Search Results - "KATOVICH, M. J"

Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis by Bruce, E, Shenoy, V, Rathinasabapathy, A, Espejo, A, Horowitz, A, Oswalt, A, Francis, J, Nair, A, Unger, T, Raizada, M K, Steckelings, U M, Sumners, C, Katovich, M J

“…Background and Purpose Pulmonary hypertension (PH) is a devastating disease characterized by increased pulmonary arterial pressure, which progressively leads…”
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Permanent cardiovascular protection from hypertension by the AT(1) receptor antisense gene therapy in hypertensive rat offspring by Reaves, P Y, Gelband, C H, Wang, H, Yang, H, Lu, D, Berecek, K H, Katovich, M J, Raizada, M K

“…Our previous studies have demonstrated that the introduction of angiotensin II type I receptor antisense (AT(1)R-AS) cDNA by a retrovirally mediated delivery…”
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Chronic Control of High Blood Pressure in the Spontaneously Hypertensive Rat by Delivery of Angiotensin Type 1 Receptor Antisense by Iyer, Shridhar N., Lu, Di, Katovich, Michael J., Raizada, Mohan K.

“…The renin-angiotensin system plays a crucial role in the development and establishment of the hypertensive state in the spontaneously hypertensive (SH) rat…”
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17β-Estradiol modulates local cardiac renin-angiotensin system to prevent cardiac remodeling in the DOCA-salt model of hypertension in rats by Shenoy, V., Grobe, J.L., Qi, Y., Ferreira, A.J., Fraga-Silva, R.A., Collamat, G., Bruce, E., Katovich, M.J.

“…Ventricular remodeling can play a detrimental role in the progression of cardiovascular diseases, leading to heart failure. The current study was designed to…”
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Losartan Versus Gene Therapy: Chronic Control of High Blood Pressure in Spontaneously Hypertensive Rats by Lu, Di, Raizada, Mohan K, Iyer, Shridhar, Reaves, Phyllis, Yang, Hong, Katovich, Michael J

“…Interruption of the renin-angiotensin system by pharmacological manipulations attenuates high blood pressure (BP) in the spontaneously hypertensive rat (SHR)…”
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Targeting of the renin-angiotensin system by antisense gene therapy: a possible strategy for the long-term control of hypertension by RAIZADA, M. K, FRANCIS, S. C, HONGWEI WANG, GELBAND, C. H, REAVES, P. Y, KATOVICH, M. J

“…Traditional pharmacological agents have been successfully used for the treatment of hypertension for a number of decades. However, this therapeutic regimen has…”
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Pharmacokinetics and metabolism of [14C]dichloroacetate in male sprague-dawley rats: Identification of glycine conjugates, including hippurate, as urinary metabolites of dichloroacetate by JAMES, M. O, ZIMENG YAN, CORNETT, R, JAYANTI, V. M. K. M, HENDERSON, G. N, DAVYDOVA, N, KATOVICH, M. J, POLLOCK, B, STACPOOLE, P. W

“…Pathways of metabolism of dichloroacetate (DCA), an investigational drug for the treatment of lactic acidosis in humans and a rodent hepatocarcinogen, are…”
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Sustained Inhibition of Angiotensin I-Converting Enzyme (ACE) Expression and Long-Term Antihypertensive Action by Virally Mediated Delivery of ACE Antisense cDNA by Wang, Hongwei, Katovich, Michael J, Gelband, Craig H, Reaves, Phyllis Y, Phillips, M Ian, Raizada, Mohan K

“…Angiotensin I-converting enzyme (ACE) inhibitors have been proven to be highly effective and are for the most part the drugs of choice in the treatment and…”
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Effect of Acute and Chronic Losartan Treatment on Glucose Tolerance and Insulin Sensitivity in Fructose-Fed Rats by Iyer, Shridhar N, Katovich, Michael J

“…The purpose of this study was to evaluate the role of angiotensin II (AII) in fructose-treated rats by assessing the effects of acute and chronic losartan…”
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Body fluid distribution in rats with cold-induced hypertension by ZHONGJIE SUN, CADE, R, KATOVICH, M. J, FREGLY, M. J

“…The purpose of this experiment was to determine body fluid distribution during chronic cold exposure and to further understand the mechanism of cold-induced…”
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Fructose feeding in rats is not associated with sodium retention by Iyer, Shridhar N., Katovich, Michael J.

“…Chronic fructose treatment in rats repeatedly has been shown to elevate blood pressure associated with insulin resistance and hyperinsulinemia. Activation of…”
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Effect of restraint on drug-induced changes in skin and core temperature in biotelemetered rats by Wright, Bruce E., Katovich, Michael J.

“…Temperature homeostasis is modulated by a number of neuroendocrine control systems. Both angiotensin II and isoproterenol have been shown to increase skin…”
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Effect of chronic losartan potassium treatment on fructose-induced hypertension by Iyer, S N, Katovich, M J

“…Carbohydrate enriched diets have been shown to elevate blood pressure in the rat. The precise mechanism by which carbohydrate feeding elevates blood pressure…”
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Angiotensin II Type 1 Receptor Antisense Gene Therapy Prevents Altered Renal Vascular Calcium Homeostasis in Hypertension by Gelband, Craig H, Reaves, Phyllis Y, Evans, Jenafer, Wang, Hongwei, Katovich, Michael J, Raizada, Mohan K

“…Intracellular Ca ([Ca]i) homeostasis regulates vascular smooth muscle tone, and alteration in [Ca]i handling is associated with the development and…”
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Erectile and copulatory dysfunction in chronically diabetic BB/WOR rats by Murray, F T, Johnson, R D, Sciadini, M, Katovich, M J, Rountree, J, Jewett, H

“…The pituitary-testicular axis, penile reflexes, and copulatory behavior were studied in male BB diabetic rats from 10 to 40 wk of diabetes. Serum testosterone…”
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The effect of nitroglycerin on the gravid uterus in sheep and rabbits by LANGEVIN, P. B, KATOVICH, M. J, WOOD, C. E, JAMES, C. F, LANGEVIN, S. O

“…Clinical reports suggest that nitroglycerin (TNG) has an effect on the uterus that is detected by the obstetrician on palpation, but not obvious by measurement…”
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Vascular reactivity to phenylephrine and angiotensin II in hypertensive rats associated with insulin resistance by Iyer, S N, Katovich, M J

“…Previous reports suggest that when rats are fed a carbohydrate-enriched diet they develop hyperinsulinemia associated with elevated blood pressure. The purpose…”
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Chronic Losartan treatment blocks isoproterenol-induced dipsogenesis by Iyer, S.N., Wright, B.E., Strubbe, G., Hanley, K., Katovich, M.J.

“…Previous studies suggest that beta-adrenergic receptor agonists and other hypotensive agents stimulate water intake via the renin-angiotensin system (RAS)…”
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Effects of streptozotocin-induced diabetes and insulin treatment on blood pressure in the male rat by Katovich, M J, Hanley, K, Strubbe, G, Wright, B E

“…Hyperinsulinemia may link diabetes to hypertension. We evaluated the effects of insulin on blood glucose and blood pressure in control and streptozotocin…”
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Beneficial effects of dietary acarbose in the streptozotocin-induced diabetic rat by Katovich, M J, Meldrum, M J, Vasselli, J R

“…Diabetes is characterized by hyperphagia, polydipsia, polyuria, and elevations in blood and urinary glucose. It has also been documented that beta-adrenergic…”
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