by Katsetos, Christos D., MD, PhD, FRCPath, Poletto, Erica, MD, Kasmire, Kathryn E., MD, Walleigh, Diana, MD, Kumar, Indira, MD, Pascasio, Judy Mae, MD, Legido, Agustin, MD, PhD, MBA, Goldsmith, Donald P., MD

“…This neuropathologic case study illustrates the discovery of metachronous hemorrhagic infarcts insinuating round mass-like lesions by magnetic resonance…”
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O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation by Ciraku, Lorela, Bacigalupa, Zachary A., Ju, Jing, Moeller, Rebecca A., Le Minh, Giang, Lee, Rusia H., Smith, Michael D., Ferrer, Christina M., Trefely, Sophie, Izzo, Luke T., Doan, Mary T., Gocal, Wiktoria A., D’Agostino, Luca, Shi, Wenyin, Jackson, Joshua G., Katsetos, Christos D., Wellen, Kathryn E., Snyder, Nathaniel W., Reginato, Mauricio J.

“…Glioblastomas (GBMs) preferentially generate acetyl-CoA from acetate as a fuel source to promote tumor growth. O-GlcNAcylation has been shown to be elevated by…”
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Brainstem Tegmental Necrosis and Olivary Hypoplasia: Raising Awareness of a Rare Neuropathologic Correlate of Congenital Apnea by Katsetos, Christos D., MD, PhD, FRCPath, Anderson, Carol E., MD, Guzman, Miguel A., MD, Pascasio, Judy Mae, MD, de Chadarévian, Jean-Pierre, MD, FRCPC, Legido, Agustin, MD, PhD, MBA

“…This case study describes an instance of death in an early term female newborn with congenital apnea in the clinical setting of multiple congenital anomalies…”
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Differential expression of human γ‐tubulin isotypes during neuronal development and oxidative stress points to a γ‐tubulin‐2 prosurvival function by Dráberová, Eduarda, Sulimenko, Vadym, Vinopal, Stanislav, Sulimenko, Tetyana, Sládková, Vladimíra, D'Agostino, Luca, Sobol, Margaryta, Hozák, Pavel, Křen, Leoš, Katsetos, Christos D., Dráber, Pavel

“…ABSTRACT γ‐Tubulins are highly conserved members of the tubulin superfamily essential for microtubule nucleation. Humans possess 2 γ‐tubulin genes. It is…”
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Class III β-Tubulin Isotype: A Key Cytoskeletal Protein at the Crossroads of Developmental Neurobiology and Tumor Neuropathology by Katsetos, Christos D., Legido, Agustin, Perentes, Elias, Mörk, Sverre J.

“…The expression of the cytoskeletal protein class III β-tubulin isotype is reviewed in the context of human central nervous system development and neoplasia…”
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Emerging Molecularly-Targeted Therapeutic Strategies in Brain Cancer. Introduction by Katsetos, Christos D

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Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. I. class III β-tubulin by Katsetos, Christos D., Dráberová, Eduarda, Legido, Agustin, Dumontet, Charles, Dráber, Pavel

“…Glioblastoma multiforme (GBM) is the most common and deadliest form of primary brain cancer in adults. Despite advances in molecular biology and genetics of…”
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Detection of JC Polyomavirus DNA Sequences and Cellular Localization of T-Antigen and Agnoprotein in Oligodendrogliomas by Del Valle, Luis, Enam, Sahnila, Lara, César, Ortiz-Hidalgo, Carlos, Katsetos, Christos D, Khalili, Kamel

“…Purpose: Productive infection of the human neurotropic polyomavirus JCPyV in oligodendrocytes leads to the development of progressive multifocal…”
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Nuclear γ-tubulin associates with nucleoli and interacts with tumor suppressor protein C53 by Hořejší, Barbora, Vinopal, Stanislav, Sládková, Vladimíra, Dráberová, Eduarda, Sulimenko, Vadym, Sulimenko, Tetyana, Vosecká, Věra, Philimonenko, Anatoly, Hozák, Pavel, Katsetos, Christos D., Dráber, Pavel

“…γ‐Tubulin is assumed to be a typical cytosolic protein necessary for nucleation of microtubules from microtubule organizing centers. Using immunolocalization…”
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Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. II. γ-tubulin by Katsetos, Christos D., Dráberová, Eduarda, Legido, Agustin, Dráber, Pavel

“…Glioblastoma multiforme (GBM) is the most common and deadliest form of primary brain cancer in adults. Despite advances in molecular biology and genetics of…”
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Expression of γ-tubulin in non-small cell lung cancer and effect on patient survival by Maounis, Nicoletta F, Dráberová, Eduarda, Trakas, Nikos, Chorti, Maria, Riga, Dimitra, Tzannis, Kimon, Kanakis, Meletis, Voralu, Kirtanaa, Ellina, Eleni, Mahera, Eleni, Demonakou, Maria, Lioulias, Achilleas, Dráber, Pavel, Katsetos, Christos D

“…It has been reported that overexpression and altered compartmentalization of γ-tubulin may contribute to tumorigenesis and tumor aggressiveness in a variety of…”
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